GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | Q | 655 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | Q | 655 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | Y | 670 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | Y | 670 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | F | 660 | 3x58 | G.H5 | L | 388 | G.H5.20 |
Polar | ICL2 | Y | 670 | - | G.H5 | H | 387 | G.H5.19 |
Aromatic | ICL2 | Y | 670 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | Y | 670 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | Y | 670 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | I | 659 | 3x57 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | T | 835 | - | G.H5 | N | 377 | G.H5.09 |
Van-der-waals | C-term | T | 835 | - | G.H5 | N | 377 | G.H5.09 |
Polar | C-term | T | 835 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | C-term | T | 835 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | C-term | G | 839 | - | G.H5 | N | 377 | G.H5.09 |
Van-der-waals | C-term | G | 839 | - | G.H5 | N | 377 | G.H5.09 |
Hydrophobic | C-term | I | 831 | - | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | C-term | I | 831 | - | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | ICL2 | S | 663 | - | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM3 | I | 659 | 3x57 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | P | 667 | - | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | P | 667 | - | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | TM2 | G | 601 | 2x35 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | W | 673 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | W | 673 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | W | 673 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | T | 664 | - | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | ICL3 | Y | 756 | - | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | V | 674 | - | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL2 | V | 674 | - | G.H5 | Q | 390 | G.H5.22 |
Polar | C-term | C | 838 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | C-term | C | 838 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | C-term | C | 838 | - | G.H5 | R | 380 | G.H5.12 |
Polar | H8 | Q | 828 | 8x55 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | H8 | Q | 828 | 8x55 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | H8 | Q | 828 | 8x55 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM3 | L | 656 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | C-term | I | 831 | - | G.H5 | L | 394 | G.H5.26 |
Polar | TM3 | F | 660 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | F | 660 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | F | 660 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | C-term | I | 831 | - | G.H5 | R | 385 | G.H5.17 |
Polar | ICL2 | S | 663 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | S | 663 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | S | 663 | - | G.H5 | H | 387 | G.H5.19 |
Polar | ICL2 | V | 674 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | V | 674 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | V | 674 | - | G.H5 | Y | 391 | G.H5.23 |
Polar | C-term | G | 839 | - | G.H5 | R | 373 | G.H5.05 |
Hydrophobic | C-term | G | 839 | - | G.H5 | R | 373 | G.H5.05 |
Van-der-waals | C-term | G | 839 | - | G.H5 | R | 373 | G.H5.05 |
Hydrophobic | ICL1 | R | 598 | 12x51 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | ICL1 | R | 598 | 12x51 | G.H5 | L | 393 | G.H5.25 |
Polar | C-term | S | 840 | - | G.H5 | R | 373 | G.H5.05 |
Hydrophobic | C-term | S | 840 | - | G.H5 | R | 373 | G.H5.05 |
Van-der-waals | C-term | S | 840 | - | G.H5 | R | 373 | G.H5.05 |
Hydrophobic | ICL2 | T | 668 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL2 | T | 664 | - | G.H5 | R | 380 | G.H5.12 |
Polar | ICL2 | Y | 670 | - | G.H5 | Q | 390 | G.H5.22 |
Polar | H8 | Q | 828 | 8x55 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | H8 | Q | 828 | 8x55 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | H8 | Q | 828 | 8x55 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM3 | R | 652 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | R | 652 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL3 | Y | 756 | - | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | Y | 756 | - | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | ICL3 | Y | 756 | - | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | I | 831 | - | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | C-term | I | 831 | - | G.H5 | D | 381 | G.H5.13 |
Polar | C-term | T | 835 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | C-term | T | 835 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | C-term | G | 839 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | C-term | G | 839 | - | G.H5 | R | 380 | G.H5.12 |
Polar | ICL1 | R | 598 | 12x51 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL1 | R | 598 | 12x51 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | ICL1 | R | 598 | 12x51 | G.H5 | L | 394 | G.H5.26 |
Aromatic | ICL2 | H | 671 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | H | 671 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | H | 671 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM3 | L | 656 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL1 | S | 599 | 12x52 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL1 | S | 599 | 12x52 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM3 | I | 659 | 3x57 | G.H5 | Q | 384 | G.H5.16 |
Polar | C-term | Q | 832 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | C-term | Q | 832 | - | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | C-term | Q | 832 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL1 | R | 598 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | I | 659 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Polar | C-term | T | 835 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | C-term | T | 835 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | C-term | T | 835 | - | G.H5 | R | 380 | G.H5.12 |
Polar | TM4 | Q | 675 | 4x28 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM4 | Q | 675 | 4x28 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM3 | I | 659 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | I | 659 | 3x57 | G.H5 | Y | 391 | G.H5.23 |