GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | Y | 327 | - | G.H3 | P | 258 | G.H3.16 |
Van-der-waals | C-term | Y | 327 | - | G.H3 | P | 258 | G.H3.16 |
Hydrophobic | C-term | F | 332 | - | G.H3 | I | 254 | G.H3.12 |
Van-der-waals | C-term | F | 332 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | H8 | K | 293 | 8x49 | G.H5 | R | 350 | G.H5.21 |
Polar | C-term | Y | 333 | - | G.s3h2 | Q | 205 | G.s3h2.03 |
Hydrophobic | C-term | Y | 333 | - | G.s3h2 | Q | 205 | G.s3h2.03 |
Van-der-waals | C-term | Y | 333 | - | G.s3h2 | Q | 205 | G.s3h2.03 |
Hydrophobic | ICL2 | R | 139 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | R | 139 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM7 | V | 288 | 7x54 | G.H5 | N | 353 | G.H5.24 |
Polar | C-term | Y | 333 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | Y | 333 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | Y | 333 | - | G.H2 | R | 209 | G.H2.04 |
Polar | C-term | Y | 333 | - | G.H2 | S | 207 | G.H2.02 |
Hydrophobic | C-term | Y | 333 | - | G.H2 | S | 207 | G.H2.02 |
Hydrophobic | ICL2 | L | 138 | 34x54 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.S1 | L | 36 | G.S1.02 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 135 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM6 | L | 226 | 6x36 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM6 | L | 226 | 6x36 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM5 | S | 215 | 5x68 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM5 | S | 215 | 5x68 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | ICL2 | L | 138 | 34x54 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | L | 138 | 34x54 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | L | 138 | 34x54 | G.S3 | I | 195 | G.S3.01 |
Hydrophobic | ICL2 | L | 138 | 34x54 | G.S1 | L | 36 | G.S1.02 |
Hydrophobic | C-term | F | 332 | - | G.H3 | L | 250 | G.H3.08 |
Van-der-waals | C-term | F | 332 | - | G.H3 | L | 250 | G.H3.08 |
Polar | TM2 | S | 64 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM2 | S | 64 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | S | 64 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | C-term | Y | 333 | - | G.H2 | R | 210 | G.H2.05 |
Van-der-waals | C-term | Y | 333 | - | G.H2 | R | 210 | G.H2.05 |
Polar | ICL3 | R | 216 | - | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL3 | R | 216 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | T | 211 | 5x64 | G.H5 | L | 345 | G.H5.16 |
Polar | ICL3 | S | 217 | - | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | ICL3 | S | 217 | - | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | ICL3 | S | 217 | - | G.H5 | Q | 346 | G.H5.17 |
Ionic | TM6 | R | 219 | 6x29 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | TM6 | R | 219 | 6x29 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | TM6 | R | 219 | 6x29 | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | TM6 | R | 219 | 6x29 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | K | 341 | G.H5.12 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | TM6 | I | 227 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | H8 | V | 292 | 8x48 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | H8 | V | 292 | 8x48 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | H8 | V | 292 | 8x48 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM3 | V | 131 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | V | 131 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM3 | V | 131 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM2 | T | 66 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | T | 66 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM6 | R | 219 | 6x29 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 219 | 6x29 | G.H5 | V | 355 | G.H5.26 |
Polar | TM3 | R | 127 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 127 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | V | 140 | 34x56 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | V | 140 | 34x56 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM3 | S | 130 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | S | 130 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Polar | ICL2 | T | 137 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | L | 135 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | C-term | F | 332 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Polar | C-term | F | 332 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | F | 332 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | F | 332 | - | G.H2 | R | 209 | G.H2.04 |
Polar | C-term | G | 329 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | G | 329 | - | G.H3 | Y | 257 | G.H3.15 |
Polar | C-term | Y | 333 | - | G.H2 | E | 208 | G.H2.03 |
Hydrophobic | C-term | Y | 333 | - | G.H2 | E | 208 | G.H2.03 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM6 | T | 223 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | L | 226 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Polar | TM6 | R | 222 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM6 | R | 222 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 222 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Polar | TM3 | S | 130 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | S | 130 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | S | 130 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | H8 | K | 293 | 8x49 | G.H5 | E | 351 | G.H5.22 |
Aromatic | TM3 | H | 126 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | H | 126 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | H | 126 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Polar | TM6 | K | 218 | 6x28 | G.h4s6 | K | 316 | G.h4s6.11 |
Van-der-waals | TM6 | K | 218 | 6x28 | G.h4s6 | K | 316 | G.h4s6.11 |
Polar | TM6 | T | 223 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | T | 223 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | T | 223 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | I | 230 | 6x40 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | S | 215 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | C-term | F | 332 | - | G.H3 | T | 253 | G.H3.11 |
Van-der-waals | C-term | F | 332 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | TM5 | L | 212 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM5 | L | 212 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Polar | C-term | Y | 333 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | Y | 333 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | Y | 333 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL2 | L | 138 | 34x54 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | H8 | G | 291 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | G | 291 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Ionic | ICL1 | E | 63 | 12x51 | G.hns1 | R | 33 | G.hns1.02 |
Polar | ICL1 | E | 63 | 12x51 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL1 | E | 63 | 12x51 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | C-term | A | 330 | - | G.H3 | Y | 257 | G.H3.15 |
Ionic | ICL1 | E | 63 | 12x51 | G.HN | K | 30 | G.HN.52 |
Polar | ICL1 | E | 63 | 12x51 | G.HN | K | 30 | G.HN.52 |
Hydrophobic | ICL1 | E | 63 | 12x51 | G.HN | K | 30 | G.HN.52 |
Van-der-waals | ICL1 | E | 63 | 12x51 | G.HN | K | 30 | G.HN.52 |
Polar | TM7 | Y | 287 | 7x53 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM7 | Y | 287 | 7x53 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM7 | Y | 287 | 7x53 | G.H5 | N | 353 | G.H5.24 |
Aromatic | C-term | F | 332 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | F | 332 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | F | 332 | - | G.H3 | Y | 257 | G.H3.15 |