Gt2 -
SST5 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 10.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | R | 137 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 137 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 137 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | L | 364 | - | G.S2 | T | 187 | G.S2.04 |
Hydrophobic | TM3 | V | 141 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 141 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | TM6 | K | 245 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 245 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 245 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL2 | P | 144 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Ionic | ICL2 | R | 149 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 149 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 149 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 149 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM5 | A | 231 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | L | 145 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | TM3 | A | 140 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | V | 235 | - | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | ICL3 | V | 235 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | C-term | M | 359 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | H8 | S | 308 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | S | 146 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | S | 146 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM5 | I | 224 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | V | 246 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | L | 145 | 34x51 | G.S3 | F | 196 | G.S3.03 |
Hydrophobic | TM4 | P | 153 | 4x39 | G.HN | D | 28 | G.HN.52 |
Van-der-waals | TM4 | P | 153 | 4x39 | G.HN | D | 28 | G.HN.52 |
Polar | TM6 | C | 237 | 6x24 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | C | 237 | 6x24 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | C | 237 | 6x24 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | V | 228 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | A | 231 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | A | 231 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | H8 | N | 310 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | T | 75 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | R | 239 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | R | 239 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL3 | V | 235 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | V | 235 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | R | 137 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | TM2 | T | 75 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Polar | TM3 | A | 140 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 140 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 140 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Ionic | ICL1 | K | 72 | 12x51 | G.HN | E | 20 | G.HN.44 |
Polar | ICL1 | K | 72 | 12x51 | G.HN | E | 20 | G.HN.44 |
Van-der-waals | ICL1 | K | 72 | 12x51 | G.HN | E | 20 | G.HN.44 |
Hydrophobic | TM6 | C | 237 | 6x24 | G.S6 | Y | 320 | G.S6.02 |
Polar | ICL2 | R | 151 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Ionic | ICL3 | R | 234 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL2 | S | 146 | 34x52 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | C-term | L | 364 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | C-term | L | 364 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | ICL2 | A | 148 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | P | 144 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | S | 362 | - | G.S2 | I | 185 | G.S2.02 |
Hydrophobic | ICL2 | L | 145 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | L | 145 | 34x51 | G.S2 | V | 191 | G.S2.08 |
Hydrophobic | TM6 | V | 246 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 246 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | Y | 221 | 5x58 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | A | 148 | 34x54 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | A | 148 | 34x54 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | L | 145 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM6 | M | 249 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | M | 249 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | P | 144 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Polar | ICL2 | L | 145 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | L | 145 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | L | 145 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM4 | R | 152 | 4x38 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM4 | R | 152 | 4x38 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL3 | V | 235 | - | G.H5 | D | 337 | G.H5.09 |
Ionic | TM4 | R | 154 | 4x40 | G.HN | E | 25 | G.HN.49 |
Hydrophobic | ICL2 | A | 148 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | A | 148 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | V | 141 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | L | 145 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | L | 145 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 145 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL3 | V | 235 | - | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | ICL3 | V | 235 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | V | 235 | - | G.S6 | Y | 320 | G.S6.02 |
Polar | ICL1 | K | 72 | 12x51 | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | TM6 | V | 246 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | S | 242 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | S | 242 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | K | 227 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | K | 227 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Ionic | TM6 | R | 239 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 239 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | R | 239 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | R | 239 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 239 | 6x26 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | R | 239 | 6x26 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM6 | R | 239 | 6x26 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | M | 249 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 249 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM6 | R | 239 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | R | 239 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | R | 239 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | R | 239 | 6x26 | G.H5 | D | 341 | G.H5.13 |