Gt2 -
VPAC2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 24.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | L | 235 | - | G.HN | D | 28 | G.HN.52 |
Van-der-waals | ICL2 | L | 235 | - | G.HN | D | 28 | G.HN.52 |
Polar | TM3 | V | 232 | 3x59 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | V | 232 | 3x59 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM3 | V | 232 | 3x59 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | Y | 226 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Ionic | TM4 | R | 238 | 4x40 | G.h2s4 | E | 216 | G.h2s4.02 |
Polar | TM4 | R | 238 | 4x40 | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | TM4 | R | 238 | 4x40 | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | TM4 | P | 237 | 4x39 | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | TM4 | P | 237 | 4x39 | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | ICL2 | M | 234 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | M | 234 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM3 | A | 233 | 3x60 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM3 | A | 233 | 3x60 | G.hns1 | K | 32 | G.hns1.03 |
Polar | ICL2 | M | 234 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | M | 234 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | M | 234 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | L | 227 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | L | 227 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | D | 314 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | D | 314 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM3 | L | 231 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | L | 235 | - | G.HN | K | 29 | G.HN.53 |
Hydrophobic | ICL2 | L | 235 | - | G.HN | K | 29 | G.HN.53 |
Van-der-waals | ICL2 | L | 235 | - | G.HN | K | 29 | G.HN.53 |
Hydrophobic | TM5 | K | 309 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | K | 309 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | L | 332 | 6x44 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 332 | 6x44 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | A | 233 | 3x60 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | TM3 | A | 233 | 3x60 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM6 | L | 336 | 6x48 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | L | 227 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | L | 227 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Polar | TM3 | L | 230 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | L | 230 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | L | 230 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Ionic | TM5 | K | 309 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | K | 309 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | K | 309 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | K | 309 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | M | 234 | - | G.HN | K | 29 | G.HN.53 |
Van-der-waals | ICL2 | M | 234 | - | G.HN | K | 29 | G.HN.53 |
Hydrophobic | TM7 | Y | 375 | 7x57 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | L | 235 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | L | 235 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | L | 235 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | L | 227 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | L | 230 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | L | 230 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | L | 333 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 333 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | V | 232 | 3x59 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | TM2 | R | 158 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | R | 158 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | R | 158 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM3 | V | 232 | 3x59 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | TM3 | V | 232 | 3x59 | G.S3 | L | 194 | G.S3.01 |
Polar | TM4 | P | 236 | 4x38 | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | TM4 | P | 236 | 4x38 | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | TM4 | P | 236 | 4x38 | G.hns1 | E | 30 | G.hns1.01 |
Polar | TM4 | R | 239 | 4x41 | G.HN | L | 23 | G.HN.47 |
Van-der-waals | TM4 | R | 239 | 4x41 | G.HN | L | 23 | G.HN.47 |
Hydrophobic | TM7 | Y | 375 | 7x57 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | Y | 375 | 7x57 | G.H5 | G | 352 | G.H5.24 |
Polar | TM2 | R | 158 | 2x46 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | TM2 | R | 158 | 2x46 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | TM4 | P | 237 | 4x39 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM4 | P | 237 | 4x39 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | L | 235 | - | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | ICL2 | L | 235 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | TM3 | L | 231 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | L | 231 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | A | 233 | 3x60 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM3 | A | 233 | 3x60 | G.hns1 | A | 31 | G.hns1.02 |
Polar | TM4 | P | 236 | 4x38 | G.HN | A | 27 | G.HN.51 |
Hydrophobic | TM4 | P | 236 | 4x38 | G.HN | A | 27 | G.HN.51 |
Van-der-waals | TM4 | P | 236 | 4x38 | G.HN | A | 27 | G.HN.51 |
Hydrophobic | TM2 | R | 158 | 2x46 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | R | 158 | 2x46 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM3 | L | 231 | 3x58 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | TM3 | L | 231 | 3x58 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | L | 235 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | L | 235 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | L | 235 | - | G.HN | A | 27 | G.HN.51 |
Van-der-waals | ICL2 | L | 235 | - | G.HN | A | 27 | G.HN.51 |
Hydrophobic | ICL2 | M | 234 | - | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | M | 234 | - | G.S1 | V | 34 | G.S1.02 |
Polar | ICL2 | M | 234 | - | G.S1 | T | 33 | G.S1.01 |
Hydrophobic | ICL2 | M | 234 | - | G.S1 | T | 33 | G.S1.01 |
Van-der-waals | ICL2 | M | 234 | - | G.S1 | T | 33 | G.S1.01 |
Hydrophobic | TM4 | R | 239 | 4x41 | G.HN | A | 27 | G.HN.51 |
Van-der-waals | TM4 | R | 239 | 4x41 | G.HN | A | 27 | G.HN.51 |
Hydrophobic | TM3 | T | 229 | 3x56 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM3 | T | 229 | 3x56 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL2 | M | 234 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | M | 234 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | M | 234 | - | G.hns1 | K | 32 | G.hns1.03 |
Polar | ICL2 | M | 234 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | ICL2 | M | 234 | - | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | ICL2 | M | 234 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | TM4 | C | 240 | 4x42 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM5 | L | 306 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | L | 306 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM2 | R | 158 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | R | 158 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM4 | P | 236 | 4x38 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM4 | P | 236 | 4x38 | G.hns1 | A | 31 | G.hns1.02 |