G12 -
V1A receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | T | 386 | - | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | C-term | T | 386 | - | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | TM3 | A | 152 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 152 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | L | 157 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | ICL3 | V | 276 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | ICL3 | V | 276 | - | G.S6 | L | 346 | G.S6.01 |
Polar | ICL2 | Q | 161 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 161 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 161 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | L | 157 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 157 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL3 | V | 276 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | V | 276 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | ICL2 | L | 160 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 160 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | Q | 162 | 34x56 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 162 | 34x56 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM2 | M | 86 | 2x39 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | V | 416 | - | H.HA | K | 114 | H.HA.28 |
Polar | C-term | S | 417 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | S | 417 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | TM2 | I | 90 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | S | 417 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | S | 417 | - | H.HA | K | 114 | H.HA.28 |
Polar | TM3 | A | 152 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 152 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 152 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | F | 413 | - | H.hdhe | F | 173 | H.hdhe.01 |
Hydrophobic | ICL3 | L | 272 | - | G.HG | M | 298 | G.HG.01 |
Polar | TM6 | R | 288 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM6 | R | 288 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | R | 288 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | I | 414 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | I | 414 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | TM5 | I | 243 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | P | 415 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | P | 415 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | P | 415 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | H8 | S | 352 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | S | 352 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | V | 153 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | F | 413 | - | H.HD | E | 172 | H.HD.12 |
Van-der-waals | C-term | F | 413 | - | H.HD | E | 172 | H.HD.12 |
Hydrophobic | TM7 | F | 351 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | F | 351 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | V | 416 | - | H.HA | A | 111 | H.HA.25 |
Hydrophobic | ICL3 | E | 260 | - | G.HG | M | 298 | G.HG.01 |
Polar | C-term | F | 387 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | F | 387 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | F | 387 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM6 | T | 289 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 289 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Polar | C-term | V | 416 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | V | 416 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | ICL2 | L | 160 | 34x54 | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | TM5 | N | 246 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | N | 246 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | T | 418 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Van-der-waals | C-term | T | 418 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Hydrophobic | ICL3 | P | 274 | - | G.S6 | H | 349 | G.S6.04 |
Polar | TM2 | R | 85 | 2x38 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM2 | R | 85 | 2x38 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | Y | 388 | - | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | C-term | Y | 388 | - | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | ICL3 | P | 274 | - | G.H5 | F | 361 | G.H5.06 |
Van-der-waals | ICL3 | P | 274 | - | G.H5 | F | 361 | G.H5.06 |
Hydrophobic | C-term | F | 413 | - | G.s4h3 | V | 260 | G.s4h3.07 |
Van-der-waals | C-term | F | 413 | - | G.s4h3 | V | 260 | G.s4h3.07 |
Hydrophobic | C-term | V | 416 | - | H.hdhe | F | 173 | H.hdhe.01 |
Van-der-waals | C-term | V | 416 | - | H.hdhe | F | 173 | H.hdhe.01 |
Hydrophobic | C-term | T | 418 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | C-term | V | 416 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | TM2 | M | 86 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | M | 86 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Polar | TM6 | S | 281 | 6x25 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | C-term | P | 415 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | ICL2 | L | 157 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | L | 157 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Polar | C-term | T | 418 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | TM6 | R | 288 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | R | 288 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | P | 156 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Ionic | TM2 | R | 85 | 2x38 | G.H5 | D | 377 | G.H5.22 |
Polar | TM2 | R | 85 | 2x38 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM2 | R | 85 | 2x38 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | R | 85 | 2x38 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM6 | A | 285 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Polar | TM3 | R | 149 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 149 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 149 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM6 | M | 292 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | M | 292 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL3 | L | 272 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | ICL3 | L | 272 | - | G.S6 | H | 349 | G.S6.04 |
Van-der-waals | ICL3 | L | 272 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | ICL2 | L | 160 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | L | 160 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | C-term | V | 416 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | V | 416 | - | H.HA | D | 110 | H.HA.24 |
Polar | ICL3 | C | 275 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | ICL3 | C | 275 | - | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | ICL3 | C | 275 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM2 | S | 84 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | S | 84 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Polar | ICL3 | S | 277 | - | G.S6 | L | 346 | G.S6.01 |
Hydrophobic | ICL3 | S | 277 | - | G.S6 | L | 346 | G.S6.01 |
Van-der-waals | ICL3 | S | 277 | - | G.S6 | L | 346 | G.S6.01 |
Polar | C-term | S | 389 | - | G.H3 | K | 284 | G.H3.16 |
Polar | C-term | I | 414 | - | H.HD | E | 172 | H.HD.12 |
Hydrophobic | C-term | I | 414 | - | H.HA | L | 115 | H.HA.29 |
Polar | ICL2 | T | 159 | 34x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | T | 159 | 34x53 | G.H5 | N | 374 | G.H5.19 |
Ionic | C-term | R | 384 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Polar | C-term | R | 384 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | C-term | R | 384 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Van-der-waals | C-term | R | 384 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | ICL2 | P | 156 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | ICL2 | L | 160 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM3 | V | 153 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 153 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Polar | ICL3 | S | 277 | - | G.h4s6 | R | 339 | G.h4s6.08 |
Polar | TM5 | N | 246 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | N | 246 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Polar | TM6 | R | 288 | 6x32 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | R | 288 | 6x32 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | R | 288 | 6x32 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | P | 156 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | F | 413 | - | H.HD | S | 171 | H.HD.11 |
Van-der-waals | C-term | F | 413 | - | H.HD | S | 171 | H.HD.11 |
Hydrophobic | ICL2 | L | 157 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM2 | H | 87 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | M | 86 | 2x39 | G.H5 | D | 377 | G.H5.22 |
Polar | C-term | Y | 388 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | C-term | Y | 388 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | Y | 388 | - | G.H2 | Q | 240 | G.H2.09 |
Polar | C-term | Y | 388 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | T | 418 | - | H.hdhe | Q | 174 | H.hdhe.02 |
Polar | ICL3 | S | 277 | - | G.H4 | D | 336 | G.H4.16 |
Hydrophobic | ICL3 | S | 277 | - | G.H4 | D | 336 | G.H4.16 |
Hydrophobic | TM2 | R | 85 | 2x38 | G.H5 | I | 378 | G.H5.23 |
Ionic | TM5 | K | 250 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | K | 250 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | K | 250 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | K | 250 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL3 | V | 276 | - | G.S6 | H | 348 | G.S6.03 |