G12 -
VPAC2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | I | 305 | 5x60 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | M | 234 | - | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | M | 234 | - | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM5 | L | 306 | 5x61 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 306 | 5x61 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | Q | 432 | - | H.HA | K | 103 | H.HA.17 |
Hydrophobic | C-term | Q | 432 | - | H.HA | K | 103 | H.HA.17 |
Van-der-waals | C-term | Q | 432 | - | H.HA | K | 103 | H.HA.17 |
Polar | TM4 | P | 236 | 4x38 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | C-term | F | 430 | - | H.HA | K | 114 | H.HA.28 |
Polar | C-term | S | 429 | - | H.hdhe | Q | 174 | H.hdhe.02 |
Polar | C-term | T | 435 | - | H.HA | K | 103 | H.HA.17 |
Van-der-waals | C-term | T | 435 | - | H.HA | K | 103 | H.HA.17 |
Ionic | C-term | E | 434 | - | G.hfs2 | R | 205 | G.hfs2.02 |
Polar | C-term | E | 434 | - | G.hfs2 | R | 205 | G.hfs2.02 |
Van-der-waals | C-term | Q | 432 | - | H.HA | G | 104 | H.HA.18 |
Hydrophobic | C-term | S | 429 | - | H.hdhe | F | 173 | H.hdhe.01 |
Van-der-waals | C-term | S | 429 | - | H.hdhe | F | 173 | H.hdhe.01 |
Hydrophobic | C-term | E | 434 | - | G.hfs2 | A | 207 | G.hfs2.04 |
Van-der-waals | C-term | E | 434 | - | G.hfs2 | A | 207 | G.hfs2.04 |
Hydrophobic | ICL2 | M | 234 | - | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | M | 234 | - | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM4 | R | 238 | 4x40 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | TM4 | R | 238 | 4x40 | G.hns1 | R | 56 | G.hns1.03 |
Polar | C-term | T | 433 | - | H.HA | K | 103 | H.HA.17 |
Van-der-waals | C-term | T | 433 | - | H.HA | K | 103 | H.HA.17 |
Hydrophobic | TM3 | L | 227 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | L | 227 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | Q | 432 | - | H.HA | V | 107 | H.HA.21 |
Polar | C-term | E | 434 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Hydrophobic | C-term | E | 434 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Van-der-waals | C-term | E | 434 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Polar | C-term | S | 429 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | S | 429 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | S | 429 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | V | 437 | - | G.hfs2 | K | 206 | G.hfs2.03 |
Van-der-waals | C-term | V | 437 | - | G.hfs2 | K | 206 | G.hfs2.03 |
Polar | TM4 | R | 238 | 4x40 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM4 | R | 238 | 4x40 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM4 | R | 238 | 4x40 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL2 | L | 235 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | L | 235 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM6 | L | 332 | 6x44 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | L | 231 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | L | 231 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | H8 | N | 379 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | N | 379 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | L | 235 | - | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | L | 235 | - | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | C-term | L | 431 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | S | 429 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | TM6 | L | 333 | 6x45 | G.H5 | I | 378 | G.H5.23 |
Polar | C-term | A | 427 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | N-term | M | 1 | - | G.HN | R | 41 | G.HN.41 |
Hydrophobic | C-term | R | 423 | - | G.s4h3 | R | 266 | G.s4h3.13 |
Hydrophobic | TM3 | L | 231 | 3x58 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | L | 231 | 3x58 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM4 | P | 237 | 4x39 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | TM4 | P | 237 | 4x39 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM5 | K | 309 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | K | 309 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Polar | C-term | F | 430 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | C-term | F | 430 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | F | 430 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | Q | 428 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | TM3 | L | 230 | 3x57 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | L | 230 | 3x57 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | L | 230 | 3x57 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM7 | L | 374 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | L | 374 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | S | 380 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | M | 234 | - | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | M | 234 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | TM4 | R | 238 | 4x40 | G.HN | A | 53 | G.HN.53 |
Van-der-waals | TM4 | R | 238 | 4x40 | G.HN | A | 53 | G.HN.53 |
Polar | C-term | S | 436 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Hydrophobic | C-term | S | 436 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Van-der-waals | C-term | S | 436 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Hydrophobic | C-term | Q | 432 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Polar | C-term | Q | 432 | - | H.hdhe | G | 176 | H.hdhe.04 |
Van-der-waals | C-term | Q | 432 | - | H.hdhe | G | 176 | H.hdhe.04 |
Van-der-waals | N-term | R | 2 | - | G.HN | R | 34 | G.HN.34 |
Ionic | TM2 | R | 158 | 2x46 | G.H5 | D | 377 | G.H5.22 |
Polar | TM2 | R | 158 | 2x46 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM2 | R | 158 | 2x46 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | R | 158 | 2x46 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | ICL2 | L | 235 | - | G.S3 | P | 222 | G.S3.02 |
Van-der-waals | ICL2 | L | 235 | - | G.S3 | P | 222 | G.S3.02 |
Hydrophobic | ICL3 | V | 315 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | TM3 | V | 232 | 3x59 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM3 | V | 232 | 3x59 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | TM3 | V | 232 | 3x59 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM7 | Y | 375 | 7x57 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | Y | 375 | 7x57 | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | S | 380 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | S | 380 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | S | 380 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL3 | D | 314 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | D | 314 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | C-term | L | 431 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Polar | C-term | T | 435 | - | H.HA | D | 99 | H.HA.13 |
Hydrophobic | C-term | T | 435 | - | H.HA | D | 99 | H.HA.13 |
Van-der-waals | C-term | T | 435 | - | H.HA | D | 99 | H.HA.13 |
Hydrophobic | TM6 | S | 329 | 6x41 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | S | 329 | 6x41 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | M | 234 | - | G.H5 | V | 366 | G.H5.11 |
Hydrophobic | TM5 | L | 306 | 5x61 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM2 | C | 156 | 2x44 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM3 | L | 231 | 3x58 | G.H5 | I | 378 | G.H5.23 |
Ionic | TM5 | K | 309 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | K | 309 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | K | 309 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | K | 309 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Polar | C-term | T | 435 | - | G.hfs2 | A | 207 | G.hfs2.04 |
Polar | C-term | Q | 428 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | Q | 428 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | Q | 428 | - | H.HA | K | 114 | H.HA.28 |