Gi2 - SST4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term Y 346 - G.H2 R 206 G.H2.01
Ionic TM6 R 250 6x26 G.H5 D 342 G.H5.13
Polar TM6 R 250 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM6 R 250 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 250 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM6 Q 249 6x25 G.h4s6 D 316 G.h4s6.09
Polar C-term R 379 - G.hfs2 T 183 G.hfs2.06
Van-der-waals C-term R 379 - G.hfs2 T 183 G.hfs2.06
Polar C-term R 377 - G.hfs2 T 182 G.hfs2.05
Hydrophobic C-term R 377 - G.hfs2 T 182 G.hfs2.05
Van-der-waals C-term R 377 - G.hfs2 T 182 G.hfs2.05
Hydrophobic TM6 W 247 6x23 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 W 247 6x23 G.h4s6 E 319 G.h4s6.12
Van-der-waals C-term Q 372 - G.hfs2 V 180 G.hfs2.03
Hydrophobic ICL2 L 152 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 P 151 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 151 34x50 G.H5 I 345 G.H5.16
Ionic C-term R 377 - G.S3 D 201 G.S3.07
Polar C-term R 377 - G.S3 D 201 G.S3.07
Van-der-waals C-term R 377 - G.S3 D 201 G.S3.07
Hydrophobic C-term L 382 - G.H2 H 214 G.H2.09
Hydrophobic TM5 M 238 5x65 G.H5 I 345 G.H5.16
Hydrophobic TM3 A 147 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 A 147 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM6 S 253 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 S 253 6x29 G.H5 F 355 G.H5.26
Polar C-term Y 347 - G.s4h3 D 238 G.s4h3.11
Hydrophobic ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 156 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 R 158 34x57 G.H5 C 352 G.H5.23
Hydrophobic ICL2 R 158 34x57 G.H5 C 352 G.H5.23
Van-der-waals ICL2 R 158 34x57 G.H5 C 352 G.H5.23
Polar H8 N 317 8x49 G.H5 K 350 G.H5.21
Van-der-waals H8 N 317 8x49 G.H5 K 350 G.H5.21
Polar TM2 T 82 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM2 T 82 2x39 G.H5 C 352 G.H5.23
Ionic C-term E 342 - G.H3 K 258 G.H3.16
Polar C-term E 342 - G.H3 K 258 G.H3.16
Hydrophobic C-term E 342 - G.H3 K 258 G.H3.16
Van-der-waals C-term E 342 - G.H3 K 258 G.H3.16
Hydrophobic C-term I 380 - G.S2 E 187 G.S2.03
Van-der-waals C-term I 380 - G.S2 E 187 G.S2.03
Ionic C-term D 345 - G.H2 R 209 G.H2.04
Polar C-term D 345 - G.H2 R 209 G.H2.04
Hydrophobic C-term D 345 - G.H2 R 209 G.H2.04
Van-der-waals C-term D 345 - G.H2 R 209 G.H2.04
Polar TM2 T 82 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM2 T 82 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 T 82 2x39 G.H5 D 351 G.H5.22
Hydrophobic C-term P 375 - H.HA Q 68 H.HA.06
Hydrophobic ICL2 P 151 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 151 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM5 V 241 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM6 W 247 6x23 G.H4 E 309 G.H4.16
Hydrophobic TM6 L 260 6x36 G.H5 L 354 G.H5.25
Hydrophobic C-term L 382 - G.S2 I 185 G.S2.01
Hydrophobic ICL2 A 155 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 A 155 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 M 238 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 M 238 5x65 G.H5 L 349 G.H5.20
Hydrophobic C-term E 374 - H.HA Y 69 H.HA.07
Polar TM3 A 147 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 147 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 147 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 152 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 152 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM5 V 241 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 V 241 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM2 T 80 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM2 T 80 2x37 G.H5 D 351 G.H5.22
Hydrophobic C-term E 374 - G.hfs2 V 180 G.hfs2.03
Hydrophobic TM3 V 148 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 148 3x54 G.H5 L 349 G.H5.20
Polar TM3 R 144 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 144 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 144 3x50 G.H5 C 352 G.H5.23
Hydrophobic ICL2 L 152 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 152 34x51 G.H5 F 337 G.H5.08
Hydrophobic C-term R 377 - G.S2 V 186 G.S2.02
Van-der-waals C-term R 377 - G.S2 V 186 G.S2.02
Polar C-term Y 347 - G.H2 R 206 G.H2.01
Hydrophobic C-term Y 347 - G.H2 R 206 G.H2.01
Van-der-waals C-term Y 347 - G.H2 R 206 G.H2.01
Hydrophobic C-term L 344 - G.H2 I 213 G.H2.08
Hydrophobic TM6 V 261 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 K 237 5x64 G.H5 I 345 G.H5.16
Hydrophobic TM6 I 257 6x33 G.H5 L 349 G.H5.20
Hydrophobic C-term Y 346 - G.H3 L 250 G.H3.08
Hydrophobic C-term L 371 - G.hfs2 K 181 G.hfs2.04
Van-der-waals C-term L 371 - G.hfs2 K 181 G.hfs2.04
Hydrophobic H8 S 315 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 S 315 8x47 G.H5 G 353 G.H5.24
Polar TM6 R 250 6x26 G.S6 Y 321 G.S6.02
Hydrophobic TM6 R 250 6x26 G.S6 Y 321 G.S6.02
Van-der-waals TM6 R 250 6x26 G.S6 Y 321 G.S6.02
Ionic C-term E 374 - G.H1 K 51 G.H1.06
Polar C-term E 374 - G.H1 K 51 G.H1.06
Hydrophobic C-term E 374 - G.H1 K 51 G.H1.06
Van-der-waals C-term E 374 - G.H1 K 51 G.H1.06
Polar C-term Q 372 - H.hbhc E 115 H.hbhc.03
Van-der-waals C-term Q 372 - H.hbhc E 115 H.hbhc.03
Hydrophobic C-term L 344 - G.H3 F 260 G.H3.18
Polar H8 D 316 8x48 G.H5 F 355 G.H5.26
Hydrophobic H8 D 316 8x48 G.H5 F 355 G.H5.26
Hydrophobic C-term L 344 - G.H3 I 254 G.H3.12
Van-der-waals C-term L 344 - G.H3 I 254 G.H3.12
Van-der-waals C-term Y 346 - G.H2 R 209 G.H2.04
Hydrophobic C-term P 375 - H.HA V 72 H.HA.10
Hydrophobic C-term L 344 - G.h2s4 F 216 G.h2s4.01
Van-der-waals C-term L 344 - G.h2s4 F 216 G.h2s4.01
Polar C-term E 342 - G.H3 N 257 G.H3.15
Polar C-term Y 346 - G.H3 E 246 G.H3.04
Hydrophobic C-term Y 346 - G.H3 E 246 G.H3.04
Van-der-waals C-term Y 346 - G.H3 E 246 G.H3.04
Aromatic TM6 K 256 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 256 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 256 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM3 V 148 3x54 G.H5 I 345 G.H5.16
Hydrophobic C-term Y 346 - G.H3 K 249 G.H3.07
Van-der-waals C-term Y 346 - G.H3 K 249 G.H3.07
Ionic TM4 R 159 4x38 G.HN E 28 G.HN.52
Polar TM4 R 159 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 159 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 159 4x38 G.HN E 28 G.HN.52
Hydrophobic C-term L 344 - G.H3 N 257 G.H3.15
Polar TM4 S 161 4x40 G.HN R 24 G.HN.48
Ionic TM6 R 250 6x26 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 250 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 250 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 250 6x26 G.h4s6 E 319 G.h4s6.12
Polar TM3 R 144 3x50 G.H5 G 353 G.H5.24
Polar C-term L 344 - G.H3 S 253 G.H3.11
Van-der-waals C-term L 344 - G.H3 S 253 G.H3.11
Polar TM6 W 247 6x23 G.S6 I 320 G.S6.01
Hydrophobic TM6 W 247 6x23 G.S6 I 320 G.S6.01
Van-der-waals TM6 W 247 6x23 G.S6 I 320 G.S6.01
Polar ICL2 P 151 34x50 G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 151 34x50 G.H5 T 341 G.H5.12
Polar TM6 Q 249 6x25 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM6 Q 249 6x25 G.h4s6 K 315 G.h4s6.08
Van-der-waals TM6 Q 249 6x25 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM3 R 144 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 144 3x50 G.H5 L 354 G.H5.25
Ionic ICL2 R 158 34x57 G.H5 D 351 G.H5.22
Polar ICL2 R 158 34x57 G.H5 D 351 G.H5.22
Hydrophobic ICL2 R 158 34x57 G.H5 D 351 G.H5.22
Van-der-waals ICL2 R 158 34x57 G.H5 D 351 G.H5.22