GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | S | 218 | 6x27 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | S | 218 | 6x27 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | S | 218 | 6x27 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | H8 | P | 281 | 8x48 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | ICL2 | W | 120 | 34x55 | G.S3 | H | 196 | G.S3.02 |
Van-der-waals | ICL2 | W | 120 | 34x55 | G.S3 | H | 196 | G.S3.02 |
Polar | TM4 | R | 124 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM4 | R | 124 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | R | 124 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL2 | F | 110 | 34x45 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | F | 110 | 34x45 | G.H5 | I | 344 | G.H5.15 |
Ionic | ICL2 | H | 113 | 34x48 | G.s2s3 | D | 194 | G.s2s3.02 |
Polar | ICL2 | H | 113 | 34x48 | G.s2s3 | D | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | H | 113 | 34x48 | G.s2s3 | D | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | H | 113 | 34x48 | G.s2s3 | D | 194 | G.s2s3.02 |
Polar | H8 | K | 284 | 8x51 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | H8 | K | 284 | 8x51 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | ICL2 | W | 120 | 34x55 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | W | 120 | 34x55 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | L | 116 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Polar | TM3 | K | 106 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | K | 106 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | K | 106 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Aromatic | ICL2 | W | 120 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | W | 120 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | W | 120 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM6 | S | 218 | 6x27 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM6 | S | 218 | 6x27 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL2 | F | 110 | 34x45 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 110 | 34x45 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | H8 | S | 280 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Ionic | TM4 | R | 124 | 4x40 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 124 | 4x40 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 124 | 4x40 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 124 | 4x40 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM5 | H | 210 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM6 | P | 217 | 6x26 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM6 | P | 217 | 6x26 | G.S6 | Y | 321 | G.S6.02 |
Ionic | TM6 | R | 222 | 6x31 | G.H5 | D | 342 | G.H5.13 |
Polar | TM6 | R | 222 | 6x31 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | R | 222 | 6x31 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | R | 222 | 6x31 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM3 | F | 102 | 3x49 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM2 | M | 43 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM6 | L | 232 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | H8 | P | 281 | 8x48 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | ICL2 | F | 110 | 34x45 | G.s2s3 | K | 193 | G.s2s3.01 |
Polar | TM6 | N | 216 | 6x25 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | A | 225 | 6x34 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | A | 225 | 6x34 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM5 | L | 203 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | K | 106 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | L | 116 | 34x51 | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | L | 116 | 34x51 | G.s2s3 | K | 193 | G.s2s3.01 |
Polar | TM3 | Y | 103 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | Y | 103 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | Y | 103 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Polar | ICL2 | W | 120 | 34x55 | G.s2s3 | D | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | W | 120 | 34x55 | G.s2s3 | D | 194 | G.s2s3.02 |
Hydrophobic | TM3 | V | 107 | 3x54 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM7 | S | 279 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM7 | S | 279 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM3 | Y | 103 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 221 | 6x30 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | H8 | P | 281 | 8x48 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | H8 | P | 281 | 8x48 | G.H5 | K | 350 | G.H5.21 |
Ionic | TM5 | H | 210 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | H | 210 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | H | 210 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | H | 210 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL2 | F | 110 | 34x45 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM6 | T | 224 | 6x33 | G.H5 | F | 355 | G.H5.26 |
Ionic | TM3 | K | 106 | 3x53 | G.H5 | D | 351 | G.H5.22 |
Polar | TM3 | K | 106 | 3x53 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM3 | K | 106 | 3x53 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM3 | K | 106 | 3x53 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM3 | V | 107 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Polar | ICL2 | R | 119 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 119 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM6 | P | 217 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | P | 217 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM3 | V | 107 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | V | 107 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | S | 228 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Ionic | TM4 | R | 124 | 4x40 | G.HN | E | 25 | G.HN.49 |
Polar | TM4 | R | 124 | 4x40 | G.HN | E | 25 | G.HN.49 |
Hydrophobic | TM4 | R | 124 | 4x40 | G.HN | E | 25 | G.HN.49 |
Van-der-waals | TM4 | R | 124 | 4x40 | G.HN | E | 25 | G.HN.49 |
Hydrophobic | TM6 | L | 229 | 6x38 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | P | 217 | 6x26 | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | TM6 | P | 217 | 6x26 | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | ICL2 | R | 119 | 34x54 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM4 | L | 123 | 4x39 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM4 | L | 123 | 4x39 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | L | 116 | 34x51 | G.s2s3 | D | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | L | 116 | 34x51 | G.s2s3 | D | 194 | G.s2s3.02 |
Ionic | H8 | R | 285 | 8x52 | G.h3s5 | D | 262 | G.h3s5.02 |
Polar | H8 | R | 285 | 8x52 | G.h3s5 | D | 262 | G.h3s5.02 |
Van-der-waals | H8 | R | 285 | 8x52 | G.h3s5 | D | 262 | G.h3s5.02 |
Polar | ICL1 | R | 41 | - | G.HN | L | 23 | G.HN.47 |
Hydrophobic | ICL1 | R | 41 | - | G.HN | L | 23 | G.HN.47 |
Van-der-waals | ICL1 | R | 41 | - | G.HN | L | 23 | G.HN.47 |
Hydrophobic | TM2 | V | 45 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | W | 120 | 34x55 | G.HN | K | 29 | G.HN.53 |
Hydrophobic | TM5 | Q | 206 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM6 | A | 221 | 6x30 | G.H5 | K | 346 | G.H5.17 |
Ionic | TM6 | K | 220 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | K | 220 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | K | 220 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | A | 225 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 225 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | A | 225 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 221 | 6x30 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM4 | L | 123 | 4x39 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL1 | R | 41 | - | G.HN | R | 24 | G.HN.48 |
Van-der-waals | ICL1 | R | 41 | - | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM6 | N | 216 | 6x25 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM6 | N | 216 | 6x25 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL2 | F | 110 | 34x45 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | F | 110 | 34x45 | G.H5 | T | 341 | G.H5.12 |