Gz - TAAR8 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 85.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals ICL2 P 136 34x50 G.H5 N 348 G.H5.19
Polar TM3 V 132 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 V 132 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 V 132 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 Q 226 5x68 G.H5 Q 346 G.H5.17
Van-der-waals TM5 Q 226 5x68 G.H5 Q 346 G.H5.17
Hydrophobic ICL2 P 136 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 136 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 137 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 137 34x51 G.H5 I 344 G.H5.15
Polar TM6 T 258 6x36 G.H5 G 353 G.H5.24
Hydrophobic TM6 T 258 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 T 258 6x36 G.H5 G 353 G.H5.24
Hydrophobic TM5 I 230 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 I 230 5x72 G.S6 Y 321 G.S6.02
Hydrophobic TM5 Q 226 5x68 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 137 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 L 137 34x51 G.H5 T 341 G.H5.12
Hydrophobic TM5 I 230 5x72 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 I 230 5x72 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 T 233 5x75 G.S6 S 322 G.S6.03
Van-der-waals TM5 T 233 5x75 G.S6 S 322 G.S6.03
Polar TM5 T 233 5x75 G.H4 Q 305 G.H4.12
Van-der-waals TM5 T 233 5x75 G.H4 Q 305 G.H4.12
Polar TM5 S 234 5x76 G.H4 E 309 G.H4.16
Hydrophobic TM5 S 234 5x76 G.H4 E 309 G.H4.16
Van-der-waals TM5 S 234 5x76 G.H4 E 309 G.H4.16
Polar TM2 S 64 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM6 L 259 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 259 6x37 G.H5 L 354 G.H5.25
Ionic TM5 K 229 5x71 G.H5 D 342 G.H5.13
Polar TM5 K 229 5x71 G.H5 D 342 G.H5.13
Hydrophobic TM5 K 229 5x71 G.H5 D 342 G.H5.13
Van-der-waals TM5 K 229 5x71 G.H5 D 342 G.H5.13
Hydrophobic TM3 V 133 3x54 G.H5 L 349 G.H5.20
Hydrophobic C-term E 342 - G.h3s5 I 261 G.h3s5.01
Van-der-waals C-term E 342 - G.h3s5 I 261 G.h3s5.01
Hydrophobic TM2 P 65 2x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM2 P 65 2x38 G.hns1 R 31 G.hns1.02
Ionic TM5 E 238 5x80 G.H4 R 306 G.H4.13
Polar TM5 E 238 5x80 G.H4 R 306 G.H4.13
Hydrophobic TM5 E 238 5x80 G.H4 R 306 G.H4.13
Van-der-waals TM5 E 238 5x80 G.H4 R 306 G.H4.13
Hydrophobic TM5 Q 226 5x68 G.H5 I 345 G.H5.16
Van-der-waals ICL3 S 239 - G.H4 R 306 G.H4.13
Hydrophobic TM3 V 133 3x54 G.H5 I 352 G.H5.23
Hydrophobic TM6 T 258 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 258 6x36 G.H5 L 354 G.H5.25
Hydrophobic C-term F 340 - G.H5 Y 351 G.H5.22
Van-der-waals C-term F 340 - G.H5 Y 351 G.H5.22
Polar TM2 N 67 2x40 G.H5 Y 351 G.H5.22
Van-der-waals TM2 N 67 2x40 G.H5 Y 351 G.H5.22
Polar TM6 K 254 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM6 K 254 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 254 6x32 G.H5 C 355 G.H5.26
Polar H8 Y 314 8x47 G.H5 I 352 G.H5.23
Hydrophobic H8 Y 314 8x47 G.H5 I 352 G.H5.23
Van-der-waals H8 Y 314 8x47 G.H5 I 352 G.H5.23
Hydrophobic ICL2 T 141 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 136 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 136 34x50 G.H5 I 344 G.H5.15
Polar ICL2 A 140 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 140 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 140 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 137 34x51 G.S3 F 197 G.S3.03
Polar TM5 Q 226 5x68 G.S6 Y 321 G.S6.02
Hydrophobic TM5 I 219 5x61 G.H5 I 352 G.H5.23
Polar TM5 Q 226 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 Q 226 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 Q 226 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM4 V 145 4x39 G.HN Q 28 G.HN.52
Van-der-waals TM4 V 145 4x39 G.HN Q 28 G.HN.52
Polar ICL1 H 63 12x51 G.hns1 R 31 G.hns1.02
Van-der-waals ICL1 H 63 12x51 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 A 140 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 A 140 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 P 136 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM5 A 223 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM5 I 219 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 I 219 5x61 G.H5 L 354 G.H5.25
Ionic TM6 K 250 6x28 G.h4s6 E 316 G.h4s6.09
Polar TM6 K 250 6x28 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 K 250 6x28 G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL2 L 137 34x51 G.S1 I 34 G.S1.02
Van-der-waals ICL2 L 137 34x51 G.S1 I 34 G.S1.02
Hydrophobic TM3 R 129 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM5 I 230 5x72 G.H5 Q 346 G.H5.17
Van-der-waals TM5 I 230 5x72 G.H5 Q 346 G.H5.17
Hydrophobic TM2 S 64 2x37 G.hns1 R 31 G.hns1.02
Van-der-waals TM2 S 64 2x37 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 V 133 3x54 G.H5 I 345 G.H5.16
Polar C-term L 341 - G.h3s5 N 262 G.h3s5.02
Van-der-waals C-term L 341 - G.h3s5 N 262 G.h3s5.02
Hydrophobic ICL2 V 138 34x52 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 V 138 34x52 G.s2s3 K 193 G.s2s3.01
Hydrophobic TM5 V 237 5x79 G.H4 R 306 G.H4.13
Van-der-waals TM5 V 237 5x79 G.H4 R 306 G.H4.13
Hydrophobic H8 Y 314 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM5 T 233 5x75 G.S6 Y 321 G.S6.02
Hydrophobic TM6 K 254 6x32 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 222 5x64 G.H5 I 345 G.H5.16
Hydrophobic TM5 V 237 5x79 G.H4 V 302 G.H4.08
Van-der-waals TM5 V 237 5x79 G.H4 V 302 G.H4.08
Hydrophobic ICL2 L 137 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 137 34x51 G.S3 L 195 G.S3.01
Polar TM6 A 255 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 255 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 255 6x33 G.H5 L 354 G.H5.25
Ionic TM6 R 251 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 251 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 251 6x29 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 251 6x29 G.h4s6 E 319 G.h4s6.12
Polar ICL2 T 141 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 T 141 34x55 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 T 141 34x55 G.s2s3 E 194 G.s2s3.02