Gz - TAS2R40 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 M 60 2x43 G.H5 I 352 G.H5.23
Van-der-waals TM2 M 60 2x43 G.H5 I 352 G.H5.23
Hydrophobic TM3 K 116 3x47 G.H5 L 354 G.H5.25
Hydrophobic ICL2 K 135 34x54 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 K 135 34x54 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM3 R 122 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 122 3x53 G.H5 I 352 G.H5.23
Hydrophobic H8 P 301 8x48 G.H5 K 350 G.H5.21
Hydrophobic ICL2 F 132 34x51 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 F 132 34x51 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM2 G 56 2x39 G.H5 I 352 G.H5.23
Van-der-waals TM2 G 56 2x39 G.H5 I 352 G.H5.23
Polar ICL2 K 135 34x54 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 K 135 34x54 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 K 135 34x54 G.s2s3 K 193 G.s2s3.01
Aromatic TM5 H 226 5x71 G.H5 F 335 G.H5.06
Hydrophobic TM5 H 226 5x71 G.H5 F 335 G.H5.06
Van-der-waals TM5 H 226 5x71 G.H5 F 335 G.H5.06
Hydrophobic TM3 R 122 3x53 G.H5 L 349 G.H5.20
Van-der-waals TM3 R 122 3x53 G.H5 L 349 G.H5.20
Polar TM6 H 242 6x31 G.H5 Q 346 G.H5.17
Hydrophobic TM2 D 57 2x40 G.H5 I 352 G.H5.23
Van-der-waals TM2 D 57 2x40 G.H5 I 352 G.H5.23
Hydrophobic TM7 G 299 7x56 G.H5 C 355 G.H5.26
Van-der-waals TM7 G 299 7x56 G.H5 C 355 G.H5.26
Hydrophobic TM6 S 238 6x27 G.H5 V 343 G.H5.14
Polar TM3 Y 119 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM3 Y 119 3x50 G.H5 G 353 G.H5.24
Van-der-waals TM3 Y 119 3x50 G.H5 G 353 G.H5.24
Polar ICL1 T 52 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL1 T 52 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL1 T 52 - G.hns1 R 31 G.hns1.02
Polar TM6 A 241 6x30 G.H5 Q 346 G.H5.17
Hydrophobic TM6 A 241 6x30 G.H5 Q 346 G.H5.17
Van-der-waals TM6 A 241 6x30 G.H5 Q 346 G.H5.17
Polar H8 R 305 8x52 G.h3s5 N 262 G.h3s5.02
Hydrophobic H8 R 305 8x52 G.h3s5 N 262 G.h3s5.02
Van-der-waals H8 R 305 8x52 G.h3s5 N 262 G.h3s5.02
Van-der-waals H8 R 305 8x52 G.h3s5 I 261 G.h3s5.01
Polar TM1 Y 43 1x57 G.H5 Y 351 G.H5.22
Van-der-waals TM1 Y 43 1x57 G.H5 Y 351 G.H5.22
Hydrophobic TM6 A 245 6x34 G.H5 Q 346 G.H5.17
Van-der-waals TM6 A 245 6x34 G.H5 Q 346 G.H5.17
Hydrophobic TM6 S 238 6x27 G.S6 Y 321 G.S6.02
Polar TM3 Y 119 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 Y 119 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 Y 119 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 245 6x34 G.H5 C 355 G.H5.26
Van-der-waals TM6 A 245 6x34 G.H5 C 355 G.H5.26
Hydrophobic TM3 F 118 3x49 G.H5 I 352 G.H5.23
Hydrophobic TM6 P 237 6x26 G.S6 Y 321 G.S6.02
Hydrophobic TM6 P 237 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 P 237 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 I 123 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM5 H 223 5x68 G.H5 A 339 G.H5.10
Polar TM4 I 139 4x39 G.hns1 R 32 G.hns1.03
Hydrophobic TM4 I 139 4x39 G.hns1 R 32 G.hns1.03
Polar H8 R 305 8x52 G.H5 Y 351 G.H5.22
Van-der-waals H8 R 305 8x52 G.H5 Y 351 G.H5.22
Hydrophobic TM6 P 237 6x26 G.S6 I 320 G.S6.01
Van-der-waals TM6 P 237 6x26 G.S6 I 320 G.S6.01
Hydrophobic ICL2 N 125 34x44 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 N 125 34x44 G.s2s3 K 193 G.s2s3.01
Polar TM3 Y 119 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 Y 119 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 Y 119 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM6 F 252 6x41 G.H5 L 354 G.H5.25
Hydrophobic TM3 F 118 3x49 G.H5 L 349 G.H5.20
Ionic TM5 H 223 5x68 G.H5 D 338 G.H5.09
Hydrophobic TM2 M 60 2x43 G.H5 G 353 G.H5.24
Van-der-waals TM2 M 60 2x43 G.H5 G 353 G.H5.24
Hydrophobic TM4 V 140 4x40 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 V 140 4x40 G.hns1 R 32 G.hns1.03
Polar H8 N 300 8x47 G.H5 K 350 G.H5.21
Hydrophobic H8 N 300 8x47 G.H5 K 350 G.H5.21
Van-der-waals H8 N 300 8x47 G.H5 K 350 G.H5.21
Hydrophobic TM6 A 248 6x37 G.H5 C 355 G.H5.26
Ionic TM5 H 223 5x68 G.H5 D 342 G.H5.13
Polar TM5 H 223 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 H 223 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 M 227 5x72 G.H5 A 339 G.H5.10
Van-der-waals TM5 M 227 5x72 G.H5 A 339 G.H5.10
Polar H8 N 300 8x47 G.H5 C 355 G.H5.26
Van-der-waals H8 N 300 8x47 G.H5 C 355 G.H5.26
Hydrophobic H8 P 301 8x48 G.H5 Y 351 G.H5.22
Polar ICL2 N 125 34x44 G.H5 D 338 G.H5.09
Hydrophobic TM3 I 123 3x54 G.H5 I 345 G.H5.16
Polar ICL1 L 53 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL1 L 53 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL1 L 53 - G.hns1 R 31 G.hns1.02
Hydrophobic TM6 H 242 6x31 G.H5 D 342 G.H5.13
Polar ICL1 T 52 - G.HN S 27 G.HN.51
Hydrophobic TM7 L 296 7x53 G.H5 G 353 G.H5.24
Van-der-waals TM7 L 296 7x53 G.H5 G 353 G.H5.24
Hydrophobic H8 G 302 8x49 G.H5 Y 351 G.H5.22
Polar ICL2 R 136 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 R 136 34x55 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 136 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM7 L 296 7x53 G.H5 L 354 G.H5.25
Hydrophobic TM2 P 54 2x37 G.hns1 R 31 G.hns1.02
Van-der-waals TM2 P 54 2x37 G.hns1 R 31 G.hns1.02
Hydrophobic TM5 N 230 5x75 G.H5 F 335 G.H5.06
Van-der-waals TM5 N 230 5x75 G.H5 F 335 G.H5.06
Hydrophobic TM3 R 122 3x53 G.H5 I 345 G.H5.16
Van-der-waals TM3 R 122 3x53 G.H5 I 345 G.H5.16
Polar TM3 Y 119 3x50 G.H5 L 349 G.H5.20
Hydrophobic TM3 Y 119 3x50 G.H5 L 349 G.H5.20
Van-der-waals TM3 Y 119 3x50 G.H5 L 349 G.H5.20
Hydrophobic TM3 L 115 3x46 G.H5 L 354 G.H5.25
Polar H8 N 300 8x47 G.H5 Y 351 G.H5.22
Hydrophobic H8 N 300 8x47 G.H5 Y 351 G.H5.22
Van-der-waals H8 N 300 8x47 G.H5 Y 351 G.H5.22
Hydrophobic H8 N 300 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 N 300 8x47 G.H5 G 353 G.H5.24