G13 -
TRH1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | P | 224 | 5x71 | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | TM6 | T | 257 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | T | 257 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | T | 373 | - | H.hbhc | Q | 134 | H.hbhc.07 |
Hydrophobic | C-term | T | 373 | - | H.hbhc | Q | 134 | H.hbhc.07 |
Hydrophobic | C-term | Y | 376 | - | G.hfs2 | R | 201 | G.hfs2.03 |
Van-der-waals | C-term | Y | 376 | - | G.hfs2 | R | 201 | G.hfs2.03 |
Hydrophobic | C-term | V | 372 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Van-der-waals | C-term | V | 372 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Ionic | TM5 | E | 229 | 5x76 | G.H4 | K | 324 | G.H4.09 |
Polar | TM5 | E | 229 | 5x76 | G.H4 | K | 324 | G.H4.09 |
Van-der-waals | TM5 | E | 229 | 5x76 | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | TM3 | I | 127 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | I | 127 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | I | 370 | - | H.hbhc | A | 133 | H.hbhc.06 |
Van-der-waals | C-term | I | 370 | - | H.hbhc | A | 133 | H.hbhc.06 |
Hydrophobic | TM6 | Q | 263 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM5 | I | 223 | 5x70 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | I | 223 | 5x70 | G.H5 | D | 364 | G.H5.13 |
Polar | TM3 | A | 126 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 126 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 126 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Ionic | C-term | E | 359 | - | G.H2 | K | 231 | G.H2.05 |
Polar | C-term | E | 359 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | C-term | L | 377 | - | G.S2 | H | 207 | G.S2.02 |
Van-der-waals | C-term | L | 377 | - | G.S2 | H | 207 | G.S2.02 |
Hydrophobic | TM5 | I | 223 | 5x70 | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | ICL2 | Q | 134 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | Q | 134 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Polar | H8 | Q | 325 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL3 | C | 253 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | ICL3 | C | 253 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | ICL3 | C | 253 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Polar | ICL3 | C | 253 | - | G.h4s6 | Q | 337 | G.h4s6.11 |
Van-der-waals | ICL3 | C | 253 | - | G.h4s6 | Q | 337 | G.h4s6.11 |
Hydrophobic | C-term | Y | 376 | - | H.hbhc | M | 136 | H.hbhc.09 |
Van-der-waals | C-term | Y | 376 | - | H.hbhc | M | 136 | H.hbhc.09 |
Ionic | C-term | D | 368 | - | H.hbhc | R | 128 | H.hbhc.01 |
Hydrophobic | C-term | I | 370 | - | H.hbhc | Q | 134 | H.hbhc.07 |
Hydrophobic | TM6 | R | 261 | 6x30 | G.H5 | L | 367 | G.H5.16 |
Polar | TM6 | Q | 263 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | Q | 263 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | N | 61 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | N | 61 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | L | 377 | - | G.S2 | Y | 209 | G.S2.04 |
Polar | H8 | K | 326 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | K | 326 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | K | 326 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | F | 135 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | F | 135 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 130 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM3 | I | 127 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | I | 127 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Ionic | C-term | E | 366 | - | H.hbhc | R | 128 | H.hbhc.01 |
Polar | C-term | E | 366 | - | H.hbhc | R | 128 | H.hbhc.01 |
Van-der-waals | C-term | E | 366 | - | H.hbhc | R | 128 | H.hbhc.01 |
Hydrophobic | TM2 | T | 60 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | T | 60 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | M | 267 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | M | 267 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | I | 131 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL3 | C | 253 | - | G.h4s6 | K | 340 | G.h4s6.19 |
Hydrophobic | TM6 | V | 264 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | V | 264 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | P | 130 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM3 | R | 123 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 123 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | C-term | I | 370 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | TM2 | T | 58 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | TM3 | I | 127 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | I | 127 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM7 | Y | 320 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | Y | 320 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL1 | M | 56 | 12x50 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | D | 368 | - | H.HB | T | 127 | H.HB.14 |
Van-der-waals | C-term | D | 368 | - | H.HB | T | 127 | H.HB.14 |
Hydrophobic | TM7 | M | 323 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Polar | H8 | F | 327 | 8x50 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | F | 327 | 8x50 | G.H5 | L | 376 | G.H5.25 |
Polar | H8 | S | 324 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | S | 324 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | S | 324 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | A | 126 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | R | 261 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | V | 264 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | I | 131 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | C-term | L | 367 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | L | 367 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Ionic | TM5 | D | 226 | 5x73 | G.S6 | H | 344 | G.S6.03 |
Polar | TM5 | D | 226 | 5x73 | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM5 | D | 226 | 5x73 | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | TM5 | D | 226 | 5x73 | G.S6 | H | 344 | G.S6.03 |
Polar | C-term | Y | 376 | - | H.HA | E | 83 | H.HA.06 |
Hydrophobic | C-term | Y | 376 | - | H.HA | E | 83 | H.HA.06 |
Van-der-waals | C-term | Y | 376 | - | H.HA | E | 83 | H.HA.06 |
Ionic | TM5 | D | 226 | 5x73 | G.H4 | R | 331 | G.H4.16 |
Polar | TM5 | D | 226 | 5x73 | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | TM5 | D | 226 | 5x73 | G.H4 | R | 331 | G.H4.16 |
Polar | H8 | S | 324 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | H8 | S | 324 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | H8 | S | 324 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Polar | TM6 | S | 260 | 6x29 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | S | 260 | 6x29 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM5 | L | 218 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 218 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | T | 365 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | H8 | K | 326 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | K | 326 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | K | 326 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Ionic | TM6 | R | 261 | 6x30 | G.H5 | D | 364 | G.H5.13 |
Polar | TM6 | R | 261 | 6x30 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM6 | R | 261 | 6x30 | G.H5 | D | 364 | G.H5.13 |
Polar | ICL2 | P | 130 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Polar | C-term | I | 370 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Hydrophobic | C-term | I | 370 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Van-der-waals | C-term | I | 370 | - | G.hfs2 | K | 204 | G.hfs2.06 |