GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 69.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | F | 292 | - | G.H3 | T | 274 | G.H3.11 |
Van-der-waals | C-term | F | 292 | - | G.H3 | T | 274 | G.H3.11 |
Polar | ICL2 | E | 143 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ICL2 | E | 143 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | E | 143 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | H | 141 | - | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | H | 141 | - | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL2 | H | 141 | - | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | V | 306 | - | H.hbhc | Q | 134 | H.hbhc.07 |
Van-der-waals | C-term | V | 306 | - | H.hbhc | Q | 134 | H.hbhc.07 |
Ionic | C-term | D | 299 | - | G.H2 | R | 227 | G.H2.01 |
Polar | C-term | D | 299 | - | G.H2 | R | 227 | G.H2.01 |
Hydrophobic | C-term | D | 299 | - | G.H2 | R | 227 | G.H2.01 |
Van-der-waals | C-term | D | 299 | - | G.H2 | R | 227 | G.H2.01 |
Polar | C-term | T | 336 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | T | 336 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | T | 336 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | P | 309 | - | G.hfs2 | R | 201 | G.hfs2.03 |
Van-der-waals | C-term | P | 309 | - | G.hfs2 | R | 201 | G.hfs2.03 |
Hydrophobic | C-term | L | 308 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Hydrophobic | C-term | D | 299 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Van-der-waals | C-term | D | 299 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Hydrophobic | TM4 | S | 144 | 4x38 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM4 | S | 144 | 4x38 | G.hns1 | K | 46 | G.hns1.02 |
Polar | C-term | Y | 333 | - | G.s1h1 | E | 58 | G.s1h1.04 |
Van-der-waals | C-term | Y | 333 | - | G.s1h1 | E | 58 | G.s1h1.04 |
Hydrophobic | C-term | A | 331 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | A | 331 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | C-term | V | 306 | - | H.hbhc | A | 133 | H.hbhc.06 |
Van-der-waals | C-term | V | 306 | - | H.hbhc | A | 133 | H.hbhc.06 |
Polar | C-term | P | 304 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Van-der-waals | C-term | P | 304 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Hydrophobic | C-term | F | 338 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | C-term | L | 308 | - | G.hfs2 | R | 201 | G.hfs2.03 |
Van-der-waals | C-term | L | 308 | - | G.hfs2 | R | 201 | G.hfs2.03 |
Polar | C-term | Y | 333 | - | G.hfs2 | R | 200 | G.hfs2.02 |
Hydrophobic | C-term | Y | 333 | - | G.hfs2 | R | 200 | G.hfs2.02 |
Van-der-waals | C-term | Y | 333 | - | G.hfs2 | R | 200 | G.hfs2.02 |
Hydrophobic | TM4 | K | 145 | 4x39 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | TM4 | K | 145 | 4x39 | G.HN | K | 42 | G.HN.51 |
Polar | C-term | S | 335 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | I | 350 | - | H.hbhc | R | 128 | H.hbhc.01 |
Van-der-waals | C-term | I | 350 | - | H.hbhc | R | 128 | H.hbhc.01 |
Polar | ICL2 | H | 141 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | H | 141 | - | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ICL2 | H | 141 | - | G.H5 | L | 374 | G.H5.23 |
Ionic | C-term | D | 305 | - | G.H2 | R | 232 | G.H2.06 |
Polar | C-term | D | 305 | - | G.H2 | R | 232 | G.H2.06 |
Hydrophobic | C-term | Y | 333 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | Y | 333 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | C-term | L | 291 | - | G.H2 | F | 234 | G.H2.08 |
Hydrophobic | C-term | T | 336 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | T | 336 | - | H.hdhe | F | 168 | H.hdhe.01 |
Polar | C-term | T | 336 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | P | 311 | - | G.S2 | H | 207 | G.S2.02 |
Van-der-waals | C-term | P | 311 | - | G.S2 | H | 207 | G.S2.02 |
Ionic | C-term | D | 305 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Hydrophobic | C-term | D | 305 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Van-der-waals | C-term | D | 305 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Hydrophobic | C-term | L | 308 | - | G.hfs2 | P | 202 | G.hfs2.04 |
Van-der-waals | C-term | L | 308 | - | G.hfs2 | P | 202 | G.hfs2.04 |
Polar | ICL2 | E | 143 | - | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | E | 143 | - | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ICL2 | E | 143 | - | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | Y | 294 | - | G.H2 | R | 227 | G.H2.01 |
Hydrophobic | ICL1 | I | 74 | - | G.h2s4 | D | 238 | G.h2s4.02 |
Van-der-waals | ICL1 | I | 74 | - | G.h2s4 | D | 238 | G.h2s4.02 |
Polar | C-term | C | 296 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | C-term | C | 296 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | C | 296 | - | G.H2 | K | 231 | G.H2.05 |
Polar | C-term | D | 349 | - | H.hbhc | R | 128 | H.hbhc.01 |
Hydrophobic | C-term | Y | 294 | - | G.H3 | N | 270 | G.H3.07 |
Van-der-waals | ICL2 | L | 142 | - | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | T | 336 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | T | 336 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | T | 336 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | F | 292 | - | G.H2 | W | 233 | G.H2.07 |
Hydrophobic | C-term | F | 292 | - | G.H3 | I | 275 | G.H3.12 |
Van-der-waals | C-term | F | 292 | - | G.H3 | I | 275 | G.H3.12 |
Polar | C-term | V | 306 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Hydrophobic | C-term | V | 306 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Van-der-waals | C-term | V | 306 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Polar | C-term | S | 334 | - | H.HA | R | 97 | H.HA.20 |
Hydrophobic | C-term | K | 289 | - | G.H3 | V | 280 | G.H3.17 |
Van-der-waals | C-term | K | 289 | - | G.H3 | V | 280 | G.H3.17 |
Ionic | C-term | K | 289 | - | G.h2s4 | D | 238 | G.h2s4.02 |
Polar | C-term | K | 289 | - | G.h2s4 | D | 238 | G.h2s4.02 |
Van-der-waals | C-term | K | 289 | - | G.h2s4 | D | 238 | G.h2s4.02 |
Polar | ICL2 | H | 141 | - | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | H | 141 | - | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ICL2 | H | 141 | - | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | G | 140 | - | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ICL2 | G | 140 | - | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | F | 338 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | C-term | F | 338 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | TM3 | F | 139 | 3x57 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | I | 290 | - | G.H3 | N | 278 | G.H3.15 |
Polar | C-term | Q | 337 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | Q | 337 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | Q | 337 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | F | 292 | - | G.H3 | I | 271 | G.H3.08 |
Polar | C-term | T | 336 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | C-term | T | 336 | - | H.HA | A | 102 | H.HA.25 |
Polar | C-term | Q | 297 | - | G.s4h3 | T | 262 | G.s4h3.14 |
Hydrophobic | C-term | Y | 294 | - | G.H3 | I | 271 | G.H3.08 |
Van-der-waals | C-term | Y | 294 | - | G.H3 | I | 271 | G.H3.08 |
Hydrophobic | C-term | F | 338 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | F | 338 | - | H.HA | K | 105 | H.HA.28 |
Polar | C-term | D | 348 | - | H.hbhc | R | 128 | H.hbhc.01 |
Van-der-waals | C-term | D | 348 | - | H.hbhc | R | 128 | H.hbhc.01 |
Polar | C-term | K | 289 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Van-der-waals | C-term | K | 289 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Van-der-waals | TM2 | P | 78 | 2x37 | G.HN | K | 42 | G.HN.51 |
Polar | C-term | Y | 294 | - | G.H3 | E | 267 | G.H3.04 |
Hydrophobic | C-term | Y | 294 | - | G.H3 | E | 267 | G.H3.04 |
Van-der-waals | C-term | Y | 294 | - | G.H3 | E | 267 | G.H3.04 |
Hydrophobic | C-term | Y | 333 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | Y | 333 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | C-term | F | 292 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Polar | C-term | Y | 294 | - | G.H2 | R | 230 | G.H2.04 |
Aromatic | C-term | Y | 294 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | C-term | Y | 294 | - | G.H2 | R | 230 | G.H2.04 |
Van-der-waals | C-term | Y | 294 | - | G.H2 | R | 230 | G.H2.04 |
Polar | C-term | S | 332 | - | H.HA | K | 94 | H.HA.17 |
Van-der-waals | C-term | S | 332 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | C-term | F | 338 | - | H.HD | E | 167 | H.HD.12 |
Polar | C-term | Q | 297 | - | G.H2 | R | 227 | G.H2.01 |
Hydrophobic | C-term | Q | 297 | - | G.H2 | R | 227 | G.H2.01 |
Van-der-waals | C-term | Q | 297 | - | G.H2 | R | 227 | G.H2.01 |
Hydrophobic | C-term | S | 335 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | S | 335 | - | H.HA | D | 101 | H.HA.24 |
Polar | ICL2 | H | 141 | - | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | H | 141 | - | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ICL2 | H | 141 | - | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | C-term | Q | 297 | - | G.s4h3 | D | 259 | G.s4h3.11 |
Hydrophobic | C-term | Y | 333 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | Y | 333 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | F | 338 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | L | 308 | - | H.hbhc | Q | 134 | H.hbhc.07 |
Hydrophobic | C-term | S | 332 | - | G.s4h3 | M | 257 | G.s4h3.09 |