Gz - TAS2R3 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM5 Q 213 5x71 G.H5 Q 334 G.H5.05
Hydrophobic TM5 H 210 5x68 G.H5 T 341 G.H5.12
Hydrophobic TM6 D 223 6x25 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 D 223 6x25 G.h4s6 E 319 G.h4s6.12
Polar TM5 Q 213 5x71 G.H5 D 338 G.H5.09
Hydrophobic TM5 Q 213 5x71 G.H5 D 338 G.H5.09
Van-der-waals TM5 Q 213 5x71 G.H5 D 338 G.H5.09
Hydrophobic TM6 T 225 6x27 G.S6 Y 321 G.S6.02
Van-der-waals TM6 T 225 6x27 G.S6 Y 321 G.S6.02
Hydrophobic TM6 H 229 6x31 G.H5 I 345 G.H5.16
Van-der-waals TM6 H 229 6x31 G.H5 I 345 G.H5.16
Hydrophobic TM6 I 236 6x38 G.H5 L 354 G.H5.25
Polar TM6 P 224 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 P 224 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 P 224 6x26 G.h4s6 E 319 G.h4s6.12
Aromatic ICL2 W 124 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 W 124 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 124 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 S 42 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM5 M 214 5x72 G.H5 D 338 G.H5.09
Hydrophobic TM5 N 217 5x75 G.H5 F 335 G.H5.06
Hydrophobic TM7 G 287 7x56 G.H5 L 354 G.H5.25
Van-der-waals TM7 G 287 7x56 G.H5 L 354 G.H5.25
Polar H8 N 288 8x47 G.H5 I 352 G.H5.23
Ionic TM5 H 210 5x68 G.H5 D 342 G.H5.13
Polar TM5 H 210 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 H 210 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 H 210 5x68 G.H5 D 342 G.H5.13
Polar TM6 T 225 6x27 G.H5 D 342 G.H5.13
Hydrophobic TM6 T 225 6x27 G.H5 D 342 G.H5.13
Van-der-waals TM6 T 225 6x27 G.H5 D 342 G.H5.13
Polar TM3 K 110 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 K 110 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 K 110 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 M 214 5x72 G.H5 D 342 G.H5.13
Hydrophobic TM5 M 214 5x72 G.H5 A 339 G.H5.10
Hydrophobic ICL2 L 120 34x51 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 L 120 34x51 G.s2s3 E 194 G.s2s3.02
Polar ICL2 W 124 34x55 G.HN Q 28 G.HN.52
Hydrophobic ICL3 T 219 - G.S6 Y 321 G.S6.02
Hydrophobic TM3 I 111 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM3 K 110 3x53 G.H5 Y 351 G.H5.22
Polar H8 N 288 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 N 288 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 N 288 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM5 M 214 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 M 214 5x72 G.S6 Y 321 G.S6.02
Polar TM6 T 225 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 T 225 6x27 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 T 225 6x27 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM7 G 287 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM3 I 111 3x54 G.H5 I 352 G.H5.23
Van-der-waals TM3 I 111 3x54 G.H5 I 352 G.H5.23
Hydrophobic TM3 I 111 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM6 A 228 6x30 G.H5 C 355 G.H5.26
Van-der-waals TM6 A 228 6x30 G.H5 C 355 G.H5.26
Ionic TM6 H 229 6x31 G.H5 D 342 G.H5.13
Polar TM6 H 229 6x31 G.H5 D 342 G.H5.13
Hydrophobic TM6 H 229 6x31 G.H5 D 342 G.H5.13
Van-der-waals TM6 H 229 6x31 G.H5 D 342 G.H5.13
Hydrophobic TM6 A 228 6x30 G.H5 Q 346 G.H5.17
Van-der-waals TM6 A 228 6x30 G.H5 Q 346 G.H5.17
Polar H8 S 289 8x48 G.H5 C 355 G.H5.26
Hydrophobic H8 S 289 8x48 G.H5 C 355 G.H5.26
Van-der-waals H8 S 289 8x48 G.H5 C 355 G.H5.26
Polar TM6 T 225 6x27 G.H5 Q 346 G.H5.17
Hydrophobic TM6 T 225 6x27 G.H5 Q 346 G.H5.17
Van-der-waals TM6 T 225 6x27 G.H5 Q 346 G.H5.17
Polar TM6 H 229 6x31 G.H5 Q 346 G.H5.17
Polar TM2 L 43 2x38 G.H5 Y 351 G.H5.22
Polar H8 S 289 8x48 G.H5 G 353 G.H5.24
Van-der-waals H8 S 289 8x48 G.H5 G 353 G.H5.24
Hydrophobic TM3 Y 107 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 111 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 111 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM3 I 111 3x54 G.H5 N 348 G.H5.19
Hydrophobic TM6 A 232 6x34 G.H5 L 349 G.H5.20
Van-der-waals TM6 A 232 6x34 G.H5 L 349 G.H5.20
Hydrophobic TM6 I 235 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 207 5x65 G.H5 I 345 G.H5.16
Polar TM5 N 217 5x75 G.H5 D 338 G.H5.09
Van-der-waals TM5 N 217 5x75 G.H5 D 338 G.H5.09
Hydrophobic TM5 H 210 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 H 210 5x68 G.H5 I 345 G.H5.16
Polar TM2 S 44 2x39 G.H5 I 352 G.H5.23
Hydrophobic TM2 S 44 2x39 G.H5 I 352 G.H5.23
Polar TM3 Y 107 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 Y 107 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 Y 107 3x50 G.H5 I 352 G.H5.23