Refined structure (7F6G) of Gq - AT1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 349 from structure (97.2%), 10 from model (2.8%)
Residue sidechains - 347 from structure (96.7%), 12 from model (3.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 Structure Structure
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure Structure
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure Structure
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure Structure
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure Structure
G.HN 20 R G.HN.38 Structure Structure
G.HN 21 I G.HN.39 Structure Structure
G.HN 22 N G.HN.40 Structure Structure
G.HN 23 D G.HN.41 Structure Structure
G.HN 24 E G.HN.42 Structure Structure
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure Structure
G.HN 27 R G.HN.45 Structure Structure
G.HN 28 Q G.HN.46 Structure Structure
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure Structure
G.HN 31 R G.HN.49 Structure Structure
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure Structure
G.HN 34 R G.HN.52 Structure Structure
G.HN 35 D G.HN.53 Structure Structure
G.hns1 36 A G.hns1.01 Structure Structure
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure Structure
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure Structure
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure Structure
G.s1h1 48 G G.s1h1.03 Structure Structure
G.s1h1 49 E G.s1h1.04 Structure Structure
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure Structure
G.H1 56 I G.H1.05 Structure Structure
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure Structure
G.H1 61 I G.H1.10 Structure Structure
G.H1 62 I G.H1.11 Structure Structure
G.H1 63 H G.H1.12 Structure Structure
G.h1ha 64 G G.h1ha.01 Structure Structure
G.h1ha 65 S G.h1ha.02 Structure Structure
G.h1ha 66 G G.h1ha.03 Structure Structure
G.h1ha 67 Y G.h1ha.04 Structure Structure
G.h1ha 68 S G.h1ha.05 Structure Structure
H.HA 69 D H.HA.01 Structure Structure
H.HA 70 E H.HA.02 Structure Structure
H.HA 71 D H.HA.03 Structure Structure
H.HA 72 K H.HA.04 Structure Structure
H.HA 73 R H.HA.05 Structure Structure
H.HA 74 G H.HA.06 Structure Structure
H.HA 75 F H.HA.07 Structure Structure
H.HA 76 T H.HA.08 Structure Structure
H.HA 77 K H.HA.09 Structure Structure
H.HA 78 L H.HA.10 Structure Structure
H.HA 79 V H.HA.11 Structure Structure
H.HA 80 Y H.HA.12 Structure Structure
H.HA 81 Q H.HA.13 Structure Structure
H.HA 82 N H.HA.14 Structure Structure
H.HA 83 I H.HA.15 Structure Structure
H.HA 84 F H.HA.16 Structure Structure
H.HA 85 T H.HA.17 Structure Structure
H.HA 86 A H.HA.18 Structure Structure
H.HA 87 M H.HA.19 Structure Structure
H.HA 88 Q H.HA.20 Structure Structure
H.HA 89 A H.HA.21 Structure Structure
H.HA 90 M H.HA.22 Structure Structure
H.HA 91 I H.HA.23 Structure Structure
H.HA 92 R H.HA.24 Structure Structure
H.HA 93 A H.HA.25 Structure Structure
H.HA 94 M H.HA.26 Structure Structure
H.HA 95 D H.HA.27 Structure Structure
H.HA 96 T H.HA.28 Structure Structure
H.HA 97 L H.HA.29 Structure Structure
H.hahb 98 K H.hahb.01 Structure Structure
H.hahb 99 I H.hahb.04 Structure Structure
H.hahb 100 P H.hahb.05 Structure Structure
H.hahb 101 Y H.hahb.06 Structure Structure
H.hahb 102 K H.hahb.07 Structure Structure
H.hahb 103 Y H.hahb.08 Structure Structure
H.hahb 104 E H.hahb.09 Structure Structure
H.HB 105 H H.HB.01 Structure Structure
H.HB 106 N H.HB.02 Structure Structure
H.HB 107 K H.HB.03 Structure Structure
H.HB 108 A H.HB.04 Structure Structure
H.HB 109 H H.HB.05 Structure Structure
H.HB 110 A H.HB.06 Structure Structure
H.HB 111 Q H.HB.07 Structure Structure
H.HB 112 L H.HB.08 Structure Structure
H.HB 113 V H.HB.09 Structure Structure
H.HB 114 R H.HB.10 Structure Structure
H.HB 115 E H.HB.11 Structure Structure
H.HB 116 V H.HB.12 Structure Structure
H.HB 117 D H.HB.13 Structure Structure
H.HB 118 V H.HB.14 Structure Structure
H.hbhc 119 E H.hbhc.01 Structure Structure
H.hbhc 120 K H.hbhc.02 Structure Structure
H.hbhc 121 V H.hbhc.03 Structure Structure
H.hbhc 122 S H.hbhc.04 Structure Structure
H.hbhc 123 A H.hbhc.05 Structure Structure
H.hbhc 124 F H.hbhc.14 Structure Structure
H.hbhc 125 E H.hbhc.15 Structure Structure
H.HC 126 N H.HC.01 Structure Structure
H.HC 127 P H.HC.02 Structure Structure
H.HC 128 Y H.HC.03 Structure Structure
H.HC 129 V H.HC.04 Structure Structure
H.HC 130 D H.HC.05 Structure Structure
H.HC 131 A H.HC.06 Structure Structure
H.HC 132 I H.HC.07 Structure Structure
H.HC 133 K H.HC.08 Structure Structure
H.HC 134 S H.HC.09 Structure Structure
H.HC 135 L H.HC.10 Structure Structure
H.HC 136 W H.HC.11 Structure Structure
H.HC 137 N H.HC.12 Structure Structure
H.hchd 138 D H.hchd.01 Structure Structure
H.HD 139 P H.HD.01 Structure Structure
H.HD 140 G H.HD.02 Structure Structure
H.HD 141 I H.HD.03 Structure Structure
H.HD 142 Q H.HD.04 Structure Structure
H.HD 143 E H.HD.05 Structure Structure
H.HD 144 C H.HD.06 Structure Structure
H.HD 145 Y H.HD.07 Structure Structure
H.HD 146 D H.HD.08 Structure Structure
H.HD 147 R H.HD.09 Structure Structure
H.HD 148 R H.HD.10 Structure Structure
H.HD 149 R H.HD.11 Structure Structure
H.HD 150 E H.HD.12 Structure Structure
H.hdhe 151 Y H.hdhe.01 Structure Structure
H.hdhe 152 Q H.hdhe.02 Structure Structure
H.hdhe 153 L H.hdhe.03 Structure Structure
H.hdhe 154 S H.hdhe.04 Structure Structure
H.hdhe 155 D H.hdhe.05 Structure Structure
H.HE 156 S H.HE.01 Structure Structure
H.HE 157 T H.HE.02 Structure Structure
H.HE 158 K H.HE.03 Structure Structure
H.HE 159 Y H.HE.04 Structure Structure
H.HE 160 Y H.HE.05 Structure Structure
H.HE 161 L H.HE.06 Structure Structure
H.HE 162 N H.HE.07 Structure Structure
H.HE 163 D H.HE.08 Structure Structure
H.HE 164 L H.HE.09 Structure Structure
H.HE 165 D H.HE.10 Structure Structure
H.HE 166 R H.HE.11 Structure Structure
H.HE 167 V H.HE.12 Structure Structure
H.HE 168 A H.HE.13 Structure Structure
H.hehf 169 D H.hehf.01 Structure Structure
H.hehf 170 P H.hehf.02 Structure Structure
H.hehf 171 A H.hehf.03 Structure Structure
H.hehf 172 Y H.hehf.04 Structure Structure
H.hehf 173 L H.hehf.05 Structure Structure
H.hehf 174 P H.hehf.06 Structure Structure
H.hehf 175 T H.hehf.07 Structure Structure
H.HF 176 Q H.HF.01 Structure Structure
H.HF 177 Q H.HF.02 Structure Structure
H.HF 178 D H.HF.03 Structure Structure
H.HF 179 V H.HF.04 Structure Structure
H.HF 180 L H.HF.05 Structure Structure
H.HF 181 R H.HF.06 Structure Structure
G.hfs2 182 V G.hfs2.01 Structure Structure
G.hfs2 183 R G.hfs2.02 Structure AF2
G.hfs2 184 V G.hfs2.03 Structure Structure
G.hfs2 185 P G.hfs2.04 Structure Structure
G.hfs2 186 T G.hfs2.05 Structure Structure
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure Structure
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure Structure
G.S2 193 P G.S2.05 Structure Structure
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure Structure
G.S2 196 L G.S2.08 Structure Structure
G.s2s3 197 Q G.s2s3.01 Structure Structure
G.s2s3 198 S G.s2s3.02 Structure Structure
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure Structure
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure Structure
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure Structure
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure Structure
G.s3h2 209 Q G.s3h2.03 Structure AF2
G.H2 210 R G.H2.01 Structure Structure
G.H2 211 S G.H2.02 Structure Structure
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure Structure
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure Structure
G.h2s4 222 N G.h2s4.03 Structure Structure
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure Structure
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure Structure
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure Structure
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure Structure
G.s4h3 232 L G.s4h3.01 Structure Structure
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure Structure
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure Structure
G.s4h3 237 Q G.s4h3.06 Structure Structure
G.s4h3 238 V G.s4h3.07 Structure Structure
G.s4h3 239 L G.s4h3.08 Structure Structure
G.s4h3 240 V G.s4h3.09 Structure Structure
G.s4h3 241 E G.s4h3.10 Structure Structure
G.s4h3 242 S G.s4h3.11 Structure Structure
G.s4h3 243 D G.s4h3.12 Structure Structure
G.s4h3 244 N G.s4h3.13 Structure Structure
G.s4h3 245 E G.s4h3.14 Structure Structure
G.s4h3 246 N G.s4h3.15 Structure Structure
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure Structure
G.H3 249 E G.H3.03 Structure Structure
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure Structure
G.H3 252 K G.H3.06 Structure Structure
G.H3 253 A G.H3.07 Structure Structure
G.H3 254 L G.H3.08 Structure Structure
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure Structure
G.H3 257 T G.H3.11 Structure Structure
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure Structure
G.H3 260 T G.H3.14 Structure Structure
G.H3 261 Y G.H3.15 Structure Structure
G.H3 262 P G.H3.16 Structure Structure
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure Structure
G.h3s5 265 Q G.h3s5.01 Structure Structure
G.h3s5 266 N G.h3s5.02 Structure Structure
G.h3s5 267 S G.h3s5.03 Structure Structure
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure Structure
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure Structure
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure Structure
G.HG 284 M G.HG.09 Structure Structure
G.HG 285 Y G.HG.12 Structure Structure
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure Structure
G.HG 288 L G.HG.15 Structure Structure
G.HG 289 V G.HG.16 Structure Structure
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 Structure Structure
G.hgh4 292 F G.hgh4.02 Structure Structure
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure Structure
G.hgh4 295 Y G.hgh4.05 Structure Structure
G.hgh4 296 D G.hgh4.06 Structure Structure
G.hgh4 297 G G.hgh4.07 Structure Structure
G.hgh4 298 P G.hgh4.08 Structure Structure
G.H4 299 Q G.H4.01 Structure Structure
G.H4 300 R G.H4.02 Structure Structure
G.H4 301 D G.H4.03 Structure Structure
G.H4 302 A G.H4.04 Structure Structure
G.H4 303 Q G.H4.05 Structure Structure
G.H4 304 A G.H4.06 Structure Structure
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure Structure
G.H4 307 E G.H4.09 Structure Structure
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure Structure
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure Structure
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure Structure
G.h4s6 317 N G.h4s6.08 Structure Structure
G.h4s6 318 P G.h4s6.09 Structure Structure
G.h4s6 319 D G.h4s6.10 Structure Structure
G.h4s6 320 S G.h4s6.11 Structure Structure
G.h4s6 321 D G.h4s6.12 Structure Structure
G.h4s6 322 K G.h4s6.13 Structure Structure
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure Structure
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure Structure
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure Structure
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure Structure
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure Structure
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure Structure
G.H5 340 V G.H5.07 Structure Structure
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure Structure
G.H5 343 A G.H5.10 Structure Structure
G.H5 344 V G.H5.11 Structure Structure
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure Structure
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure Structure
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure Structure
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 310 from structure (93.9%), 20 from model (6.1%)
Residue sidechains - 308 from structure (93.3%), 22 from model (6.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 I - AF2 AF2
N-term 3 L - AF2 AF2
N-term 4 N - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 T - AF2 AF2
N-term 8 E - AF2 AF2
N-term 9 D - AF2 AF2
N-term 10 G - AF2 AF2
N-term 11 I - Structure Structure
N-term 12 K - Structure Structure
N-term 13 R - Structure Structure
N-term 14 I - Structure Structure
N-term 15 Q - Structure Structure
N-term 16 D - Structure Structure
N-term 17 D - Structure Structure
N-term 18 C - Structure Structure
N-term 19 P - Structure Structure
N-term 20 K - Structure Structure
N-term 21 A - Structure Structure
N-term 22 G - Structure Structure
N-term 23 R - Structure Structure
TM1 24 H 1.28x28 Structure Structure
TM1 25 N 1.29x29 Structure Structure
TM1 26 Y 1.30x30 Structure Structure
TM1 27 I 1.31x31 Structure Structure
TM1 28 F 1.32x32 Structure Structure
TM1 29 V 1.33x33 Structure Structure
TM1 30 M 1.34x34 Structure Structure
TM1 31 I 1.35x35 Structure Structure
TM1 32 P 1.36x36 Structure Structure
TM1 33 T 1.37x37 Structure Structure
TM1 34 L 1.38x38 Structure Structure
TM1 35 Y 1.39x39 Structure Structure
TM1 36 S 1.40x40 Structure Structure
TM1 37 I 1.41x41 Structure Structure
TM1 38 I 1.42x42 Structure Structure
TM1 39 F 1.43x43 Structure Structure
TM1 40 V 1.44x44 Structure Structure
TM1 41 V 1.45x45 Structure Structure
TM1 42 G 1.46x46 Structure Structure
TM1 43 I 1.47x47 Structure Structure
TM1 44 F 1.48x48 Structure Structure
TM1 45 G 1.49x49 Structure Structure
TM1 46 N 1.50x50 Structure Structure
TM1 47 S 1.51x51 Structure Structure
TM1 48 L 1.52x52 Structure Structure
TM1 49 V 1.53x53 Structure Structure
TM1 50 V 1.54x54 Structure Structure
TM1 51 I 1.55x55 Structure Structure
TM1 52 V 1.56x56 Structure Structure
TM1 53 I 1.57x57 Structure Structure
TM1 54 Y 1.58x58 Structure Structure
TM1 55 F 1.59x59 Structure Structure
TM1 56 Y 1.60x60 Structure Structure
ICL1 57 M 12.48x48 Structure Structure
ICL1 58 K 12.49x49 Structure Structure
ICL1 59 L 12.50x50 Structure Structure
ICL1 60 K 12.51x51 Structure Structure
TM2 61 T 2.37x37 Structure Structure
TM2 62 V 2.38x38 Structure Structure
TM2 63 A 2.39x39 Structure Structure
TM2 64 S 2.40x40 Structure Structure
TM2 65 V 2.41x41 Structure Structure
TM2 66 F 2.42x42 Structure Structure
TM2 67 L 2.43x43 Structure Structure
TM2 68 L 2.44x44 Structure Structure
TM2 69 N 2.45x45 Structure Structure
TM2 70 L 2.46x46 Structure Structure
TM2 71 A 2.47x47 Structure Structure
TM2 72 L 2.48x48 Structure Structure
TM2 73 A 2.49x49 Structure Structure
TM2 74 D 2.50x50 Structure Structure
TM2 75 L 2.51x51 Structure Structure
TM2 76 C 2.52x52 Structure Structure
TM2 77 F 2.53x53 Structure AF2
TM2 78 L 2.54x54 Structure Structure
TM2 79 L 2.55x55 Structure Structure
TM2 80 T 2.56x56 Structure Structure
TM2 81 L 2.57x57 Structure Structure
TM2 82 P 2.58x58 Structure Structure
TM2 83 L 2.59x59 Structure Structure
TM2 84 W 2.60x60 Structure Structure
TM2 85 A 2.61x61 Structure Structure
TM2 86 V 2.62x62 Structure Structure
TM2 87 Y 2.63x63 Structure Structure
TM2 88 T 2.64x64 Structure Structure
TM2 89 A 2.65x65 Structure Structure
TM2 90 M 2.66x66 Structure Structure
TM2 91 E 2.67x67 Structure Structure
ECL1 92 Y - Structure Structure
ECL1 93 R 23.49x49 Structure Structure
ECL1 94 W 23.50x50 Structure Structure
ECL1 95 P 23.51x51 Structure Structure
ECL1 96 F 23.52x52 Structure Structure
TM3 97 G 3.21x21 Structure Structure
TM3 98 N 3.22x22 Structure Structure
TM3 99 Y 3.23x23 Structure Structure
TM3 100 L 3.24x24 Structure Structure
TM3 101 C 3.25x25 Structure Structure
TM3 102 K 3.26x26 Structure Structure
TM3 103 I 3.27x27 Structure Structure
TM3 104 A 3.28x28 Structure Structure
TM3 105 S 3.29x29 Structure Structure
TM3 106 A 3.30x30 Structure Structure
TM3 107 S 3.31x31 Structure Structure
TM3 108 V 3.32x32 Structure Structure
TM3 109 S 3.33x33 Structure Structure
TM3 110 F 3.34x34 Structure Structure
TM3 111 N 3.35x35 Structure Structure
TM3 112 L 3.36x36 Structure Structure
TM3 113 Y 3.37x37 Structure Structure
TM3 114 A 3.38x38 Structure Structure
TM3 115 S 3.39x39 Structure Structure
TM3 116 V 3.40x40 Structure Structure
TM3 117 F 3.41x41 Structure Structure
TM3 118 L 3.42x42 Structure Structure
TM3 119 L 3.43x43 Structure Structure
TM3 120 T 3.44x44 Structure Structure
TM3 121 C 3.45x45 Structure Structure
TM3 122 L 3.46x46 Structure Structure
TM3 123 S 3.47x47 Structure Structure
TM3 124 I 3.48x48 Structure Structure
TM3 125 D 3.49x49 Structure Structure
TM3 126 R 3.50x50 Structure Structure
TM3 127 Y 3.51x51 Structure Structure
TM3 128 L 3.52x52 Structure Structure
TM3 129 A 3.53x53 Structure Structure
TM3 130 I 3.54x54 Structure Structure
TM3 131 V 3.55x55 Structure Structure
TM3 132 H 3.56x56 Structure Structure
ICL2 133 P 34.50x50 Structure Structure
ICL2 134 M 34.51x51 Structure Structure
ICL2 135 K 34.52x52 Structure Structure
ICL2 136 S 34.53x53 Structure Structure
ICL2 137 R 34.54x54 Structure Structure
ICL2 138 L 34.55x55 Structure Structure
ICL2 139 R 34.56x56 Structure Structure
ICL2 140 R 34.57x57 Structure Structure
TM4 141 T 4.38x38 Structure Structure
TM4 142 M 4.39x39 Structure Structure
TM4 143 L 4.40x40 Structure Structure
TM4 144 V 4.41x41 Structure Structure
TM4 145 A 4.42x42 Structure Structure
TM4 146 K 4.43x43 Structure Structure
TM4 147 V 4.44x44 Structure Structure
TM4 148 T 4.45x45 Structure Structure
TM4 149 C 4.46x46 Structure Structure
TM4 150 I 4.47x47 Structure Structure
TM4 151 I 4.48x48 Structure Structure
TM4 152 I 4.49x49 Structure Structure
TM4 153 W 4.50x50 Structure Structure
TM4 154 L 4.51x51 Structure Structure
TM4 155 L 4.52x52 Structure Structure
TM4 156 A 4.53x53 Structure Structure
TM4 157 G 4.54x54 Structure Structure
TM4 158 L 4.55x55 Structure Structure
TM4 159 A 4.56x56 Structure Structure
TM4 160 S 4.57x57 Structure Structure
TM4 161 L 4.58x59 Structure Structure
TM4 162 P 4.59x60 Structure Structure
TM4 163 A 4.60x61 Structure Structure
TM4 164 I 4.61x62 Structure Structure
TM4 165 I 4.62x63 Structure Structure
TM4 166 H 4.63x64 Structure Structure
TM4 167 R 4.64x65 Structure Structure
ECL2 168 N - Structure Structure
ECL2 169 V - Structure Structure
ECL2 170 F - Structure Structure
ECL2 171 F - Structure Structure
ECL2 172 I - Structure Structure
ECL2 173 E - Structure Structure
ECL2 174 N - Structure Structure
ECL2 175 T - Structure Structure
ECL2 176 N - Structure Structure
ECL2 177 I - Structure Structure
ECL2 178 T - Structure Structure
ECL2 179 V - Structure Structure
ECL2 180 C 45.50x50 Structure Structure
ECL2 181 A 45.51x51 Structure Structure
ECL2 182 F 45.52x52 Structure Structure
ECL2 183 H - Structure Structure
ECL2 184 Y - Structure Structure
ECL2 185 E - Structure Structure
ECL2 186 S - Structure Structure
ECL2 187 Q - Structure Structure
ECL2 188 N - Structure Structure
ECL2 189 S - Structure Structure
ECL2 190 T - Structure Structure
TM5 191 L 5.34x35 Structure Structure
TM5 192 P 5.35x36 Structure Structure
TM5 193 I 5.36x37 Structure Structure
TM5 194 G 5.37x38 Structure Structure
TM5 195 L 5.38x39 Structure Structure
TM5 196 G 5.39x40 Structure Structure
TM5 197 L 5.40x41 Structure Structure
TM5 198 T 5.41x42 Structure Structure
TM5 199 K 5.42x43 Structure Structure
TM5 200 N 5.43x44 Structure Structure
TM5 201 I 5.44x45 Structure Structure
TM5 202 L 5.45x46 Structure Structure
TM5 203 G 5.46x461 Structure Structure
TM5 204 F 5.47x47 Structure Structure
TM5 205 L 5.48x48 Structure Structure
TM5 206 F 5.49x49 Structure Structure
TM5 207 P 5.50x50 Structure Structure
TM5 208 F 5.51x51 Structure Structure
TM5 209 L 5.52x52 Structure Structure
TM5 210 I 5.53x53 Structure Structure
TM5 211 I 5.54x54 Structure Structure
TM5 212 L 5.55x55 Structure Structure
TM5 213 T 5.56x56 Structure Structure
TM5 214 S 5.57x57 Structure Structure
TM5 215 Y 5.58x58 Structure Structure
TM5 216 T 5.59x59 Structure Structure
TM5 217 L 5.60x60 Structure Structure
TM5 218 I 5.61x61 Structure Structure
TM5 219 W 5.62x62 Structure Structure
TM5 220 K 5.63x63 Structure Structure
TM5 221 A 5.64x64 Structure Structure
TM5 222 L 5.65x65 Structure Structure
TM5 223 K 5.66x66 Structure Structure
TM5 224 K 5.67x67 Structure Structure
TM5 225 A 5.68x68 Structure Structure
ICL3 226 Y - Structure Structure
ICL3 227 E - Structure Structure
ICL3 228 I - Structure Structure
ICL3 229 Q - Structure Structure
ICL3 230 K - Structure Structure
ICL3 231 N - Structure Structure
ICL3 232 K - Structure Structure
TM6 233 P 6.28x28 Structure Structure
TM6 234 R 6.29x29 Structure Structure
TM6 235 N 6.30x30 Structure Structure
TM6 236 D 6.31x31 Structure Structure
TM6 237 D 6.32x32 Structure Structure
TM6 238 I 6.33x33 Structure Structure
TM6 239 F 6.34x34 Structure Structure
TM6 240 K 6.35x35 Structure Structure
TM6 241 I 6.36x36 Structure Structure
TM6 242 I 6.37x37 Structure Structure
TM6 243 M 6.38x38 Structure Structure
TM6 244 A 6.39x39 Structure Structure
TM6 245 I 6.40x40 Structure Structure
TM6 246 V 6.41x41 Structure Structure
TM6 247 L 6.42x42 Structure Structure
TM6 248 F 6.43x43 Structure Structure
TM6 249 F 6.44x44 Structure Structure
TM6 250 F 6.45x45 Structure Structure
TM6 251 F 6.46x46 Structure Structure
TM6 252 S 6.47x47 Structure Structure
TM6 253 W 6.48x48 Structure Structure
TM6 254 I 6.49x49 Structure Structure
TM6 255 P 6.50x50 Structure Structure
TM6 256 H 6.51x51 Structure Structure
TM6 257 Q 6.52x52 Structure Structure
TM6 258 I 6.53x53 Structure Structure
TM6 259 F 6.54x54 Structure Structure
TM6 260 T 6.55x55 Structure Structure
TM6 261 F 6.56x56 Structure Structure
TM6 262 L 6.57x57 Structure Structure
TM6 263 D 6.58x58 Structure Structure
TM6 264 V 6.59x59 Structure Structure
TM6 265 L 6.60x60 Structure Structure
TM6 266 I 6.61x61 Structure Structure
TM6 267 Q 6.62x62 Structure Structure
TM6 268 L 6.63x63 Structure Structure
TM6 269 G 6.64x64 Structure Structure
ECL3 270 I - Structure Structure
ECL3 271 I - Structure Structure
ECL3 272 R - Structure Structure
TM7 273 D 7.24x23 Structure Structure
TM7 274 C 7.25x24 Structure Structure
TM7 275 R 7.26x25 Structure Structure
TM7 276 I 7.27x26 Structure Structure
TM7 277 A 7.28x27 Structure Structure
TM7 278 D 7.29x28 Structure Structure
TM7 279 I 7.30x29 Structure Structure
TM7 280 V 7.31x30 Structure Structure
TM7 281 D 7.32x31 Structure Structure
TM7 282 T 7.33x32 Structure Structure
TM7 283 A 7.34x33 Structure Structure
TM7 284 M 7.35x34 Structure Structure
TM7 285 P 7.36x35 Structure Structure
TM7 286 I 7.37x36 Structure Structure
TM7 287 T 7.38x37 Structure Structure
TM7 288 I 7.39x38 Structure Structure
TM7 289 C 7.40x39 Structure Structure
TM7 290 I 7.41x40 Structure Structure
TM7 291 A 7.42x41 Structure Structure
TM7 292 Y 7.43x42 Structure Structure
TM7 293 F 7.44x43 Structure Structure
TM7 294 N 7.45x45 Structure Structure
TM7 295 N 7.46x46 Structure AF2
TM7 296 C 7.47x47 Structure Structure
TM7 297 L 7.48x48 Structure Structure
TM7 298 N 7.49x49 Structure Structure
TM7 299 P 7.50x50 Structure Structure
TM7 300 L 7.51x51 Structure Structure
TM7 301 F 7.52x52 Structure Structure
TM7 302 Y 7.53x53 Structure Structure
TM7 303 G 7.54x54 Structure Structure
TM7 304 F 7.55x55 Structure Structure
TM7 305 L 7.56x56 Structure Structure
H8 306 G 8.47x47 Structure Structure
H8 307 K 8.48x48 Structure Structure
H8 308 K 8.49x49 Structure Structure
H8 309 F 8.50x50 Structure Structure
H8 310 K 8.51x51 Structure Structure
H8 311 R 8.52x52 Structure Structure
H8 312 Y 8.53x53 Structure Structure
H8 313 F 8.54x54 Structure Structure
H8 314 L 8.55x55 Structure Structure
H8 315 Q 8.56x56 Structure Structure
H8 316 L 8.57x57 Structure Structure
H8 317 L 8.58x58 Structure Structure
H8 318 K 8.59x59 Structure Structure
H8 319 Y 8.60x60 Structure Structure
H8 320 I 8.61x61 Structure Structure
C-term 321 P - AF2 AF2
C-term 322 P - AF2 AF2
C-term 323 K - AF2 AF2
C-term 324 A - AF2 AF2
C-term 325 K - AF2 AF2
C-term 326 S - AF2 AF2
C-term 327 H - AF2 AF2
C-term 328 S - AF2 AF2
C-term 329 N - AF2 AF2
C-term 330 L - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 134 34x51 G.S3 V 199 G.S3.01
Polar ICL2 L 138 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 I 238 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM3 A 129 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 129 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 M 134 34x51 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 R 137 34x54 G.S3 V 199 G.S3.01
Hydrophobic TM3 I 130 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 130 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM6 I 238 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM3 I 130 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 130 3x54 G.H5 L 353 G.H5.20
Polar TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 Q 229 - G.S6 Y 325 G.S6.02
Hydrophobic TM3 R 126 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 126 3x50 G.H5 L 358 G.H5.25
Polar TM3 A 129 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 129 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 P 133 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 P 133 34x50 G.H5 L 349 G.H5.16
Polar ICL2 R 140 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 140 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 M 134 34x51 G.H5 K 345 G.H5.12
Hydrophobic ICL2 P 133 34x50 G.H5 K 345 G.H5.12
Polar H8 G 306 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 G 306 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 K 308 8x49 G.H5 K 354 G.H5.21
Hydrophobic TM6 I 241 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 I 241 6x36 G.H5 L 358 G.H5.25
Ionic H8 K 307 8x48 G.h4s6 D 321 G.h4s6.12
Hydrophobic ICL2 M 134 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 M 134 34x51 G.H5 F 341 G.H5.08
Polar H8 K 307 8x48 G.H5 V 359 G.H5.26
Hydrophobic H8 K 307 8x48 G.H5 V 359 G.H5.26
Van-der-waals H8 K 307 8x48 G.H5 V 359 G.H5.26
Hydrophobic TM2 A 63 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 A 63 2x39 G.H5 Y 356 G.H5.23
Polar ICL3 Q 229 - G.H5 D 346 G.H5.13
Hydrophobic ICL3 Q 229 - G.H5 D 346 G.H5.13
Ionic ICL2 R 140 34x57 G.H5 E 355 G.H5.22
Polar ICL2 R 140 34x57 G.H5 E 355 G.H5.22
Polar TM3 D 125 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 125 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 125 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM2 A 63 2x39 G.H5 E 355 G.H5.22
Hydrophobic ICL2 R 137 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 R 137 34x54 G.S1 L 40 G.S1.02
Hydrophobic TM5 L 222 5x65 G.H5 L 353 G.H5.20
Polar ICL2 R 137 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 137 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 M 134 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 M 134 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM3 I 130 3x54 G.H5 L 358 G.H5.25
Polar TM4 T 141 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic TM4 T 141 4x38 G.hns1 R 37 G.hns1.02
Hydrophobic H8 G 306 8x47 G.H5 V 359 G.H5.26
Hydrophobic ICL2 L 138 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 I 238 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM7 G 303 7x54 G.H5 N 357 G.H5.24
Van-der-waals TM7 G 303 7x54 G.H5 N 357 G.H5.24
Polar H8 F 309 8x50 G.H5 N 357 G.H5.24
Hydrophobic H8 F 309 8x50 G.H5 N 357 G.H5.24
Van-der-waals H8 F 309 8x50 G.H5 N 357 G.H5.24
Polar ICL2 R 137 34x54 G.S1 E 39 G.S1.01