GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | H | 198 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | H | 198 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | H | 198 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | L | 116 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | L | 116 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Polar | ICL2 | Q | 120 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 120 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 120 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM6 | A | 220 | 6x34 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM6 | H | 217 | 6x31 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM6 | H | 217 | 6x31 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | A | 216 | 6x30 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM3 | I | 107 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | I | 107 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | H8 | I | 276 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | I | 276 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | P | 277 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | H8 | P | 277 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Ionic | H8 | R | 278 | 8x49 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | R | 278 | 8x49 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | R | 278 | 8x49 | G.H5 | D | 369 | G.H5.21 |
Polar | TM2 | Y | 44 | 2x39 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM2 | Y | 44 | 2x39 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM2 | Y | 44 | 2x39 | G.H5 | N | 372 | G.H5.24 |
Polar | TM3 | Y | 103 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | Y | 103 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | Y | 103 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM1 | W | 30 | 1x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM1 | W | 30 | 1x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | K | 106 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | K | 106 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM5 | H | 198 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | H | 198 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | K | 106 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | H8 | P | 277 | 8x48 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | H | 217 | 6x31 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | H | 217 | 6x31 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL3 | R | 209 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Van-der-waals | ICL3 | R | 209 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Hydrophobic | TM3 | F | 102 | 3x49 | G.H5 | I | 371 | G.H5.23 |
Polar | ICL2 | T | 109 | 34x44 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | T | 109 | 34x44 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | T | 109 | 34x44 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM3 | I | 107 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | I | 107 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Ionic | TM5 | H | 198 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | H | 198 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | H | 198 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | H | 198 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM6 | R | 213 | 6x27 | G.S6 | F | 340 | G.S6.02 |
Van-der-waals | TM6 | R | 213 | 6x27 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | TM6 | R | 213 | 6x27 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | R | 213 | 6x27 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | A | 220 | 6x34 | G.H5 | L | 373 | G.H5.25 |
Ionic | TM3 | K | 106 | 3x53 | G.H5 | E | 370 | G.H5.22 |
Polar | TM3 | K | 106 | 3x53 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM3 | K | 106 | 3x53 | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | Q | 120 | 34x55 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | ICL2 | Q | 120 | 34x55 | G.HN | K | 37 | G.HN.52 |
Van-der-waals | ICL2 | Q | 120 | 34x55 | G.HN | K | 37 | G.HN.52 |
Polar | H8 | R | 278 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | R | 278 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | R | 278 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | M | 202 | 5x72 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | TM5 | M | 202 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | M | 202 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Polar | H8 | P | 277 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | P | 277 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | P | 277 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | Y | 103 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | Y | 103 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | K | 119 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | K | 119 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | K | 119 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | H8 | P | 277 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | P | 277 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Polar | TM2 | Y | 44 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM2 | Y | 44 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM2 | Y | 44 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM2 | Y | 44 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | Y | 44 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Polar | TM5 | K | 201 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | K | 201 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | ICL2 | Q | 120 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL2 | P | 113 | 34x48 | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | ICL2 | P | 113 | 34x48 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | TM3 | I | 107 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | I | 107 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Ionic | ICL2 | D | 111 | 34x46 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM3 | I | 107 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Polar | TM5 | H | 205 | 5x75 | G.H5 | K | 357 | G.H5.09 |
Aromatic | TM5 | H | 205 | 5x75 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | TM5 | H | 205 | 5x75 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | H | 205 | 5x75 | G.H5 | K | 357 | G.H5.09 |