Refined structure (7LLY) of Gs - GLP-1 receptor

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 196 from structure (49.7%), 198 from model (50.3%)
Residue sidechains - 189 from structure (48.0%), 205 from model (52.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 AF2 AF2
G.s1h1 49 G G.s1h1.03 AF2 AF2
G.s1h1 50 E G.s1h1.04 AF2 AF2
G.s1h1 51 S G.s1h1.05 AF2 AF2
G.s1h1 52 G G.s1h1.06 AF2 AF2
G.H1 53 K G.H1.01 AF2 AF2
G.H1 54 S G.H1.02 AF2 AF2
G.H1 55 T G.H1.03 AF2 AF2
G.H1 56 I G.H1.04 AF2 AF2
G.H1 57 V G.H1.05 AF2 AF2
G.H1 58 K G.H1.06 AF2 AF2
G.H1 59 Q G.H1.07 AF2 AF2
G.H1 60 M G.H1.08 AF2 AF2
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 AF2 AF2
G.hfs2 206 G G.hfs2.07 AF2 AF2
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 AF2 AF2
G.s4h3 251 S G.s4h3.02 AF2 AF2
G.s4h3 252 S G.s4h3.03 AF2 AF2
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure AF2
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure AF2
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure AF2
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure AF2
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure AF2
G.h3s5 285 I G.h3s5.03 Structure AF2
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 AF2 AF2
G.HG 294 Q G.HG.01 AF2 AF2
G.HG 295 D G.HG.02 AF2 AF2
G.HG 296 L G.HG.03 AF2 AF2
G.HG 297 L G.HG.04 AF2 AF2
G.HG 298 A G.HG.05 AF2 AF2
G.HG 299 E G.HG.06 AF2 AF2
G.HG 300 K G.HG.07 AF2 AF2
G.HG 301 V G.HG.08 AF2 AF2
G.HG 302 L G.HG.09 AF2 AF2
G.HG 303 A G.HG.10 AF2 AF2
G.HG 304 G G.HG.11 AF2 AF2
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 AF2 AF2
G.HG 307 K G.HG.14 AF2 AF2
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 355 from structure (80.5%), 86 from model (19.5%)
Residue sidechains - 286 from structure (64.9%), 155 from model (35.1%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 A - AF2 AF2
N-term 3 G - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 P - AF2 AF2
N-term 6 G - AF2 AF2
N-term 7 P - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 R - AF2 AF2
N-term 10 L - AF2 AF2
N-term 11 A - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 L - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 L - AF2 AF2
N-term 16 G - AF2 AF2
N-term 17 M - AF2 AF2
N-term 18 V - AF2 AF2
N-term 19 G - AF2 AF2
N-term 20 R - AF2 AF2
N-term 21 A - AF2 AF2
N-term 22 G - AF2 AF2
N-term 23 P - AF2 AF2
N-term 24 R - AF2 AF2
N-term 25 P - AF2 AF2
N-term 26 Q - AF2 AF2
N-term 27 G - AF2 AF2
N-term 28 A - AF2 AF2
N-term 29 T - AF2 AF2
N-term 30 V - AF2 AF2
N-term 31 S - AF2 AF2
N-term 32 L - AF2 AF2
N-term 33 W - AF2 AF2
N-term 34 E - AF2 AF2
N-term 35 T - Structure AF2
N-term 36 V - Structure AF2
N-term 37 Q - Structure AF2
N-term 38 K - Structure AF2
N-term 39 W - Structure AF2
N-term 40 R - Structure AF2
N-term 41 E - Structure AF2
N-term 42 Y - Structure AF2
N-term 43 R - Structure AF2
N-term 44 R - Structure AF2
N-term 45 Q - Structure AF2
N-term 46 C - Structure Structure
N-term 47 Q - Structure AF2
N-term 48 R - Structure AF2
N-term 49 S - Structure Structure
N-term 50 L - Structure AF2
N-term 51 T - Structure AF2
N-term 52 E - Structure AF2
N-term 53 D - Structure AF2
N-term 54 P - Structure AF2
N-term 55 P - Structure AF2
N-term 56 P - Structure AF2
N-term 57 A - Structure Structure
N-term 58 T - Structure AF2
N-term 59 D - Structure AF2
N-term 60 L - Structure AF2
N-term 61 F - Structure AF2
N-term 62 C - Structure Structure
N-term 63 N - Structure AF2
N-term 64 R - Structure AF2
N-term 65 T - Structure AF2
N-term 66 F - Structure AF2
N-term 67 D - Structure AF2
N-term 68 E - AF2 AF2
N-term 69 Y - AF2 AF2
N-term 70 A - Structure Structure
N-term 71 C - Structure Structure
N-term 72 W - Structure AF2
N-term 73 P - Structure AF2
N-term 74 D - Structure AF2
N-term 75 G - Structure Structure
N-term 76 E - Structure AF2
N-term 77 P - Structure AF2
N-term 78 G - Structure Structure
N-term 79 S - Structure Structure
N-term 80 F - Structure AF2
N-term 81 V - Structure AF2
N-term 82 N - Structure AF2
N-term 83 V - Structure AF2
N-term 84 S - Structure Structure
N-term 85 C - Structure Structure
N-term 86 P - Structure AF2
N-term 87 W - Structure AF2
N-term 88 Y - Structure AF2
N-term 89 L - Structure AF2
N-term 90 P - Structure AF2
N-term 91 W - Structure AF2
N-term 92 A - Structure Structure
N-term 93 S - Structure Structure
N-term 94 S - Structure Structure
N-term 95 V - Structure AF2
N-term 96 P - Structure AF2
N-term 97 Q - Structure AF2
N-term 98 G - Structure Structure
N-term 99 H - Structure AF2
N-term 100 V - Structure AF2
N-term 101 Y - Structure AF2
N-term 102 R - Structure AF2
N-term 103 F - Structure AF2
N-term 104 C - Structure Structure
N-term 105 T - Structure AF2
N-term 106 A - Structure Structure
N-term 107 E - Structure AF2
N-term 108 G - Structure Structure
N-term 109 L - Structure AF2
N-term 110 W - Structure AF2
N-term 111 L - Structure AF2
N-term 112 Q - Structure AF2
N-term 113 K - Structure AF2
N-term 114 D - Structure AF2
N-term 115 N - Structure AF2
N-term 116 S - Structure Structure
N-term 117 S - Structure Structure
N-term 118 L - Structure AF2
N-term 119 P - Structure AF2
N-term 120 W - Structure AF2
N-term 121 R - Structure AF2
N-term 122 D - Structure AF2
N-term 123 L - Structure AF2
N-term 124 S - Structure Structure
N-term 125 E - Structure AF2
N-term 126 C - Structure Structure
N-term 127 E - AF2 AF2
N-term 128 E - AF2 AF2
N-term 129 S - AF2 AF2
N-term 130 K - AF2 AF2
N-term 131 R - AF2 AF2
N-term 132 G - AF2 AF2
N-term 133 E - AF2 AF2
N-term 134 R - AF2 AF2
N-term 135 S - AF2 AF2
N-term 136 S - AF2 AF2
N-term 137 P - AF2 AF2
TM1 138 E 1.33x33 Structure Structure
TM1 139 E 1.34x34 Structure Structure
TM1 140 Q 1.35x35 Structure Structure
TM1 141 L 1.36x36 Structure Structure
TM1 142 L 1.37x37 Structure Structure
TM1 143 F 1.38x38 Structure Structure
TM1 144 L 1.39x39 Structure Structure
TM1 145 Y 1.40x40 Structure Structure
TM1 146 I 1.41x41 Structure Structure
TM1 147 I 1.42x42 Structure Structure
TM1 148 Y 1.43x43 Structure Structure
TM1 149 T 1.44x44 Structure Structure
TM1 150 V 1.45x45 Structure Structure
TM1 151 G 1.46x46 Structure Structure
TM1 152 Y 1.47x47 Structure Structure
TM1 153 A 1.48x48 Structure Structure
TM1 154 L 1.49x49 Structure Structure
TM1 155 S 1.50x50 Structure Structure
TM1 156 F 1.51x51 Structure Structure
TM1 157 S 1.52x52 Structure Structure
TM1 158 A 1.53x53 Structure Structure
TM1 159 L 1.54x54 Structure Structure
TM1 160 V 1.55x55 Structure Structure
TM1 161 I 1.56x56 Structure Structure
TM1 162 A 1.57x57 Structure Structure
TM1 163 S 1.58x58 Structure Structure
TM1 164 A 1.59x59 Structure Structure
TM1 165 I 1.60x60 Structure Structure
TM1 166 L 1.61x61 Structure Structure
TM1 167 L 1.62x62 Structure Structure
TM1 168 G 1.63x63 Structure Structure
TM1 169 F 1.64x64 Structure Structure
ICL1 170 R 12.48x48 Structure Structure
ICL1 171 H 12.49x49 Structure Structure
ICL1 172 L 12.50x50 Structure Structure
ICL1 173 H 12.51x51 Structure Structure
TM2 174 C 2.44x44 Structure Structure
TM2 175 T 2.45x45 Structure Structure
TM2 176 R 2.46x46 Structure Structure
TM2 177 N 2.47x47 Structure Structure
TM2 178 Y 2.48x48 Structure Structure
TM2 179 I 2.49x49 Structure Structure
TM2 180 H 2.50x50 Structure Structure
TM2 181 L 2.51x51 Structure Structure
TM2 182 N 2.52x52 Structure Structure
TM2 183 L 2.53x53 Structure Structure
TM2 184 F 2.54x54 Structure Structure
TM2 185 A 2.55x55 Structure Structure
TM2 186 S 2.56x56 Structure Structure
TM2 187 F 2.57x57 Structure Structure
TM2 188 I 2.58x58 Structure Structure
TM2 189 L 2.59x59 Structure Structure
TM2 190 R 2.60x60 Structure Structure
TM2 191 A 2.61x61 Structure Structure
TM2 192 L 2.62x62 Structure Structure
TM2 193 S 2.63x63 Structure Structure
TM2 194 V 2.64x64 Structure Structure
TM2 195 F 2.65x65 Structure Structure
TM2 196 I 2.66x66 Structure Structure
TM2 197 K 2.67x67 Structure Structure
TM2 198 D 2.68x68 Structure Structure
TM2 199 A 2.69x69 Structure Structure
TM2 200 A 2.70x70 Structure Structure
TM2 201 L 2.71x71 Structure Structure
TM2 202 K 2.72x72 Structure Structure
TM2 203 W 2.73x73 Structure Structure
TM2 204 M 2.74x74 Structure Structure
TM2 205 Y 2.75x75 Structure Structure
TM2 206 S 2.76x76 Structure Structure
ECL1 207 T - AF2 AF2
ECL1 208 A - AF2 AF2
ECL1 209 A - AF2 AF2
ECL1 210 Q - AF2 AF2
ECL1 211 Q - AF2 AF2
ECL1 212 H - AF2 AF2
ECL1 213 Q - AF2 AF2
ECL1 214 W - AF2 AF2
ECL1 215 D - AF2 AF2
ECL1 216 G - AF2 AF2
ECL1 217 L - AF2 AF2
ECL1 218 L - AF2 AF2
ECL1 219 S - Structure Structure
ECL1 220 Y - Structure Structure
ECL1 221 Q - Structure Structure
ECL1 222 D - Structure Structure
ECL1 223 S - Structure Structure
TM3 224 L 3.27x27 Structure Structure
TM3 225 S 3.28x28 Structure Structure
TM3 226 C 3.29x29 Structure Structure
TM3 227 R 3.30x30 Structure Structure
TM3 228 L 3.31x31 Structure Structure
TM3 229 V 3.32x32 Structure Structure
TM3 230 F 3.33x33 Structure Structure
TM3 231 L 3.34x34 Structure Structure
TM3 232 L 3.35x35 Structure Structure
TM3 233 M 3.36x36 Structure Structure
TM3 234 Q 3.37x37 Structure Structure
TM3 235 Y 3.38x38 Structure Structure
TM3 236 C 3.39x39 Structure Structure
TM3 237 V 3.40x40 Structure Structure
TM3 238 A 3.41x41 Structure Structure
TM3 239 A 3.42x42 Structure Structure
TM3 240 N 3.43x43 Structure Structure
TM3 241 Y 3.44x44 Structure Structure
TM3 242 Y 3.45x45 Structure Structure
TM3 243 W 3.46x46 Structure Structure
TM3 244 L 3.47x47 Structure Structure
TM3 245 L 3.48x48 Structure Structure
TM3 246 V 3.49x49 Structure Structure
TM3 247 E 3.50x50 Structure Structure
TM3 248 G 3.51x51 Structure Structure
TM3 249 V 3.52x52 Structure Structure
TM3 250 Y 3.53x53 Structure Structure
TM3 251 L 3.54x54 Structure Structure
TM3 252 Y 3.55x55 Structure Structure
TM3 253 T 3.56x56 Structure Structure
TM3 254 L 3.57x57 Structure Structure
TM3 255 L 3.58x58 Structure Structure
TM3 256 A 3.59x59 Structure Structure
TM3 257 F 3.60x60 Structure Structure
ICL2 258 S - Structure Structure
ICL2 259 V - Structure Structure
ICL2 260 L - Structure AF2
TM4 261 S 4.37x38 Structure Structure
TM4 262 E 4.38x39 Structure Structure
TM4 263 Q 4.39x40 Structure Structure
TM4 264 W 4.40x41 Structure Structure
TM4 265 I 4.41x42 Structure Structure
TM4 266 F 4.42x43 Structure Structure
TM4 267 R 4.43x44 Structure Structure
TM4 268 L 4.44x45 Structure Structure
TM4 269 Y 4.45x46 Structure Structure
TM4 270 V 4.46x47 Structure Structure
TM4 271 S 4.47x48 Structure Structure
TM4 272 I 4.48x49 Structure Structure
TM4 273 G 4.49x491 Structure Structure
TM4 274 W 4.50x50 Structure Structure
TM4 275 G 4.51x51 Structure Structure
TM4 276 V 4.52x52 Structure Structure
TM4 277 P 4.53x53 Structure Structure
TM4 278 L 4.54x54 Structure Structure
TM4 279 L 4.55x55 Structure Structure
TM4 280 F 4.56x56 Structure Structure
TM4 281 V 4.57x57 Structure Structure
TM4 282 V 4.58x58 Structure Structure
TM4 283 P 4.59x59 Structure Structure
TM4 284 W 4.60x60 Structure Structure
TM4 285 G 4.61x61 Structure Structure
TM4 286 I 4.62x62 Structure Structure
TM4 287 V 4.63x63 Structure Structure
TM4 288 K 4.64x64 Structure Structure
TM4 289 Y 4.65x65 Structure Structure
TM4 290 L 4.66x66 Structure Structure
TM4 291 Y 4.67x67 Structure Structure
TM4 292 E 4.68x68 Structure Structure
ECL2 293 D - Structure Structure
ECL2 294 E - Structure Structure
ECL2 295 G - Structure Structure
ECL2 296 C 45.50x50 Structure Structure
ECL2 297 W 45.51x51 Structure Structure
ECL2 298 T 45.52x52 Structure Structure
ECL2 299 R - Structure Structure
ECL2 300 N - Structure Structure
ECL2 301 S - Structure Structure
TM5 302 N 5.32x33 Structure Structure
TM5 303 M 5.33x34 Structure Structure
TM5 304 N 5.34x35 Structure Structure
TM5 305 Y 5.35x36 Structure Structure
TM5 306 W 5.36x37 Structure Structure
TM5 307 L 5.37x38 Structure Structure
TM5 308 I 5.38x381 Structure Structure
TM5 309 I 5.39x39 Structure Structure
TM5 310 R 5.40x40 Structure Structure
TM5 311 L 5.41x41 Structure Structure
TM5 312 P 5.42x42 Structure Structure
TM5 313 I 5.43x43 Structure Structure
TM5 314 L 5.44x44 Structure Structure
TM5 315 F 5.45x45 Structure Structure
TM5 316 A 5.46x46 Structure Structure
TM5 317 I 5.47x47 Structure Structure
TM5 318 G 5.48x48 Structure Structure
TM5 319 V 5.49x49 Structure Structure
TM5 320 N 5.50x50 Structure Structure
TM5 321 F 5.51x51 Structure Structure
TM5 322 L 5.52x52 Structure Structure
TM5 323 I 5.53x53 Structure Structure
TM5 324 F 5.54x54 Structure Structure
TM5 325 V 5.55x55 Structure Structure
TM5 326 R 5.56x56 Structure Structure
TM5 327 V 5.57x57 Structure Structure
TM5 328 I 5.58x58 Structure Structure
TM5 329 C 5.59x59 Structure Structure
TM5 330 I 5.60x60 Structure Structure
TM5 331 V 5.61x61 Structure Structure
TM5 332 V 5.62x62 Structure Structure
TM5 333 S 5.63x63 Structure Structure
TM5 334 K 5.64x64 Structure Structure
TM5 335 L 5.65x65 Structure Structure
TM5 336 K 5.66x66 Structure Structure
TM5 337 A 5.67x67 Structure Structure
TM5 338 N 5.68x68 AF2 AF2
TM5 339 L 5.69x69 AF2 AF2
ICL3 340 M - AF2 AF2
TM6 341 C 6.30x30 AF2 AF2
TM6 342 K 6.31x31 AF2 AF2
TM6 343 T 6.32x32 AF2 AF2
TM6 344 D 6.33x33 AF2 AF2
TM6 345 I 6.34x34 Structure Structure
TM6 346 K 6.35x35 Structure Structure
TM6 347 C 6.36x36 Structure Structure
TM6 348 R 6.37x37 Structure Structure
TM6 349 L 6.38x38 Structure Structure
TM6 350 A 6.39x39 Structure Structure
TM6 351 K 6.40x40 Structure Structure
TM6 352 S 6.41x41 Structure Structure
TM6 353 T 6.42x42 Structure Structure
TM6 354 L 6.43x43 Structure Structure
TM6 355 T 6.44x44 Structure Structure
TM6 356 L 6.45x45 Structure Structure
TM6 357 I 6.46x46 Structure Structure
TM6 358 P 6.47x47 Structure Structure
TM6 359 L 6.48x48 Structure Structure
TM6 360 L 6.49x49 Structure Structure
TM6 361 G 6.50x50 Structure Structure
TM6 362 T 6.51x51 Structure Structure
TM6 363 H 6.52x52 Structure Structure
TM6 364 E 6.53x53 Structure Structure
TM6 365 V 6.54x54 Structure Structure
TM6 366 I 6.55x55 Structure Structure
TM6 367 F 6.56x56 Structure Structure
TM6 368 A 6.57x57 Structure Structure
TM6 369 F 6.58x58 Structure Structure
TM6 370 V 6.59x59 Structure Structure
TM6 371 M 6.60x60 Structure Structure
ECL3 372 D - Structure Structure
ECL3 373 E - Structure Structure
ECL3 374 H - Structure Structure
ECL3 375 A - Structure Structure
ECL3 376 R - Structure Structure
TM7 377 G 7.32x31 Structure Structure
TM7 378 T 7.33x32 Structure Structure
TM7 379 L 7.34x33 Structure Structure
TM7 380 R 7.35x34 Structure Structure
TM7 381 F 7.36x35 Structure Structure
TM7 382 I 7.37x36 Structure Structure
TM7 383 K 7.38x37 Structure Structure
TM7 384 L 7.39x38 Structure Structure
TM7 385 F 7.40x39 Structure Structure
TM7 386 T 7.41x40 Structure Structure
TM7 387 E 7.42x41 Structure Structure
TM7 388 L 7.43x42 Structure Structure
TM7 389 S 7.44x43 Structure Structure
TM7 390 F 7.45x44 Structure Structure
TM7 391 T 7.46x45 Structure Structure
TM7 392 S 7.47x46 Structure Structure
TM7 393 F 7.48x47 Structure Structure
TM7 394 Q 7.49x49 Structure Structure
TM7 395 G 7.50x50 Structure Structure
TM7 396 L 7.51x51 Structure Structure
TM7 397 M 7.52x52 Structure Structure
TM7 398 V 7.53x53 Structure Structure
TM7 399 A 7.54x54 Structure Structure
TM7 400 I 7.55x55 Structure Structure
TM7 401 L 7.56x56 Structure Structure
TM7 402 Y 7.57x57 Structure Structure
TM7 403 C 7.58x58 Structure Structure
TM7 404 F 7.59x59 Structure Structure
TM7 405 V 7.60x60 Structure Structure
H8 406 N 8.47x47 Structure Structure
H8 407 N 8.48x48 Structure Structure
H8 408 E 8.49x49 Structure Structure
H8 409 V 8.50x50 Structure Structure
H8 410 Q 8.51x51 Structure Structure
H8 411 L 8.52x52 Structure Structure
H8 412 E 8.53x53 Structure Structure
H8 413 F 8.54x54 Structure Structure
H8 414 R 8.55x55 Structure Structure
H8 415 K 8.56x56 Structure Structure
H8 416 S 8.57x57 Structure Structure
H8 417 W 8.58x58 Structure Structure
H8 418 E 8.59x59 Structure Structure
H8 419 R 8.60x60 Structure Structure
H8 420 W 8.61x61 Structure Structure
H8 421 R 8.62x62 Structure Structure
H8 422 L 8.63x63 AF2 AF2
H8 423 E 8.64x64 AF2 AF2
H8 424 H 8.65x65 AF2 AF2
H8 425 L 8.66x66 AF2 AF2
H8 426 H 8.67x67 AF2 AF2
H8 427 I 8.68x68 AF2 AF2
H8 428 Q 8.69x69 AF2 AF2
H8 429 R 8.70x70 AF2 AF2
H8 430 D 8.71x71 AF2 AF2
H8 431 S 8.72x72 AF2 AF2
C-term 432 S - AF2 AF2
C-term 433 M - AF2 AF2
C-term 434 K - AF2 AF2
C-term 435 P - AF2 AF2
C-term 436 L - AF2 AF2
C-term 437 K - AF2 AF2
C-term 438 C - AF2 AF2
C-term 439 P - AF2 AF2
C-term 440 T - AF2 AF2
C-term 441 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 335 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM4 S 261 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM3 F 257 3x60 G.S3 V 217 G.S3.01
Van-der-waals TM3 F 257 3x60 G.S3 V 217 G.S3.01
Hydrophobic TM3 L 255 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 255 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM5 V 331 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM5 K 334 5x64 G.H5 L 394 G.H5.26
Polar TM6 K 351 6x40 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 351 6x40 G.H5 L 394 G.H5.26
Polar TM6 K 351 6x40 G.H5 L 393 G.H5.25
Polar TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Polar TM6 S 352 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 352 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 352 6x41 G.H5 L 393 G.H5.25
Polar H8 N 407 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 V 331 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM3 F 257 3x60 G.S1 H 41 G.S1.02
Van-der-waals TM3 F 257 3x60 G.S1 H 41 G.S1.02
Polar H8 N 406 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 406 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 F 257 3x60 G.H5 R 380 G.H5.12
Van-der-waals TM3 F 257 3x60 G.H5 R 380 G.H5.12
Polar TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 176 2x46 G.H5 Q 390 G.H5.22
Ionic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM3 L 254 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 254 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 F 257 3x60 G.H5 I 383 G.H5.15
Hydrophobic TM5 V 327 5x57 G.H5 L 393 G.H5.25
Hydrophobic TM3 Y 250 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 250 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 176 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 331 5x61 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 331 5x61 G.H5 L 388 G.H5.20
Polar TM5 N 338 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 N 338 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 N 338 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM3 L 251 3x54 G.H5 Y 391 G.H5.23
Polar TM5 K 334 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 334 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 334 5x64 G.H5 R 385 G.H5.17