Gs -
SST3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Van-der-waals | TM5 | R | 239 | 5x71 | G.H5 | R | 380 | G.H5.12 |
Ionic | C-term | D | 357 | - | G.HN | K | 24 | G.HN.41 |
Polar | C-term | D | 357 | - | G.HN | K | 24 | G.HN.41 |
Van-der-waals | C-term | D | 357 | - | G.HN | K | 24 | G.HN.41 |
Polar | C-term | N | 371 | - | G.H1 | H | 64 | G.H1.12 |
Hydrophobic | ICL2 | T | 149 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL3 | W | 241 | - | G.H4 | Y | 339 | G.H4.08 |
Polar | TM6 | R | 247 | 6x25 | G.h4s6 | G | 353 | G.h4s6.09 |
Hydrophobic | TM6 | R | 247 | 6x25 | G.h4s6 | G | 353 | G.h4s6.09 |
Van-der-waals | TM6 | R | 247 | 6x25 | G.h4s6 | G | 353 | G.h4s6.09 |
Hydrophobic | ICL3 | W | 241 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | C-term | E | 356 | - | G.HN | K | 28 | G.HN.45 |
Hydrophobic | TM6 | M | 258 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | M | 258 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Polar | C-term | Q | 397 | - | G.H2 | R | 228 | G.H2.01 |
Polar | ICL2 | R | 155 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Aromatic | ICL2 | R | 155 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | R | 155 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | R | 155 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Polar | TM5 | R | 239 | 5x71 | G.H5 | N | 377 | G.H5.09 |
Hydrophobic | C-term | G | 372 | - | G.h1ha | V | 65 | G.h1ha.01 |
Hydrophobic | TM6 | S | 251 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | S | 251 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Ionic | C-term | E | 349 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | C-term | E | 349 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | C-term | E | 349 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | C-term | E | 349 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | M | 258 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | M | 258 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Polar | C-term | E | 354 | - | G.HN | Q | 31 | G.HN.48 |
Hydrophobic | C-term | E | 354 | - | G.HN | Q | 31 | G.HN.48 |
Van-der-waals | C-term | E | 354 | - | G.HN | Q | 31 | G.HN.48 |
Hydrophobic | TM6 | V | 255 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Polar | C-term | S | 375 | - | G.S2 | E | 209 | G.S2.03 |
Van-der-waals | C-term | S | 375 | - | G.S2 | E | 209 | G.S2.03 |
Hydrophobic | C-term | L | 399 | - | G.H3 | S | 275 | G.H3.11 |
Hydrophobic | C-term | L | 399 | - | G.H3 | N | 271 | G.H3.07 |
Van-der-waals | C-term | L | 399 | - | G.H3 | N | 271 | G.H3.07 |
Polar | TM3 | A | 144 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 144 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 144 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | C-term | E | 351 | - | G.HN | K | 34 | G.HN.51 |
Polar | H8 | S | 317 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | S | 317 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | S | 317 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | N | 371 | - | G.S2 | F | 212 | G.S2.06 |
Van-der-waals | C-term | N | 371 | - | G.S2 | F | 212 | G.S2.06 |
Hydrophobic | C-term | Q | 376 | - | G.S2 | F | 208 | G.S2.02 |
Hydrophobic | ICL2 | T | 149 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Ionic | TM6 | R | 254 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | R | 254 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | T | 149 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL3 | W | 241 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | W | 241 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | C-term | N | 371 | - | G.h1ha | V | 65 | G.h1ha.01 |
Van-der-waals | C-term | N | 371 | - | G.h1ha | V | 65 | G.h1ha.01 |
Polar | C-term | E | 354 | - | G.HN | K | 28 | G.HN.45 |
Van-der-waals | C-term | E | 354 | - | G.HN | K | 28 | G.HN.45 |
Ionic | H8 | K | 321 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | L | 400 | - | G.H3 | S | 275 | G.H3.11 |
Van-der-waals | C-term | L | 400 | - | G.H3 | S | 275 | G.H3.11 |
Hydrophobic | C-term | P | 401 | - | G.H2 | R | 231 | G.H2.04 |
Van-der-waals | C-term | Q | 376 | - | G.S2 | I | 207 | G.S2.01 |
Van-der-waals | C-term | E | 353 | - | G.HN | Q | 31 | G.HN.48 |
Van-der-waals | TM6 | R | 248 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | C-term | L | 400 | - | G.H2 | W | 234 | G.H2.07 |
Van-der-waals | C-term | L | 400 | - | G.H2 | W | 234 | G.H2.07 |
Polar | C-term | I | 377 | - | G.S2 | I | 207 | G.S2.01 |
Hydrophobic | C-term | I | 377 | - | G.S2 | I | 207 | G.S2.01 |
Van-der-waals | C-term | I | 377 | - | G.S2 | I | 207 | G.S2.01 |
Hydrophobic | C-term | P | 344 | - | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | C-term | E | 354 | - | G.HN | E | 27 | G.HN.44 |
Van-der-waals | C-term | E | 354 | - | G.HN | E | 27 | G.HN.44 |
Polar | H8 | Y | 318 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | Y | 318 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | Y | 318 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | P | 243 | - | G.H4 | L | 346 | G.H4.16 |
Polar | ICL2 | R | 155 | 34x57 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | R | 155 | 34x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | I | 377 | - | G.S2 | E | 209 | G.S2.03 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM6 | R | 254 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | R | 254 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | R | 254 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Ionic | TM6 | R | 248 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Polar | TM6 | R | 248 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | C-term | V | 374 | - | G.S2 | F | 208 | G.S2.02 |
Hydrophobic | ICL3 | W | 241 | - | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | ICL3 | W | 241 | - | G.H4 | R | 342 | G.H4.12 |
Polar | TM2 | T | 79 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | C-term | V | 374 | - | G.S2 | E | 209 | G.S2.03 |
Van-der-waals | C-term | V | 374 | - | G.S2 | E | 209 | G.S2.03 |
Hydrophobic | ICL2 | A | 152 | 34x54 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | TM5 | V | 240 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | V | 240 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Ionic | C-term | K | 366 | - | G.h1ha | E | 75 | G.h1ha.11 |
Hydrophobic | C-term | N | 371 | - | G.S2 | K | 211 | G.S2.05 |
Van-der-waals | C-term | N | 371 | - | G.S2 | K | 211 | G.S2.05 |
Polar | TM6 | V | 255 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | V | 255 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | V | 255 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | L | 400 | - | G.H3 | I | 276 | G.H3.12 |
Van-der-waals | C-term | L | 400 | - | G.H3 | I | 276 | G.H3.12 |
Hydrophobic | TM3 | V | 145 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | V | 145 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | C-term | L | 399 | - | G.H2 | R | 231 | G.H2.04 |
Van-der-waals | C-term | L | 399 | - | G.H2 | R | 231 | G.H2.04 |
Ionic | C-term | D | 352 | - | G.HN | K | 34 | G.HN.51 |
Polar | C-term | D | 352 | - | G.HN | K | 34 | G.HN.51 |
Van-der-waals | C-term | D | 352 | - | G.HN | K | 34 | G.HN.51 |
Ionic | C-term | E | 403 | - | G.H3 | R | 280 | G.H3.16 |
Polar | C-term | E | 403 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | E | 403 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | E | 403 | - | G.H3 | R | 280 | G.H3.16 |
Polar | H8 | R | 319 | 8x49 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | H8 | R | 319 | 8x49 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | H8 | R | 319 | 8x49 | G.H5 | Q | 390 | G.H5.22 |
Ionic | C-term | E | 351 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | C-term | E | 351 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | C-term | E | 351 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | C-term | E | 351 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | C-term | N | 371 | - | G.S2 | Q | 213 | G.S2.07 |
Hydrophobic | C-term | N | 371 | - | G.S2 | Q | 213 | G.S2.07 |
Van-der-waals | C-term | N | 371 | - | G.S2 | Q | 213 | G.S2.07 |
Hydrophobic | C-term | E | 403 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | C-term | E | 403 | - | G.H3 | W | 281 | G.H3.17 |
Polar | C-term | K | 347 | - | G.hns1 | Y | 37 | G.hns1.01 |
Hydrophobic | TM2 | T | 79 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | T | 79 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | R | 141 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Polar | C-term | D | 352 | - | G.HN | Q | 31 | G.HN.48 |
Van-der-waals | C-term | D | 352 | - | G.HN | Q | 31 | G.HN.48 |
Hydrophobic | TM3 | V | 145 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Polar | C-term | E | 350 | - | G.HN | K | 34 | G.HN.51 |
Hydrophobic | C-term | E | 350 | - | G.HN | K | 34 | G.HN.51 |
Van-der-waals | C-term | E | 350 | - | G.HN | K | 34 | G.HN.51 |
Hydrophobic | C-term | V | 374 | - | G.S2 | T | 210 | G.S2.04 |
Hydrophobic | C-term | I | 377 | - | G.S3 | F | 222 | G.S3.06 |
Van-der-waals | C-term | I | 377 | - | G.S3 | F | 222 | G.S3.06 |
Hydrophobic | ICL3 | W | 241 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Van-der-waals | ICL3 | W | 241 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Hydrophobic | TM5 | V | 233 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | V | 233 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | V | 240 | 5x72 | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | TM5 | V | 240 | 5x72 | G.S6 | Y | 360 | G.S6.02 |
Ionic | C-term | E | 355 | - | G.HN | K | 24 | G.HN.41 |
Polar | C-term | E | 355 | - | G.HN | K | 24 | G.HN.41 |
Hydrophobic | TM7 | L | 316 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | L | 316 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | L | 399 | - | G.H3 | E | 268 | G.H3.04 |
Van-der-waals | C-term | L | 399 | - | G.H3 | E | 268 | G.H3.04 |
Hydrophobic | TM5 | K | 232 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | K | 232 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | C-term | L | 399 | - | G.H3 | L | 272 | G.H3.08 |
Polar | C-term | D | 357 | - | G.HN | K | 28 | G.HN.45 |
Van-der-waals | C-term | D | 357 | - | G.HN | K | 28 | G.HN.45 |
Ionic | C-term | K | 347 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | C-term | K | 347 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | C-term | K | 347 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | C-term | K | 347 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | TM4 | T | 156 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM5 | A | 236 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | A | 236 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | C-term | L | 400 | - | G.H3 | N | 279 | G.H3.15 |
Van-der-waals | C-term | L | 400 | - | G.H3 | N | 279 | G.H3.15 |
Polar | TM3 | D | 140 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | D | 140 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | D | 140 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | V | 145 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | V | 145 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | V | 145 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | C-term | M | 370 | - | G.S2 | K | 211 | G.S2.05 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM3 | A | 144 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | A | 144 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | C-term | Q | 379 | - | G.H2 | Q | 236 | G.H2.09 |
Hydrophobic | C-term | Q | 379 | - | G.H2 | Q | 236 | G.H2.09 |
Van-der-waals | C-term | Q | 379 | - | G.H2 | Q | 236 | G.H2.09 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | C-term | V | 374 | - | G.H1 | R | 61 | G.H1.09 |
Polar | C-term | K | 347 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | C-term | K | 347 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | C-term | K | 347 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Polar | C-term | Q | 376 | - | G.hfs2 | S | 205 | G.hfs2.06 |
Hydrophobic | ICL2 | T | 149 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | T | 149 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Ionic | ICL2 | R | 150 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | C-term | P | 401 | - | G.H2 | R | 232 | G.H2.05 |