Gs - TAAR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 231 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM3 V 133 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM3 V 133 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 137 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 137 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 T 140 34x54 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 T 140 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 H 227 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 227 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 136 34x50 G.H5 Q 384 G.H5.16
Polar TM3 A 132 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 132 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 132 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 V 223 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 223 5x64 G.H5 Q 384 G.H5.16
Aromatic TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 S 224 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 231 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 231 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 L 258 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 258 6x37 G.H5 L 393 G.H5.25
Polar TM3 V 133 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 133 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 133 3x54 G.H5 Q 384 G.H5.16
Hydrophobic H8 W 315 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 W 315 8x49 G.H5 Q 390 G.H5.22
Polar ICL2 L 137 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 137 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 137 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM7 F 312 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 F 312 7x56 G.H5 E 392 G.H5.24
Aromatic ICL2 Y 139 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 139 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 137 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 137 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM3 A 132 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 132 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 137 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM4 T 144 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 144 4x38 G.HN Q 35 G.HN.52
Polar TM5 S 224 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 S 224 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 S 224 5x65 G.H5 L 393 G.H5.25
Polar ICL1 H 63 12x51 G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 H 63 12x51 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 137 34x51 G.H5 R 380 G.H5.12
Ionic TM6 K 253 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 253 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 253 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 253 6x32 G.H5 E 392 G.H5.24
Polar ICL2 T 140 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 T 140 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 T 140 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 231 5x72 G.H5 L 394 G.H5.26
Van-der-waals TM5 I 231 5x72 G.H5 L 394 G.H5.26
Polar C-term E 341 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM5 I 220 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 220 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 257 6x36 G.H5 L 393 G.H5.25
Polar TM6 T 257 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 257 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 A 254 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 254 6x33 G.H5 L 393 G.H5.25
Polar TM6 K 253 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 253 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 253 6x32 G.H5 L 394 G.H5.26
Polar TM5 H 227 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 227 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 227 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 H 138 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 H 138 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 137 34x51 G.H5 C 379 G.H5.11
Hydrophobic H8 P 314 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 P 314 8x48 G.H5 E 392 G.H5.24
Polar C-term H 343 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term H 343 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term H 343 - G.h4s6 R 356 G.h4s6.12
Polar TM5 H 227 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 227 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 227 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 141 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 T 141 34x55 G.hns1 A 39 G.hns1.03
Polar ICL2 H 138 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 H 138 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic TM5 V 223 5x64 G.H5 L 388 G.H5.20
Hydrophobic C-term A 342 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term A 342 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM3 V 133 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 H 227 5x68 G.H5 L 394 G.H5.26
Van-der-waals TM5 H 227 5x68 G.H5 L 394 G.H5.26
Hydrophobic ICL2 P 136 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 136 34x50 G.H5 R 380 G.H5.12
Hydrophobic ICL2 H 138 34x52 G.H5 F 376 G.H5.08
Van-der-waals TM6 K 250 6x29 G.H5 L 394 G.H5.26
Polar TM5 K 239 5x80 G.h4s6 A 351 G.h4s6.04
Hydrophobic ICL2 P 136 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 136 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 V 234 5x75 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 L 137 34x51 G.S3 V 217 G.S3.01
Ionic TM5 H 227 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 227 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 227 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 227 5x68 G.H5 D 381 G.H5.13