GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Van-der-waals | ICL2 | N | 112 | 34x44 | G.H5 | T | 340 | G.H5.12 |
Ionic | TM5 | H | 212 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Polar | TM5 | H | 212 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | H | 212 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | H | 212 | 5x75 | G.H5 | D | 337 | G.H5.09 |
Ionic | TM6 | H | 224 | 6x31 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | H | 224 | 6x31 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | H | 224 | 6x31 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | I | 110 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | P | 219 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | L | 202 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Ionic | TM5 | H | 205 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | H | 205 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | H | 205 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | H | 205 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | A | 227 | 6x34 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | V | 231 | 6x38 | G.H5 | L | 353 | G.H5.25 |
Ionic | ICL3 | K | 214 | - | G.H5 | D | 341 | G.H5.13 |
Polar | H8 | N | 283 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | N | 283 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | N | 283 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | TM6 | S | 220 | 6x27 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | S | 220 | 6x27 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | S | 220 | 6x27 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | K | 109 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | V | 223 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | V | 223 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | F | 105 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Ionic | ICL2 | R | 123 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 123 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 123 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Aromatic | TM5 | H | 212 | 5x75 | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM5 | H | 212 | 5x75 | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | TM5 | H | 212 | 5x75 | G.H5 | F | 334 | G.H5.06 |
Polar | H8 | K | 284 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | K | 284 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | K | 284 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | I | 110 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | Y | 106 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | V | 223 | 6x30 | G.H5 | L | 348 | G.H5.20 |
Polar | TM3 | K | 109 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | K | 109 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | K | 109 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | T | 230 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 230 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL3 | K | 214 | - | G.S6 | Y | 320 | G.S6.02 |
Aromatic | ICL3 | K | 214 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL3 | K | 214 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | K | 214 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | P | 219 | 6x26 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM5 | H | 205 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Polar | TM6 | S | 220 | 6x27 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | S | 220 | 6x27 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | S | 220 | 6x27 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | A | 227 | 6x34 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | A | 227 | 6x34 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | L | 119 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | L | 119 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Ionic | ICL3 | K | 214 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | K | 214 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | K | 214 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | V | 223 | 6x30 | G.H5 | K | 345 | G.H5.17 |
Ionic | TM3 | K | 109 | 3x53 | G.H5 | E | 350 | G.H5.22 |
Polar | TM3 | K | 109 | 3x53 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM3 | K | 109 | 3x53 | G.H5 | E | 350 | G.H5.22 |
Polar | TM3 | Y | 106 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | Y | 106 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | Y | 106 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM5 | K | 208 | 5x71 | G.H5 | Q | 333 | G.H5.05 |
Hydrophobic | TM3 | I | 110 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | M | 209 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | M | 209 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM3 | I | 110 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 110 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | H | 224 | 6x31 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM7 | G | 282 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | M | 209 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | H | 205 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | H | 205 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Polar | TM6 | K | 226 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 226 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 226 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM7 | G | 282 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | G | 282 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | P | 219 | 6x26 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | P | 219 | 6x26 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM3 | I | 110 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | R | 123 | 34x55 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | R | 123 | 34x55 | G.HN | E | 28 | G.HN.52 |
Ionic | TM5 | K | 208 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Polar | TM5 | K | 208 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | K | 208 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | K | 208 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Polar | ICL3 | K | 214 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | TM6 | H | 224 | 6x31 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM6 | H | 224 | 6x31 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | R | 123 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 123 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM5 | M | 209 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | TM4 | S | 127 | 4x40 | G.HN | R | 24 | G.HN.48 |
Polar | TM7 | G | 282 | 7x56 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM7 | G | 282 | 7x56 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM2 | A | 44 | 2x39 | G.H5 | C | 351 | G.H5.23 |