G11 -
TP receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 87.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | S | 239 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | S | 239 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | R | 235 | 6x25 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM6 | R | 235 | 6x25 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | H8 | R | 312 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | H8 | R | 312 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | F | 138 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | F | 138 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM1 | L | 49 | 1x57 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | H8 | R | 318 | 8x53 | G.H5 | V | 359 | G.H5.26 |
Polar | TM2 | S | 61 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | S | 61 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | S | 61 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | R | 140 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | R | 140 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | R | 140 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | H8 | A | 314 | 8x49 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | L | 222 | 5x65 | G.H5 | L | 349 | G.H5.16 |
Ionic | TM6 | R | 235 | 6x25 | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | R | 235 | 6x25 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM6 | R | 235 | 6x25 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM6 | R | 235 | 6x25 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM2 | L | 67 | 2x43 | G.H5 | L | 358 | G.H5.25 |
Polar | TM6 | R | 235 | 6x25 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | R | 235 | 6x25 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | R | 235 | 6x25 | G.H5 | Q | 350 | G.H5.17 |
Aromatic | ICL2 | F | 138 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | F | 138 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | F | 138 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Polar | TM6 | E | 240 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | E | 240 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Ionic | ICL1 | H | 58 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL1 | H | 58 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | A | 144 | 34x57 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | A | 144 | 34x57 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | H8 | A | 314 | 8x49 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | V | 143 | 34x56 | G.HN | K | 33 | G.HN.51 |
Polar | ICL2 | P | 137 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM7 | I | 309 | 7x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 137 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | ICL2 | F | 138 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | F | 138 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM5 | V | 225 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | F | 138 | 34x51 | G.S3 | F | 201 | G.S3.03 |
Hydrophobic | TM2 | L | 64 | 2x40 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM2 | L | 64 | 2x40 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL3 | A | 231 | - | G.H5 | F | 339 | G.H5.06 |
Polar | TM6 | Q | 234 | 6x24 | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | TM6 | Q | 234 | 6x24 | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | TM6 | Q | 234 | 6x24 | G.S6 | S | 326 | G.S6.03 |
Polar | TM3 | G | 133 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | G | 133 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | G | 133 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Aromatic | TM3 | R | 130 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 130 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | L | 222 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | E | 240 | 6x30 | G.H5 | L | 353 | G.H5.20 |
Polar | H8 | R | 312 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | R | 312 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | R | 312 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | S | 239 | 6x29 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | F | 138 | 34x51 | G.H5 | V | 344 | G.H5.11 |
Hydrophobic | ICL3 | A | 231 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | A | 231 | - | G.S6 | Y | 325 | G.S6.02 |
Polar | TM3 | E | 129 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | E | 129 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | E | 129 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | M | 243 | 6x33 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM6 | M | 243 | 6x33 | G.H5 | Y | 356 | G.H5.23 |
Polar | H8 | R | 318 | 8x53 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | I | 134 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | P | 137 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | F | 138 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | F | 138 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | TM6 | M | 243 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | M | 243 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | M | 243 | 6x33 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | M | 243 | 6x33 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | V | 315 | 8x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | I | 134 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM6 | S | 239 | 6x29 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | S | 239 | 6x29 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | E | 242 | 6x32 | G.H5 | N | 357 | G.H5.24 |
Polar | H8 | R | 312 | 8x47 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | H8 | R | 312 | 8x47 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | H8 | R | 312 | 8x47 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL2 | R | 140 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | R | 140 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | R | 140 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Ionic | H8 | R | 328 | 8x63 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | H8 | R | 328 | 8x63 | G.h4s6 | D | 321 | G.h4s6.12 |
Aromatic | TM2 | F | 63 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | F | 63 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | F | 63 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | Q | 234 | 6x24 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM6 | Q | 234 | 6x24 | G.S6 | Y | 325 | G.S6.02 |
Polar | TM3 | G | 133 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | G | 133 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | G | 133 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | F | 138 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | F | 138 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Hydrophobic | H8 | L | 330 | 8x65 | G.h4s6 | S | 320 | G.h4s6.11 |
Ionic | ICL2 | R | 140 | 34x53 | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | R | 140 | 34x53 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | R | 140 | 34x53 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | R | 140 | 34x53 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM3 | I | 134 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | P | 141 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | P | 141 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |