Gs - TAS2R19 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 18.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 A 44 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 A 44 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM6 A 227 6x34 G.H5 L 388 G.H5.20
Van-der-waals TM6 A 227 6x34 G.H5 L 388 G.H5.20
Polar TM5 H 205 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 205 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 205 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 110 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 110 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM6 V 223 6x30 G.H5 L 394 G.H5.26
Van-der-waals TM6 V 223 6x30 G.H5 L 394 G.H5.26
Van-der-waals H8 R 284 8x48 G.H5 R 389 G.H5.21
Hydrophobic TM6 V 223 6x30 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 V 223 6x30 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 V 231 6x38 G.H5 L 393 G.H5.25
Ionic H8 R 284 8x48 G.h4s6 D 354 G.h4s6.10
Polar H8 R 284 8x48 G.h4s6 D 354 G.h4s6.10
Hydrophobic H8 R 284 8x48 G.h4s6 D 354 G.h4s6.10
Van-der-waals H8 R 284 8x48 G.h4s6 D 354 G.h4s6.10
Hydrophobic H8 L 286 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 L 286 8x50 G.H5 E 392 G.H5.24
Hydrophobic TM6 H 224 6x31 G.H5 L 388 G.H5.20
Hydrophobic TM6 P 219 6x26 G.h4s6 Y 358 G.h4s6.20
Polar TM6 S 220 6x27 G.H5 D 381 G.H5.13
Van-der-waals TM6 S 220 6x27 G.H5 D 381 G.H5.13
Hydrophobic TM6 T 230 6x37 G.H5 L 393 G.H5.25
Ionic TM5 H 205 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 205 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 205 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 205 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM3 I 110 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 110 3x54 G.H5 L 393 G.H5.25
Aromatic TM3 F 105 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 F 105 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 F 105 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 N 112 34x44 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 N 112 34x44 G.H5 Q 384 G.H5.16
Ionic ICL3 K 214 - G.hgh4 E 327 G.hgh4.17
Polar ICL3 K 214 - G.hgh4 E 327 G.hgh4.17
Van-der-waals ICL3 K 214 - G.hgh4 E 327 G.hgh4.17
Polar ICL3 K 214 - G.hgh4 P 326 G.hgh4.16
Polar H8 R 284 8x48 G.h4s6 G 355 G.h4s6.11
Hydrophobic H8 R 284 8x48 G.h4s6 G 355 G.h4s6.11
Van-der-waals H8 R 284 8x48 G.h4s6 G 355 G.h4s6.11
Polar ICL3 K 214 - G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL3 K 214 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 K 214 - G.hgh4 T 325 G.hgh4.15
Polar TM3 I 110 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 110 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 110 3x54 G.H5 Q 384 G.H5.16
Hydrophobic H8 S 283 8x47 G.H5 L 394 G.H5.26
Hydrophobic TM3 I 110 3x54 G.H5 H 387 G.H5.19
Polar TM5 H 212 5x75 G.H5 N 377 G.H5.09
Ionic TM6 H 224 6x31 G.H5 D 381 G.H5.13
Polar TM6 H 224 6x31 G.H5 D 381 G.H5.13
Van-der-waals TM6 H 224 6x31 G.H5 D 381 G.H5.13
Hydrophobic TM5 M 209 5x72 G.S6 Y 360 G.S6.02
Polar TM7 G 282 7x56 G.H5 L 394 G.H5.26
Hydrophobic TM7 G 282 7x56 G.H5 L 394 G.H5.26
Van-der-waals TM7 G 282 7x56 G.H5 L 394 G.H5.26
Hydrophobic TM5 K 208 5x71 G.H5 R 380 G.H5.12
Van-der-waals TM5 K 208 5x71 G.H5 R 380 G.H5.12
Polar TM6 S 220 6x27 G.H5 R 385 G.H5.17
Hydrophobic TM6 S 220 6x27 G.H5 R 385 G.H5.17
Van-der-waals TM6 S 220 6x27 G.H5 R 385 G.H5.17
Polar H8 S 283 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 283 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 283 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 202 5x65 G.H5 L 388 G.H5.20
Polar TM3 K 109 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 K 109 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 K 109 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 C 106 3x50 G.H5 L 393 G.H5.25
Polar TM3 K 109 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 K 109 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 K 109 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 110 3x54 G.H5 Y 391 G.H5.23
Polar H8 R 284 8x48 G.H5 L 394 G.H5.26
Hydrophobic H8 R 284 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 R 284 8x48 G.H5 L 394 G.H5.26
Polar TM6 A 227 6x34 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 227 6x34 G.H5 L 393 G.H5.25
Polar TM5 H 205 5x68 G.H5 R 380 G.H5.12
Hydrophobic TM5 H 205 5x68 G.H5 R 380 G.H5.12
Van-der-waals TM5 H 205 5x68 G.H5 R 380 G.H5.12
Hydrophobic TM6 V 223 6x30 G.H5 R 385 G.H5.17
Hydrophobic TM6 H 224 6x31 G.H5 Q 384 G.H5.16
Van-der-waals TM6 H 224 6x31 G.H5 Q 384 G.H5.16
Hydrophobic TM7 G 282 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 G 282 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM2 L 48 2x43 G.H5 E 392 G.H5.24
Van-der-waals TM2 L 48 2x43 G.H5 E 392 G.H5.24
Polar TM5 K 208 5x71 G.H5 N 377 G.H5.09
Hydrophobic TM5 K 208 5x71 G.H5 N 377 G.H5.09
Van-der-waals TM5 K 208 5x71 G.H5 N 377 G.H5.09
Polar ICL2 N 112 34x44 G.H5 R 380 G.H5.12
Hydrophobic ICL2 N 112 34x44 G.H5 R 380 G.H5.12
Van-der-waals ICL2 N 112 34x44 G.H5 R 380 G.H5.12
Hydrophobic TM3 C 106 3x50 G.H5 Y 391 G.H5.23
Polar TM6 P 219 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 P 219 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 K 226 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM5 M 209 5x72 G.H5 D 381 G.H5.13
Van-der-waals TM5 M 209 5x72 G.H5 D 381 G.H5.13
Hydrophobic TM2 S 42 2x37 G.H5 Q 390 G.H5.22