GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | I | 139 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | I | 139 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | L | 148 | 34x51 | G.s2s3 | N | 194 | G.s2s3.02 |
Polar | ICL2 | F | 147 | 34x50 | G.hns1 | R | 34 | G.hns1.03 |
Aromatic | ICL2 | F | 147 | 34x50 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | F | 147 | 34x50 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | F | 147 | 34x50 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM3 | I | 139 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | I | 139 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 256 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Polar | TM2 | S | 72 | 2x39 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM2 | S | 72 | 2x39 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | S | 72 | 2x39 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM6 | A | 263 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | A | 263 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | R | 151 | 34x54 | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | R | 151 | 34x54 | G.S3 | I | 195 | G.S3.01 |
Polar | ICL2 | S | 143 | 34x46 | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | S | 143 | 34x46 | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | S | 143 | 34x46 | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | TM6 | I | 264 | 6x38 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | H | 257 | 6x31 | G.H5 | L | 349 | G.H5.20 |
Polar | TM4 | R | 153 | 4x37 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | TM4 | R | 153 | 4x37 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | R | 151 | 34x54 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | R | 151 | 34x54 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM3 | I | 139 | 3x54 | G.H5 | F | 352 | G.H5.23 |
Polar | ICL2 | L | 148 | 34x51 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | L | 148 | 34x51 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | N | 141 | 34x44 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | ICL2 | N | 141 | 34x44 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM7 | L | 311 | 7x53 | G.H5 | N | 353 | G.H5.24 |
Polar | ICL2 | N | 141 | 34x44 | G.s2s3 | E | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | N | 141 | 34x44 | G.s2s3 | E | 193 | G.s2s3.01 |
Hydrophobic | TM2 | S | 72 | 2x39 | G.H5 | N | 353 | G.H5.24 |
Polar | TM4 | T | 155 | 4x39 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM4 | T | 155 | 4x39 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | TM4 | T | 155 | 4x39 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | R | 151 | 34x54 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | ICL2 | R | 151 | 34x54 | G.H5 | L | 345 | G.H5.16 |
Ionic | TM4 | R | 153 | 4x37 | G.HN | D | 31 | G.HN.53 |
Polar | TM4 | R | 153 | 4x37 | G.HN | D | 31 | G.HN.53 |
Hydrophobic | TM3 | Y | 135 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | Y | 135 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | W | 152 | 34x55 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | W | 152 | 34x55 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | W | 152 | 34x55 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM4 | R | 153 | 4x37 | G.HN | K | 30 | G.HN.52 |
Van-der-waals | TM4 | R | 153 | 4x37 | G.HN | K | 30 | G.HN.52 |
Hydrophobic | TM2 | S | 72 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | W | 152 | 34x55 | G.hns1 | A | 32 | G.hns1.01 |
Van-der-waals | ICL2 | W | 152 | 34x55 | G.hns1 | A | 32 | G.hns1.01 |
Polar | TM3 | Y | 135 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | Y | 135 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | Y | 135 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM7 | D | 314 | 7x56 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM7 | D | 314 | 7x56 | G.H5 | V | 355 | G.H5.26 |
Ionic | H8 | R | 320 | 8x52 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | H8 | R | 320 | 8x52 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | H8 | R | 320 | 8x52 | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | H8 | R | 320 | 8x52 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | TM1 | H | 59 | 1x57 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | H8 | N | 315 | 8x47 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | ICL2 | W | 152 | 34x55 | G.HN | D | 28 | G.HN.50 |
Polar | TM3 | Y | 135 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM3 | Y | 135 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | W | 152 | 34x55 | G.HN | K | 29 | G.HN.51 |
Hydrophobic | TM5 | L | 235 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL2 | W | 152 | 34x55 | G.HN | D | 31 | G.HN.53 |
Hydrophobic | ICL2 | W | 152 | 34x55 | G.HN | D | 31 | G.HN.53 |
Van-der-waals | ICL2 | W | 152 | 34x55 | G.HN | D | 31 | G.HN.53 |
Polar | TM3 | K | 138 | 3x53 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | TM3 | K | 138 | 3x53 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | W | 152 | 34x55 | G.HN | K | 30 | G.HN.52 |
Van-der-waals | ICL2 | W | 152 | 34x55 | G.HN | K | 30 | G.HN.52 |
Ionic | H8 | R | 324 | 8x56 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | H8 | R | 324 | 8x56 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | H8 | R | 324 | 8x56 | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | H8 | R | 324 | 8x56 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | TM6 | G | 259 | 6x33 | G.H5 | V | 355 | G.H5.26 |
Polar | TM1 | E | 62 | 1x60 | G.h3s5 | N | 262 | G.h3s5.02 |
Ionic | TM5 | H | 238 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | H | 238 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | H | 238 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | H | 238 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | ICL2 | F | 142 | 34x45 | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | F | 142 | 34x45 | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | F | 142 | 34x45 | G.s2s3 | N | 194 | G.s2s3.02 |
Polar | TM6 | S | 253 | 6x27 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | S | 253 | 6x27 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | S | 253 | 6x27 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | ICL2 | N | 141 | 34x44 | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | N | 141 | 34x44 | G.S3 | I | 195 | G.S3.01 |
Hydrophobic | H8 | P | 316 | 8x48 | G.H5 | R | 350 | G.H5.21 |
Hydrophobic | TM5 | L | 231 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Polar | TM6 | H | 257 | 6x31 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | H | 257 | 6x31 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | H | 257 | 6x31 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | F | 267 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | F | 267 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 256 | 6x30 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | A | 256 | 6x30 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM7 | D | 314 | 7x56 | G.H5 | L | 354 | G.H5.25 |
Aromatic | TM3 | F | 134 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | F | 134 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | F | 134 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Ionic | H8 | R | 320 | 8x52 | G.h4s6 | D | 315 | G.h4s6.10 |
Polar | H8 | R | 320 | 8x52 | G.h4s6 | D | 315 | G.h4s6.10 |
Hydrophobic | H8 | R | 320 | 8x52 | G.h4s6 | D | 315 | G.h4s6.10 |
Van-der-waals | H8 | R | 320 | 8x52 | G.h4s6 | D | 315 | G.h4s6.10 |
Hydrophobic | TM3 | K | 138 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | K | 138 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Polar | ICL2 | Y | 144 | 34x47 | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | Y | 144 | 34x47 | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | Y | 144 | 34x47 | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | H8 | P | 316 | 8x48 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | H8 | P | 316 | 8x48 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM2 | L | 76 | 2x43 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM2 | L | 76 | 2x43 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.S2 | D | 191 | G.S2.07 |
Hydrophobic | ICL2 | W | 152 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | W | 152 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM6 | A | 260 | 6x34 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | A | 260 | 6x34 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM5 | M | 242 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | M | 242 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Polar | H8 | N | 315 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | H8 | N | 315 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | N | 315 | 8x47 | G.H5 | N | 353 | G.H5.24 |