Ggust - TA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 130 34x52 G.S3 L 194 G.S3.01
Van-der-waals ICL2 R 130 34x52 G.S3 L 194 G.S3.01
Hydrophobic ICL2 K 134 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 134 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 133 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 133 34x55 G.hns1 R 32 G.hns1.03
Polar H8 Y 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 Y 308 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 Y 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 Y 308 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 Y 308 8x47 G.H5 D 350 G.H5.22
Polar TM4 N 136 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 N 136 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 N 136 4x38 G.HN E 28 G.HN.52
Polar TM6 K 248 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 248 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 248 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 Q 220 5x68 G.H5 L 348 G.H5.20
Ionic TM6 K 245 6x29 G.h4s6 E 318 G.h4s6.12
Polar C-term E 336 - G.h4s6 D 316 G.h4s6.10
Hydrophobic C-term E 336 - G.h4s6 D 316 G.h4s6.10
Van-der-waals C-term E 336 - G.h4s6 D 316 G.h4s6.10
Hydrophobic TM5 I 213 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 213 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 129 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 129 34x51 G.S1 V 34 G.S1.02
Ionic ICL2 R 130 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 130 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 130 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 130 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 A 133 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 A 133 34x55 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 A 133 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic H8 W 310 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 W 310 8x49 G.H5 D 350 G.H5.22
Van-der-waals TM3 V 125 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 Q 220 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM3 A 124 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 124 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 128 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 128 34x50 G.H5 I 344 G.H5.16
Ionic C-term E 336 - G.h4s6 K 313 G.h4s6.04
Polar C-term E 336 - G.h4s6 K 313 G.h4s6.04
Hydrophobic C-term E 336 - G.h4s6 K 313 G.h4s6.04
Van-der-waals C-term E 336 - G.h4s6 K 313 G.h4s6.04
Hydrophobic TM6 K 245 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 245 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 125 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 133 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 A 133 34x55 G.HN E 28 G.HN.52
Polar TM5 Q 220 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 220 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 220 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 224 5x72 G.H5 K 345 G.H5.17
Hydrophobic TM5 A 217 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 D 127 3x56 G.S3 L 194 G.S3.01
Van-der-waals TM3 D 127 3x56 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 129 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 129 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 R 130 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 130 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic TM4 L 138 4x40 G.HN Q 24 G.HN.48
Van-der-waals TM4 L 138 4x40 G.HN Q 24 G.HN.48
Hydrophobic TM3 V 125 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 V 125 3x54 G.H5 L 353 G.H5.25
Polar TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 129 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM6 L 253 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 253 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 125 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 125 3x54 G.H5 L 348 G.H5.20
Polar C-term L 337 - G.h4s6 D 316 G.h4s6.10
Hydrophobic C-term L 337 - G.h4s6 D 316 G.h4s6.10
Van-der-waals C-term L 337 - G.h4s6 D 316 G.h4s6.10
Hydrophobic ICL2 L 129 34x51 G.S3 F 196 G.S3.03
Van-der-waals ICL2 L 129 34x51 G.S3 F 196 G.S3.03
Hydrophobic TM5 I 224 5x72 G.H5 F 354 G.H5.26
Van-der-waals TM5 I 224 5x72 G.H5 F 354 G.H5.26
Polar ICL2 P 128 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 128 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 128 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 129 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 129 34x51 G.hns1 R 32 G.hns1.03
Polar H8 Y 308 8x47 G.H5 C 351 G.H5.23
Hydrophobic H8 Y 308 8x47 G.H5 C 351 G.H5.23
Van-der-waals H8 Y 308 8x47 G.H5 C 351 G.H5.23
Hydrophobic C-term L 335 - G.h4s6 D 316 G.h4s6.10
Van-der-waals C-term L 335 - G.h4s6 D 316 G.h4s6.10
Polar TM6 A 249 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 249 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 249 6x33 G.H5 L 353 G.H5.25
Polar ICL2 K 132 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 K 132 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 132 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic C-term L 337 - G.h4s6 E 315 G.h4s6.09
Van-der-waals C-term L 337 - G.h4s6 E 315 G.h4s6.09
Hydrophobic ICL2 L 129 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 129 34x51 G.S3 L 194 G.S3.01
Polar TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 C 351 G.H5.23