Gt1 - SST2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 V 242 - G.H5 D 333 G.H5.09
Van-der-waals ICL3 V 242 - G.H5 D 333 G.H5.09
Hydrophobic TM3 R 140 3x50 G.H5 L 349 G.H5.25
Van-der-waals TM3 R 140 3x50 G.H5 L 349 G.H5.25
Hydrophobic TM3 V 144 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 V 144 3x54 G.H5 L 344 G.H5.20
Hydrophobic ICL2 I 148 34x51 G.s2s3 D 189 G.s2s3.02
Hydrophobic ICL3 V 242 - G.H5 F 330 G.H5.06
Polar TM6 K 246 6x25 G.h4s6 R 310 G.h4s6.08
Hydrophobic TM6 K 246 6x25 G.h4s6 R 310 G.h4s6.08
Van-der-waals TM6 K 246 6x25 G.h4s6 R 310 G.h4s6.08
Hydrophobic TM5 V 235 5x65 G.H5 L 344 G.H5.20
Hydrophobic C-term I 369 - G.H3 H 244 G.H3.07
Van-der-waals C-term I 369 - G.H3 H 244 G.H3.07
Polar ICL2 R 154 34x57 G.H5 N 343 G.H5.19
Polar H8 N 318 8x49 G.H5 K 345 G.H5.21
Hydrophobic ICL3 V 242 - G.S6 Y 316 G.S6.02
Van-der-waals ICL3 V 242 - G.S6 Y 316 G.S6.02
Polar TM5 S 238 5x68 G.H5 D 337 G.H5.13
Hydrophobic H8 S 316 8x47 G.H5 G 348 G.H5.24
Hydrophobic TM6 S 250 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 S 250 6x29 G.H5 F 350 G.H5.26
Hydrophobic TM6 M 257 6x36 G.H5 G 348 G.H5.24
Van-der-waals TM6 M 257 6x36 G.H5 G 348 G.H5.24
Hydrophobic TM5 K 234 5x64 G.H5 I 340 G.H5.16
Van-der-waals TM5 K 234 5x64 G.H5 I 340 G.H5.16
Hydrophobic TM4 R 155 4x38 G.HN K 20 G.HN.48
Van-der-waals TM4 R 155 4x38 G.HN K 20 G.HN.48
Hydrophobic C-term L 361 - G.H2 K 205 G.H2.05
Van-der-waals C-term L 361 - G.H2 K 205 G.H2.05
Hydrophobic ICL2 K 152 34x55 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 K 152 34x55 G.hns1 R 28 G.hns1.03
Polar TM6 K 246 6x25 G.h4s6 K 313 G.h4s6.11
Van-der-waals TM6 K 246 6x25 G.h4s6 K 313 G.h4s6.11
Polar TM3 A 143 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 A 143 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 343 G.H5.19
Hydrophobic C-term L 360 - G.H2 I 208 G.H2.08
Van-der-waals C-term L 360 - G.H2 I 208 G.H2.08
Hydrophobic ICL3 V 242 - G.H5 D 337 G.H5.13
Hydrophobic TM6 V 254 6x33 G.H5 L 349 G.H5.25
Van-der-waals TM6 V 254 6x33 G.H5 L 349 G.H5.25
Polar TM6 K 253 6x32 G.H5 F 350 G.H5.26
Hydrophobic TM6 K 253 6x32 G.H5 F 350 G.H5.26
Van-der-waals TM6 K 253 6x32 G.H5 F 350 G.H5.26
Polar ICL2 I 148 34x51 G.hns1 R 28 G.hns1.03
Polar C-term T 356 - G.H3 R 253 G.H3.16
Ionic ICL2 K 149 34x52 G.s2s3 D 189 G.s2s3.02
Hydrophobic ICL2 K 149 34x52 G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 K 149 34x52 G.s2s3 D 189 G.s2s3.02
Polar TM3 R 140 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM6 V 258 6x37 G.H5 L 349 G.H5.25
Hydrophobic ICL2 P 147 34x50 G.H5 I 340 G.H5.16
Ionic TM4 R 157 4x40 G.HN E 16 G.HN.44
Polar TM4 R 157 4x40 G.HN E 16 G.HN.44
Van-der-waals TM4 R 157 4x40 G.HN E 16 G.HN.44
Hydrophobic ICL2 I 148 34x51 G.H5 F 332 G.H5.08
Van-der-waals ICL2 I 148 34x51 G.H5 F 332 G.H5.08
Polar ICL2 K 149 34x52 G.hns1 R 28 G.hns1.03
Hydrophobic TM3 A 143 3x53 G.H5 C 347 G.H5.23
Hydrophobic TM2 T 78 2x39 G.H5 C 347 G.H5.23
Hydrophobic TM5 S 238 5x68 G.H5 I 340 G.H5.16
Hydrophobic ICL3 V 242 - G.H5 A 334 G.H5.10
Hydrophobic TM6 M 257 6x36 G.H5 L 349 G.H5.25
Van-der-waals TM6 M 257 6x36 G.H5 L 349 G.H5.25
Ionic TM6 R 247 6x26 G.H5 D 337 G.H5.13
Polar TM6 R 247 6x26 G.H5 D 337 G.H5.13
Hydrophobic TM6 R 247 6x26 G.H5 D 337 G.H5.13
Van-der-waals TM6 R 247 6x26 G.H5 D 337 G.H5.13
Hydrophobic C-term T 356 - G.H2 I 208 G.H2.08
Polar TM6 S 244 6x23 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM6 S 244 6x23 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 S 244 6x23 G.h4s6 E 314 G.h4s6.12
Hydrophobic ICL2 P 147 34x50 G.H5 T 336 G.H5.12
Polar TM2 T 78 2x39 G.H5 D 346 G.H5.22
Van-der-waals TM2 T 78 2x39 G.H5 D 346 G.H5.22
Hydrophobic TM3 V 144 3x54 G.H5 I 340 G.H5.16
Van-der-waals TM3 V 144 3x54 G.H5 I 340 G.H5.16
Ionic TM4 R 155 4x38 G.HN E 24 G.HN.52
Polar TM4 R 155 4x38 G.HN E 24 G.HN.52
Hydrophobic TM4 R 155 4x38 G.HN E 24 G.HN.52
Van-der-waals TM4 R 155 4x38 G.HN E 24 G.HN.52
Hydrophobic C-term L 365 - G.H3 S 248 G.H3.11
Van-der-waals C-term L 365 - G.H3 S 248 G.H3.11
Hydrophobic ICL2 P 147 34x50 G.H5 I 339 G.H5.15
Van-der-waals ICL2 P 147 34x50 G.H5 I 339 G.H5.15
Ionic ICL3 R 241 - G.H5 D 333 G.H5.09
Polar ICL3 R 241 - G.H5 D 333 G.H5.09
Hydrophobic ICL3 R 241 - G.H5 D 333 G.H5.09
Hydrophobic ICL2 I 148 34x51 G.S3 L 190 G.S3.01
Van-der-waals ICL2 I 148 34x51 G.S3 L 190 G.S3.01
Hydrophobic TM6 V 254 6x33 G.H5 L 344 G.H5.20
Polar ICL2 R 154 34x57 G.H5 C 347 G.H5.23