G11 -
TRH1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Aromatic | ICL2 | F | 135 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | F | 135 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Polar | C-term | S | 360 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | S | 360 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | S | 360 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | ICL2 | Q | 134 | 34x54 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | ICL2 | F | 135 | 34x55 | G.hns1 | R | 37 | G.hns1.02 |
Ionic | C-term | D | 386 | - | G.H5 | K | 345 | G.H5.12 |
Polar | C-term | D | 386 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | C-term | D | 386 | - | G.H5 | K | 345 | G.H5.12 |
Polar | H8 | Q | 325 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | Q | 325 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | Q | 325 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM5 | P | 224 | 5x71 | G.S6 | Y | 325 | G.S6.02 |
Polar | TM7 | N | 321 | 7x54 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | T | 257 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | T | 257 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | I | 131 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM3 | I | 127 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Polar | C-term | T | 371 | - | G.S2 | I | 189 | G.S2.01 |
Van-der-waals | C-term | T | 371 | - | G.S2 | I | 189 | G.S2.01 |
Polar | H8 | S | 324 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | S | 324 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | S | 324 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Polar | TM2 | T | 60 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | T | 60 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | T | 60 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM6 | V | 264 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | V | 264 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | T | 371 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | T | 371 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | C-term | T | 365 | - | G.H2 | H | 218 | G.H2.09 |
Van-der-waals | C-term | T | 365 | - | G.H2 | H | 218 | G.H2.09 |
Hydrophobic | C-term | Y | 376 | - | G.H1 | I | 56 | G.H1.05 |
Hydrophobic | TM5 | P | 224 | 5x71 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM3 | I | 127 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 127 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Ionic | C-term | D | 369 | - | G.H2 | K | 215 | G.H2.06 |
Polar | C-term | D | 369 | - | G.H2 | K | 215 | G.H2.06 |
Van-der-waals | C-term | D | 369 | - | G.H2 | K | 215 | G.H2.06 |
Polar | C-term | K | 381 | - | G.s2s3 | N | 198 | G.s2s3.02 |
Hydrophobic | C-term | K | 381 | - | G.s2s3 | N | 198 | G.s2s3.02 |
Van-der-waals | C-term | K | 381 | - | G.s2s3 | N | 198 | G.s2s3.02 |
Polar | C-term | L | 377 | - | G.S2 | P | 193 | G.S2.05 |
Hydrophobic | C-term | L | 377 | - | G.S2 | P | 193 | G.S2.05 |
Van-der-waals | C-term | L | 377 | - | G.S2 | P | 193 | G.S2.05 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | TM6 | V | 264 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Polar | ICL3 | S | 231 | - | G.H4 | Q | 303 | G.H4.05 |
Polar | C-term | F | 384 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Van-der-waals | C-term | F | 384 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Polar | C-term | I | 357 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | I | 357 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | I | 357 | - | G.H2 | R | 214 | G.H2.05 |
Polar | C-term | Y | 376 | - | G.H1 | R | 60 | G.H1.09 |
Aromatic | C-term | Y | 376 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | C-term | Y | 376 | - | G.H1 | R | 60 | G.H1.09 |
Van-der-waals | C-term | Y | 376 | - | G.H1 | R | 60 | G.H1.09 |
Aromatic | C-term | Y | 376 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | C-term | Y | 376 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | Y | 376 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | TM2 | L | 64 | 2x43 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | S | 383 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Hydrophobic | C-term | Y | 376 | - | G.S2 | F | 194 | G.S2.06 |
Hydrophobic | TM6 | T | 257 | 6x26 | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | C-term | T | 373 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | T | 373 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | TM5 | I | 223 | 5x70 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM5 | I | 223 | 5x70 | G.S6 | Y | 325 | G.S6.02 |
Polar | C-term | S | 378 | - | G.h1ha | A | 65 | G.h1ha.02 |
Hydrophobic | C-term | S | 378 | - | G.h1ha | A | 65 | G.h1ha.02 |
Van-der-waals | C-term | S | 378 | - | G.h1ha | A | 65 | G.h1ha.02 |
Hydrophobic | ICL3 | W | 234 | - | G.S6 | F | 328 | G.S6.05 |
Polar | ICL3 | W | 234 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | ICL3 | W | 234 | - | G.H4 | E | 307 | G.H4.09 |
Van-der-waals | ICL3 | W | 234 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | C-term | F | 384 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM3 | A | 126 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 126 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | C | 253 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | C-term | V | 382 | - | G.H1 | H | 63 | G.H1.12 |
Van-der-waals | C-term | V | 382 | - | G.H1 | H | 63 | G.H1.12 |
Van-der-waals | TM6 | S | 260 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Polar | C-term | D | 369 | - | G.S2 | I | 189 | G.S2.01 |
Van-der-waals | C-term | D | 369 | - | G.S2 | I | 189 | G.S2.01 |
Polar | ICL2 | C | 137 | 34x57 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM3 | R | 123 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 123 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 123 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM3 | R | 123 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | R | 123 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Ionic | TM5 | E | 229 | 5x76 | G.H4 | R | 306 | G.H4.08 |
Polar | TM5 | E | 229 | 5x76 | G.H4 | R | 306 | G.H4.08 |
Hydrophobic | TM5 | E | 229 | 5x76 | G.H4 | R | 306 | G.H4.08 |
Van-der-waals | TM5 | E | 229 | 5x76 | G.H4 | R | 306 | G.H4.08 |
Polar | ICL2 | P | 130 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Polar | C-term | Y | 376 | - | G.h1ha | Y | 67 | G.h1ha.04 |
Hydrophobic | TM5 | E | 229 | 5x76 | G.S6 | F | 328 | G.S6.05 |
Van-der-waals | TM5 | E | 229 | 5x76 | G.S6 | F | 328 | G.S6.05 |
Hydrophobic | TM5 | P | 224 | 5x71 | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | TM5 | P | 224 | 5x71 | G.H5 | F | 339 | G.H5.06 |
Polar | H8 | S | 324 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | S | 324 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Ionic | TM5 | D | 226 | 5x73 | G.S6 | H | 327 | G.S6.04 |
Polar | TM5 | D | 226 | 5x73 | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | TM5 | D | 226 | 5x73 | G.S6 | H | 327 | G.S6.04 |
Van-der-waals | TM5 | D | 226 | 5x73 | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | C-term | F | 384 | - | G.S2 | L | 196 | G.S2.08 |
Hydrophobic | TM6 | L | 268 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | P | 224 | 5x71 | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | TM5 | P | 224 | 5x71 | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | C-term | V | 382 | - | G.S2 | L | 196 | G.S2.08 |
Polar | ICL3 | C | 253 | - | G.h4s6 | K | 322 | G.h4s6.13 |
Hydrophobic | ICL3 | C | 253 | - | G.h4s6 | K | 322 | G.h4s6.13 |
Hydrophobic | TM6 | M | 267 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | I | 370 | - | G.S2 | E | 191 | G.S2.03 |
Polar | ICL3 | C | 253 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | C-term | Y | 376 | - | G.S2 | P | 193 | G.S2.05 |
Polar | TM3 | E | 122 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | E | 122 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | E | 122 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | C-term | I | 370 | - | G.S2 | I | 189 | G.S2.01 |
Van-der-waals | C-term | I | 370 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | C-term | T | 373 | - | G.S2 | I | 190 | G.S2.02 |
Hydrophobic | TM5 | S | 225 | 5x72 | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | C-term | F | 384 | - | G.H5 | R | 338 | G.H5.05 |
Van-der-waals | C-term | F | 384 | - | G.H5 | R | 338 | G.H5.05 |
Hydrophobic | TM3 | F | 119 | 3x46 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | T | 60 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | T | 60 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Ionic | TM6 | R | 261 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | R | 261 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM6 | R | 261 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Polar | TM3 | A | 126 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 126 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 126 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | Q | 134 | 34x54 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | Q | 134 | 34x54 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | C-term | V | 356 | - | G.H2 | R | 210 | G.H2.01 |
Van-der-waals | C-term | V | 356 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | V | 372 | - | G.S2 | E | 191 | G.S2.03 |
Aromatic | C-term | F | 384 | - | G.H1 | H | 63 | G.H1.12 |
Hydrophobic | C-term | F | 384 | - | G.H1 | H | 63 | G.H1.12 |
Van-der-waals | C-term | F | 384 | - | G.H1 | H | 63 | G.H1.12 |
Hydrophobic | C-term | L | 352 | - | G.H3 | T | 257 | G.H3.11 |
Polar | TM3 | R | 123 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM5 | L | 218 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM5 | P | 224 | 5x71 | G.H5 | A | 343 | G.H5.10 |
Van-der-waals | TM5 | P | 224 | 5x71 | G.H5 | A | 343 | G.H5.10 |
Polar | TM2 | T | 58 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | T | 58 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | T | 58 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | C-term | T | 371 | - | G.S2 | I | 190 | G.S2.02 |
Van-der-waals | C-term | T | 371 | - | G.S2 | I | 190 | G.S2.02 |
Polar | TM5 | D | 226 | 5x73 | G.S6 | F | 328 | G.S6.05 |
Van-der-waals | TM5 | D | 226 | 5x73 | G.S6 | F | 328 | G.S6.05 |
Polar | C-term | S | 378 | - | G.h1ha | G | 64 | G.h1ha.01 |
Hydrophobic | C-term | S | 378 | - | G.h1ha | G | 64 | G.h1ha.01 |
Van-der-waals | C-term | S | 378 | - | G.h1ha | G | 64 | G.h1ha.01 |
Hydrophobic | C-term | T | 373 | - | G.S2 | P | 193 | G.S2.05 |
Polar | TM7 | Y | 320 | 7x53 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM7 | Y | 320 | 7x53 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | Y | 320 | 7x53 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | V | 382 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Van-der-waals | C-term | V | 382 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | F | 384 | - | G.H5 | I | 337 | G.H5.04 |
Van-der-waals | C-term | F | 384 | - | G.H5 | I | 337 | G.H5.04 |
Hydrophobic | TM3 | I | 127 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | I | 127 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | V | 264 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | M | 267 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | I | 131 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Hydrophobic | C-term | T | 373 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | T | 373 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | C-term | I | 357 | - | G.H2 | R | 213 | G.H2.04 |
Polar | C-term | Y | 354 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | Y | 354 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | Y | 354 | - | G.H2 | R | 214 | G.H2.05 |
Polar | ICL3 | S | 231 | - | G.H4 | E | 307 | G.H4.09 |
Polar | C-term | T | 380 | - | G.h1ha | G | 64 | G.h1ha.01 |
Van-der-waals | C-term | T | 380 | - | G.h1ha | G | 64 | G.h1ha.01 |
Hydrophobic | C-term | F | 363 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | F | 363 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | ICL3 | W | 234 | - | G.H4 | L | 310 | G.H4.12 |
Van-der-waals | ICL3 | W | 234 | - | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | TM4 | T | 138 | 4x38 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM4 | T | 138 | 4x38 | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL3 | T | 249 | - | G.H4 | D | 315 | G.H4.17 |
Van-der-waals | ICL3 | T | 249 | - | G.H4 | D | 315 | G.H4.17 |
Hydrophobic | C-term | L | 352 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | L | 352 | - | G.H3 | Y | 261 | G.H3.15 |