Refined structure (7F4I) of Gs - MC1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 234 from structure (59.4%), 160 from model (40.6%)
Residue sidechains - 214 from structure (54.3%), 180 from model (45.7%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 AF2 AF2
G.HN 12 Q G.HN.29 Structure AF2
G.HN 13 R G.HN.30 Structure AF2
G.HN 14 N G.HN.31 Structure AF2
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure AF2
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure AF2
G.HN 20 R G.HN.37 Structure AF2
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure AF2
G.HN 23 N G.HN.40 Structure AF2
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure AF2
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure AF2
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure Structure
G.H1 62 I G.H1.10 Structure Structure
G.H1 63 L G.H1.11 Structure AF2
G.H1 64 H G.H1.12 Structure Structure
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 Structure Structure
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure AF2
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure AF2
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure AF2
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure AF2
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure AF2
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure AF2
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure AF2
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 266 from structure (83.9%), 51 from model (16.1%)
Residue sidechains - 265 from structure (83.6%), 52 from model (16.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 V - AF2 AF2
N-term 4 Q - AF2 AF2
N-term 5 G - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 Q - AF2 AF2
N-term 8 R - AF2 AF2
N-term 9 R - AF2 AF2
N-term 10 L - AF2 AF2
N-term 11 L - AF2 AF2
N-term 12 G - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 N - AF2 AF2
N-term 16 S - AF2 AF2
N-term 17 T - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 T - AF2 AF2
N-term 20 A - AF2 AF2
N-term 21 I - AF2 AF2
N-term 22 P - AF2 AF2
N-term 23 Q - AF2 AF2
N-term 24 L - AF2 AF2
N-term 25 G - AF2 AF2
N-term 26 L - AF2 AF2
N-term 27 A - AF2 AF2
N-term 28 A - AF2 AF2
N-term 29 N - AF2 AF2
N-term 30 Q - AF2 AF2
N-term 31 T - AF2 AF2
N-term 32 G - AF2 AF2
N-term 33 A - AF2 AF2
N-term 34 R - AF2 AF2
N-term 35 C - AF2 AF2
N-term 36 L - Structure Structure
N-term 37 E - Structure Structure
N-term 38 V - Structure Structure
N-term 39 S - Structure Structure
N-term 40 I - Structure Structure
TM1 41 S 1.35x35 Structure Structure
TM1 42 D 1.36x36 Structure Structure
TM1 43 G 1.37x37 Structure Structure
TM1 44 L 1.38x38 Structure Structure
TM1 45 F 1.39x39 Structure Structure
TM1 46 L 1.40x40 Structure Structure
TM1 47 S 1.41x41 Structure Structure
TM1 48 L 1.42x42 Structure Structure
TM1 49 G 1.43x43 Structure Structure
TM1 50 L 1.44x44 Structure Structure
TM1 51 V 1.45x45 Structure Structure
TM1 52 S 1.46x46 Structure Structure
TM1 53 L 1.47x47 Structure Structure
TM1 54 V 1.48x48 Structure Structure
TM1 55 E 1.49x49 Structure Structure
TM1 56 N 1.50x50 Structure Structure
TM1 57 A 1.51x51 Structure Structure
TM1 58 L 1.52x52 Structure Structure
TM1 59 V 1.53x53 Structure Structure
TM1 60 V 1.54x54 Structure Structure
TM1 61 A 1.55x55 Structure Structure
TM1 62 T 1.56x56 Structure Structure
TM1 63 I 1.57x57 Structure Structure
TM1 64 A 1.58x58 Structure Structure
TM1 65 K 1.59x59 Structure Structure
TM1 66 N 1.60x60 Structure Structure
ICL1 67 R 12.48x48 Structure Structure
ICL1 68 N 12.49x49 Structure Structure
ICL1 69 L 12.50x50 Structure Structure
ICL1 70 H 12.51x51 Structure Structure
TM2 71 S 2.37x37 Structure Structure
TM2 72 P 2.38x38 Structure Structure
TM2 73 M 2.39x39 Structure Structure
TM2 74 Y 2.40x40 Structure Structure
TM2 75 C 2.41x41 Structure Structure
TM2 76 F 2.42x42 Structure Structure
TM2 77 I 2.43x43 Structure Structure
TM2 78 C 2.44x44 Structure Structure
TM2 79 C 2.45x45 Structure Structure
TM2 80 L 2.46x46 Structure Structure
TM2 81 A 2.47x47 Structure Structure
TM2 82 L 2.48x48 Structure Structure
TM2 83 S 2.49x49 Structure Structure
TM2 84 D 2.50x50 Structure Structure
TM2 85 L 2.51x51 Structure Structure
TM2 86 L 2.52x52 Structure Structure
TM2 87 V 2.53x53 Structure Structure
TM2 88 S 2.54x54 Structure Structure
TM2 89 G 2.55x55 Structure Structure
TM2 90 S 2.56x56 Structure Structure
TM2 91 N 2.57x57 Structure Structure
TM2 92 V 2.58x58 Structure Structure
TM2 93 L 2.59x59 Structure Structure
TM2 94 E 2.60x60 Structure Structure
TM2 95 T 2.61x61 Structure Structure
TM2 96 A 2.62x62 Structure Structure
TM2 97 V 2.63x63 Structure Structure
TM2 98 I 2.64x64 Structure Structure
TM2 99 L 2.65x65 Structure Structure
TM2 100 L 2.66x66 Structure Structure
TM2 101 L 2.67x67 Structure Structure
TM2 102 E 2.68x68 Structure AF2
TM2 103 A 2.69x69 Structure Structure
TM2 104 G 2.70x70 Structure Structure
ECL1 105 A - Structure Structure
ECL1 106 L - Structure Structure
ECL1 107 V - Structure Structure
ECL1 108 A - Structure Structure
TM3 109 R 3.17x17 Structure Structure
TM3 110 A 3.18x18 Structure Structure
TM3 111 A 3.19x19 Structure Structure
TM3 112 V 3.20x20 Structure Structure
TM3 113 L 3.21x21 Structure Structure
TM3 114 Q 3.22x22 Structure Structure
TM3 115 Q 3.23x23 Structure Structure
TM3 116 L 3.24x24 Structure Structure
TM3 117 D 3.25x25 Structure Structure
TM3 118 N 3.26x26 Structure Structure
TM3 119 V 3.27x27 Structure Structure
TM3 120 I 3.28x28 Structure Structure
TM3 121 D 3.29x29 Structure Structure
TM3 122 V 3.30x30 Structure Structure
TM3 123 I 3.31x31 Structure Structure
TM3 124 T 3.32x32 Structure Structure
TM3 125 C 3.33x33 Structure Structure
TM3 126 S 3.34x34 Structure Structure
TM3 127 S 3.35x35 Structure Structure
TM3 128 M 3.36x36 Structure Structure
TM3 129 L 3.37x37 Structure Structure
TM3 130 S 3.38x38 Structure Structure
TM3 131 S 3.39x39 Structure Structure
TM3 132 L 3.40x40 Structure Structure
TM3 133 C 3.41x41 Structure Structure
TM3 134 F 3.42x42 Structure Structure
TM3 135 L 3.43x43 Structure Structure
TM3 136 G 3.44x44 Structure Structure
TM3 137 A 3.45x45 Structure Structure
TM3 138 I 3.46x46 Structure Structure
TM3 139 A 3.47x47 Structure Structure
TM3 140 V 3.48x48 Structure Structure
TM3 141 D 3.49x49 Structure Structure
TM3 142 R 3.50x50 Structure Structure
TM3 143 Y 3.51x51 Structure Structure
TM3 144 I 3.52x52 Structure Structure
TM3 145 S 3.53x53 Structure Structure
TM3 146 I 3.54x54 Structure Structure
TM3 147 F 3.55x55 Structure Structure
TM3 148 Y 3.56x56 Structure Structure
ICL2 149 A 34.50x50 Structure Structure
ICL2 150 L 34.51x51 Structure Structure
ICL2 151 R 34.52x52 Structure Structure
ICL2 152 Y 34.53x53 Structure Structure
ICL2 153 H 34.54x54 Structure Structure
ICL2 154 S 34.55x55 Structure Structure
ICL2 155 I 34.56x56 Structure Structure
ICL2 156 V 34.57x57 Structure Structure
TM4 157 T 4.38x38 Structure Structure
TM4 158 L 4.39x39 Structure Structure
TM4 159 P 4.40x40 Structure Structure
TM4 160 R 4.41x41 Structure Structure
TM4 161 A 4.42x42 Structure Structure
TM4 162 R 4.43x43 Structure Structure
TM4 163 R 4.44x44 Structure Structure
TM4 164 A 4.45x45 Structure Structure
TM4 165 V 4.46x46 Structure Structure
TM4 166 A 4.47x47 Structure Structure
TM4 167 A 4.48x48 Structure Structure
TM4 168 I 4.49x49 Structure Structure
TM4 169 W 4.50x50 Structure Structure
TM4 170 V 4.51x51 Structure Structure
TM4 171 A 4.52x52 Structure Structure
TM4 172 S 4.53x53 Structure Structure
TM4 173 V 4.54x54 Structure Structure
TM4 174 V 4.55x55 Structure Structure
TM4 175 F 4.56x56 Structure Structure
TM4 176 S 4.57x57 Structure Structure
TM4 177 T 4.58x58 Structure Structure
TM4 178 L 4.59x59 Structure Structure
TM4 179 F 4.60x60 Structure Structure
TM4 180 I 4.61x61 Structure Structure
TM4 181 A 4.62x62 Structure Structure
TM4 182 Y 4.63x63 Structure Structure
ECL2 183 Y - Structure Structure
ECL2 184 D - Structure Structure
TM5 185 H 5.36x36 Structure Structure
TM5 186 V 5.37x37 Structure Structure
TM5 187 A 5.38x38 Structure Structure
TM5 188 V 5.39x39 Structure Structure
TM5 189 L 5.40x40 Structure Structure
TM5 190 L 5.41x41 Structure Structure
TM5 191 C 5.42x42 Structure Structure
TM5 192 L 5.43x43 Structure Structure
TM5 193 V 5.44x44 Structure Structure
TM5 194 V 5.45x45 Structure Structure
TM5 195 F 5.46x46 Structure Structure
TM5 196 F 5.47x47 Structure Structure
TM5 197 L 5.48x48 Structure Structure
TM5 198 A 5.49x49 Structure Structure
TM5 199 M 5.50x50 Structure Structure
TM5 200 L 5.51x51 Structure Structure
TM5 201 V 5.52x52 Structure Structure
TM5 202 L 5.53x53 Structure Structure
TM5 203 M 5.54x54 Structure Structure
TM5 204 A 5.55x55 Structure Structure
TM5 205 V 5.56x56 Structure Structure
TM5 206 L 5.57x57 Structure Structure
TM5 207 Y 5.58x58 Structure Structure
TM5 208 V 5.59x59 Structure Structure
TM5 209 H 5.60x60 Structure Structure
TM5 210 M 5.61x61 Structure Structure
TM5 211 L 5.62x62 Structure Structure
TM5 212 A 5.63x63 Structure Structure
TM5 213 R 5.64x64 Structure Structure
TM5 214 A 5.65x65 Structure Structure
TM5 215 C 5.66x66 Structure Structure
TM5 216 Q 5.67x67 Structure Structure
TM5 217 H 5.68x68 Structure Structure
TM5 218 A 5.69x69 Structure Structure
TM5 219 Q 5.70x70 Structure Structure
TM5 220 G 5.71x71 Structure Structure
TM5 221 I 5.72x72 Structure Structure
TM5 222 A 5.73x73 Structure Structure
TM5 223 R 5.74x74 Structure Structure
TM5 224 L 5.75x75 Structure Structure
TM5 225 H 5.76x76 Structure Structure
TM5 226 K 5.77x77 Structure Structure
ICL3 227 R - AF2 AF2
ICL3 228 Q - AF2 AF2
ICL3 229 R - AF2 AF2
ICL3 230 P - AF2 AF2
ICL3 231 V - AF2 AF2
ICL3 232 H - AF2 AF2
TM6 233 Q 6.27x27 AF2 AF2
TM6 234 G 6.28x28 AF2 AF2
TM6 235 F 6.29x29 AF2 AF2
TM6 236 G 6.30x30 AF2 AF2
TM6 237 L 6.31x31 Structure Structure
TM6 238 K 6.32x32 Structure Structure
TM6 239 G 6.33x33 Structure Structure
TM6 240 A 6.34x34 Structure Structure
TM6 241 V 6.35x35 Structure Structure
TM6 242 T 6.36x36 Structure Structure
TM6 243 L 6.37x37 Structure Structure
TM6 244 T 6.38x38 Structure Structure
TM6 245 I 6.39x39 Structure Structure
TM6 246 L 6.40x40 Structure Structure
TM6 247 L 6.41x41 Structure Structure
TM6 248 G 6.42x42 Structure Structure
TM6 249 I 6.43x43 Structure Structure
TM6 250 F 6.44x44 Structure Structure
TM6 251 F 6.45x45 Structure Structure
TM6 252 L 6.46x46 Structure Structure
TM6 253 C 6.47x47 Structure Structure
TM6 254 W 6.48x48 Structure Structure
TM6 255 G 6.49x49 Structure Structure
TM6 256 P 6.50x50 Structure Structure
TM6 257 F 6.51x51 Structure Structure
TM6 258 F 6.52x52 Structure Structure
TM6 259 L 6.53x53 Structure Structure
TM6 260 H 6.54x54 Structure Structure
TM6 261 L 6.55x55 Structure Structure
TM6 262 T 6.56x56 Structure Structure
TM6 263 L 6.57x57 Structure Structure
TM6 264 I 6.58x58 Structure Structure
TM6 265 V 6.59x59 Structure Structure
TM6 266 L 6.60x60 Structure Structure
TM6 267 C 6.61x61 Structure Structure
ECL3 268 P - Structure Structure
ECL3 269 E - Structure Structure
ECL3 270 H - Structure Structure
ECL3 271 P - Structure Structure
ECL3 272 T - Structure Structure
ECL3 273 C - Structure Structure
ECL3 274 G - Structure Structure
ECL3 275 C - Structure Structure
ECL3 276 I - Structure Structure
ECL3 277 F - Structure Structure
ECL3 278 K - Structure Structure
TM7 279 N 7.34x33 Structure Structure
TM7 280 F 7.35x34 Structure Structure
TM7 281 N 7.36x35 Structure Structure
TM7 282 L 7.37x36 Structure Structure
TM7 283 F 7.38x37 Structure Structure
TM7 284 L 7.39x38 Structure Structure
TM7 285 A 7.40x39 Structure Structure
TM7 286 L 7.41x40 Structure Structure
TM7 287 I 7.42x41 Structure Structure
TM7 288 I 7.43x42 Structure Structure
TM7 289 C 7.44x43 Structure Structure
TM7 290 N 7.45x45 Structure Structure
TM7 291 A 7.46x46 Structure Structure
TM7 292 I 7.47x47 Structure Structure
TM7 293 I 7.48x48 Structure Structure
TM7 294 D 7.49x49 Structure Structure
TM7 295 P 7.50x50 Structure Structure
TM7 296 L 7.51x51 Structure Structure
TM7 297 I 7.52x52 Structure Structure
TM7 298 Y 7.53x53 Structure Structure
TM7 299 A 7.54x54 Structure Structure
TM7 300 F 7.55x55 Structure Structure
TM7 301 H 7.56x56 Structure Structure
H8 302 S 8.47x47 Structure Structure
H8 303 Q 8.48x48 Structure Structure
H8 304 E 8.49x49 Structure Structure
H8 305 L 8.50x50 Structure Structure
H8 306 R 8.51x51 Structure Structure
H8 307 R 8.52x52 Structure Structure
H8 308 T 8.53x53 Structure Structure
C-term 309 L - Structure Structure
C-term 310 K - Structure Structure
C-term 311 E - Structure Structure
C-term 312 V - AF2 AF2
C-term 313 L - AF2 AF2
C-term 314 T - AF2 AF2
C-term 315 C - AF2 AF2
C-term 316 S - AF2 AF2
C-term 317 W - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 211 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 214 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 H 217 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 217 5x68 G.H5 L 388 G.H5.20
Ionic TM6 K 238 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 238 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 238 6x32 G.H5 E 392 G.H5.24
Polar TM5 R 213 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 213 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 R 227 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 R 227 - G.H4 R 342 G.H4.12
Hydrophobic TM5 L 224 5x75 G.H4 L 346 G.H4.16
Polar TM3 S 145 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 145 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 145 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 M 210 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 210 5x61 G.H5 L 393 G.H5.25
Aromatic TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Aromatic ICL2 H 153 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 153 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 146 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 146 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 R 213 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL3 R 227 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 R 227 - G.H4 L 346 G.H4.16
Hydrophobic TM5 A 214 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 150 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 150 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL3 Q 228 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 Q 228 - G.H4 L 346 G.H4.16
Polar ICL2 H 153 34x54 G.HN Q 35 G.HN.52
Van-der-waals ICL2 H 153 34x54 G.HN Q 35 G.HN.52
Hydrophobic TM5 H 217 5x68 G.H5 D 381 G.H5.13
Hydrophobic ICL2 R 151 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 150 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 150 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 150 34x51 G.H5 F 376 G.H5.08
Polar TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 150 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM7 H 301 7x56 G.H5 Y 391 G.H5.23
Polar ICL2 R 151 34x52 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 151 34x52 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 Y 152 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 146 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 146 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 150 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 H 217 5x68 G.H5 L 394 G.H5.26
Hydrophobic ICL2 A 149 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 Q 228 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 Q 228 - G.h4s6 T 350 G.h4s6.03
Polar TM5 H 217 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 217 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 217 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 224 5x75 G.S6 P 361 G.S6.03
Hydrophobic ICL2 A 149 34x50 G.H5 I 383 G.H5.15
Polar ICL3 Q 228 - G.H4 R 347 G.H4.17
Hydrophobic ICL3 Q 228 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 Q 228 - G.H4 R 347 G.H4.17
Polar TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Ionic TM5 R 213 5x64 G.H5 D 381 G.H5.13
Polar TM5 R 213 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 I 221 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 221 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 A 214 5x65 G.H5 L 393 G.H5.25
Polar TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM7 H 301 7x56 G.H5 Q 390 G.H5.22
Ionic ICL3 R 227 - G.H4 D 343 G.H4.13
Polar ICL3 R 227 - G.H4 D 343 G.H4.13
Hydrophobic ICL3 R 227 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 R 227 - G.H4 D 343 G.H4.13
Polar TM5 H 225 5x76 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 H 225 5x76 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 H 225 5x76 G.h4s6 T 350 G.h4s6.03
Polar TM6 T 242 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 242 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 242 6x36 G.H5 E 392 G.H5.24
Ionic ICL3 R 227 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 R 227 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 R 227 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 R 227 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 I 221 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 T 242 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 146 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 146 3x54 G.H5 H 387 G.H5.19
Ionic TM5 K 226 5x77 G.hgh4 E 322 G.hgh4.12
Polar TM5 K 226 5x77 G.hgh4 E 322 G.hgh4.12
Van-der-waals TM5 K 226 5x77 G.hgh4 E 322 G.hgh4.12
Hydrophobic TM6 F 235 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 F 235 6x29 G.H5 L 394 G.H5.26
Polar TM6 G 239 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 239 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 239 6x33 G.H5 L 393 G.H5.25
Polar TM6 K 238 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 238 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM7 H 301 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 H 301 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM2 M 73 2x39 G.H5 Y 391 G.H5.23
Polar ICL2 L 150 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 150 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 150 34x51 G.S1 H 41 G.S1.02