GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ECL2 | M | 169 | - | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | ECL2 | M | 169 | - | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | ECL1 | F | 76 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ECL1 | F | 76 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM2 | W | 66 | 2x61 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | W | 66 | 2x61 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ECL2 | W | 155 | - | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | ECL2 | W | 155 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ECL2 | F | 172 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM2 | A | 69 | 2x64 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | A | 69 | 2x64 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | W | 89 | 3x32 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | W | 89 | 3x32 | G.H5 | Q | 377 | G.H5.26 |
Polar | ECL1 | F | 76 | - | G.H5 | D | 369 | G.H5.18 |
Hydrophobic | ECL1 | F | 76 | - | G.H5 | D | 369 | G.H5.18 |
Van-der-waals | ECL1 | F | 76 | - | G.H5 | D | 369 | G.H5.18 |
Polar | ECL2 | Y | 159 | - | G.H5 | T | 365 | G.H5.14 |
Hydrophobic | ECL2 | Y | 159 | - | G.H5 | T | 365 | G.H5.14 |
Van-der-waals | ECL2 | Y | 159 | - | G.H5 | T | 365 | G.H5.14 |
Hydrophobic | ECL2 | E | 160 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | ECL2 | F | 172 | - | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | M | 85 | 3x28 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM3 | M | 85 | 3x28 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ECL2 | F | 175 | - | G.H5 | H | 368 | G.H5.17 |
Polar | ECL2 | S | 168 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | ECL2 | S | 168 | - | G.H5 | D | 361 | G.H5.10 |
Van-der-waals | ECL2 | S | 168 | - | G.H5 | D | 361 | G.H5.10 |
Polar | TM2 | L | 63 | 2x58 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | L | 63 | 2x58 | G.H5 | Q | 377 | G.H5.26 |
Polar | ECL2 | W | 155 | - | G.H5 | H | 368 | G.H5.17 |
Aromatic | ECL2 | W | 155 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ECL2 | W | 155 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ECL2 | W | 155 | - | G.H5 | H | 368 | G.H5.17 |
Polar | TM2 | A | 69 | 2x64 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM2 | A | 69 | 2x64 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | A | 69 | 2x64 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ECL2 | W | 165 | - | G.H5 | L | 357 | G.H5.06 |
Van-der-waals | ECL2 | W | 165 | - | G.H5 | L | 357 | G.H5.06 |
Polar | TM2 | I | 62 | 2x57 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | I | 62 | 2x57 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | I | 62 | 2x57 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | M | 85 | 3x28 | G.H5 | L | 374 | G.H5.23 |
Polar | TM2 | Y | 72 | 2x67 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | Y | 72 | 2x67 | G.H5 | Q | 373 | G.H5.22 |
Aromatic | ECL2 | Y | 159 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | ECL2 | Y | 159 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | ECL2 | Y | 159 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM3 | L | 82 | 3x25 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM3 | L | 82 | 3x25 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ECL1 | F | 76 | - | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ECL1 | F | 76 | - | G.H5 | N | 370 | G.H5.19 |
Polar | TM1 | E | 2 | 1x28 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM1 | E | 2 | 1x28 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | TM1 | E | 2 | 1x28 | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | TM2 | S | 65 | 2x60 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | S | 65 | 2x60 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | S | 65 | 2x60 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ECL1 | F | 76 | - | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ECL1 | F | 76 | - | G.H5 | L | 374 | G.H5.23 |
Polar | ECL2 | N | 166 | - | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | ECL2 | N | 166 | - | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | TM3 | W | 89 | 3x32 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ECL2 | F | 172 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ECL2 | F | 172 | - | G.H5 | L | 371 | G.H5.20 |
Aromatic | ECL2 | F | 175 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ECL2 | F | 175 | - | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | ECL2 | F | 175 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM3 | M | 85 | 3x28 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM3 | M | 85 | 3x28 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | K | 180 | 5x41 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM5 | K | 180 | 5x41 | G.H5 | M | 375 | G.H5.24 |
Polar | TM2 | E | 61 | 2x56 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | E | 61 | 2x56 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | E | 61 | 2x56 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | L | 82 | 3x25 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM3 | L | 82 | 3x25 | G.H5 | K | 372 | G.H5.21 |
Polar | TM2 | H | 71 | 2x66 | G.hns1 | K | 46 | G.hns1.02 |
Aromatic | TM2 | H | 71 | 2x66 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM2 | H | 71 | 2x66 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM2 | H | 71 | 2x66 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM2 | E | 61 | 2x56 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ECL1 | V | 77 | - | G.S5 | S | 285 | G.S5.01 |
Hydrophobic | TM1 | P | 6 | 1x32 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM2 | L | 68 | 2x63 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM2 | L | 68 | 2x63 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ECL1 | F | 76 | - | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | ECL1 | F | 76 | - | G.H5 | K | 372 | G.H5.21 |
Polar | TM2 | W | 66 | 2x61 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | W | 66 | 2x61 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | W | 66 | 2x61 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM2 | S | 65 | 2x60 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM2 | S | 65 | 2x60 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | S | 65 | 2x60 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | I | 86 | 3x29 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM3 | I | 86 | 3x29 | G.H5 | L | 376 | G.H5.25 |
Polar | ECL1 | V | 77 | - | G.H5 | D | 369 | G.H5.18 |
Hydrophobic | ECL1 | V | 77 | - | G.H5 | D | 369 | G.H5.18 |
Van-der-waals | ECL1 | V | 77 | - | G.H5 | D | 369 | G.H5.18 |
Polar | ECL2 | M | 169 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | TM2 | L | 70 | 2x65 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ECL1 | L | 73 | - | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ECL1 | L | 73 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ECL2 | N | 166 | - | G.H5 | L | 357 | G.H5.06 |
Van-der-waals | ECL2 | N | 166 | - | G.H5 | L | 357 | G.H5.06 |
Aromatic | ECL2 | F | 172 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ECL2 | F | 172 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ECL2 | F | 172 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ECL1 | L | 73 | - | G.H5 | D | 369 | G.H5.18 |
Polar | TM2 | S | 65 | 2x60 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | S | 65 | 2x60 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ECL2 | S | 176 | - | G.H5 | M | 375 | G.H5.24 |
Polar | ECL2 | Y | 159 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | ECL2 | T | 163 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ECL2 | T | 163 | - | G.S6 | H | 344 | G.S6.03 |
Polar | ECL2 | M | 169 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ECL2 | M | 169 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ECL2 | M | 169 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ECL1 | L | 73 | - | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | ECL1 | I | 75 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ECL1 | I | 75 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ECL1 | F | 76 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ECL1 | F | 76 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ECL2 | M | 169 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ECL2 | M | 169 | - | G.s2s3 | K | 214 | G.s2s3.01 |