G11 -
TSH receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 11.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | I | 742 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | C-term | H | 746 | - | G.H3 | A | 253 | G.H3.07 |
Hydrophobic | TM2 | P | 449 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | P | 449 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Ionic | ICL2 | K | 532 | 34x56 | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | K | 532 | 34x56 | G.H5 | E | 355 | G.H5.22 |
Polar | TM3 | A | 522 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 522 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | L | 529 | 34x53 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | L | 529 | 34x53 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | C-term | Y | 739 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | Y | 739 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | TM5 | V | 608 | 5x65 | G.H5 | L | 349 | G.H5.16 |
Polar | TM6 | R | 625 | 6x36 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | R | 625 | 6x36 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | R | 625 | 6x36 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | I | 742 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | C-term | V | 738 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | V | 738 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | C-term | L | 741 | - | G.H3 | Y | 261 | G.H3.15 |
Polar | ICL2 | D | 530 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM3 | I | 523 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | E | 743 | - | G.H2 | R | 210 | G.H2.01 |
Ionic | ICL2 | D | 530 | 34x54 | G.hns1 | R | 38 | G.hns1.03 |
Polar | ICL2 | D | 530 | 34x54 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | D | 530 | 34x54 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | D | 530 | 34x54 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | C-term | S | 745 | - | G.H3 | A | 253 | G.H3.07 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | ICL3 | Y | 613 | - | G.H5 | D | 346 | G.H5.13 |
Ionic | C-term | H | 746 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Van-der-waals | C-term | H | 746 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Ionic | C-term | H | 746 | - | G.H3 | E | 250 | G.H3.04 |
Polar | C-term | H | 746 | - | G.H3 | E | 250 | G.H3.04 |
Polar | C-term | I | 742 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | I | 742 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | I | 742 | - | G.H2 | R | 213 | G.H2.04 |
Aromatic | ICL3 | Y | 613 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | ICL3 | Y | 613 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | Y | 613 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM3 | I | 523 | 3x54 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | M | 527 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Polar | TM7 | L | 677 | 7x52 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL3 | Y | 613 | - | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | ICL3 | Y | 613 | - | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | ICL2 | L | 529 | 34x53 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | L | 529 | 34x53 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | C-term | M | 735 | - | G.H2 | I | 217 | G.H2.08 |
Polar | C-term | S | 745 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | C-term | S | 745 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | ICL3 | Q | 612 | - | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | ICL3 | Q | 612 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | TM5 | Y | 601 | 5x58 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | I | 523 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.H5 | V | 344 | G.H5.11 |
Hydrophobic | C-term | E | 743 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | Y | 739 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | Y | 739 | - | G.H2 | I | 217 | G.H2.08 |
Polar | ICL3 | Y | 613 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL3 | Y | 613 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | ICL3 | Y | 613 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL2 | L | 529 | 34x53 | G.H5 | I | 348 | G.H5.15 |
Polar | C-term | V | 738 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | V | 738 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | V | 738 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM6 | I | 622 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | I | 622 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Ionic | H8 | K | 683 | 8x48 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | ICL3 | Y | 613 | - | G.H5 | A | 342 | G.H5.09 |
Polar | C-term | S | 745 | - | G.H3 | E | 250 | G.H3.04 |
Ionic | C-term | E | 743 | - | G.H2 | R | 214 | G.H2.05 |
Polar | C-term | E | 743 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | E | 743 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | E | 743 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | M | 527 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Polar | C-term | S | 745 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | TM6 | I | 622 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | I | 742 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | I | 742 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | ICL2 | A | 526 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | I | 742 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Van-der-waals | C-term | I | 742 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | TM4 | R | 534 | 4x38 | G.HN | R | 34 | G.HN.52 |
Van-der-waals | TM4 | R | 534 | 4x38 | G.HN | R | 34 | G.HN.52 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | M | 527 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | Q | 709 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Van-der-waals | C-term | Q | 709 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Polar | C-term | H | 746 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | H | 746 | - | G.H2 | R | 210 | G.H2.01 |
Van-der-waals | C-term | H | 746 | - | G.H2 | R | 210 | G.H2.01 |
Polar | TM3 | R | 519 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 519 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 519 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | M | 626 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.S3 | F | 201 | G.S3.03 |
Hydrophobic | TM6 | K | 621 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | K | 621 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | R | 625 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | R | 625 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Polar | TM6 | R | 625 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | R | 625 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Polar | H8 | T | 682 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | T | 682 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | T | 682 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | I | 742 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | TM6 | I | 622 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | I | 622 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Polar | TM7 | F | 681 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM7 | F | 681 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | F | 681 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | M | 527 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | C-term | I | 742 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | TM3 | A | 522 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 522 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | T | 607 | 5x64 | G.H5 | L | 349 | G.H5.16 |
Polar | C-term | L | 741 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | L | 741 | - | G.H3 | T | 257 | G.H3.11 |
Polar | TM3 | E | 518 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | E | 518 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | E | 518 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | L | 629 | 6x40 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | V | 608 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM3 | I | 523 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Polar | ICL1 | N | 447 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL1 | N | 447 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | A | 526 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | A | 526 | 34x50 | G.H5 | I | 348 | G.H5.15 |