GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 26.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Aromatic | TM2 | F | 72 | 2x67 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM2 | F | 72 | 2x67 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM2 | F | 72 | 2x67 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | T | 78 | 3x21 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM3 | T | 78 | 3x21 | G.H5 | H | 368 | G.H5.17 |
Polar | ECL1 | A | 74 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ECL1 | A | 74 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ECL1 | A | 74 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ECL2 | T | 164 | - | G.H4 | Q | 323 | G.H4.08 |
Polar | ECL2 | S | 169 | - | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | ECL2 | S | 169 | - | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | ECL2 | S | 169 | - | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | ECL1 | F | 76 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ECL1 | F | 76 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ECL1 | A | 74 | - | G.S3 | V | 216 | G.S3.01 |
Ionic | TM3 | E | 79 | 3x22 | G.H5 | K | 372 | G.H5.21 |
Polar | TM3 | E | 79 | 3x22 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM3 | E | 79 | 3x22 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM3 | E | 79 | 3x22 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ECL1 | P | 73 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ECL1 | A | 77 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ECL1 | A | 77 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ECL1 | L | 75 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ECL1 | L | 75 | - | G.H5 | L | 371 | G.H5.20 |
Ionic | TM3 | E | 79 | 3x22 | G.H5 | H | 368 | G.H5.17 |
Polar | TM3 | E | 79 | 3x22 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM3 | E | 79 | 3x22 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM3 | E | 79 | 3x22 | G.H5 | H | 368 | G.H5.17 |
Polar | ECL2 | Y | 159 | - | G.H5 | D | 361 | G.H5.10 |
Polar | ECL2 | R | 160 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | ECL2 | R | 160 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Polar | ECL2 | K | 163 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ECL2 | K | 163 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ECL2 | K | 163 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM3 | T | 78 | 3x21 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | T | 78 | 3x21 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ECL1 | P | 73 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ECL1 | P | 73 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | ECL2 | K | 163 | - | G.S6 | F | 346 | G.S6.05 |
Hydrophobic | TM3 | M | 81 | 3x24 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | M | 81 | 3x24 | G.H5 | L | 371 | G.H5.20 |
Polar | ECL3 | L | 257 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | ECL2 | R | 161 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ECL3 | L | 257 | - | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | ECL2 | Y | 159 | - | G.H5 | T | 365 | G.H5.14 |
Hydrophobic | ECL2 | R | 160 | - | G.h4s6 | K | 340 | G.h4s6.19 |
Polar | TM2 | F | 71 | 2x66 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM2 | F | 71 | 2x66 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM2 | F | 71 | 2x66 | G.hns1 | R | 47 | G.hns1.03 |
Polar | ECL2 | R | 160 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ECL2 | R | 160 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ECL2 | S | 167 | - | G.H5 | D | 361 | G.H5.10 |
Van-der-waals | ECL2 | S | 167 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | TM2 | F | 72 | 2x67 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ECL1 | A | 74 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ECL1 | A | 74 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM3 | K | 80 | 3x23 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM3 | K | 80 | 3x23 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM3 | M | 81 | 3x24 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | M | 81 | 3x24 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ECL2 | Y | 159 | - | G.S6 | Y | 343 | G.S6.02 |
Polar | TM3 | T | 78 | 3x21 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM3 | T | 78 | 3x21 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | T | 78 | 3x21 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ECL1 | P | 73 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ECL2 | R | 160 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | ECL2 | R | 160 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | ECL2 | K | 163 | - | G.S6 | H | 345 | G.S6.04 |
Van-der-waals | ECL2 | K | 163 | - | G.S6 | H | 345 | G.S6.04 |
Polar | TM3 | T | 78 | 3x21 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM3 | T | 78 | 3x21 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM3 | T | 78 | 3x21 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ECL1 | P | 73 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ECL1 | P | 73 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ECL1 | A | 74 | - | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | TM3 | M | 84 | 3x27 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | M | 84 | 3x27 | G.H5 | M | 375 | G.H5.24 |
Polar | ECL2 | T | 164 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ECL2 | T | 164 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ECL2 | T | 164 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM3 | T | 78 | 3x21 | G.H5 | D | 369 | G.H5.18 |
Van-der-waals | TM3 | T | 78 | 3x21 | G.H5 | D | 369 | G.H5.18 |
Hydrophobic | TM3 | K | 80 | 3x23 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM3 | K | 80 | 3x23 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ECL1 | L | 75 | - | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ECL1 | L | 75 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ECL2 | T | 164 | - | G.H4 | V | 327 | G.H4.12 |
Hydrophobic | ECL2 | T | 164 | - | G.S6 | F | 346 | G.S6.05 |
Van-der-waals | ECL2 | T | 164 | - | G.S6 | F | 346 | G.S6.05 |
Polar | ECL1 | A | 77 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ECL1 | A | 77 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ECL1 | A | 77 | - | G.H5 | L | 367 | G.H5.16 |
Polar | ECL2 | K | 163 | - | G.S6 | L | 342 | G.S6.01 |
Hydrophobic | ECL2 | K | 163 | - | G.S6 | L | 342 | G.S6.01 |
Van-der-waals | ECL2 | K | 163 | - | G.S6 | L | 342 | G.S6.01 |
Hydrophobic | ECL2 | K | 163 | - | G.H4 | V | 327 | G.H4.12 |
Hydrophobic | ECL2 | S | 169 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | ECL2 | S | 167 | - | G.H5 | L | 357 | G.H5.06 |
Van-der-waals | ECL2 | S | 167 | - | G.H5 | L | 357 | G.H5.06 |
Hydrophobic | TM3 | K | 80 | 3x23 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | K | 80 | 3x23 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ECL1 | A | 77 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ECL1 | A | 77 | - | G.H5 | D | 364 | G.H5.13 |
Polar | ECL1 | A | 77 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ECL1 | A | 77 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ECL1 | A | 77 | - | G.H5 | H | 368 | G.H5.17 |
Polar | TM3 | T | 78 | 3x21 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM3 | T | 78 | 3x21 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | T | 78 | 3x21 | G.H5 | L | 367 | G.H5.16 |
Polar | ECL2 | R | 160 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | ECL2 | R | 160 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Polar | ECL2 | K | 163 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | ECL2 | K | 163 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | ECL2 | K | 163 | - | G.S6 | Y | 343 | G.S6.02 |