Refined structure (7S8P) of Gq - MRGPRX4

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 205 from structure (57.1%), 154 from model (42.9%)
Residue sidechains - 93 from structure (25.9%), 266 from model (74.1%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 I G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 AF2 AF2
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure AF2
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 E G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 A G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 A G.HN.36 Structure Structure
G.HN 19 R G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 D G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 R G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure Structure
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure Structure
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure AF2
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure AF2
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure AF2
G.s1h1 48 G G.s1h1.03 Structure AF2
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure AF2
G.H1 56 I G.H1.05 Structure AF2
G.H1 57 K G.H1.06 Structure AF2
G.H1 58 Q G.H1.07 AF2 AF2
G.H1 59 M G.H1.08 AF2 AF2
G.H1 60 R G.H1.09 AF2 AF2
G.H1 61 I G.H1.10 AF2 AF2
G.H1 62 I G.H1.11 AF2 AF2
G.H1 63 H G.H1.12 AF2 AF2
G.h1ha 64 G G.h1ha.01 AF2 AF2
G.h1ha 65 S G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 D H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 D H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 P H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 H H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 H H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 Q H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 V H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 S H.hbhc.04 AF2 AF2
H.hbhc 123 A H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 N H.HC.01 AF2 AF2
H.HC 127 P H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 D H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 S H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 N H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 T H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 N H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 L H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 V H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 D H.hehf.01 AF2 AF2
H.hehf 170 P H.hehf.02 AF2 AF2
H.hehf 171 A H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 AF2 AF2
G.hfs2 187 T G.hfs2.06 AF2 AF2
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure AF2
G.S2 191 E G.S2.03 Structure AF2
G.S2 192 Y G.S2.04 Structure AF2
G.S2 193 P G.S2.05 Structure AF2
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure AF2
G.S2 196 L G.S2.08 Structure AF2
G.s2s3 197 Q G.s2s3.01 Structure AF2
G.s2s3 198 S G.s2s3.02 Structure AF2
G.S3 199 V G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure AF2
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure AF2
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure AF2
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 AF2 AF2
G.s3h2 209 Q G.s3h2.03 AF2 AF2
G.H2 210 R G.H2.01 AF2 AF2
G.H2 211 S G.H2.02 AF2 AF2
G.H2 212 E G.H2.03 AF2 AF2
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure AF2
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure AF2
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure AF2
G.h2s4 222 N G.h2s4.03 Structure AF2
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure AF2
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure AF2
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure AF2
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure AF2
G.s4h3 232 L G.s4h3.01 Structure AF2
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure AF2
G.s4h3 237 Q G.s4h3.06 AF2 AF2
G.s4h3 238 V G.s4h3.07 AF2 AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 AF2 AF2
G.s4h3 244 N G.s4h3.13 AF2 AF2
G.s4h3 245 E G.s4h3.14 AF2 AF2
G.s4h3 246 N G.s4h3.15 AF2 AF2
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure AF2
G.H3 249 E G.H3.03 Structure AF2
G.H3 250 E G.H3.04 Structure AF2
G.H3 251 S G.H3.05 Structure AF2
G.H3 252 K G.H3.06 Structure AF2
G.H3 253 A G.H3.07 Structure AF2
G.H3 254 L G.H3.08 Structure AF2
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure AF2
G.H3 257 T G.H3.11 Structure AF2
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure AF2
G.H3 260 T G.H3.14 Structure AF2
G.H3 261 Y G.H3.15 Structure AF2
G.H3 262 P G.H3.16 Structure AF2
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure AF2
G.h3s5 265 Q G.h3s5.01 Structure AF2
G.h3s5 266 N G.h3s5.02 Structure AF2
G.h3s5 267 S G.h3s5.03 Structure AF2
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure AF2
G.HG 277 D G.HG.02 Structure Structure
G.HG 278 L G.HG.03 Structure Structure
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure AF2
G.HG 281 E G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure AF2
G.HG 283 I G.HG.08 Structure AF2
G.HG 284 M G.HG.09 Structure AF2
G.HG 285 Y G.HG.12 Structure AF2
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure AF2
G.HG 288 L G.HG.15 Structure AF2
G.HG 289 V G.HG.16 Structure AF2
G.HG 290 D G.HG.17 Structure AF2
G.hgh4 291 Y G.hgh4.01 Structure Structure
G.hgh4 292 F G.hgh4.02 Structure Structure
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure AF2
G.hgh4 295 Y G.hgh4.05 Structure AF2
G.hgh4 296 D G.hgh4.06 Structure AF2
G.hgh4 297 G G.hgh4.07 Structure AF2
G.hgh4 298 P G.hgh4.08 Structure AF2
G.H4 299 Q G.H4.01 Structure AF2
G.H4 300 R G.H4.02 Structure AF2
G.H4 301 D G.H4.03 Structure AF2
G.H4 302 A G.H4.04 Structure AF2
G.H4 303 Q G.H4.05 Structure AF2
G.H4 304 A G.H4.06 Structure AF2
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure AF2
G.H4 307 E G.H4.09 Structure AF2
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure AF2
G.H4 311 K G.H4.13 Structure AF2
G.H4 312 M G.H4.14 Structure AF2
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure AF2
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure AF2
G.h4s6 319 D G.h4s6.10 Structure AF2
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure AF2
G.h4s6 322 K G.h4s6.13 Structure AF2
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure AF2
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure AF2
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure AF2
G.s6h5 333 D G.s6h5.05 Structure AF2
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure AF2
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure AF2
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure AF2
G.H5 340 V G.H5.07 Structure AF2
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure AF2
G.H5 343 A G.H5.10 Structure AF2
G.H5 344 V G.H5.11 Structure AF2
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure AF2
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure AF2
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure AF2
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 247 from structure (85.5%), 42 from model (14.5%)
Residue sidechains - 212 from structure (73.4%), 77 from model (26.6%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 V - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 V - AF2 AF2
N-term 8 F - AF2 AF2
N-term 9 G - AF2 AF2
N-term 10 T - AF2 AF2
N-term 11 K - AF2 AF2
N-term 12 L - AF2 AF2
N-term 13 T - AF2 AF2
N-term 14 P - AF2 AF2
N-term 15 I - AF2 AF2
N-term 16 N - AF2 AF2
N-term 17 G - AF2 AF2
N-term 18 R - AF2 AF2
N-term 19 E - AF2 AF2
N-term 20 E - AF2 AF2
N-term 21 T - AF2 AF2
N-term 22 P - AF2 AF2
N-term 23 C - AF2 AF2
N-term 24 Y - AF2 AF2
N-term 25 N - AF2 AF2
TM1 26 Q 1.31x31 Structure AF2
TM1 27 T 1.32x32 Structure AF2
TM1 28 L 1.33x33 Structure Structure
TM1 29 S 1.34x34 Structure Structure
TM1 30 F 1.35x35 Structure Structure
TM1 31 T 1.36x36 Structure Structure
TM1 32 V 1.37x37 Structure AF2
TM1 33 L 1.38x38 Structure AF2
TM1 34 T 1.39x39 Structure AF2
TM1 35 C 1.40x40 Structure Structure
TM1 36 I 1.41x41 Structure AF2
TM1 37 I 1.42x42 Structure Structure
TM1 38 S 1.43x43 Structure Structure
TM1 39 L 1.44x44 Structure Structure
TM1 40 V 1.45x45 Structure Structure
TM1 41 G 1.46x46 Structure Structure
TM1 42 L 1.47x47 Structure Structure
TM1 43 T 1.48x48 Structure Structure
TM1 44 G 1.49x49 Structure Structure
TM1 45 N 1.50x50 Structure Structure
TM1 46 A 1.51x51 Structure Structure
TM1 47 V 1.52x52 Structure Structure
TM1 48 V 1.53x53 Structure Structure
TM1 49 L 1.54x54 Structure Structure
TM1 50 W 1.55x55 Structure Structure
TM1 51 L 1.56x56 Structure Structure
TM1 52 L 1.57x57 Structure Structure
TM1 53 G 1.58x58 Structure Structure
TM1 54 Y 1.59x59 Structure AF2
TM1 55 R 1.60x60 Structure AF2
TM1 56 M 1.61x61 Structure AF2
ICL1 57 R - Structure AF2
ICL1 58 R - Structure Structure
TM2 59 N 2.37x37 Structure AF2
TM2 60 A 2.38x38 Structure Structure
TM2 61 V 2.39x39 Structure Structure
TM2 62 S 2.40x40 Structure Structure
TM2 63 I 2.41x41 Structure Structure
TM2 64 Y 2.42x42 Structure Structure
TM2 65 I 2.43x43 Structure Structure
TM2 66 L 2.44x44 Structure Structure
TM2 67 N 2.45x45 Structure Structure
TM2 68 L 2.46x46 Structure Structure
TM2 69 A 2.47x47 Structure Structure
TM2 70 A 2.48x48 Structure Structure
TM2 71 A 2.49x49 Structure Structure
TM2 72 D 2.50x50 Structure Structure
TM2 73 F 2.51x51 Structure Structure
TM2 74 L 2.52x52 Structure Structure
TM2 75 F 2.53x53 Structure Structure
TM2 76 L 2.54x54 Structure Structure
TM2 77 S 2.55x55 Structure Structure
TM2 78 F 2.56x56 Structure Structure
TM2 79 Q 2.57x57 Structure Structure
TM2 80 I 2.58x58 Structure Structure
TM2 81 I 2.59x59 Structure Structure
TM2 82 R 2.60x60 Structure Structure
TM2 83 L 2.61x61 Structure Structure
TM2 84 P 2.62x62 Structure AF2
TM2 85 L 2.63x63 Structure AF2
TM2 86 R 2.64x64 Structure AF2
TM2 87 L 2.65x65 Structure Structure
ECL1 88 I - Structure Structure
ECL1 89 N - Structure AF2
ECL1 90 I - Structure AF2
TM3 91 S 3.21x21 Structure Structure
TM3 92 H 3.22x22 Structure Structure
TM3 93 L 3.23x23 Structure AF2
TM3 94 I 3.24x24 Structure AF2
TM3 95 R 3.25x25 Structure Structure
TM3 96 K 3.26x26 Structure Structure
TM3 97 I 3.27x27 Structure Structure
TM3 98 L 3.28x28 Structure Structure
TM3 99 V 3.29x29 Structure Structure
TM3 100 S 3.30x30 Structure Structure
TM3 101 V 3.31x31 Structure Structure
TM3 102 M 3.32x32 Structure Structure
TM3 103 T 3.33x33 Structure Structure
TM3 104 F 3.34x34 Structure Structure
TM3 105 P 3.35x35 Structure Structure
TM3 106 Y 3.36x36 Structure Structure
TM3 107 F 3.37x37 Structure Structure
TM3 108 T 3.38x38 Structure Structure
TM3 109 G 3.39x39 Structure Structure
TM3 110 L 3.40x40 Structure Structure
TM3 111 S 3.41x41 Structure Structure
TM3 112 M 3.42x42 Structure Structure
TM3 113 L 3.43x43 Structure Structure
TM3 114 S 3.44x44 Structure Structure
TM3 115 A 3.45x45 Structure Structure
TM3 116 I 3.46x46 Structure Structure
TM3 117 S 3.47x47 Structure Structure
TM3 118 T 3.48x48 Structure Structure
TM3 119 E 3.49x49 Structure Structure
TM3 120 R 3.50x50 Structure Structure
TM3 121 C 3.51x51 Structure Structure
TM3 122 L 3.52x52 Structure Structure
TM3 123 S 3.53x53 Structure Structure
TM3 124 V 3.54x54 Structure Structure
TM3 125 L 3.55x55 Structure Structure
TM3 126 W 3.56x56 Structure Structure
ICL2 127 P 34.50x50 Structure Structure
ICL2 128 I 34.51x51 Structure Structure
ICL2 129 W 34.52x52 Structure Structure
ICL2 130 Y 34.53x53 Structure Structure
ICL2 131 R 34.54x54 Structure Structure
ICL2 132 C 34.55x55 Structure Structure
ICL2 133 R 34.56x56 Structure Structure
ICL2 134 R 34.57x57 Structure Structure
ICL2 135 P - Structure Structure
ICL2 136 T - Structure Structure
TM4 137 H 4.40x40 Structure Structure
TM4 138 L 4.41x41 Structure Structure
TM4 139 S 4.42x42 Structure Structure
TM4 140 A 4.43x43 Structure Structure
TM4 141 V 4.44x44 Structure Structure
TM4 142 V 4.45x45 Structure Structure
TM4 143 C 4.46x46 Structure Structure
TM4 144 V 4.47x47 Structure Structure
TM4 145 L 4.48x48 Structure Structure
TM4 146 L 4.49x49 Structure Structure
TM4 147 W 4.50x50 Structure Structure
TM4 148 G 4.51x51 Structure Structure
TM4 149 L 4.52x52 Structure Structure
TM4 150 S 4.53x53 Structure Structure
TM4 151 L 4.54x54 Structure Structure
TM4 152 L 4.55x55 Structure Structure
TM4 153 F 4.56x56 Structure Structure
TM4 154 S 4.57x57 Structure Structure
TM4 155 M 4.58x58 Structure Structure
TM4 156 L 4.59x59 Structure Structure
TM4 157 E 4.60x60 Structure Structure
TM4 158 W 4.61x61 Structure Structure
TM4 159 R 4.62x62 Structure Structure
TM4 160 F 4.63x63 Structure Structure
TM4 161 C 4.64x64 Structure Structure
ECL2 162 D - Structure Structure
ECL2 163 F - Structure Structure
ECL2 164 L - AF2 AF2
ECL2 165 F - AF2 AF2
ECL2 166 S - AF2 AF2
ECL2 167 G - AF2 AF2
ECL2 168 A - AF2 AF2
TM5 169 D 5.32x32 AF2 AF2
TM5 170 S 5.33x33 AF2 AF2
TM5 171 S 5.34x34 AF2 AF2
TM5 172 W 5.35x35 Structure AF2
TM5 173 C 5.36x36 Structure Structure
TM5 174 E 5.37x37 Structure AF2
TM5 175 T 5.38x38 Structure AF2
TM5 176 S 5.39x39 Structure Structure
TM5 177 D 5.40x40 Structure AF2
TM5 178 F 5.41x41 Structure Structure
TM5 179 I 5.42x42 Structure Structure
TM5 180 P 5.43x43 Structure Structure
TM5 181 V 5.44x44 Structure Structure
TM5 182 A 5.45x45 Structure Structure
TM5 183 W 5.46x46 Structure Structure
TM5 184 L 5.47x47 Structure Structure
TM5 185 I 5.48x48 Structure Structure
TM5 186 F 5.49x49 Structure Structure
TM5 187 L 5.50x50 Structure Structure
TM5 188 C 5.51x51 Structure Structure
TM5 189 V 5.52x52 Structure Structure
TM5 190 V 5.53x53 Structure Structure
TM5 191 L 5.54x54 Structure Structure
TM5 192 C 5.55x55 Structure Structure
TM5 193 V 5.56x56 Structure Structure
TM5 194 S 5.57x57 Structure Structure
TM5 195 S 5.58x58 Structure Structure
TM5 196 L 5.59x59 Structure Structure
TM5 197 V 5.60x60 Structure Structure
TM5 198 L 5.61x61 Structure Structure
TM5 199 L 5.62x62 Structure Structure
TM5 200 V 5.63x63 Structure Structure
TM5 201 R 5.64x64 Structure Structure
TM5 202 I 5.65x65 Structure Structure
TM5 203 L 5.66x66 Structure Structure
TM5 204 C 5.67x67 Structure Structure
ICL3 205 G - Structure Structure
ICL3 206 S - Structure Structure
ICL3 207 R - Structure AF2
ICL3 208 K - Structure AF2
ICL3 209 M - Structure AF2
TM6 210 P 6.29x29 Structure AF2
TM6 211 L 6.30x30 Structure Structure
TM6 212 T 6.31x31 Structure Structure
TM6 213 R 6.32x32 Structure Structure
TM6 214 L 6.33x33 Structure Structure
TM6 215 Y 6.34x34 Structure Structure
TM6 216 V 6.35x35 Structure Structure
TM6 217 T 6.36x36 Structure Structure
TM6 218 I 6.37x37 Structure Structure
TM6 219 L 6.38x38 Structure Structure
TM6 220 L 6.39x39 Structure Structure
TM6 221 T 6.40x40 Structure Structure
TM6 222 V 6.41x41 Structure Structure
TM6 223 L 6.42x42 Structure Structure
TM6 224 V 6.43x43 Structure Structure
TM6 225 F 6.44x44 Structure Structure
TM6 226 L 6.45x45 Structure Structure
TM6 227 L 6.46x46 Structure Structure
TM6 228 C 6.47x47 Structure Structure
TM6 229 G 6.48x48 Structure Structure
TM6 230 L 6.49x49 Structure Structure
TM6 231 P 6.50x50 Structure Structure
TM6 232 F 6.51x51 Structure Structure
TM6 233 G 6.52x52 Structure Structure
TM6 234 I 6.53x53 Structure Structure
TM6 235 L 6.54x54 Structure Structure
TM6 236 G 6.55x55 Structure Structure
TM6 237 A 6.56x56 Structure Structure
TM6 238 L 6.57x57 Structure Structure
ECL3 239 I - Structure Structure
ECL3 240 Y - Structure Structure
ECL3 241 R - Structure Structure
ECL3 242 M - Structure AF2
ECL3 243 H - Structure AF2
ECL3 244 L - Structure AF2
ECL3 245 N - Structure AF2
ECL3 246 L - Structure AF2
ECL3 247 E - Structure AF2
TM7 248 V 7.29x28 Structure AF2
TM7 249 L 7.30x29 Structure Structure
TM7 250 Y 7.31x30 Structure Structure
TM7 251 C 7.32x31 Structure Structure
TM7 252 H 7.33x32 Structure Structure
TM7 253 V 7.34x33 Structure Structure
TM7 254 Y 7.35x34 Structure Structure
TM7 255 L 7.36x35 Structure Structure
TM7 256 V 7.37x36 Structure Structure
TM7 257 C 7.38x37 Structure Structure
TM7 258 M 7.39x38 Structure Structure
TM7 259 S 7.40x39 Structure Structure
TM7 260 L 7.41x40 Structure Structure
TM7 261 S 7.42x41 Structure Structure
TM7 262 S 7.43x42 Structure Structure
TM7 263 L 7.44x43 Structure Structure
TM7 264 N 7.45x45 Structure Structure
TM7 265 S 7.46x46 Structure Structure
TM7 266 S 7.47x47 Structure Structure
TM7 267 A 7.48x48 Structure Structure
TM7 268 N 7.49x49 Structure Structure
TM7 269 P 7.50x50 Structure Structure
TM7 270 I 7.51x51 Structure Structure
TM7 271 I 7.52x52 Structure Structure
TM7 272 Y 7.53x53 Structure Structure
TM7 273 F 7.54x54 Structure Structure
TM7 274 F 7.55x55 Structure Structure
TM7 275 V 7.56x56 Structure Structure
TM7 276 G 7.57x57 Structure Structure
TM7 277 S 7.58x58 Structure Structure
TM7 278 F 7.59x59 Structure AF2
TM7 279 R 7.60x60 Structure AF2
C-term 280 Q - Structure Structure
C-term 281 R - AF2 AF2
C-term 282 Q - AF2 AF2
C-term 283 N - AF2 AF2
C-term 284 R - AF2 AF2
C-term 285 Q - AF2 AF2
C-term 286 N - AF2 AF2
C-term 287 L - AF2 AF2
C-term 288 K - AF2 AF2
C-term 289 L - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 128 34x51 G.H5 I 348 G.H5.15
Hydrophobic ICL2 R 131 34x54 G.H5 L 351 G.H5.18
Hydrophobic TM6 L 214 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 214 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL2 I 128 34x51 G.S3 V 199 G.S3.01
Polar ICL2 R 131 34x54 G.H5 N 352 G.H5.19
Van-der-waals ICL2 R 131 34x54 G.H5 N 352 G.H5.19
Hydrophobic TM7 G 276 7x57 G.H5 N 357 G.H5.24
Van-der-waals TM7 G 276 7x57 G.H5 N 357 G.H5.24
Polar TM3 R 120 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 Y 356 G.H5.23
Polar ICL2 R 134 34x57 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 134 34x57 G.hns1 R 37 G.hns1.02
Polar TM7 R 279 7x60 G.H5 N 357 G.H5.24
Hydrophobic TM7 R 279 7x60 G.H5 N 357 G.H5.24
Van-der-waals TM7 R 279 7x60 G.H5 N 357 G.H5.24
Ionic ICL2 R 131 34x54 G.H5 E 355 G.H5.22
Polar ICL2 R 131 34x54 G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 131 34x54 G.H5 E 355 G.H5.22
Hydrophobic ICL2 I 128 34x51 G.H5 F 341 G.H5.08
Polar ICL2 P 127 34x50 G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 127 34x50 G.H5 N 352 G.H5.19
Hydrophobic TM2 V 61 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 V 61 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM3 V 124 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM3 R 120 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM6 R 213 6x32 G.H5 V 359 G.H5.26
Hydrophobic ICL2 P 127 34x50 G.H5 I 348 G.H5.15
Hydrophobic ICL2 P 127 34x50 G.H5 L 349 G.H5.16
Polar ICL2 C 132 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 C 132 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 C 132 34x55 G.hns1 R 37 G.hns1.02
Polar ICL2 R 131 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic C-term L 287 - G.h3s5 Q 265 G.h3s5.01
Van-der-waals C-term L 287 - G.h3s5 Q 265 G.h3s5.01
Polar ICL2 C 132 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 C 132 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 C 132 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 Y 130 34x53 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Y 130 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 P 127 34x50 G.H5 K 345 G.H5.12
Polar TM3 S 123 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 S 123 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 I 128 34x51 G.H5 K 345 G.H5.12
Hydrophobic TM2 N 59 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 N 59 2x37 G.H5 E 355 G.H5.22
Polar ICL2 T 136 - G.hns1 R 37 G.hns1.02
Hydrophobic TM6 P 210 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 P 210 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM6 I 218 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM3 S 123 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 S 123 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM5 I 202 5x65 G.H5 L 353 G.H5.20
Polar TM7 R 279 7x60 G.H5 V 359 G.H5.26
Hydrophobic TM7 R 279 7x60 G.H5 V 359 G.H5.26
Van-der-waals TM7 R 279 7x60 G.H5 V 359 G.H5.26
Hydrophobic TM5 L 198 5x61 G.H5 L 358 G.H5.25