Gq - VPAC1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 10.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 K 322 5x64 G.H5 L 349 G.H5.16
Van-der-waals TM5 K 322 5x64 G.H5 L 349 G.H5.16
Hydrophobic C-term V 440 - G.H3 A 253 G.H3.07
Hydrophobic TM5 L 319 5x61 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 248 - G.S1 L 40 G.S1.02
Hydrophobic C-term V 434 - G.H2 I 217 G.H2.08
Polar C-term G 443 - G.s4h3 E 245 G.s4h3.14
Aromatic ICL2 F 248 - G.H5 F 341 G.H5.08
Hydrophobic ICL2 F 248 - G.H5 F 341 G.H5.08
Van-der-waals ICL2 F 248 - G.H5 F 341 G.H5.08
Hydrophobic TM3 V 246 3x60 G.H5 K 345 G.H5.12
Hydrophobic TM3 L 244 3x58 G.H5 N 352 G.H5.19
Polar C-term Q 433 - G.H3 W 263 G.H3.17
Hydrophobic C-term Q 433 - G.H3 W 263 G.H3.17
Van-der-waals C-term Q 433 - G.H3 W 263 G.H3.17
Polar TM3 A 245 3x59 G.H5 K 345 G.H5.12
Van-der-waals TM3 A 245 3x59 G.H5 K 345 G.H5.12
Hydrophobic ICL2 F 248 - G.H5 V 344 G.H5.11
Hydrophobic TM5 L 319 5x61 G.H5 L 353 G.H5.20
Van-der-waals C-term T 438 - G.H2 R 210 G.H2.01
Hydrophobic ICL2 F 248 - G.s2s3 S 198 G.s2s3.02
Hydrophobic C-term L 437 - G.H2 R 213 G.H2.04
Van-der-waals C-term L 437 - G.H2 R 213 G.H2.04
Hydrophobic C-term V 434 - G.H2 R 214 G.H2.05
Polar C-term Q 433 - G.H3 Y 261 G.H3.15
Hydrophobic C-term T 438 - G.H2 R 214 G.H2.05
Van-der-waals C-term T 438 - G.H2 R 214 G.H2.05
Ionic ICL3 K 330 - G.h4s6 D 321 G.h4s6.12
Polar ICL3 K 330 - G.h4s6 D 321 G.h4s6.12
Van-der-waals ICL3 K 330 - G.h4s6 D 321 G.h4s6.12
Hydrophobic C-term L 437 - G.h2s4 F 220 G.h2s4.01
Polar H8 N 392 8x47 G.H5 N 357 G.H5.24
Hydrophobic C-term P 442 - G.s4h3 E 245 G.s4h3.14
Hydrophobic C-term L 437 - G.H3 T 257 G.H3.11
Polar C-term L 437 - G.H3 Y 261 G.H3.15
Hydrophobic C-term L 437 - G.H3 Y 261 G.H3.15
Van-der-waals C-term L 437 - G.H3 Y 261 G.H3.15
Hydrophobic ICL2 F 248 - G.S3 V 199 G.S3.01
Polar TM6 S 342 6x41 G.H5 L 358 G.H5.25
Hydrophobic TM6 S 342 6x41 G.H5 L 358 G.H5.25
Van-der-waals TM6 S 342 6x41 G.H5 L 358 G.H5.25
Aromatic TM2 R 174 2x46 G.H5 Y 356 G.H5.23
Hydrophobic TM2 R 174 2x46 G.H5 Y 356 G.H5.23
Van-der-waals TM2 R 174 2x46 G.H5 Y 356 G.H5.23
Hydrophobic TM3 Y 239 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 Y 239 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 F 248 - G.H5 K 345 G.H5.12
Van-der-waals ICL2 F 248 - G.H5 K 345 G.H5.12
Hydrophobic C-term S 441 - G.H2 R 210 G.H2.01
Van-der-waals C-term S 441 - G.H2 R 210 G.H2.01
Hydrophobic TM3 L 240 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM3 L 244 3x58 G.H5 L 349 G.H5.16
Van-der-waals TM3 L 244 3x58 G.H5 L 349 G.H5.16
Hydrophobic ICL2 S 247 - G.H5 I 348 G.H5.15
Hydrophobic ICL2 F 248 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 F 248 - G.H5 I 348 G.H5.15
Hydrophobic TM3 L 243 3x57 G.H5 Y 356 G.H5.23
Hydrophobic C-term M 436 - G.H3 Y 261 G.H3.15
Van-der-waals C-term M 436 - G.H3 Y 261 G.H3.15
Hydrophobic TM5 K 322 5x64 G.H5 L 353 G.H5.20
Hydrophobic TM3 L 244 3x58 G.H5 L 353 G.H5.20
Van-der-waals TM3 L 244 3x58 G.H5 L 353 G.H5.20
Hydrophobic C-term V 440 - G.H3 T 257 G.H3.11
Van-der-waals C-term V 440 - G.H3 T 257 G.H3.11
Hydrophobic ICL2 S 247 - G.H5 K 345 G.H5.12
Van-der-waals ICL2 S 247 - G.H5 K 345 G.H5.12
Hydrophobic C-term Q 433 - G.H2 I 217 G.H2.08
Van-der-waals C-term Q 433 - G.H2 I 217 G.H2.08
Hydrophobic C-term L 437 - G.H3 I 258 G.H3.12
Ionic TM5 K 322 5x64 G.H5 D 346 G.H5.13
Polar TM5 K 322 5x64 G.H5 D 346 G.H5.13
Hydrophobic TM5 K 322 5x64 G.H5 D 346 G.H5.13
Van-der-waals TM5 K 322 5x64 G.H5 D 346 G.H5.13
Polar TM3 L 243 3x57 G.H5 N 352 G.H5.19
Hydrophobic TM3 L 243 3x57 G.H5 N 352 G.H5.19
Van-der-waals TM3 L 243 3x57 G.H5 N 352 G.H5.19
Hydrophobic TM3 L 240 3x54 G.H5 Y 356 G.H5.23
Van-der-waals TM3 L 240 3x54 G.H5 Y 356 G.H5.23
Hydrophobic TM6 L 346 6x45 G.H5 L 358 G.H5.25
Hydrophobic TM5 L 319 5x61 G.H5 V 359 G.H5.26
Hydrophobic C-term S 441 - G.s4h3 E 245 G.s4h3.14
Polar ICL3 K 330 - G.h4s6 S 320 G.h4s6.11
Hydrophobic ICL3 K 330 - G.h4s6 S 320 G.h4s6.11
Van-der-waals ICL3 K 330 - G.h4s6 S 320 G.h4s6.11
Ionic TM2 R 174 2x46 G.H5 E 355 G.H5.22
Polar TM2 R 174 2x46 G.H5 E 355 G.H5.22
Hydrophobic TM2 R 174 2x46 G.H5 E 355 G.H5.22
Van-der-waals TM2 R 174 2x46 G.H5 E 355 G.H5.22
Hydrophobic C-term L 437 - G.H2 W 216 G.H2.07