GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | F | 660 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | F | 660 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Polar | ICL2 | S | 663 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | S | 663 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | S | 663 | - | G.hns1 | R | 47 | G.hns1.03 |
Polar | ICL2 | T | 668 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | H | 671 | - | G.S3 | P | 217 | G.S3.02 |
Polar | TM3 | R | 652 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | R | 652 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | R | 652 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | H | 671 | - | G.HN | Y | 44 | G.HN.53 |
Hydrophobic | ICL2 | H | 671 | - | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | ICL2 | H | 671 | - | G.HN | Y | 44 | G.HN.53 |
Polar | H8 | Q | 828 | 8x55 | G.H5 | T | 365 | G.H5.14 |
Hydrophobic | H8 | Q | 828 | 8x55 | G.H5 | T | 365 | G.H5.14 |
Van-der-waals | H8 | Q | 828 | 8x55 | G.H5 | T | 365 | G.H5.14 |
Hydrophobic | C-term | I | 831 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | C-term | I | 831 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM3 | I | 659 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | I | 659 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | S | 663 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | S | 663 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | Y | 670 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Y | 670 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | Q | 832 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | C-term | Q | 832 | - | G.H5 | D | 364 | G.H5.13 |
Polar | C-term | T | 835 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | C-term | T | 835 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | ICL2 | V | 666 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | V | 666 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | V | 666 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | G | 839 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | C-term | G | 839 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | H8 | E | 825 | 8x52 | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | H8 | E | 825 | 8x52 | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | H8 | Q | 828 | 8x55 | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | H8 | Q | 828 | 8x55 | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | H8 | Q | 828 | 8x55 | G.S6 | Y | 343 | G.S6.02 |
Polar | C-term | Q | 832 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | ICL2 | Y | 670 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | C-term | R | 836 | - | G.H5 | D | 364 | G.H5.13 |
Polar | C-term | Q | 832 | - | G.H5 | T | 365 | G.H5.14 |
Van-der-waals | C-term | Q | 832 | - | G.H5 | T | 365 | G.H5.14 |
Hydrophobic | ICL2 | H | 671 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | S | 663 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL2 | S | 663 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | S | 663 | - | G.S3 | V | 216 | G.S3.01 |
Polar | H8 | F | 827 | 8x54 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | H8 | F | 827 | 8x54 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | H8 | F | 827 | 8x54 | G.H5 | H | 368 | G.H5.17 |
Polar | ICL3 | Y | 756 | - | G.H5 | H | 368 | G.H5.17 |
Aromatic | ICL3 | Y | 756 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL3 | Y | 756 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL3 | Y | 756 | - | G.H5 | H | 368 | G.H5.17 |
Ionic | C-term | R | 836 | - | G.H5 | D | 361 | G.H5.10 |
Polar | C-term | R | 836 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | C-term | R | 836 | - | G.H5 | D | 361 | G.H5.10 |
Van-der-waals | C-term | R | 836 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | TM3 | L | 656 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | L | 656 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM4 | Q | 675 | 4x28 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM4 | Q | 675 | 4x28 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | V | 674 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | H8 | F | 827 | 8x54 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ICL2 | T | 664 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL3 | Y | 756 | - | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL3 | Y | 756 | - | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL1 | R | 598 | 12x51 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ICL1 | R | 598 | 12x51 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | F | 662 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | F | 662 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | F | 662 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Y | 670 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | T | 664 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | T | 664 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | P | 667 | - | G.HN | T | 43 | G.HN.52 |
Polar | ICL2 | H | 671 | - | G.hns1 | R | 47 | G.hns1.03 |
Aromatic | ICL2 | H | 671 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | H | 671 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | H | 671 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | I | 659 | 3x57 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | T | 664 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | T | 835 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | C-term | R | 836 | - | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | ICL2 | T | 668 | - | G.HN | R | 40 | G.HN.49 |
Polar | H8 | T | 824 | 8x51 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | H8 | T | 824 | 8x51 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | H8 | T | 824 | 8x51 | G.H5 | K | 372 | G.H5.21 |
Polar | ICL2 | V | 674 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | V | 674 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | V | 674 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL3 | Y | 756 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | I | 831 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | C-term | I | 831 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM4 | Q | 675 | 4x28 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | I | 831 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | C-term | I | 831 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ICL1 | S | 599 | 12x52 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL1 | S | 599 | 12x52 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | H | 671 | - | G.HN | R | 40 | G.HN.49 |
Van-der-waals | ICL2 | H | 671 | - | G.HN | R | 40 | G.HN.49 |
Van-der-waals | H8 | Q | 828 | 8x55 | G.H5 | K | 372 | G.H5.21 |
Polar | C-term | T | 835 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | C-term | T | 835 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | C-term | T | 835 | - | G.H5 | D | 364 | G.H5.13 |
Polar | ICL2 | P | 667 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | P | 667 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | P | 667 | - | G.hns1 | R | 47 | G.hns1.03 |
Polar | ICL2 | H | 671 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | H | 671 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | H | 671 | - | G.HN | T | 43 | G.HN.52 |
Polar | TM4 | Q | 675 | 4x28 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM4 | Q | 675 | 4x28 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | TM4 | Q | 675 | 4x28 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ICL2 | T | 664 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL2 | T | 664 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | ICL3 | Y | 756 | - | G.H5 | K | 372 | G.H5.21 |
Polar | H8 | Q | 828 | 8x55 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | H8 | Q | 828 | 8x55 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | H8 | Q | 828 | 8x55 | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | C | 838 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | C-term | C | 838 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | H8 | Q | 828 | 8x55 | G.H5 | D | 369 | G.H5.18 |
Hydrophobic | H8 | Q | 828 | 8x55 | G.H5 | D | 369 | G.H5.18 |
Van-der-waals | H8 | Q | 828 | 8x55 | G.H5 | D | 369 | G.H5.18 |