GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL3 | T | 232 | - | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | H8 | P | 301 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | P | 301 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Polar | H8 | N | 300 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | N | 300 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | N | 300 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Polar | TM7 | G | 299 | 7x56 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM7 | G | 299 | 7x56 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | I | 123 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Polar | TM5 | H | 223 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | H | 223 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | H | 223 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM5 | H | 223 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM5 | H | 223 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM5 | H | 223 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM2 | M | 60 | 2x43 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | M | 60 | 2x43 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL2 | N | 125 | 34x44 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM3 | Y | 119 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Aromatic | TM3 | Y | 119 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | Y | 119 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | Y | 119 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Polar | H8 | N | 300 | 8x47 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL2 | F | 132 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM5 | M | 227 | 5x72 | G.S6 | Y | 360 | G.S6.02 |
Polar | TM6 | A | 245 | 6x34 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | A | 245 | 6x34 | G.H5 | L | 393 | G.H5.25 |
Aromatic | TM3 | F | 118 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | F | 118 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | F | 118 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | I | 123 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL3 | T | 232 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | ICL3 | T | 232 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Ionic | TM6 | H | 242 | 6x31 | G.H5 | D | 381 | G.H5.13 |
Polar | TM6 | H | 242 | 6x31 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | H | 242 | 6x31 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | H | 242 | 6x31 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | N | 125 | 34x44 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | N | 125 | 34x44 | G.H5 | R | 380 | G.H5.12 |
Polar | ICL3 | T | 232 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | TM2 | G | 56 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | L | 220 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | H8 | P | 301 | 8x48 | G.H5 | R | 389 | G.H5.21 |
Ionic | TM5 | H | 223 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | H | 223 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | H | 223 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | H | 223 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Polar | TM3 | R | 122 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Aromatic | TM3 | R | 122 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | R | 122 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | R | 122 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Polar | TM3 | R | 122 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 122 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 122 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | Y | 119 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | Y | 119 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | A | 248 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Polar | TM3 | I | 123 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 123 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | H8 | L | 303 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | L | 303 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL3 | G | 233 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | G | 233 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | G | 233 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Ionic | TM6 | D | 236 | 6x25 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | H8 | R | 305 | 8x52 | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | ICL2 | R | 136 | 34x55 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL2 | R | 136 | 34x55 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | R | 136 | 34x55 | G.HN | Q | 35 | G.HN.52 |
Polar | ICL3 | T | 232 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | T | 232 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | T | 232 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | TM6 | S | 238 | 6x27 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | S | 238 | 6x27 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | A | 245 | 6x34 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM6 | A | 245 | 6x34 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | M | 227 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | M | 227 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | I | 123 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Polar | TM6 | S | 238 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | S | 238 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | S | 238 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | L | 216 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | P | 237 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | A | 241 | 6x30 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | A | 241 | 6x30 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | P | 237 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM7 | G | 299 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | G | 299 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | H | 242 | 6x31 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM1 | Y | 43 | 1x57 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM1 | Y | 43 | 1x57 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM1 | Y | 43 | 1x57 | G.H5 | E | 392 | G.H5.24 |