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V1A receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL3 | S | 278 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | S | 278 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | S | 278 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | Q | 161 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 161 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | V | 153 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | S | 397 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | ICL3 | S | 277 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | S | 277 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | P | 394 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | P | 394 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | TM6 | T | 289 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 289 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | V | 153 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 153 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | ICL3 | V | 276 | - | G.S6 | I | 319 | G.S6.01 |
Polar | C-term | M | 400 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | C-term | M | 400 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | M | 400 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | TM5 | I | 243 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | I | 243 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | R | 288 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | R | 288 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | P | 274 | - | G.S6 | C | 321 | G.S6.03 |
Van-der-waals | ICL3 | P | 274 | - | G.S6 | C | 321 | G.S6.03 |
Hydrophobic | TM6 | M | 292 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 292 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | C-term | S | 393 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | TM5 | I | 239 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | A | 152 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL3 | S | 277 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | ICL3 | S | 277 | - | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | ICL3 | S | 277 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | ICL2 | L | 160 | 34x54 | G.S3 | L | 195 | G.S3.01 |
Ionic | C-term | D | 403 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Polar | C-term | D | 403 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | C-term | D | 403 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | D | 403 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Polar | TM5 | N | 246 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | N | 246 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Ionic | ICL3 | E | 260 | - | G.HG | K | 272 | G.HG.01 |
Polar | ICL3 | E | 260 | - | G.HG | K | 272 | G.HG.01 |
Van-der-waals | ICL3 | E | 260 | - | G.HG | K | 272 | G.HG.01 |
Polar | TM3 | A | 152 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 152 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 152 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | L | 157 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Polar | C-term | S | 393 | - | G.s3h2 | Q | 205 | G.s3h2.03 |
Van-der-waals | C-term | S | 393 | - | G.s3h2 | Q | 205 | G.s3h2.03 |
Hydrophobic | C-term | M | 381 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | M | 381 | - | G.H3 | K | 258 | G.H3.16 |
Polar | TM6 | R | 288 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 288 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 288 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | P | 156 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | TM7 | F | 351 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | K | 406 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | C-term | W | 401 | - | H.hdhe | N | 150 | H.hdhe.04 |
Van-der-waals | C-term | W | 401 | - | H.hdhe | N | 150 | H.hdhe.04 |
Hydrophobic | C-term | M | 400 | - | H.HA | R | 86 | H.HA.24 |
Van-der-waals | C-term | M | 400 | - | H.HA | R | 86 | H.HA.24 |
Polar | TM3 | R | 149 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 149 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 149 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | M | 400 | - | H.HB | V | 111 | H.HB.13 |
Van-der-waals | C-term | M | 400 | - | H.HB | V | 111 | H.HB.13 |
Hydrophobic | TM6 | A | 285 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 285 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | P | 274 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | C-term | S | 404 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Van-der-waals | C-term | S | 404 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Hydrophobic | ICL3 | L | 272 | - | G.S6 | H | 322 | G.S6.04 |
Polar | ICL2 | T | 159 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | T | 159 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | P | 274 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL3 | P | 274 | - | G.H5 | V | 334 | G.H5.06 |
Hydrophobic | ICL2 | P | 156 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 156 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL3 | V | 276 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | A | 285 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Ionic | TM5 | K | 250 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | K | 250 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | K | 250 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | K | 250 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | E | 260 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | ICL3 | E | 260 | - | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | ICL3 | E | 260 | - | G.S6 | H | 322 | G.S6.04 |
Aromatic | C-term | W | 401 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Hydrophobic | C-term | W | 401 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Polar | C-term | W | 401 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | C-term | W | 401 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | W | 401 | - | H.HA | Q | 79 | H.HA.17 |
Polar | TM6 | R | 288 | 6x32 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | R | 288 | 6x32 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | R | 288 | 6x32 | G.H5 | G | 352 | G.H5.24 |
Polar | TM6 | S | 281 | 6x25 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | S | 281 | 6x25 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | S | 281 | 6x25 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | P | 156 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 156 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | W | 401 | - | H.HA | N | 76 | H.HA.14 |
Van-der-waals | C-term | W | 401 | - | H.HA | N | 76 | H.HA.14 |
Polar | C-term | T | 395 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | T | 395 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | T | 395 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | TM6 | A | 285 | 6x29 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | L | 160 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Polar | C-term | T | 395 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | C-term | R | 392 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL2 | L | 157 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 157 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | C-term | P | 394 | - | G.H3 | E | 246 | G.H3.04 |
Van-der-waals | C-term | P | 394 | - | G.H3 | E | 246 | G.H3.04 |
Polar | C-term | S | 397 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Polar | C-term | N | 396 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | N | 396 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | N | 396 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Ionic | C-term | K | 409 | - | H.HA | E | 64 | H.HA.02 |
Polar | C-term | K | 409 | - | H.HA | E | 64 | H.HA.02 |
Van-der-waals | C-term | K | 409 | - | H.HA | E | 64 | H.HA.02 |
Polar | C-term | N | 396 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | N | 396 | - | G.H2 | R | 206 | G.H2.01 |
Polar | TM2 | R | 85 | 2x38 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM2 | R | 85 | 2x38 | G.H5 | N | 347 | G.H5.19 |
Polar | TM6 | S | 281 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | S | 281 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Ionic | C-term | K | 402 | - | H.hbhc | D | 116 | H.hbhc.04 |
Polar | C-term | K | 402 | - | H.hbhc | D | 116 | H.hbhc.04 |
Hydrophobic | C-term | K | 402 | - | H.hbhc | D | 116 | H.hbhc.04 |
Van-der-waals | C-term | K | 402 | - | H.hbhc | D | 116 | H.hbhc.04 |
Polar | C-term | K | 402 | - | H.hbhc | M | 114 | H.hbhc.02 |
Hydrophobic | C-term | K | 402 | - | H.hbhc | M | 114 | H.hbhc.02 |
Van-der-waals | C-term | K | 402 | - | H.hbhc | M | 114 | H.hbhc.02 |
Hydrophobic | C-term | T | 386 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | T | 386 | - | G.H2 | K | 210 | G.H2.05 |
Polar | C-term | K | 402 | - | H.hbhc | T | 117 | H.hbhc.05 |
Hydrophobic | C-term | K | 402 | - | H.hbhc | T | 117 | H.hbhc.05 |
Polar | ICL3 | C | 275 | - | G.S6 | C | 321 | G.S6.03 |
Van-der-waals | ICL3 | C | 275 | - | G.S6 | C | 321 | G.S6.03 |
Hydrophobic | ICL2 | L | 160 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 160 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | L | 160 | 34x54 | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | ICL3 | S | 277 | - | G.H4 | E | 309 | G.H4.16 |
Polar | C-term | S | 393 | - | G.H2 | S | 207 | G.H2.02 |
Hydrophobic | ICL3 | V | 276 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | V | 276 | - | G.S6 | Y | 320 | G.S6.02 |