Refined structure (7E33) of Gi1 - 5-HT1E receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 217 from structure (61.3%), 137 from model (38.7%)
Residue sidechains - 213 from structure (60.2%), 141 from model (39.8%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 257 from structure (80.3%), 63 from model (19.7%)
Residue sidechains - 256 from structure (80.0%), 64 from model (20.0%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 I - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 C - AF2 AF2
N-term 7 T - AF2 AF2
N-term 8 T - AF2 AF2
N-term 9 E - AF2 AF2
N-term 10 A - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 M - AF2 AF2
N-term 13 A - AF2 AF2
N-term 14 I - AF2 AF2
N-term 15 R - AF2 AF2
N-term 16 P - AF2 AF2
N-term 17 K - AF2 AF2
TM1 18 T 1.28x28 AF2 AF2
TM1 19 I 1.29x29 AF2 AF2
TM1 20 T 1.30x30 Structure Structure
TM1 21 E 1.31x31 Structure Structure
TM1 22 K 1.32x32 Structure Structure
TM1 23 M 1.33x33 Structure Structure
TM1 24 L 1.34x34 Structure Structure
TM1 25 I 1.35x35 Structure Structure
TM1 26 C 1.36x36 Structure Structure
TM1 27 M 1.37x37 Structure Structure
TM1 28 T 1.38x38 Structure Structure
TM1 29 L 1.39x39 Structure Structure
TM1 30 V 1.40x40 Structure Structure
TM1 31 V 1.41x41 Structure Structure
TM1 32 I 1.42x42 Structure Structure
TM1 33 T 1.43x43 Structure Structure
TM1 34 T 1.44x44 Structure Structure
TM1 35 L 1.45x45 Structure Structure
TM1 36 T 1.46x46 Structure Structure
TM1 37 T 1.47x47 Structure Structure
TM1 38 L 1.48x48 Structure Structure
TM1 39 L 1.49x49 Structure Structure
TM1 40 N 1.50x50 Structure Structure
TM1 41 L 1.51x51 Structure Structure
TM1 42 A 1.52x52 Structure Structure
TM1 43 V 1.53x53 Structure Structure
TM1 44 I 1.54x54 Structure Structure
TM1 45 M 1.55x55 Structure Structure
TM1 46 A 1.56x56 Structure Structure
TM1 47 I 1.57x57 Structure Structure
TM1 48 G 1.58x58 Structure Structure
TM1 49 T 1.59x59 Structure Structure
TM1 50 T 1.60x60 Structure Structure
ICL1 51 K 12.48x48 Structure Structure
ICL1 52 K 12.49x49 Structure Structure
ICL1 53 L 12.50x50 Structure Structure
ICL1 54 H 12.51x51 Structure Structure
TM2 55 Q 2.37x37 Structure Structure
TM2 56 P 2.38x38 Structure Structure
TM2 57 A 2.39x39 Structure Structure
TM2 58 N 2.40x40 Structure Structure
TM2 59 Y 2.41x41 Structure Structure
TM2 60 L 2.42x42 Structure Structure
TM2 61 I 2.43x43 Structure Structure
TM2 62 C 2.44x44 Structure Structure
TM2 63 S 2.45x45 Structure Structure
TM2 64 L 2.46x46 Structure Structure
TM2 65 A 2.47x47 Structure Structure
TM2 66 V 2.48x48 Structure Structure
TM2 67 T 2.49x49 Structure Structure
TM2 68 D 2.50x50 Structure Structure
TM2 69 L 2.51x51 Structure Structure
TM2 70 L 2.52x52 Structure Structure
TM2 71 V 2.53x53 Structure Structure
TM2 72 A 2.54x54 Structure Structure
TM2 73 V 2.55x55 Structure Structure
TM2 74 L 2.56x551 Structure Structure
TM2 75 V 2.57x56 Structure Structure
TM2 76 M 2.58x57 Structure Structure
TM2 77 P 2.59x58 Structure Structure
TM2 78 L 2.60x59 Structure Structure
TM2 79 S 2.61x60 Structure Structure
TM2 80 I 2.62x61 Structure Structure
TM2 81 I 2.63x62 Structure Structure
TM2 82 Y 2.64x63 Structure Structure
TM2 83 I 2.65x64 Structure Structure
TM2 84 V 2.66x65 Structure Structure
TM2 85 M 2.67x66 Structure Structure
TM2 86 D 2.68x67 Structure Structure
ECL1 87 R 23.49x49 Structure Structure
ECL1 88 W 23.50x50 Structure Structure
ECL1 89 K 23.51x51 Structure Structure
ECL1 90 L 23.52x52 Structure Structure
TM3 91 G 3.21x21 Structure Structure
TM3 92 Y 3.22x22 Structure Structure
TM3 93 F 3.23x23 Structure Structure
TM3 94 L 3.24x24 Structure Structure
TM3 95 C 3.25x25 Structure Structure
TM3 96 E 3.26x26 Structure Structure
TM3 97 V 3.27x27 Structure Structure
TM3 98 W 3.28x28 Structure Structure
TM3 99 L 3.29x29 Structure Structure
TM3 100 S 3.30x30 Structure Structure
TM3 101 V 3.31x31 Structure Structure
TM3 102 D 3.32x32 Structure Structure
TM3 103 M 3.33x33 Structure Structure
TM3 104 T 3.34x34 Structure Structure
TM3 105 C 3.35x35 Structure Structure
TM3 106 C 3.36x36 Structure Structure
TM3 107 T 3.37x37 Structure Structure
TM3 108 C 3.38x38 Structure Structure
TM3 109 S 3.39x39 Structure Structure
TM3 110 I 3.40x40 Structure Structure
TM3 111 L 3.41x41 Structure AF2
TM3 112 H 3.42x42 Structure Structure
TM3 113 L 3.43x43 Structure Structure
TM3 114 C 3.44x44 Structure Structure
TM3 115 V 3.45x45 Structure Structure
TM3 116 I 3.46x46 Structure Structure
TM3 117 A 3.47x47 Structure Structure
TM3 118 L 3.48x48 Structure Structure
TM3 119 D 3.49x49 Structure Structure
TM3 120 R 3.50x50 Structure Structure
TM3 121 Y 3.51x51 Structure Structure
TM3 122 W 3.52x52 Structure Structure
TM3 123 A 3.53x53 Structure Structure
TM3 124 I 3.54x54 Structure Structure
TM3 125 T 3.55x55 Structure Structure
TM3 126 N 3.56x56 Structure Structure
ICL2 127 A 34.50x50 Structure Structure
ICL2 128 I 34.51x51 Structure Structure
ICL2 129 E 34.52x52 Structure Structure
ICL2 130 Y 34.53x53 Structure Structure
ICL2 131 A 34.54x54 Structure Structure
ICL2 132 R 34.55x55 Structure Structure
ICL2 133 K 34.56x56 Structure Structure
ICL2 134 R 34.57x57 Structure Structure
TM4 135 T 4.38x38 Structure Structure
TM4 136 A 4.39x39 Structure Structure
TM4 137 K 4.40x40 Structure Structure
TM4 138 R 4.41x41 Structure Structure
TM4 139 A 4.42x42 Structure Structure
TM4 140 A 4.43x43 Structure Structure
TM4 141 L 4.44x44 Structure Structure
TM4 142 M 4.45x45 Structure Structure
TM4 143 I 4.46x46 Structure Structure
TM4 144 L 4.47x47 Structure Structure
TM4 145 T 4.48x48 Structure Structure
TM4 146 V 4.49x49 Structure Structure
TM4 147 W 4.50x50 Structure Structure
TM4 148 T 4.51x51 Structure Structure
TM4 149 I 4.52x52 Structure Structure
TM4 150 S 4.53x53 Structure Structure
TM4 151 I 4.54x54 Structure Structure
TM4 152 F 4.55x55 Structure Structure
TM4 153 I 4.56x56 Structure Structure
TM4 154 S 4.57x57 Structure Structure
TM4 155 M 4.58x58 Structure Structure
TM4 156 P 4.59x59 Structure Structure
TM4 157 P 4.60x60 Structure Structure
TM4 158 L 4.61x61 Structure Structure
TM4 159 F 4.62x62 AF2 AF2
TM4 160 W 4.63x63 AF2 AF2
ECL2 161 R - AF2 AF2
ECL2 162 S - AF2 AF2
ECL2 163 H - AF2 AF2
ECL2 164 R - AF2 AF2
ECL2 165 R - AF2 AF2
ECL2 166 L - AF2 AF2
ECL2 167 S - AF2 AF2
ECL2 168 P - AF2 AF2
ECL2 169 P - AF2 AF2
ECL2 170 P - AF2 AF2
ECL2 171 S - AF2 AF2
ECL2 172 Q - Structure Structure
ECL2 173 C 45.50x50 Structure Structure
ECL2 174 T 45.51x51 Structure Structure
ECL2 175 I 45.52x52 Structure Structure
ECL2 176 Q - Structure Structure
ECL2 177 H - Structure Structure
ECL2 178 D - Structure Structure
TM5 179 H 5.35x36 Structure Structure
TM5 180 V 5.36x37 Structure Structure
TM5 181 I 5.37x38 Structure Structure
TM5 182 Y 5.38x39 Structure Structure
TM5 183 T 5.39x40 Structure Structure
TM5 184 I 5.40x41 Structure Structure
TM5 185 Y 5.41x42 Structure Structure
TM5 186 S 5.42x43 Structure Structure
TM5 187 T 5.43x44 Structure Structure
TM5 188 L 5.44x45 Structure Structure
TM5 189 G 5.45x46 Structure Structure
TM5 190 A 5.46x461 Structure Structure
TM5 191 F 5.47x47 Structure Structure
TM5 192 Y 5.48x48 Structure Structure
TM5 193 I 5.49x49 Structure Structure
TM5 194 P 5.50x50 Structure Structure
TM5 195 L 5.51x51 Structure Structure
TM5 196 T 5.52x52 Structure Structure
TM5 197 L 5.53x53 Structure Structure
TM5 198 I 5.54x54 Structure Structure
TM5 199 L 5.55x55 Structure Structure
TM5 200 I 5.56x56 Structure Structure
TM5 201 L 5.57x57 Structure Structure
TM5 202 Y 5.58x58 Structure Structure
TM5 203 Y 5.59x59 Structure Structure
TM5 204 R 5.60x60 Structure Structure
TM5 205 I 5.61x61 Structure Structure
TM5 206 Y 5.62x62 Structure Structure
TM5 207 H 5.63x63 Structure Structure
TM5 208 A 5.64x64 Structure Structure
TM5 209 A 5.65x65 Structure Structure
TM5 210 K 5.66x66 Structure Structure
TM5 211 S 5.67x67 Structure Structure
TM5 212 L 5.68x68 Structure Structure
TM5 213 Y 5.69x69 AF2 AF2
TM5 214 Q 5.70x70 AF2 AF2
TM5 215 K 5.71x71 AF2 AF2
TM5 216 R 5.72x72 AF2 AF2
TM5 217 G 5.73x73 AF2 AF2
TM5 218 S 5.74x74 AF2 AF2
TM5 219 S 5.75x75 AF2 AF2
TM5 220 R 5.76x76 AF2 AF2
ICL3 221 H - AF2 AF2
ICL3 222 L - AF2 AF2
ICL3 223 S - AF2 AF2
ICL3 224 N - AF2 AF2
ICL3 225 R - AF2 AF2
ICL3 226 S - AF2 AF2
ICL3 227 T - AF2 AF2
ICL3 273 D - AF2 AF2
ICL3 274 H - AF2 AF2
ICL3 275 P - AF2 AF2
ICL3 276 G - AF2 AF2
ICL3 277 E - AF2 AF2
ICL3 278 R - AF2 AF2
ICL3 279 Q - AF2 AF2
TM6 280 Q 6.24x24 AF2 AF2
TM6 281 I 6.25x25 AF2 AF2
TM6 282 S 6.26x26 Structure Structure
TM6 283 S 6.27x27 Structure Structure
TM6 284 T 6.28x28 Structure Structure
TM6 285 R 6.29x29 Structure Structure
TM6 286 E 6.30x30 Structure Structure
TM6 287 R 6.31x31 Structure Structure
TM6 288 K 6.32x32 Structure Structure
TM6 289 A 6.33x33 Structure Structure
TM6 290 A 6.34x34 Structure Structure
TM6 291 R 6.35x35 Structure Structure
TM6 292 I 6.36x36 Structure Structure
TM6 293 L 6.37x37 Structure Structure
TM6 294 G 6.38x38 Structure Structure
TM6 295 L 6.39x39 Structure Structure
TM6 296 I 6.40x40 Structure Structure
TM6 297 L 6.41x41 Structure Structure
TM6 298 G 6.42x42 Structure Structure
TM6 299 A 6.43x43 Structure Structure
TM6 300 F 6.44x44 Structure Structure
TM6 301 I 6.45x45 Structure Structure
TM6 302 L 6.46x46 Structure Structure
TM6 303 S 6.47x47 Structure Structure
TM6 304 W 6.48x48 Structure Structure
TM6 305 L 6.49x49 Structure Structure
TM6 306 P 6.50x50 Structure Structure
TM6 307 F 6.51x51 Structure Structure
TM6 308 F 6.52x52 Structure Structure
TM6 309 I 6.53x53 Structure Structure
TM6 310 K 6.54x54 Structure Structure
TM6 311 E 6.55x55 Structure Structure
TM6 312 L 6.56x56 Structure Structure
TM6 313 I 6.57x57 Structure Structure
TM6 314 V 6.58x58 Structure Structure
TM6 315 G 6.59x59 Structure Structure
TM6 316 L 6.60x60 Structure Structure
TM6 317 S 6.61x61 Structure Structure
ECL3 318 I - Structure Structure
ECL3 319 Y - Structure Structure
ECL3 320 T - Structure Structure
ECL3 321 V - Structure Structure
TM7 322 S 7.31x30 Structure Structure
TM7 323 S 7.32x31 Structure Structure
TM7 324 E 7.33x32 Structure Structure
TM7 325 V 7.34x33 Structure Structure
TM7 326 A 7.35x34 Structure Structure
TM7 327 D 7.36x35 Structure Structure
TM7 328 F 7.37x36 Structure Structure
TM7 329 L 7.38x37 Structure Structure
TM7 330 T 7.39x38 Structure Structure
TM7 331 W 7.40x39 Structure Structure
TM7 332 L 7.41x40 Structure Structure
TM7 333 G 7.42x41 Structure Structure
TM7 334 Y 7.43x42 Structure Structure
TM7 335 V 7.44x43 Structure Structure
TM7 336 N 7.45x45 Structure Structure
TM7 337 S 7.46x46 Structure Structure
TM7 338 L 7.47x47 Structure Structure
TM7 339 I 7.48x48 Structure Structure
TM7 340 N 7.49x49 Structure Structure
TM7 341 P 7.50x50 Structure Structure
TM7 342 L 7.51x51 Structure Structure
TM7 343 L 7.52x52 Structure Structure
TM7 344 Y 7.53x53 Structure Structure
TM7 345 T 7.54x54 Structure Structure
TM7 346 S 7.55x55 Structure Structure
TM7 347 F 7.56x56 Structure Structure
H8 348 N 8.47x47 Structure Structure
H8 349 E 8.48x48 Structure Structure
H8 350 D 8.49x49 Structure Structure
H8 351 F 8.50x50 Structure Structure
H8 352 K 8.51x51 Structure Structure
H8 353 L 8.52x52 Structure Structure
H8 354 A 8.53x53 Structure Structure
H8 355 F 8.54x54 Structure Structure
H8 356 K 8.55x55 Structure Structure
H8 357 K 8.56x56 Structure Structure
H8 358 L 8.57x57 Structure Structure
C-term 359 I - AF2 AF2
C-term 360 R - AF2 AF2
C-term 361 C - AF2 AF2
C-term 362 R - AF2 AF2
C-term 363 E - AF2 AF2
C-term 364 H - AF2 AF2
C-term 365 T - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 281 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 I 281 6x25 G.h4s6 D 315 G.h4s6.09
Polar TM7 F 347 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 F 347 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 F 347 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL3 L 222 - G.H4 E 297 G.H4.04
Van-der-waals ICL3 L 222 - G.H4 E 297 G.H4.04
Hydrophobic ICL2 A 127 34x50 G.H5 I 343 G.H5.15
Ionic ICL3 R 278 - G.H4 E 308 G.H4.16
Polar ICL3 R 278 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 R 278 - G.H4 E 308 G.H4.16
Hydrophobic TM6 L 293 6x37 G.H5 L 353 G.H5.25
Polar H8 N 348 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 N 348 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 N 348 8x47 G.H5 D 350 G.H5.22
Hydrophobic ICL3 H 274 - G.H4 E 308 G.H4.16
Hydrophobic TM6 I 292 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 I 292 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 212 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 212 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 I 128 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 I 128 34x51 G.S3 L 194 G.S3.01
Van-der-waals H8 E 349 8x48 G.H5 K 349 G.H5.21
Hydrophobic ICL2 I 128 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 I 128 34x51 G.H5 T 340 G.H5.12
Polar TM5 R 220 5x76 G.H4 Q 304 G.H4.12
Hydrophobic TM5 R 220 5x76 G.H4 Q 304 G.H4.12
Van-der-waals TM5 R 220 5x76 G.H4 Q 304 G.H4.12
Polar TM5 Y 213 5x69 G.H5 L 353 G.H5.25
Van-der-waals TM5 Y 213 5x69 G.H5 L 353 G.H5.25
Polar TM5 R 216 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 R 216 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 R 216 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 I 205 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 205 5x61 G.H5 L 353 G.H5.25
Ionic ICL3 H 274 - G.H4 D 309 G.H4.17
Polar ICL3 H 274 - G.H4 D 309 G.H4.17
Hydrophobic ICL3 H 274 - G.H4 D 309 G.H4.17
Van-der-waals ICL3 H 274 - G.H4 D 309 G.H4.17
Hydrophobic TM6 A 289 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 289 6x33 G.H5 L 353 G.H5.25
Polar ICL3 H 274 - G.H4 C 305 G.H4.13
Hydrophobic ICL3 H 274 - G.H4 C 305 G.H4.13
Van-der-waals ICL3 H 274 - G.H4 C 305 G.H4.13
Hydrophobic TM3 I 124 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 124 3x54 G.H5 I 344 G.H5.16
Aromatic TM5 Y 213 5x69 G.H5 F 354 G.H5.26
Hydrophobic TM5 Y 213 5x69 G.H5 F 354 G.H5.26
Van-der-waals TM5 Y 213 5x69 G.H5 F 354 G.H5.26
Polar TM3 A 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 I 128 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 A 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 127 34x50 G.H5 I 344 G.H5.16
Polar TM5 R 220 5x76 G.H4 C 305 G.H4.13
Hydrophobic TM5 R 220 5x76 G.H4 C 305 G.H4.13
Van-der-waals TM5 R 220 5x76 G.H4 C 305 G.H4.13
Polar ICL3 S 226 - G.H4 C 305 G.H4.13
Hydrophobic ICL3 S 226 - G.H4 C 305 G.H4.13
Van-der-waals ICL3 S 226 - G.H4 C 305 G.H4.13
Hydrophobic ICL3 S 223 - G.H4 A 301 G.H4.08
Hydrophobic TM5 R 216 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 216 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 I 124 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 R 216 5x72 G.H5 K 345 G.H5.17
Van-der-waals TM5 R 216 5x72 G.H5 K 345 G.H5.17
Ionic ICL3 E 277 - G.h4s6 K 314 G.h4s6.08
Polar ICL3 E 277 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 E 277 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 E 277 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 R 132 34x55 G.S3 L 194 G.S3.01
Van-der-waals ICL2 R 132 34x55 G.S3 L 194 G.S3.01
Hydrophobic TM6 I 281 6x25 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 I 281 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM5 L 212 5x68 G.H5 F 354 G.H5.26
Van-der-waals TM5 L 212 5x68 G.H5 F 354 G.H5.26
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 C 351 G.H5.23
Polar ICL2 R 132 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 132 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 132 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 I 292 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 285 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 285 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 124 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 212 5x68 G.H5 K 345 G.H5.17
Hydrophobic ICL2 R 132 34x55 G.hns1 R 32 G.hns1.03
Ionic TM5 R 220 5x76 G.H4 E 308 G.H4.16
Polar TM5 R 220 5x76 G.H4 E 308 G.H4.16
Van-der-waals TM5 R 220 5x76 G.H4 E 308 G.H4.16
Ionic TM5 R 216 5x72 G.H5 D 341 G.H5.13
Polar TM5 R 216 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 216 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 216 5x72 G.H5 D 341 G.H5.13