G12 - TAAR5 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 139 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 140 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 140 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM5 A 226 5x65 G.H5 M 379 G.H5.24
Van-der-waals TM5 A 226 5x65 G.H5 M 379 G.H5.24
Van-der-waals TM6 E 247 6x30 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 140 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 140 34x51 G.H5 I 370 G.H5.15
Polar ICL2 P 143 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 143 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 K 249 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 249 6x32 G.H5 Q 381 G.H5.26
Hydrophobic H8 Y 309 8x47 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 140 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 140 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 L 141 34x52 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 141 34x52 G.S3 I 221 G.S3.01
Hydrophobic TM3 I 136 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 136 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 A 251 6x34 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 251 6x34 G.H5 M 379 G.H5.24
Hydrophobic TM5 Q 229 5x68 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 139 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 139 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 L 254 6x37 G.H5 M 379 G.H5.24
Hydrophobic ICL3 L 236 - G.S6 F 347 G.S6.02
Hydrophobic ICL2 L 140 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 140 34x51 G.S1 V 58 G.S1.02
Polar TM6 T 253 6x36 G.H5 M 379 G.H5.24
Polar TM7 S 308 7x56 G.H5 Q 381 G.H5.26
Polar TM6 H 246 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 H 246 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 H 246 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 A 250 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 A 250 6x33 G.H5 Q 381 G.H5.26
Polar TM5 Q 229 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 Q 229 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 229 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 I 136 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 136 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 T 253 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 253 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 250 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 250 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM7 S 308 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 S 308 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM3 A 135 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 135 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM4 T 147 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 147 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 E 247 6x30 G.H5 L 375 G.H5.20
Hydrophobic H8 Y 309 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 Y 309 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM5 A 226 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 139 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 143 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 143 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM4 V 148 4x39 G.HN R 52 G.HN.52
Hydrophobic TM5 V 225 5x64 G.H5 L 371 G.H5.16
Polar ICL2 S 144 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 144 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 144 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 L 240 6x23 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 L 240 6x23 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM3 R 132 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 132 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 140 34x51 G.H5 K 367 G.H5.12
Polar H8 Q 310 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 Q 310 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 Q 310 8x48 G.H5 Q 381 G.H5.26
Polar TM3 A 135 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 135 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 135 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 L 240 6x23 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM3 I 136 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM5 Q 229 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 Q 229 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 I 233 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 233 5x72 G.H5 Q 372 G.H5.17
Hydrophobic H8 Y 309 8x47 G.H5 D 377 G.H5.22
Van-der-waals H8 Y 309 8x47 G.H5 D 377 G.H5.22
Hydrophobic TM6 L 240 6x23 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 L 240 6x23 G.h4s6 P 345 G.h4s6.20
Hydrophobic H8 W 311 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 W 311 8x49 G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 140 34x51 G.H5 V 366 G.H5.11