G12 - TAS2R8 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 76.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 24.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 W 121 34x52 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 W 121 34x52 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 W 121 34x52 G.s2s3 K 220 G.s2s3.02
Polar TM4 D 127 4x39 G.hns1 R 55 G.hns1.02
Hydrophobic TM4 D 127 4x39 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 D 127 4x39 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 W 132 4x44 G.HN R 52 G.HN.52
Polar ICL2 W 121 34x52 G.hns1 R 56 G.hns1.03
Aromatic ICL2 W 121 34x52 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 W 121 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 M 128 4x40 G.HN A 53 G.HN.53
Van-der-waals TM4 M 128 4x40 G.HN A 53 G.HN.53
Polar ICL1 I 41 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 I 41 - G.hns1 R 55 G.hns1.02
Aromatic TM5 Y 218 5x75 G.H5 F 361 G.H5.06
Hydrophobic TM5 Y 218 5x75 G.H5 F 361 G.H5.06
Van-der-waals TM5 Y 218 5x75 G.H5 F 361 G.H5.06
Hydrophobic TM3 Y 107 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 Y 107 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM4 K 125 4x37 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 K 125 4x37 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 P 225 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 P 225 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 W 124 34x55 G.HN A 53 G.HN.53
Van-der-waals ICL2 W 124 34x55 G.HN A 53 G.HN.53
Polar H8 N 289 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 N 289 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 289 8x47 G.H5 M 379 G.H5.24
Polar H8 K 291 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 291 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM3 K 110 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 K 110 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 K 123 34x54 G.H5 L 371 G.H5.16
Van-der-waals ICL2 K 123 34x54 G.H5 L 371 G.H5.16
Polar TM5 H 211 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 H 211 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 211 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM6 A 233 6x34 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 233 6x34 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 120 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 120 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM6 V 229 6x30 G.H5 K 376 G.H5.21
Van-der-waals TM6 V 229 6x30 G.H5 K 376 G.H5.21
Hydrophobic H8 N 289 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 289 8x47 G.H5 L 380 G.H5.25
Polar H8 N 290 8x48 G.H5 L 380 G.H5.25
Hydrophobic H8 N 290 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 N 290 8x48 G.H5 L 380 G.H5.25
Hydrophobic H8 K 291 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 291 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 111 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 111 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM4 M 128 4x40 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 M 128 4x40 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 W 124 34x55 G.S1 L 57 G.S1.01
Van-der-waals ICL2 W 124 34x55 G.S1 L 57 G.S1.01
Hydrophobic ICL2 S 113 34x44 G.H5 K 367 G.H5.12
Hydrophobic TM7 L 288 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 288 7x56 G.H5 L 380 G.H5.25
Polar ICL2 W 124 34x55 G.S3 P 222 G.S3.02
Hydrophobic ICL2 W 124 34x55 G.S3 P 222 G.S3.02
Van-der-waals ICL2 W 124 34x55 G.S3 P 222 G.S3.02
Ionic TM5 H 211 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 211 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 211 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 211 5x68 G.H5 D 368 G.H5.13
Hydrophobic ICL2 P 117 34x48 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 P 117 34x48 G.s2s3 K 219 G.s2s3.01
Hydrophobic TM6 T 236 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 236 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM2 V 44 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 V 44 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM3 K 110 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 K 110 3x53 G.H5 L 375 G.H5.20
Polar ICL2 S 113 34x44 G.H5 D 368 G.H5.13
Hydrophobic ICL2 S 113 34x44 G.H5 D 368 G.H5.13
Van-der-waals ICL2 S 113 34x44 G.H5 D 368 G.H5.13
Hydrophobic ICL2 S 113 34x44 G.H5 L 371 G.H5.16
Van-der-waals ICL2 S 113 34x44 G.H5 L 371 G.H5.16
Hydrophobic ICL2 K 123 34x54 G.S3 I 221 G.S3.01
Hydrophobic TM3 I 111 3x54 G.H5 M 379 G.H5.24
Van-der-waals TM3 I 111 3x54 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 120 34x51 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 L 120 34x51 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 W 124 34x55 G.S3 I 221 G.S3.01
Van-der-waals ICL2 W 124 34x55 G.S3 I 221 G.S3.01
Polar H8 N 289 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 289 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 289 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM2 T 43 2x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 T 43 2x38 G.hns1 R 55 G.hns1.02
Polar TM6 H 230 6x31 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 230 6x31 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 230 6x31 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 120 34x51 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 L 120 34x51 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 L 118 34x49 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM4 M 128 4x40 G.HN R 49 G.HN.49
Van-der-waals TM4 M 128 4x40 G.HN R 49 G.HN.49
Hydrophobic TM3 F 106 3x49 G.H5 I 378 G.H5.23
Van-der-waals TM3 F 106 3x49 G.H5 I 378 G.H5.23
Hydrophobic TM6 S 226 6x27 G.S6 F 347 G.S6.02
Polar ICL2 W 124 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 W 124 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 W 124 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 P 117 34x48 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 P 117 34x48 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 P 117 34x48 G.s2s3 K 220 G.s2s3.02
Polar TM5 Q 214 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM5 Q 214 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 Q 214 5x71 G.H5 H 364 G.H5.09
Polar TM4 M 128 4x40 G.HN R 52 G.HN.52
Hydrophobic TM4 M 128 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 M 128 4x40 G.HN R 52 G.HN.52
Polar ICL2 S 115 34x46 G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL2 S 115 34x46 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 S 115 34x46 G.s2s3 K 219 G.s2s3.01
Hydrophobic TM3 Y 107 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 Y 107 3x50 G.H5 I 378 G.H5.23