G13 -
SST2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | H8 | D | 317 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | R | 349 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | R | 349 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | R | 349 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | Q | 357 | - | G.H2 | K | 231 | G.H2.05 |
Polar | H8 | D | 317 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | D | 317 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | F | 319 | 8x50 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | K | 234 | 5x64 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | K | 234 | 5x64 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | I | 148 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | I | 148 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | TM6 | K | 253 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | I | 148 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | I | 369 | - | G.H2 | R | 230 | G.H2.04 |
Van-der-waals | C-term | I | 369 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | ICL2 | K | 152 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | V | 254 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | V | 254 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | T | 367 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | C-term | T | 367 | - | G.H2 | R | 230 | G.H2.04 |
Van-der-waals | C-term | T | 367 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Polar | TM3 | V | 145 | 3x55 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | C-term | S | 368 | - | G.H2 | R | 227 | G.H2.01 |
Polar | TM6 | K | 246 | 6x25 | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | TM6 | K | 246 | 6x25 | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | C-term | I | 369 | - | G.s1h1 | G | 55 | G.s1h1.01 |
Van-der-waals | C-term | I | 369 | - | G.s1h1 | G | 55 | G.s1h1.01 |
Polar | TM6 | R | 247 | 6x26 | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | TM6 | R | 247 | 6x26 | G.S6 | Y | 343 | G.S6.02 |
Polar | H8 | S | 316 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | H8 | S | 316 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | L | 361 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | I | 369 | - | G.H1 | K | 61 | G.H1.01 |
Hydrophobic | TM6 | S | 244 | 6x23 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL3 | V | 242 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | ICL3 | V | 242 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Ionic | TM6 | R | 247 | 6x26 | G.H5 | D | 364 | G.H5.13 |
Polar | TM6 | R | 247 | 6x26 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM6 | R | 247 | 6x26 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM6 | R | 247 | 6x26 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | C-term | I | 369 | - | G.S1 | L | 54 | G.S1.07 |
Hydrophobic | TM2 | I | 82 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | V | 144 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 147 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | I | 369 | - | G.H3 | I | 271 | G.H3.08 |
Hydrophobic | ICL3 | R | 241 | - | G.H5 | R | 360 | G.H5.09 |
Polar | H8 | S | 316 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | S | 316 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | S | 316 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | A | 143 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | A | 143 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | T | 367 | - | G.H3 | E | 267 | G.H3.04 |
Hydrophobic | ICL2 | A | 151 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | L | 365 | - | G.H3 | T | 274 | G.H3.11 |
Van-der-waals | TM7 | L | 315 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL1 | K | 73 | 12x49 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | ICL1 | K | 73 | 12x49 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | P | 147 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM6 | K | 253 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | S | 250 | 6x29 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | I | 369 | - | G.H2 | F | 234 | G.H2.08 |
Polar | H8 | N | 318 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | N | 318 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | N | 318 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | K | 234 | 5x64 | G.H5 | K | 363 | G.H5.12 |
Ionic | C-term | E | 352 | - | G.H3 | R | 279 | G.H3.16 |
Polar | C-term | E | 352 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | E | 352 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | E | 352 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | I | 369 | - | G.H3 | I | 275 | G.H3.12 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM6 | M | 257 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | M | 257 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | I | 148 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Polar | TM5 | S | 238 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | S | 238 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | S | 238 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ICL3 | V | 242 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM6 | R | 247 | 6x26 | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | C-term | I | 369 | - | G.s3h2 | G | 225 | G.s3h2.02 |
Van-der-waals | C-term | I | 369 | - | G.s3h2 | G | 225 | G.s3h2.02 |
Hydrophobic | ICL2 | I | 148 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | I | 148 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | TM5 | V | 235 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | V | 235 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Polar | H8 | N | 318 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | N | 318 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | N | 318 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL3 | V | 242 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | ICL3 | V | 242 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM6 | K | 246 | 6x25 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | TM2 | T | 78 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Polar | TM4 | R | 155 | 4x38 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM4 | R | 155 | 4x38 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM4 | R | 155 | 4x38 | G.HN | T | 43 | G.HN.52 |
Polar | TM6 | K | 246 | 6x25 | G.h4s6 | D | 336 | G.h4s6.10 |
Hydrophobic | TM6 | V | 254 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | V | 254 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Polar | TM3 | A | 143 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 143 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 143 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Polar | ICL2 | R | 154 | 34x57 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Polar | C-term | T | 353 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | T | 353 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | T | 353 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | TM6 | S | 250 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | S | 250 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM1 | R | 70 | 1x59 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM1 | R | 70 | 1x59 | G.HN | M | 1 | G.HN.01 |