Gt1 -
SST3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 11.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | R | 247 | 6x25 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | TM6 | R | 247 | 6x25 | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | TM6 | R | 247 | 6x25 | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | C-term | V | 374 | - | G.S2 | E | 182 | G.S2.03 |
Polar | TM3 | A | 144 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | A | 144 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM3 | A | 144 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM5 | Y | 226 | 5x58 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM6 | V | 255 | 6x33 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | TM5 | I | 229 | 5x61 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | TM3 | V | 145 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | V | 145 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Ionic | ICL2 | R | 150 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Polar | ICL2 | R | 150 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 150 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 150 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | TM3 | V | 145 | 3x54 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | TM3 | V | 145 | 3x54 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM5 | V | 233 | 5x65 | G.H5 | I | 340 | G.H5.16 |
Aromatic | ICL3 | W | 241 | - | G.S6 | Y | 316 | G.S6.02 |
Hydrophobic | ICL3 | W | 241 | - | G.S6 | Y | 316 | G.S6.02 |
Van-der-waals | ICL3 | W | 241 | - | G.S6 | Y | 316 | G.S6.02 |
Hydrophobic | TM5 | V | 240 | 5x72 | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | ICL2 | R | 153 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | R | 153 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Polar | C-term | S | 375 | - | G.S2 | E | 182 | G.S2.03 |
Hydrophobic | C-term | L | 400 | - | G.H3 | I | 249 | G.H3.12 |
Ionic | C-term | E | 403 | - | G.H3 | R | 253 | G.H3.16 |
Polar | C-term | E | 403 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | C-term | E | 403 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | E | 403 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | C-term | P | 401 | - | G.H2 | I | 208 | G.H2.08 |
Polar | C-term | E | 403 | - | G.H3 | Y | 254 | G.H3.17 |
Hydrophobic | C-term | E | 403 | - | G.H3 | Y | 254 | G.H3.17 |
Van-der-waals | C-term | E | 403 | - | G.H3 | Y | 254 | G.H3.17 |
Hydrophobic | TM2 | T | 79 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM5 | V | 240 | 5x72 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | H8 | S | 317 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | C-term | L | 400 | - | G.H2 | W | 207 | G.H2.07 |
Van-der-waals | C-term | L | 400 | - | G.H2 | W | 207 | G.H2.07 |
Ionic | TM6 | R | 247 | 6x25 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | TM6 | R | 247 | 6x25 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | TM6 | R | 247 | 6x25 | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | TM6 | R | 247 | 6x25 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | TM5 | A | 236 | 5x68 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM6 | S | 251 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | S | 251 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | C-term | L | 399 | - | G.H2 | R | 204 | G.H2.04 |
Van-der-waals | C-term | L | 399 | - | G.H2 | R | 204 | G.H2.04 |
Polar | TM3 | R | 141 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | R | 141 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Ionic | TM5 | R | 239 | 5x71 | G.H5 | D | 333 | G.H5.09 |
Polar | TM5 | R | 239 | 5x71 | G.H5 | D | 333 | G.H5.09 |
Hydrophobic | TM5 | R | 239 | 5x71 | G.H5 | D | 333 | G.H5.09 |
Van-der-waals | TM5 | R | 239 | 5x71 | G.H5 | D | 333 | G.H5.09 |
Hydrophobic | TM5 | K | 232 | 5x64 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | C-term | P | 401 | - | G.H2 | R | 204 | G.H2.04 |
Van-der-waals | C-term | P | 401 | - | G.H2 | R | 204 | G.H2.04 |
Hydrophobic | TM4 | T | 156 | 4x38 | G.HN | K | 20 | G.HN.48 |
Hydrophobic | ICL3 | W | 241 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | ICL3 | W | 241 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | C-term | I | 377 | - | G.S2 | I | 180 | G.S2.01 |
Hydrophobic | C-term | I | 377 | - | G.S2 | I | 180 | G.S2.01 |
Van-der-waals | C-term | I | 377 | - | G.S2 | I | 180 | G.S2.01 |
Hydrophobic | ICL2 | T | 149 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | T | 149 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | C-term | L | 400 | - | G.H3 | S | 248 | G.H3.11 |
Van-der-waals | C-term | L | 400 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | ICL3 | W | 241 | - | G.S6 | I | 315 | G.S6.01 |
Van-der-waals | ICL3 | W | 241 | - | G.S6 | I | 315 | G.S6.01 |
Hydrophobic | TM5 | V | 240 | 5x72 | G.H5 | D | 333 | G.H5.09 |
Van-der-waals | TM5 | V | 240 | 5x72 | G.H5 | D | 333 | G.H5.09 |
Ionic | H8 | R | 319 | 8x49 | G.H5 | E | 342 | G.H5.18 |
Hydrophobic | ICL2 | A | 152 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM6 | M | 258 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | L | 400 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | C-term | P | 401 | - | G.H2 | K | 205 | G.H2.05 |
Polar | TM6 | R | 247 | 6x25 | G.h4s6 | R | 310 | G.h4s6.08 |
Hydrophobic | TM6 | R | 247 | 6x25 | G.h4s6 | R | 310 | G.h4s6.08 |
Van-der-waals | TM6 | R | 247 | 6x25 | G.h4s6 | R | 310 | G.h4s6.08 |
Polar | TM6 | R | 254 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Aromatic | TM6 | R | 254 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | R | 254 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | R | 254 | 6x32 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | V | 255 | 6x33 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM3 | A | 144 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM5 | V | 233 | 5x65 | G.H5 | L | 344 | G.H5.20 |
Polar | TM6 | R | 247 | 6x25 | G.h4s6 | K | 313 | G.h4s6.11 |
Hydrophobic | TM6 | R | 247 | 6x25 | G.h4s6 | K | 313 | G.h4s6.11 |
Van-der-waals | TM6 | R | 247 | 6x25 | G.h4s6 | K | 313 | G.h4s6.11 |
Polar | ICL3 | W | 241 | - | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | ICL3 | W | 241 | - | G.H5 | D | 337 | G.H5.13 |
Ionic | H8 | R | 319 | 8x49 | G.H5 | D | 346 | G.H5.22 |
Polar | H8 | R | 319 | 8x49 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | H8 | R | 319 | 8x49 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | H8 | R | 319 | 8x49 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | C-term | L | 400 | - | G.H3 | H | 252 | G.H3.15 |
Van-der-waals | C-term | L | 400 | - | G.H3 | H | 252 | G.H3.15 |
Polar | TM2 | T | 79 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM2 | T | 79 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | V | 374 | - | G.S2 | I | 181 | G.S2.02 |
Van-der-waals | C-term | V | 374 | - | G.S2 | I | 181 | G.S2.02 |
Hydrophobic | C-term | L | 399 | - | G.H3 | E | 241 | G.H3.04 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Polar | TM6 | R | 247 | 6x25 | G.h4s6 | V | 312 | G.h4s6.10 |
Van-der-waals | TM6 | R | 247 | 6x25 | G.h4s6 | V | 312 | G.h4s6.10 |
Hydrophobic | TM5 | V | 240 | 5x72 | G.H5 | A | 334 | G.H5.10 |
Van-der-waals | TM5 | V | 240 | 5x72 | G.H5 | A | 334 | G.H5.10 |
Hydrophobic | C-term | L | 399 | - | G.H3 | L | 245 | G.H3.08 |
Hydrophobic | ICL2 | R | 153 | 34x55 | G.HN | E | 24 | G.HN.52 |
Hydrophobic | C-term | L | 399 | - | G.H3 | H | 244 | G.H3.07 |
Van-der-waals | C-term | L | 399 | - | G.H3 | H | 244 | G.H3.07 |
Hydrophobic | C-term | E | 403 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | TM5 | V | 240 | 5x72 | G.S6 | Y | 316 | G.S6.02 |
Polar | TM5 | G | 237 | 5x69 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | C-term | Q | 376 | - | G.S2 | I | 181 | G.S2.02 |