G12 - TAS2R9 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 77.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 W 121 34x52 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM2 S 42 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 S 42 2x37 G.hns1 R 55 G.hns1.02
Polar ICL1 I 41 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 I 41 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 I 41 - G.hns1 R 55 G.hns1.02
Hydrophobic TM7 G 285 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 G 285 7x56 G.H5 M 379 G.H5.24
Polar TM3 Y 107 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM3 Y 107 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 Y 107 3x50 G.H5 M 379 G.H5.24
Polar H8 N 286 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 N 286 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 286 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM4 K 125 4x37 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 K 125 4x37 G.hns1 R 56 G.hns1.03
Hydrophobic H8 K 288 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 288 8x49 G.H5 Q 381 G.H5.26
Ionic ICL1 D 40 - G.HN R 51 G.HN.51
Polar ICL1 D 40 - G.HN R 51 G.HN.51
Hydrophobic ICL1 D 40 - G.HN R 51 G.HN.51
Van-der-waals ICL1 D 40 - G.HN R 51 G.HN.51
Hydrophobic ICL2 L 124 34x55 G.S2 V 217 G.S2.07
Polar TM7 G 285 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM7 G 285 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 G 285 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM4 N 127 4x39 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 N 127 4x39 G.hns1 R 56 G.hns1.03
Polar TM1 R 39 1x65 G.HN R 51 G.HN.51
Hydrophobic TM6 S 223 6x27 G.S6 F 347 G.S6.02
Hydrophobic TM3 K 110 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 K 110 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 S 223 6x27 G.H5 Q 372 G.H5.17
Van-der-waals TM6 S 223 6x27 G.H5 Q 372 G.H5.17
Hydrophobic H8 R 290 8x51 G.H5 L 380 G.H5.25
Van-der-waals H8 R 290 8x51 G.H5 L 380 G.H5.25
Hydrophobic TM6 P 222 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 P 222 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 I 111 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 111 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 K 123 34x54 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 K 123 34x54 G.s2s3 K 220 G.s2s3.02
Polar H8 N 286 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 286 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 286 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM6 A 226 6x30 G.H5 K 376 G.H5.21
Van-der-waals TM6 A 226 6x30 G.H5 K 376 G.H5.21
Van-der-waals ICL2 N 113 34x44 G.H5 K 367 G.H5.12
Ionic ICL1 D 40 - G.hns1 R 55 G.hns1.02
Polar ICL1 D 40 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 D 40 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 D 40 - G.hns1 R 55 G.hns1.02
Polar TM6 P 222 6x26 G.H5 K 376 G.H5.21
Polar H8 K 288 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 288 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 124 34x55 G.S3 P 222 G.S3.02
Polar TM5 H 208 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 H 208 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 208 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM2 I 44 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 I 44 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM2 I 44 2x39 G.H5 Q 381 G.H5.26
Van-der-waals TM2 I 44 2x39 G.H5 Q 381 G.H5.26
Hydrophobic TM3 K 110 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 K 110 3x53 G.H5 L 375 G.H5.20
Polar ICL2 N 113 34x44 G.H5 D 368 G.H5.13
Van-der-waals ICL2 N 113 34x44 G.H5 D 368 G.H5.13
Hydrophobic ICL2 N 113 34x44 G.H5 L 371 G.H5.16
Van-der-waals ICL2 N 113 34x44 G.H5 L 371 G.H5.16
Hydrophobic ICL2 K 123 34x54 G.S3 I 221 G.S3.01
Van-der-waals ICL2 K 123 34x54 G.S3 I 221 G.S3.01
Hydrophobic TM6 A 230 6x34 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 230 6x34 G.H5 M 379 G.H5.24
Hydrophobic H8 N 286 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 286 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 N 113 34x44 G.s2s3 K 219 G.s2s3.01
Aromatic TM5 H 215 5x75 G.H5 F 361 G.H5.06
Hydrophobic TM5 H 215 5x75 G.H5 F 361 G.H5.06
Van-der-waals TM5 H 215 5x75 G.H5 F 361 G.H5.06
Hydrophobic TM3 I 111 3x54 G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 120 34x51 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 F 120 34x51 G.s2s3 K 220 G.s2s3.02
Van-der-waals TM2 L 43 2x38 G.hns1 R 55 G.hns1.02
Polar H8 S 287 8x48 G.H5 L 380 G.H5.25
Hydrophobic H8 S 287 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 S 287 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM4 I 126 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 I 126 4x38 G.hns1 R 56 G.hns1.03
Ionic TM5 H 208 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 208 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 208 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 208 5x68 G.H5 D 368 G.H5.13
Hydrophobic ICL2 F 120 34x51 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 F 120 34x51 G.s2s3 K 219 G.s2s3.01
Polar ICL2 K 123 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 123 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 123 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 F 106 3x49 G.H5 I 378 G.H5.23
Van-der-waals TM3 F 106 3x49 G.H5 I 378 G.H5.23
Polar ICL2 L 124 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 L 124 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 L 124 34x55 G.s2s3 K 220 G.s2s3.02
Polar H8 S 287 8x48 G.H5 D 377 G.H5.22
Polar ICL2 L 124 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 124 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 124 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 P 117 34x48 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 P 117 34x48 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM4 K 128 4x40 G.HN R 52 G.HN.52
Polar TM6 H 227 6x31 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 227 6x31 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 227 6x31 G.H5 Q 372 G.H5.17
Hydrophobic TM3 Y 107 3x50 G.H5 I 378 G.H5.23
Polar ICL2 L 122 34x53 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 122 34x53 G.hns1 R 56 G.hns1.03
Polar TM4 N 127 4x39 G.HN R 52 G.HN.52
Hydrophobic TM4 N 127 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 N 127 4x39 G.HN R 52 G.HN.52