Gt2 - TAS2R5 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 T 109 34x44 G.H5 I 344 G.H5.16
Ionic TM5 H 198 5x68 G.H5 D 341 G.H5.13
Polar TM5 H 198 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 H 198 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 198 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 M 202 5x72 G.H5 F 334 G.H5.06
Hydrophobic TM3 I 107 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM3 Y 103 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 195 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 T 109 34x44 G.H5 T 340 G.H5.12
Polar TM3 Y 103 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 103 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 103 3x50 G.H5 C 351 G.H5.23
Polar TM6 R 213 6x27 G.S6 I 319 G.S6.01
Hydrophobic TM6 R 213 6x27 G.S6 I 319 G.S6.01
Van-der-waals TM6 R 213 6x27 G.S6 I 319 G.S6.01
Ionic TM5 K 201 5x71 G.H5 D 337 G.H5.09
Polar TM5 K 201 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 K 201 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 K 201 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM3 I 107 3x54 G.H5 N 347 G.H5.19
Polar TM6 R 213 6x27 G.S6 Y 320 G.S6.02
Aromatic TM6 R 213 6x27 G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 213 6x27 G.S6 Y 320 G.S6.02
Van-der-waals TM6 R 213 6x27 G.S6 Y 320 G.S6.02
Hydrophobic TM5 H 198 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 198 5x68 G.H5 I 344 G.H5.16
Polar TM6 V 212 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 V 212 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 L 116 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 L 116 34x51 G.s2s3 D 193 G.s2s3.02
Ionic TM3 K 106 3x53 G.H5 D 350 G.H5.22
Polar TM3 K 106 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 K 106 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 K 106 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 195 5x65 G.H5 I 344 G.H5.16
Van-der-waals TM5 L 195 5x65 G.H5 I 344 G.H5.16
Aromatic TM5 H 205 5x75 G.H5 F 334 G.H5.06
Hydrophobic TM5 H 205 5x75 G.H5 F 334 G.H5.06
Van-der-waals TM5 H 205 5x75 G.H5 F 334 G.H5.06
Hydrophobic TM6 S 223 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 223 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 202 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM3 F 102 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 107 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 107 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 H 217 6x31 G.H5 I 344 G.H5.16
Van-der-waals TM6 H 217 6x31 G.H5 I 344 G.H5.16
Hydrophobic TM6 A 220 6x34 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 220 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 107 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 109 34x44 G.s2s3 K 192 G.s2s3.01
Polar TM5 H 198 5x68 G.H5 D 337 G.H5.09
Polar TM3 K 106 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 106 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 106 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM7 G 275 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 G 275 7x56 G.H5 G 352 G.H5.24
Ionic TM6 R 213 6x27 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 213 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 213 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 213 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 H 198 5x68 G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 116 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic H8 I 276 8x47 G.H5 G 352 G.H5.24
Polar ICL2 Q 120 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 M 202 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 M 202 5x72 G.H5 D 341 G.H5.13
Ionic ICL2 D 111 34x46 G.s2s3 K 192 G.s2s3.01
Polar ICL2 D 111 34x46 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 D 111 34x46 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 D 111 34x46 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 A 216 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM3 I 107 3x54 G.H5 C 351 G.H5.23
Polar TM6 A 220 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 220 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 220 6x34 G.H5 L 353 G.H5.25
Ionic TM6 H 217 6x31 G.H5 D 341 G.H5.13
Polar TM6 H 217 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM6 H 217 6x31 G.H5 D 341 G.H5.13
Van-der-waals TM6 H 217 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM6 L 224 6x38 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 202 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 M 202 5x72 G.H5 A 338 G.H5.10
Polar TM2 Y 44 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 Y 44 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 Y 44 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 216 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 216 6x30 G.H5 F 354 G.H5.26