Gz - UT receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 152 3x54 G.H5 I 352 G.H5.23
Hydrophobic H8 R 320 8x48 G.H5 K 350 G.H5.21
Hydrophobic ICL2 L 156 34x51 G.H5 F 337 G.H5.08
Polar TM6 A 256 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 256 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 256 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 155 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM6 F 246 6x23 G.S6 I 320 G.S6.01
Van-der-waals TM6 F 246 6x23 G.S6 I 320 G.S6.01
Hydrophobic TM6 P 252 6x29 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 P 252 6x29 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 A 244 - G.H5 D 338 G.H5.09
Polar TM5 S 241 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 S 241 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 S 241 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM6 I 263 6x40 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 148 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 148 3x50 G.H5 L 354 G.H5.25
Aromatic TM6 F 246 6x23 G.S6 Y 321 G.S6.02
Hydrophobic TM6 F 246 6x23 G.S6 Y 321 G.S6.02
Van-der-waals TM6 F 246 6x23 G.S6 Y 321 G.S6.02
Polar TM3 R 148 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 148 3x50 G.H5 I 352 G.H5.23
Hydrophobic ICL2 P 155 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 155 34x50 G.H5 I 344 G.H5.15
Polar ICL3 S 245 - G.H5 D 338 G.H5.09
Van-der-waals ICL3 S 245 - G.H5 D 338 G.H5.09
Polar TM6 R 250 6x27 G.S6 I 320 G.S6.01
Van-der-waals TM6 R 250 6x27 G.S6 I 320 G.S6.01
Hydrophobic ICL2 P 155 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 155 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM6 R 255 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 R 255 6x32 G.H5 C 355 G.H5.26
Hydrophobic ICL2 V 159 34x54 G.H5 I 344 G.H5.15
Polar TM3 A 151 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 151 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 151 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 L 234 5x61 G.H5 L 354 G.H5.25
Hydrophobic ICL3 S 245 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 S 245 - G.S6 Y 321 G.S6.02
Ionic TM6 R 250 6x27 G.H4 E 309 G.H4.16
Polar TM6 R 250 6x27 G.H4 E 309 G.H4.16
Polar TM5 Y 238 5x65 G.H5 Q 346 G.H5.17
Hydrophobic TM5 Y 238 5x65 G.H5 Q 346 G.H5.17
Van-der-waals TM5 Y 238 5x65 G.H5 Q 346 G.H5.17
Polar TM3 R 148 3x50 G.H5 G 353 G.H5.24
Van-der-waals TM3 R 148 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM5 Y 238 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 Y 238 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM5 S 241 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 S 241 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM5 Y 238 5x65 G.H5 I 345 G.H5.16
Polar ICL3 S 245 - G.H5 A 339 G.H5.10
Van-der-waals ICL3 S 245 - G.H5 A 339 G.H5.10
Polar ICL2 Q 160 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 160 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 160 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 P 155 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 155 34x50 G.H5 N 348 G.H5.19
Hydrophobic TM2 M 86 2x39 G.H5 I 352 G.H5.23
Hydrophobic ICL3 S 245 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 S 245 - G.H5 D 342 G.H5.13
Hydrophobic TM6 L 259 6x36 G.H5 L 354 G.H5.25
Ionic H8 D 324 8x52 G.H5 K 350 G.H5.21
Polar H8 D 324 8x52 G.H5 K 350 G.H5.21
Hydrophobic H8 D 324 8x52 G.H5 K 350 G.H5.21
Van-der-waals H8 D 324 8x52 G.H5 K 350 G.H5.21
Van-der-waals TM5 Q 242 5x69 G.H5 Q 346 G.H5.17
Hydrophobic TM3 V 152 3x54 G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 156 34x51 G.S1 I 34 G.S1.02
Hydrophobic ICL2 L 156 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 156 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM3 V 152 3x54 G.H5 L 349 G.H5.20
Polar H8 N 321 8x49 G.H5 K 350 G.H5.21
Hydrophobic H8 N 321 8x49 G.H5 K 350 G.H5.21
Van-der-waals H8 N 321 8x49 G.H5 K 350 G.H5.21
Polar H8 R 320 8x48 G.H5 C 355 G.H5.26
Hydrophobic H8 R 320 8x48 G.H5 C 355 G.H5.26
Van-der-waals H8 R 320 8x48 G.H5 C 355 G.H5.26
Hydrophobic TM6 F 246 6x23 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 F 246 6x23 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 L 156 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 156 34x51 G.H5 I 344 G.H5.15
Hydrophobic H8 R 320 8x48 G.h4s6 T 317 G.h4s6.10
Van-der-waals H8 R 320 8x48 G.h4s6 T 317 G.h4s6.10
Hydrophobic H8 T 319 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 T 319 8x47 G.H5 C 355 G.H5.26
Polar TM2 S 85 2x38 G.H5 Y 351 G.H5.22
Hydrophobic TM3 A 151 3x53 G.H5 I 352 G.H5.23
Hydrophobic TM6 V 260 6x37 G.H5 L 354 G.H5.25
Polar TM5 Q 242 5x69 G.H5 D 342 G.H5.13
Hydrophobic TM5 Q 242 5x69 G.H5 D 342 G.H5.13
Van-der-waals TM5 Q 242 5x69 G.H5 D 342 G.H5.13
Polar ICL2 T 158 34x53 G.H5 N 348 G.H5.19
Van-der-waals ICL2 T 158 34x53 G.H5 N 348 G.H5.19
Ionic TM6 R 250 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 250 6x27 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 250 6x27 G.h4s6 E 319 G.h4s6.12