Golf - TAS2R39 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 139 3x54 G.H5 L 380 G.H5.25
Van-der-waals TM3 I 139 3x54 G.H5 L 380 G.H5.25
Hydrophobic TM6 F 267 6x41 G.H5 L 380 G.H5.25
Hydrophobic ICL2 W 152 34x55 G.HN R 36 G.HN.51
Van-der-waals ICL2 W 152 34x55 G.HN R 36 G.HN.51
Polar TM6 S 253 6x27 G.H5 D 368 G.H5.13
Van-der-waals TM6 S 253 6x27 G.H5 D 368 G.H5.13
Polar TM6 S 253 6x27 G.H5 R 372 G.H5.17
Hydrophobic TM6 S 253 6x27 G.H5 R 372 G.H5.17
Van-der-waals TM6 S 253 6x27 G.H5 R 372 G.H5.17
Hydrophobic TM6 A 260 6x34 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 260 6x34 G.H5 L 375 G.H5.20
Polar TM3 K 138 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 K 138 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 K 138 3x53 G.H5 H 374 G.H5.19
Hydrophobic H8 P 316 8x48 G.H5 E 379 G.H5.24
Hydrophobic TM6 P 252 6x26 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM3 Y 135 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 263 6x37 G.H5 L 380 G.H5.25
Ionic TM5 H 238 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 238 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 238 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 238 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 I 139 3x54 G.H5 H 374 G.H5.19
Hydrophobic TM5 H 241 5x71 G.H5 N 364 G.H5.09
Van-der-waals TM5 H 241 5x71 G.H5 N 364 G.H5.09
Polar ICL2 N 141 34x44 G.H5 R 367 G.H5.12
Hydrophobic ICL2 N 141 34x44 G.H5 R 367 G.H5.12
Van-der-waals ICL2 N 141 34x44 G.H5 R 367 G.H5.12
Hydrophobic ICL2 W 152 34x55 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 W 152 34x55 G.hns1 K 40 G.hns1.02
Polar TM6 P 252 6x26 G.H5 R 372 G.H5.17
Hydrophobic TM6 P 252 6x26 G.H5 R 372 G.H5.17
Van-der-waals TM6 P 252 6x26 G.H5 R 372 G.H5.17
Hydrophobic TM6 A 256 6x30 G.H5 L 381 G.H5.26
Van-der-waals TM6 A 256 6x30 G.H5 L 381 G.H5.26
Hydrophobic TM6 A 256 6x30 G.H5 R 372 G.H5.17
Hydrophobic TM6 A 260 6x34 G.H5 L 380 G.H5.25
Hydrophobic TM2 S 72 2x39 G.H5 Y 378 G.H5.23
Hydrophobic TM3 I 139 3x54 G.H5 L 375 G.H5.20
Aromatic TM5 H 241 5x71 G.H5 R 367 G.H5.12
Polar TM7 D 314 7x56 G.H5 L 381 G.H5.26
Polar TM3 Y 135 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 Y 135 3x50 G.H5 Y 378 G.H5.23
Van-der-waals TM3 Y 135 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 K 138 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 K 138 3x53 G.H5 Y 378 G.H5.23
Hydrophobic ICL3 T 247 - G.S6 P 348 G.S6.03
Hydrophobic ICL2 N 141 34x44 G.H5 Q 371 G.H5.16
Van-der-waals ICL2 N 141 34x44 G.H5 Q 371 G.H5.16
Polar TM3 I 139 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 I 139 3x54 G.H5 Q 371 G.H5.16
Hydrophobic TM5 L 235 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 139 3x54 G.H5 Y 378 G.H5.23
Ionic TM1 H 59 1x57 G.H5 E 379 G.H5.24
Polar TM5 H 238 5x68 G.H5 R 367 G.H5.12
Hydrophobic TM5 H 238 5x68 G.H5 R 367 G.H5.12
Van-der-waals TM5 H 238 5x68 G.H5 R 367 G.H5.12
Polar H8 N 315 8x47 G.H5 E 379 G.H5.24
Hydrophobic H8 N 315 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 N 315 8x47 G.H5 E 379 G.H5.24
Polar ICL2 W 152 34x55 G.HN L 37 G.HN.52
Hydrophobic ICL2 W 152 34x55 G.HN L 37 G.HN.52
Van-der-waals ICL2 W 152 34x55 G.HN L 37 G.HN.52
Polar TM6 H 257 6x31 G.H5 R 372 G.H5.17
Van-der-waals TM6 H 257 6x31 G.H5 R 372 G.H5.17
Polar TM5 H 238 5x68 G.H5 Q 371 G.H5.16
Hydrophobic TM5 H 238 5x68 G.H5 Q 371 G.H5.16
Van-der-waals TM5 H 238 5x68 G.H5 Q 371 G.H5.16
Aromatic TM3 F 134 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM3 F 134 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 F 134 3x49 G.H5 Y 378 G.H5.23
Polar H8 G 317 8x49 G.H5 E 379 G.H5.24
Hydrophobic TM5 M 242 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 M 242 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM6 H 257 6x31 G.H5 L 375 G.H5.20
Polar TM2 S 72 2x39 G.H5 Q 377 G.H5.22
Hydrophobic TM5 M 242 5x72 G.S6 Y 347 G.S6.02
Ionic TM6 H 257 6x31 G.H5 D 368 G.H5.13
Polar TM6 H 257 6x31 G.H5 D 368 G.H5.13
Van-der-waals TM6 H 257 6x31 G.H5 D 368 G.H5.13
Hydrophobic TM6 H 257 6x31 G.H5 Q 371 G.H5.16
Van-der-waals TM6 H 257 6x31 G.H5 Q 371 G.H5.16
Hydrophobic H8 P 316 8x48 G.H5 L 381 G.H5.26
Van-der-waals H8 P 316 8x48 G.H5 L 381 G.H5.26