Refined structure (7S8N) of Gq - MRGPRX2

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 204 from structure (56.8%), 155 from model (43.2%)
Residue sidechains - 96 from structure (26.7%), 263 from model (73.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 AF2 AF2
G.HN 11 L G.HN.11 Structure AF2
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure Structure
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure Structure
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure AF2
G.H1 58 Q G.H1.07 AF2 AF2
G.H1 59 M G.H1.08 AF2 AF2
G.H1 60 R G.H1.09 AF2 AF2
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 AF2 AF2
G.hfs2 187 T G.hfs2.06 AF2 AF2
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure AF2
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 AF2 AF2
G.s3h2 209 Q G.s3h2.03 AF2 AF2
G.H2 210 R G.H2.01 AF2 AF2
G.H2 211 S G.H2.02 AF2 AF2
G.H2 212 E G.H2.03 AF2 AF2
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure AF2
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure Structure
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure AF2
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 Structure Structure
G.hgh4 292 F G.hgh4.02 Structure Structure
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure AF2
G.hgh4 295 Y G.hgh4.05 Structure AF2
G.hgh4 296 D G.hgh4.06 Structure AF2
G.hgh4 297 G G.hgh4.07 Structure AF2
G.hgh4 298 P G.hgh4.08 Structure AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure AF2
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure AF2
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure AF2
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 248 from structure (84.1%), 47 from model (15.9%)
Residue sidechains - 225 from structure (76.3%), 70 from model (23.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 T - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 W - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 T - AF2 AF2
N-term 11 E - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 T - AF2 AF2
N-term 15 V - AF2 AF2
N-term 16 N - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 N - AF2 AF2
N-term 19 D - AF2 AF2
N-term 20 Q - AF2 AF2
N-term 21 A - AF2 AF2
N-term 22 L - AF2 AF2
N-term 23 L - AF2 AF2
N-term 24 L - AF2 AF2
N-term 25 L - AF2 AF2
N-term 26 C - AF2 AF2
N-term 27 G - AF2 AF2
N-term 28 K - AF2 AF2
N-term 29 E - AF2 AF2
TM1 30 T 1.32x32 Structure AF2
TM1 31 L 1.33x33 Structure Structure
TM1 32 I 1.34x34 Structure AF2
TM1 33 P 1.35x35 Structure AF2
TM1 34 V 1.36x36 Structure Structure
TM1 35 F 1.37x37 Structure Structure
TM1 36 L 1.38x38 Structure Structure
TM1 37 I 1.39x39 Structure Structure
TM1 38 L 1.40x40 Structure Structure
TM1 39 F 1.41x41 Structure AF2
TM1 40 I 1.42x42 Structure Structure
TM1 41 A 1.43x43 Structure Structure
TM1 42 L 1.44x44 Structure Structure
TM1 43 V 1.45x45 Structure Structure
TM1 44 G 1.46x46 Structure Structure
TM1 45 L 1.47x47 Structure Structure
TM1 46 V 1.48x48 Structure Structure
TM1 47 G 1.49x49 Structure Structure
TM1 48 N 1.50x50 Structure Structure
TM1 49 G 1.51x51 Structure Structure
TM1 50 F 1.52x52 Structure AF2
TM1 51 V 1.53x53 Structure Structure
TM1 52 L 1.54x54 Structure Structure
TM1 53 W 1.55x55 Structure Structure
TM1 54 L 1.56x56 Structure Structure
TM1 55 L 1.57x57 Structure Structure
TM1 56 G 1.58x58 Structure Structure
TM1 57 F 1.59x59 Structure AF2
TM1 58 R 1.60x60 Structure AF2
TM1 59 M 1.61x61 Structure AF2
ICL1 60 R - Structure AF2
ICL1 61 R - Structure AF2
TM2 62 N 2.37x37 Structure Structure
TM2 63 A 2.38x38 Structure Structure
TM2 64 F 2.39x39 Structure Structure
TM2 65 S 2.40x40 Structure Structure
TM2 66 V 2.41x41 Structure Structure
TM2 67 Y 2.42x42 Structure Structure
TM2 68 V 2.43x43 Structure Structure
TM2 69 L 2.44x44 Structure Structure
TM2 70 S 2.45x45 Structure Structure
TM2 71 L 2.46x46 Structure Structure
TM2 72 A 2.47x47 Structure Structure
TM2 73 G 2.48x48 Structure Structure
TM2 74 A 2.49x49 Structure Structure
TM2 75 D 2.50x50 Structure Structure
TM2 76 F 2.51x51 Structure Structure
TM2 77 L 2.52x52 Structure Structure
TM2 78 F 2.53x53 Structure Structure
TM2 79 L 2.54x54 Structure Structure
TM2 80 C 2.55x55 Structure Structure
TM2 81 F 2.56x56 Structure Structure
TM2 82 Q 2.57x57 Structure Structure
TM2 83 I 2.58x58 Structure Structure
TM2 84 I 2.59x59 Structure Structure
TM2 85 N 2.60x60 Structure Structure
TM2 86 C 2.61x61 Structure Structure
TM2 87 L 2.62x62 Structure Structure
TM2 88 V 2.63x63 Structure Structure
TM2 89 Y 2.64x64 Structure Structure
TM2 90 L 2.65x65 Structure Structure
TM2 91 S 2.66x66 Structure Structure
TM2 92 N 2.67x67 Structure AF2
TM2 93 F 2.68x68 Structure Structure
TM2 94 F 2.69x69 Structure AF2
TM2 95 C 2.70x70 Structure Structure
TM2 96 S 2.71x71 Structure Structure
ECL1 97 I - Structure AF2
ECL1 98 S - Structure Structure
ECL1 99 I - Structure AF2
ECL1 100 N - Structure AF2
ECL1 101 F - Structure AF2
TM3 102 P 3.25x25 Structure Structure
TM3 103 S 3.26x26 Structure Structure
TM3 104 F 3.27x27 Structure Structure
TM3 105 F 3.28x28 Structure Structure
TM3 106 T 3.29x29 Structure Structure
TM3 107 T 3.30x30 Structure Structure
TM3 108 V 3.31x31 Structure Structure
TM3 109 M 3.32x32 Structure Structure
TM3 110 T 3.33x33 Structure Structure
TM3 111 C 3.34x34 Structure Structure
TM3 112 A 3.35x35 Structure Structure
TM3 113 Y 3.36x36 Structure Structure
TM3 114 L 3.37x37 Structure Structure
TM3 115 A 3.38x38 Structure Structure
TM3 116 G 3.39x39 Structure Structure
TM3 117 L 3.40x40 Structure Structure
TM3 118 S 3.41x41 Structure Structure
TM3 119 M 3.42x42 Structure Structure
TM3 120 L 3.43x43 Structure Structure
TM3 121 S 3.44x44 Structure Structure
TM3 122 T 3.45x45 Structure Structure
TM3 123 V 3.46x46 Structure Structure
TM3 124 S 3.47x47 Structure Structure
TM3 125 T 3.48x48 Structure Structure
TM3 126 E 3.49x49 Structure Structure
TM3 127 R 3.50x50 Structure Structure
TM3 128 C 3.51x51 Structure Structure
TM3 129 L 3.52x52 Structure Structure
TM3 130 S 3.53x53 Structure Structure
TM3 131 V 3.54x54 Structure Structure
TM3 132 L 3.55x55 Structure Structure
TM3 133 W 3.56x56 Structure Structure
ICL2 134 P 34.50x50 Structure Structure
ICL2 135 I 34.51x51 Structure Structure
ICL2 136 W 34.52x52 Structure Structure
ICL2 137 Y 34.53x53 Structure Structure
ICL2 138 R 34.54x54 Structure Structure
ICL2 139 C 34.55x55 Structure Structure
ICL2 140 R 34.56x56 Structure Structure
ICL2 141 R 34.57x57 Structure Structure
TM4 142 P 4.38x38 Structure Structure
TM4 143 R 4.39x39 Structure AF2
TM4 144 H 4.40x40 Structure Structure
TM4 145 L 4.41x41 Structure Structure
TM4 146 S 4.42x42 Structure Structure
TM4 147 A 4.43x43 Structure Structure
TM4 148 V 4.44x44 Structure Structure
TM4 149 V 4.45x45 Structure Structure
TM4 150 C 4.46x46 Structure Structure
TM4 151 V 4.47x47 Structure Structure
TM4 152 L 4.48x48 Structure Structure
TM4 153 L 4.49x49 Structure Structure
TM4 154 W 4.50x50 Structure Structure
TM4 155 A 4.51x51 Structure Structure
TM4 156 L 4.52x52 Structure Structure
TM4 157 S 4.53x53 Structure Structure
TM4 158 L 4.54x54 Structure Structure
TM4 159 L 4.55x55 Structure Structure
TM4 160 L 4.56x56 Structure Structure
TM4 161 S 4.57x57 Structure Structure
TM4 162 I 4.58x58 Structure Structure
TM4 163 L 4.59x59 Structure AF2
TM4 164 E 4.60x60 Structure Structure
TM4 165 G 4.61x61 Structure Structure
TM4 166 K 4.62x62 Structure AF2
TM4 167 F 4.63x63 Structure Structure
TM4 168 C 4.64x64 Structure Structure
ECL2 169 G - Structure Structure
ECL2 170 F - Structure Structure
ECL2 171 L - Structure Structure
ECL2 172 F - Structure AF2
ECL2 173 S - Structure Structure
ECL2 174 D - Structure AF2
ECL2 175 G - Structure Structure
TM5 176 D 5.32x32 Structure AF2
TM5 177 S 5.33x33 Structure Structure
TM5 178 G 5.34x34 Structure Structure
TM5 179 W 5.35x35 Structure Structure
TM5 180 C 5.36x36 Structure Structure
TM5 181 Q 5.37x37 Structure Structure
TM5 182 T 5.38x38 Structure Structure
TM5 183 F 5.39x39 Structure Structure
TM5 184 D 5.40x40 Structure Structure
TM5 185 F 5.41x41 Structure Structure
TM5 186 I 5.42x42 Structure Structure
TM5 187 T 5.43x43 Structure Structure
TM5 188 A 5.44x44 Structure Structure
TM5 189 A 5.45x45 Structure Structure
TM5 190 W 5.46x46 Structure Structure
TM5 191 L 5.47x47 Structure Structure
TM5 192 I 5.48x48 Structure Structure
TM5 193 F 5.49x49 Structure Structure
TM5 194 L 5.50x50 Structure Structure
TM5 195 F 5.51x51 Structure Structure
TM5 196 M 5.52x52 Structure Structure
TM5 197 V 5.53x53 Structure Structure
TM5 198 L 5.54x54 Structure Structure
TM5 199 C 5.55x55 Structure Structure
TM5 200 G 5.56x56 Structure Structure
TM5 201 S 5.57x57 Structure Structure
TM5 202 S 5.58x58 Structure Structure
TM5 203 L 5.59x59 Structure Structure
TM5 204 A 5.60x60 Structure Structure
TM5 205 L 5.61x61 Structure Structure
TM5 206 L 5.62x62 Structure Structure
TM5 207 V 5.63x63 Structure Structure
TM5 208 R 5.64x64 Structure Structure
TM5 209 I 5.65x65 Structure Structure
TM5 210 L 5.66x66 Structure Structure
TM5 211 C 5.67x67 Structure Structure
TM5 212 G 5.68x68 Structure Structure
ICL3 213 S - AF2 AF2
ICL3 214 R - AF2 AF2
ICL3 215 G - AF2 AF2
ICL3 216 L - AF2 AF2
TM6 217 P 6.29x29 AF2 AF2
TM6 218 L 6.30x30 Structure Structure
TM6 219 T 6.31x31 Structure Structure
TM6 220 R 6.32x32 Structure Structure
TM6 221 L 6.33x33 Structure Structure
TM6 222 Y 6.34x34 Structure Structure
TM6 223 L 6.35x35 Structure Structure
TM6 224 T 6.36x36 Structure Structure
TM6 225 I 6.37x37 Structure Structure
TM6 226 L 6.38x38 Structure Structure
TM6 227 L 6.39x39 Structure Structure
TM6 228 T 6.40x40 Structure Structure
TM6 229 V 6.41x41 Structure Structure
TM6 230 L 6.42x42 Structure Structure
TM6 231 V 6.43x43 Structure Structure
TM6 232 F 6.44x44 Structure Structure
TM6 233 L 6.45x45 Structure Structure
TM6 234 L 6.46x46 Structure Structure
TM6 235 C 6.47x47 Structure Structure
TM6 236 G 6.48x48 Structure Structure
TM6 237 L 6.49x49 Structure Structure
TM6 238 P 6.50x50 Structure Structure
TM6 239 F 6.51x51 Structure Structure
TM6 240 G 6.52x52 Structure Structure
TM6 241 I 6.53x53 Structure Structure
TM6 242 Q 6.54x54 Structure Structure
TM6 243 W 6.55x55 Structure Structure
TM6 244 F 6.56x56 Structure Structure
TM6 245 L 6.57x57 Structure Structure
TM6 246 I 6.58x58 Structure Structure
TM6 247 L 6.59x59 Structure Structure
TM6 248 W 6.60x60 Structure Structure
TM6 249 I 6.61x61 Structure Structure
TM6 250 W 6.62x62 Structure Structure
ECL3 251 K - AF2 AF2
ECL3 252 D - AF2 AF2
ECL3 253 S - AF2 AF2
ECL3 254 D - Structure Structure
ECL3 255 V - Structure Structure
TM7 256 L 7.30x29 Structure AF2
TM7 257 F 7.31x30 Structure Structure
TM7 258 C 7.32x31 Structure Structure
TM7 259 H 7.33x32 Structure Structure
TM7 260 I 7.34x33 Structure Structure
TM7 261 H 7.35x34 Structure Structure
TM7 262 P 7.36x35 Structure Structure
TM7 263 V 7.37x36 Structure Structure
TM7 264 S 7.38x37 Structure Structure
TM7 265 V 7.39x38 Structure Structure
TM7 266 V 7.40x39 Structure Structure
TM7 267 L 7.41x40 Structure Structure
TM7 268 S 7.42x41 Structure Structure
TM7 269 S 7.43x42 Structure Structure
TM7 270 L 7.44x43 Structure Structure
TM7 271 N 7.45x45 Structure Structure
TM7 272 S 7.46x46 Structure Structure
TM7 273 S 7.47x47 Structure Structure
TM7 274 A 7.48x48 Structure Structure
TM7 275 N 7.49x49 Structure Structure
TM7 276 P 7.50x50 Structure Structure
TM7 277 I 7.51x51 Structure Structure
TM7 278 I 7.52x52 Structure Structure
TM7 279 Y 7.53x53 Structure Structure
TM7 280 F 7.54x54 Structure Structure
TM7 281 F 7.55x55 Structure Structure
TM7 282 V 7.56x56 Structure Structure
TM7 283 G 7.57x57 Structure Structure
TM7 284 S 7.58x58 Structure Structure
TM7 285 F 7.59x59 Structure Structure
C-term 286 R - AF2 AF2
C-term 287 K - AF2 AF2
C-term 288 Q - AF2 AF2
C-term 289 W - AF2 AF2
C-term 290 R - AF2 AF2
C-term 291 L - AF2 AF2
C-term 292 Q - AF2 AF2
C-term 293 Q - AF2 AF2
C-term 294 P - AF2 AF2
C-term 295 I - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term R 286 - G.H5 V 359 G.H5.26
Van-der-waals C-term R 286 - G.H5 V 359 G.H5.26
Polar TM6 L 221 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 L 221 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 221 6x33 G.H5 L 358 G.H5.25
Polar TM3 S 130 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 S 130 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL3 L 216 - G.H5 L 353 G.H5.20
Van-der-waals ICL3 L 216 - G.H5 L 353 G.H5.20
Ionic C-term R 290 - G.h4s6 D 321 G.h4s6.12
Polar C-term R 290 - G.h4s6 D 321 G.h4s6.12
Van-der-waals C-term R 290 - G.h4s6 D 321 G.h4s6.12
Polar TM6 R 220 6x32 G.H5 N 357 G.H5.24
Hydrophobic TM3 V 131 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM6 L 221 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 L 221 6x33 G.H5 V 359 G.H5.26
Polar ICL2 R 138 34x54 G.H5 N 352 G.H5.19
Van-der-waals ICL2 R 138 34x54 G.H5 N 352 G.H5.19
Hydrophobic C-term P 294 - G.h3s5 Q 265 G.h3s5.01
Van-der-waals C-term P 294 - G.h3s5 Q 265 G.h3s5.01
Aromatic TM2 F 64 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 F 64 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 F 64 2x39 G.H5 Y 356 G.H5.23
Polar ICL2 R 138 34x54 G.H5 L 351 G.H5.18
Hydrophobic ICL2 R 138 34x54 G.H5 L 351 G.H5.18
Van-der-waals ICL2 R 138 34x54 G.H5 L 351 G.H5.18
Polar ICL2 C 139 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 C 139 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 R 220 6x32 G.H5 V 359 G.H5.26
Hydrophobic ICL2 P 134 34x50 G.H5 K 345 G.H5.12
Hydrophobic TM7 G 283 7x57 G.H5 N 357 G.H5.24
Van-der-waals TM7 G 283 7x57 G.H5 N 357 G.H5.24
Polar ICL2 P 134 34x50 G.H5 N 352 G.H5.19
Hydrophobic TM4 R 143 4x39 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 R 143 4x39 G.hns1 R 37 G.hns1.02
Van-der-waals TM2 F 64 2x39 G.H5 N 357 G.H5.24
Ionic ICL2 R 138 34x54 G.H5 E 355 G.H5.22
Polar ICL2 R 138 34x54 G.H5 E 355 G.H5.22
Hydrophobic ICL2 R 138 34x54 G.H5 I 348 G.H5.15
Hydrophobic ICL2 I 135 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM6 R 220 6x32 G.H5 L 358 G.H5.25
Van-der-waals TM6 R 220 6x32 G.H5 L 358 G.H5.25
Polar ICL2 C 139 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 C 139 34x55 G.hns1 R 37 G.hns1.02
Polar ICL2 R 141 34x57 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 141 34x57 G.hns1 R 37 G.hns1.02
Polar ICL2 Y 137 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Y 137 34x53 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Y 137 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 L 216 - G.H5 Q 350 G.H5.17
Hydrophobic ICL3 L 216 - G.H5 V 359 G.H5.26
Van-der-waals ICL3 L 216 - G.H5 V 359 G.H5.26
Van-der-waals C-term Q 293 - G.h4s6 D 319 G.h4s6.10
Hydrophobic ICL2 I 135 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 I 135 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM3 R 127 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 358 G.H5.25
Hydrophobic ICL3 L 216 - G.H5 L 349 G.H5.16
Hydrophobic ICL2 Y 137 34x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 I 135 34x51 G.H5 K 345 G.H5.12
Hydrophobic TM6 T 224 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM3 E 126 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 134 34x50 G.H5 I 348 G.H5.15
Polar TM3 R 127 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 134 34x50 G.H5 L 349 G.H5.16
Hydrophobic ICL2 R 140 34x56 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 P 217 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 P 217 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM5 L 205 5x61 G.H5 L 358 G.H5.25