Gi2 - SST3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 255 6x33 G.H5 L 349 G.H5.20
Hydrophobic C-term L 400 - G.H3 N 257 G.H3.15
Van-der-waals C-term L 400 - G.H3 N 257 G.H3.15
Hydrophobic TM3 V 145 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 V 145 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM5 A 236 5x68 G.H5 I 345 G.H5.16
Polar TM3 R 141 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 C 352 G.H5.23
Polar TM2 T 79 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM2 T 79 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 T 79 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM5 V 240 5x72 G.H5 F 335 G.H5.06
Ionic C-term K 395 - G.s4h3 D 238 G.s4h3.11
Aromatic ICL3 W 241 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 W 241 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 W 241 - G.S6 Y 321 G.S6.02
Ionic ICL2 R 150 34x52 G.s2s3 D 194 G.s2s3.02
Polar ICL2 R 150 34x52 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 R 150 34x52 G.s2s3 D 194 G.s2s3.02
Polar TM6 R 247 6x25 G.h4s6 T 317 G.h4s6.10
Van-der-waals TM6 R 247 6x25 G.h4s6 T 317 G.h4s6.10
Hydrophobic TM5 V 240 5x72 G.H5 D 342 G.H5.13
Ionic H8 R 319 8x49 G.H5 D 351 G.H5.22
Polar H8 R 319 8x49 G.H5 D 351 G.H5.22
Hydrophobic H8 R 319 8x49 G.H5 D 351 G.H5.22
Van-der-waals H8 R 319 8x49 G.H5 D 351 G.H5.22
Ionic C-term K 395 - G.s4h3 E 240 G.s4h3.13
Polar C-term K 395 - G.s4h3 E 240 G.s4h3.13
Van-der-waals C-term K 395 - G.s4h3 E 240 G.s4h3.13
Hydrophobic TM3 R 141 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 141 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 A 152 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic C-term L 400 - G.H3 I 254 G.H3.12
Hydrophobic TM2 T 79 2x39 G.H5 C 352 G.H5.23
Van-der-waals ICL3 W 241 - G.H5 K 346 G.H5.17
Hydrophobic TM5 V 240 5x72 G.H5 D 338 G.H5.09
Van-der-waals TM5 V 240 5x72 G.H5 D 338 G.H5.09
Hydrophobic ICL2 P 148 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL2 P 148 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 148 34x50 G.H5 I 344 G.H5.15
Hydrophobic H8 R 319 8x49 G.H5 K 350 G.H5.21
Ionic TM6 R 247 6x25 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 247 6x25 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 247 6x25 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 K 232 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 K 232 5x64 G.H5 I 345 G.H5.16
Hydrophobic ICL2 T 149 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 T 149 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM5 V 233 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM3 V 145 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 145 3x54 G.H5 L 349 G.H5.20
Polar TM5 G 237 5x69 G.H5 D 342 G.H5.13
Hydrophobic TM6 M 258 6x36 G.H5 L 354 G.H5.25
Polar ICL2 R 153 34x55 G.HN R 24 G.HN.48
Polar TM6 R 254 6x32 G.H5 F 355 G.H5.26
Aromatic TM6 R 254 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 R 254 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 254 6x32 G.H5 F 355 G.H5.26
Polar TM6 R 247 6x25 G.h4s6 K 318 G.h4s6.11
Hydrophobic TM6 R 247 6x25 G.h4s6 K 318 G.h4s6.11
Van-der-waals TM6 R 247 6x25 G.h4s6 K 318 G.h4s6.11
Polar TM6 R 247 6x25 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM6 R 247 6x25 G.h4s6 K 315 G.h4s6.08
Van-der-waals TM6 R 247 6x25 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM5 I 229 5x61 G.H5 L 354 G.H5.25
Polar ICL3 W 241 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 W 241 - G.H5 D 342 G.H5.13
Ionic TM5 R 239 5x71 G.H5 D 338 G.H5.09
Polar TM5 R 239 5x71 G.H5 D 338 G.H5.09
Hydrophobic TM5 R 239 5x71 G.H5 D 338 G.H5.09
Van-der-waals TM5 R 239 5x71 G.H5 D 338 G.H5.09
Hydrophobic TM5 V 233 5x65 G.H5 I 345 G.H5.16
Hydrophobic C-term L 400 - G.H3 S 253 G.H3.11
Van-der-waals C-term L 400 - G.H3 S 253 G.H3.11
Hydrophobic ICL2 R 153 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 153 34x55 G.HN E 28 G.HN.52
Ionic TM6 R 250 6x28 G.h4s6 D 316 G.h4s6.09
Polar TM6 R 250 6x28 G.h4s6 D 316 G.h4s6.09
Hydrophobic ICL2 P 148 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM5 Y 226 5x58 G.H5 L 354 G.H5.25
Hydrophobic TM5 V 240 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 V 240 5x72 G.S6 Y 321 G.S6.02
Polar TM3 A 144 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL3 W 241 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 W 241 - G.h4s6 E 319 G.h4s6.12
Hydrophobic H8 S 317 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM3 A 144 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM5 V 240 5x72 G.H5 A 339 G.H5.10
Van-der-waals TM5 V 240 5x72 G.H5 A 339 G.H5.10
Polar TM6 R 247 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 R 247 6x25 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 R 247 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic ICL3 W 241 - G.S6 I 320 G.S6.01
Van-der-waals ICL3 W 241 - G.S6 I 320 G.S6.01
Polar C-term Q 398 - G.H2 K 210 G.H2.05
Hydrophobic ICL2 R 153 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 153 34x55 G.hns1 R 32 G.hns1.03