GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | S | 109 | 34x44 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | S | 109 | 34x44 | G.S3 | V | 216 | G.S3.01 |
Polar | TM6 | P | 223 | 6x31 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | P | 223 | 6x31 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | P | 223 | 6x31 | G.H5 | H | 368 | G.H5.17 |
Polar | TM4 | R | 121 | 4x37 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM4 | R | 121 | 4x37 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM4 | R | 121 | 4x37 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM2 | A | 42 | 2x37 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | A | 42 | 2x37 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM3 | K | 106 | 3x53 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM5 | M | 208 | 5x72 | G.H5 | D | 361 | G.H5.10 |
Van-der-waals | TM5 | M | 208 | 5x72 | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | TM6 | A | 226 | 6x34 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM3 | Y | 103 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Polar | ICL2 | R | 111 | 34x46 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 111 | 34x46 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 111 | 34x46 | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | ICL2 | I | 116 | 34x51 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | I | 116 | 34x51 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | I | 116 | 34x51 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM4 | R | 121 | 4x37 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM4 | R | 121 | 4x37 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM4 | R | 121 | 4x37 | G.hns1 | K | 46 | G.hns1.02 |
Polar | H8 | Q | 286 | 8x52 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | H8 | Q | 286 | 8x52 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | H8 | Q | 286 | 8x52 | G.h4s6 | Q | 339 | G.h4s6.13 |
Polar | TM4 | R | 121 | 4x37 | G.HN | K | 36 | G.HN.45 |
Polar | ICL2 | M | 120 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | M | 120 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | M | 120 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | V | 110 | 34x45 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | V | 110 | 34x45 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | H8 | P | 282 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | P | 282 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | V | 212 | 5x76 | G.H5 | D | 361 | G.H5.10 |
Van-der-waals | TM5 | V | 212 | 5x76 | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | TM3 | F | 102 | 3x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | F | 102 | 3x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | K | 119 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | K | 119 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Ionic | TM5 | H | 204 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | H | 204 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | H | 204 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | H | 204 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Polar | H8 | N | 281 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | N | 281 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | N | 281 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | H | 204 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | H | 204 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM3 | K | 106 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | K | 106 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | V | 107 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | V | 107 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | W | 117 | 34x52 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | W | 117 | 34x52 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM2 | L | 44 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | L | 44 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Polar | TM3 | Y | 103 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | Y | 103 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | Y | 103 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | F | 102 | 3x49 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | F | 102 | 3x49 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | M | 120 | 34x55 | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | ICL2 | M | 120 | 34x55 | G.HN | Y | 44 | G.HN.53 |
Polar | ICL2 | F | 115 | 34x50 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | F | 115 | 34x50 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | F | 115 | 34x50 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM5 | Q | 207 | 5x71 | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | TM5 | Q | 207 | 5x71 | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | TM5 | Q | 207 | 5x71 | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | ICL2 | M | 120 | 34x55 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | M | 120 | 34x55 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | M | 120 | 34x55 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM6 | A | 226 | 6x34 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM4 | R | 121 | 4x37 | G.HN | R | 40 | G.HN.49 |
Hydrophobic | TM3 | V | 107 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Polar | TM5 | T | 211 | 5x75 | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | TM5 | T | 211 | 5x75 | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | TM5 | T | 211 | 5x75 | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | TM5 | M | 208 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | M | 208 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM6 | A | 222 | 6x30 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM4 | K | 124 | 4x40 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | TM4 | K | 124 | 4x40 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM2 | L | 44 | 2x39 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM2 | L | 44 | 2x39 | G.H5 | M | 375 | G.H5.24 |
Polar | TM2 | L | 44 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | L | 44 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | L | 44 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM4 | R | 121 | 4x37 | G.HN | S | 39 | G.HN.48 |
Hydrophobic | TM4 | R | 121 | 4x37 | G.HN | S | 39 | G.HN.48 |
Van-der-waals | TM4 | R | 121 | 4x37 | G.HN | S | 39 | G.HN.48 |
Polar | ICL2 | R | 111 | 34x46 | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | R | 111 | 34x46 | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 111 | 34x46 | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | TM5 | L | 201 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM4 | K | 124 | 4x40 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM4 | K | 124 | 4x40 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM2 | P | 43 | 2x38 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | M | 120 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | M | 120 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM6 | A | 222 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | A | 222 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | A | 222 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL2 | M | 120 | 34x55 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ICL2 | M | 120 | 34x55 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ICL2 | K | 119 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | K | 119 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM4 | S | 123 | 4x39 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM4 | S | 123 | 4x39 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM6 | A | 226 | 6x34 | G.H5 | H | 368 | G.H5.17 |