Gs - TAAR5 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 S 144 34x55 G.hns1 A 39 G.hns1.03
Ionic C-term E 337 - G.h4s6 R 356 G.h4s6.12
Polar C-term E 337 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term E 337 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term E 337 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM3 I 136 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 139 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 139 34x50 G.H5 R 380 G.H5.12
Polar TM6 A 250 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 250 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 250 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 H 246 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 H 246 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM5 Q 229 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 233 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 233 5x72 G.h4s6 Y 358 G.h4s6.20
Polar H8 Q 310 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 310 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 310 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 A 230 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM4 T 147 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 147 4x38 G.HN Q 35 G.HN.52
Hydrophobic H8 Y 309 8x47 G.H5 Y 391 G.H5.23
Aromatic TM3 R 132 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 132 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM7 S 308 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 S 308 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 140 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 L 141 34x52 G.s2s3 K 216 G.s2s3.02
Polar TM6 T 253 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 253 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 253 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 139 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 136 3x54 G.H5 Y 391 G.H5.23
Polar TM6 K 249 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 249 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 249 6x32 G.H5 L 394 G.H5.26
Polar TM3 A 135 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 135 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 135 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 141 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 141 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM5 Q 229 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 Q 229 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 233 5x72 G.H5 R 385 G.H5.17
Polar ICL2 L 140 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 140 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 140 34x51 G.S1 H 41 G.S1.02
Ionic H8 R 313 8x51 G.H5 E 392 G.H5.24
Polar H8 R 313 8x51 G.H5 E 392 G.H5.24
Van-der-waals H8 R 313 8x51 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 233 5x72 G.H5 L 394 G.H5.26
Van-der-waals TM5 I 233 5x72 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 140 34x51 G.S3 F 219 G.S3.03
Hydrophobic TM5 A 226 5x65 G.H5 L 388 G.H5.20
Polar TM5 Q 229 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 229 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 229 5x68 G.H5 Q 384 G.H5.16
Polar TM3 I 136 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 136 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 136 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 136 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 254 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 254 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 135 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 A 226 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 253 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 140 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 140 34x51 G.H5 F 376 G.H5.08
Hydrophobic C-term Y 335 - G.H5 Q 390 G.H5.22
Van-der-waals C-term Y 335 - G.H5 Q 390 G.H5.22
Hydrophobic H8 W 311 8x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 L 236 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 L 236 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 139 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 143 34x54 G.hns1 A 39 G.hns1.03
Polar TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 V 225 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 225 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 140 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 140 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 I 222 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 222 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 139 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 139 34x50 G.H5 I 383 G.H5.15
Polar TM5 Q 229 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 Q 229 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 Q 229 5x68 G.H5 D 381 G.H5.13
Hydrophobic H8 W 311 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 W 311 8x49 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 L 140 34x51 G.H5 R 380 G.H5.12
Ionic TM6 K 249 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 249 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 249 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 249 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 Y 142 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 136 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 143 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 143 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 140 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 140 34x51 G.H5 I 383 G.H5.15