Refined structure (7VUI) of Gs - GPR139

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 234 from structure (59.4%), 160 from model (40.6%)
Residue sidechains - 220 from structure (55.8%), 174 from model (44.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 Structure Structure
G.HN 10 E G.HN.27 Structure Structure
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure AF2
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure Structure
G.H1 62 I G.H1.10 Structure Structure
G.H1 63 L G.H1.11 Structure Structure
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 AF2 AF2
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure Structure
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure AF2
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure AF2
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 Structure Structure
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 AF2 AF2
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure Structure
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure AF2
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure AF2
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure AF2
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure AF2
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure AF2
G.H5 385 R G.H5.17 Structure AF2
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure AF2
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure AF2
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure AF2
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure AF2

REFINED GPCR RESIDUES

Residue backbones - 278 from structure (88.5%), 36 from model (11.5%)
Residue sidechains - 277 from structure (88.2%), 37 from model (11.8%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 H - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 H - AF2 AF2
N-term 6 A - AF2 AF2
N-term 7 H - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 A - AF2 AF2
N-term 10 A - AF2 AF2
N-term 11 N - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 S - AF2 AF2
N-term 14 L - AF2 AF2
N-term 15 S - AF2 AF2
N-term 16 W - AF2 AF2
N-term 17 W - AF2 AF2
N-term 18 S - AF2 AF2
N-term 19 P - AF2 AF2
N-term 20 G - AF2 AF2
N-term 21 S - AF2 AF2
N-term 22 A - AF2 AF2
N-term 23 C - AF2 AF2
N-term 24 G - AF2 AF2
N-term 25 L - AF2 AF2
N-term 26 G - AF2 AF2
TM1 27 F 1.33x33 Structure Structure
TM1 28 V 1.34x34 Structure Structure
TM1 29 P 1.35x35 Structure Structure
TM1 30 V 1.36x36 Structure Structure
TM1 31 V 1.37x37 Structure Structure
TM1 32 Y 1.38x38 Structure Structure
TM1 33 Y 1.39x39 Structure Structure
TM1 34 S 1.40x40 Structure Structure
TM1 35 L 1.41x41 Structure Structure
TM1 36 L 1.42x42 Structure Structure
TM1 37 L 1.43x43 Structure Structure
TM1 38 C 1.44x44 Structure Structure
TM1 39 L 1.45x45 Structure Structure
TM1 40 G 1.46x46 Structure Structure
TM1 41 L 1.47x47 Structure Structure
TM1 42 P 1.48x48 Structure Structure
TM1 43 A 1.49x49 Structure Structure
TM1 44 N 1.50x50 Structure Structure
TM1 45 I 1.51x51 Structure Structure
TM1 46 L 1.52x52 Structure Structure
TM1 47 T 1.53x53 Structure Structure
TM1 48 V 1.54x54 Structure Structure
TM1 49 I 1.55x55 Structure Structure
TM1 50 I 1.56x56 Structure Structure
TM1 51 L 1.57x57 Structure Structure
TM1 52 S 1.58x58 Structure Structure
ICL1 53 Q 12.47x47 Structure Structure
ICL1 54 L 12.48x48 Structure Structure
ICL1 55 V 12.49x49 Structure Structure
ICL1 56 A 12.50x50 Structure Structure
ICL1 57 R 12.51x51 Structure Structure
ICL1 58 R 12.52x52 Structure Structure
ICL1 59 Q 12.53x53 Structure Structure
TM2 60 K 2.37x37 Structure Structure
TM2 61 S 2.38x38 Structure Structure
TM2 62 S 2.39x39 Structure AF2
TM2 63 Y 2.40x40 Structure Structure
TM2 64 N 2.41x41 Structure Structure
TM2 65 Y 2.42x42 Structure Structure
TM2 66 L 2.43x43 Structure Structure
TM2 67 L 2.44x44 Structure Structure
TM2 68 A 2.45x45 Structure Structure
TM2 69 L 2.46x46 Structure Structure
TM2 70 A 2.47x47 Structure Structure
TM2 71 A 2.48x48 Structure Structure
TM2 72 A 2.49x49 Structure Structure
TM2 73 D 2.50x50 Structure Structure
TM2 74 I 2.51x51 Structure Structure
TM2 75 L 2.52x52 Structure Structure
TM2 76 V 2.53x53 Structure Structure
TM2 77 L 2.54x54 Structure Structure
TM2 78 F 2.55x55 Structure Structure
TM2 79 F 2.56x56 Structure Structure
TM2 80 I 2.57x57 Structure Structure
TM2 81 V 2.58x58 Structure Structure
TM2 82 F 2.59x59 Structure Structure
TM2 83 V 2.60x60 Structure Structure
TM2 84 D 2.61x61 Structure Structure
TM2 85 F 2.62x62 Structure Structure
TM2 86 L 2.63x63 Structure Structure
TM2 87 L 2.64x64 Structure Structure
TM2 88 E 2.65x65 Structure Structure
TM2 89 D 2.66x66 Structure Structure
TM2 90 F 2.67x67 Structure Structure
TM2 91 I 2.68x68 Structure Structure
TM2 92 L 2.69x69 Structure Structure
ECL1 93 N - Structure Structure
ECL1 94 M - Structure Structure
ECL1 95 Q - Structure Structure
TM3 96 M 3.20x20 Structure Structure
TM3 97 P 3.21x21 Structure Structure
TM3 98 Q 3.22x22 Structure Structure
TM3 99 V 3.23x23 Structure Structure
TM3 100 P 3.24x24 Structure Structure
TM3 101 D 3.25x25 Structure Structure
TM3 102 K 3.26x26 Structure Structure
TM3 103 I 3.27x27 Structure Structure
TM3 104 I 3.28x28 Structure Structure
TM3 105 E 3.29x29 Structure Structure
TM3 106 V 3.30x30 Structure Structure
TM3 107 L 3.31x31 Structure Structure
TM3 108 E 3.32x32 Structure Structure
TM3 109 F 3.33x33 Structure Structure
TM3 110 S 3.34x34 Structure Structure
TM3 111 S 3.35x35 Structure Structure
TM3 112 I 3.36x36 Structure Structure
TM3 113 H 3.37x37 Structure Structure
TM3 114 T 3.38x38 Structure Structure
TM3 115 S 3.39x39 Structure Structure
TM3 116 I 3.40x40 Structure Structure
TM3 117 W 3.41x41 Structure Structure
TM3 118 I 3.42x42 Structure Structure
TM3 119 T 3.43x43 Structure Structure
TM3 120 V 3.44x44 Structure Structure
TM3 121 P 3.45x45 Structure Structure
TM3 122 L 3.46x46 Structure Structure
TM3 123 T 3.47x47 Structure Structure
TM3 124 I 3.48x48 Structure Structure
TM3 125 D 3.49x49 Structure Structure
TM3 126 R 3.50x50 Structure Structure
TM3 127 Y 3.51x51 Structure Structure
TM3 128 I 3.52x52 Structure Structure
TM3 129 A 3.53x53 Structure Structure
TM3 130 V 3.54x54 Structure Structure
TM3 131 C 3.55x55 Structure Structure
TM3 132 H 3.56x56 Structure Structure
ICL2 133 P 34.50x50 Structure Structure
ICL2 134 L 34.51x51 Structure Structure
ICL2 135 K 34.52x52 Structure Structure
ICL2 136 Y 34.53x53 Structure Structure
ICL2 137 H 34.54x54 Structure Structure
ICL2 138 T 34.55x55 Structure Structure
ICL2 139 V 34.56x56 Structure Structure
ICL2 140 S 34.57x57 Structure Structure
TM4 141 Y 4.38x38 Structure Structure
TM4 142 P 4.39x39 Structure Structure
TM4 143 A 4.40x40 Structure Structure
TM4 144 R 4.41x41 Structure Structure
TM4 145 T 4.42x42 Structure Structure
TM4 146 R 4.43x43 Structure Structure
TM4 147 K 4.44x44 Structure Structure
TM4 148 V 4.45x45 Structure Structure
TM4 149 I 4.46x46 Structure Structure
TM4 150 V 4.47x47 Structure Structure
TM4 151 S 4.48x48 Structure Structure
TM4 152 V 4.49x49 Structure Structure
TM4 153 Y 4.50x50 Structure Structure
TM4 154 I 4.51x51 Structure Structure
TM4 155 T 4.52x52 Structure Structure
TM4 156 C 4.53x53 Structure Structure
TM4 157 F 4.54x54 Structure Structure
TM4 158 L 4.55x55 Structure Structure
TM4 159 T 4.56x56 Structure Structure
TM4 160 S 4.57x57 Structure Structure
TM4 161 I 4.58x59 Structure Structure
TM4 162 P 4.59x60 Structure Structure
TM4 163 Y 4.60x61 Structure Structure
TM4 164 Y 4.61x62 Structure Structure
TM4 165 W 4.62x63 Structure Structure
ECL2 166 W - Structure Structure
ECL2 167 P - Structure Structure
ECL2 168 N - Structure Structure
ECL2 169 I - Structure Structure
ECL2 170 W - Structure Structure
ECL2 171 T - Structure Structure
ECL2 172 E - Structure Structure
ECL2 173 D - Structure Structure
ECL2 174 Y - Structure Structure
ECL2 175 I - Structure Structure
ECL2 176 S - Structure Structure
TM5 177 T 5.32x33 Structure Structure
TM5 178 S 5.33x34 Structure Structure
TM5 179 V 5.34x35 Structure Structure
TM5 180 H 5.35x36 Structure Structure
TM5 181 H 5.36x37 Structure Structure
TM5 182 V 5.37x38 Structure Structure
TM5 183 L 5.38x39 Structure Structure
TM5 184 I 5.39x40 Structure Structure
TM5 185 W 5.40x41 Structure Structure
TM5 186 I 5.41x42 Structure Structure
TM5 187 H 5.42x43 Structure Structure
TM5 188 C 5.43x44 Structure Structure
TM5 189 F 5.44x45 Structure Structure
TM5 190 T 5.45x46 Structure Structure
TM5 191 V 5.46x461 Structure Structure
TM5 192 Y 5.47x47 Structure Structure
TM5 193 L 5.48x48 Structure Structure
TM5 194 V 5.49x49 Structure Structure
TM5 195 P 5.50x50 Structure Structure
TM5 196 C 5.51x51 Structure Structure
TM5 197 S 5.52x52 Structure Structure
TM5 198 I 5.53x53 Structure Structure
TM5 199 F 5.54x54 Structure Structure
TM5 200 F 5.55x55 Structure Structure
TM5 201 I 5.56x56 Structure Structure
TM5 202 L 5.57x57 Structure Structure
TM5 203 N 5.58x58 Structure Structure
TM5 204 S 5.59x59 Structure Structure
TM5 205 I 5.60x60 Structure Structure
TM5 206 I 5.61x61 Structure Structure
TM5 207 V 5.62x62 Structure Structure
TM5 208 Y 5.63x63 Structure Structure
TM5 209 K 5.64x64 Structure Structure
TM5 210 L 5.65x65 Structure Structure
TM5 211 R 5.66x66 Structure Structure
TM5 212 R 5.67x67 Structure Structure
TM5 213 K 5.68x68 Structure Structure
ICL3 214 S - Structure Structure
ICL3 215 N - Structure Structure
ICL3 216 F - Structure Structure
ICL3 217 R - Structure Structure
ICL3 218 L - Structure Structure
ICL3 219 R - Structure Structure
TM6 220 G 6.27x27 Structure Structure
TM6 221 Y 6.28x28 Structure Structure
TM6 222 S 6.29x29 Structure Structure
TM6 223 T 6.30x30 Structure Structure
TM6 224 G 6.31x31 Structure Structure
TM6 225 K 6.32x32 Structure Structure
TM6 226 T 6.33x33 Structure Structure
TM6 227 T 6.34x34 Structure Structure
TM6 228 A 6.35x35 Structure Structure
TM6 229 I 6.36x36 Structure Structure
TM6 230 L 6.37x37 Structure Structure
TM6 231 F 6.38x38 Structure Structure
TM6 232 T 6.39x39 Structure Structure
TM6 233 I 6.40x40 Structure Structure
TM6 234 T 6.41x41 Structure Structure
TM6 235 S 6.42x42 Structure Structure
TM6 236 I 6.43x43 Structure Structure
TM6 237 F 6.44x44 Structure Structure
TM6 238 A 6.45x45 Structure Structure
TM6 239 T 6.46x46 Structure Structure
TM6 240 L 6.47x47 Structure Structure
TM6 241 W 6.48x48 Structure Structure
TM6 242 A 6.49x49 Structure Structure
TM6 243 P 6.50x50 Structure Structure
TM6 244 R 6.51x51 Structure Structure
TM6 245 I 6.52x52 Structure Structure
TM6 246 I 6.53x53 Structure Structure
TM6 247 M 6.54x54 Structure Structure
TM6 248 I 6.55x55 Structure Structure
TM6 249 L 6.56x56 Structure Structure
TM6 250 Y 6.57x57 Structure Structure
TM6 251 H 6.58x58 Structure Structure
TM6 252 L 6.59x59 Structure Structure
TM6 253 Y 6.60x60 Structure Structure
TM6 254 G 6.61x61 Structure Structure
ECL3 255 A - Structure Structure
ECL3 256 P - Structure Structure
ECL3 257 I - Structure Structure
ECL3 258 Q - Structure Structure
TM7 259 N 7.27x26 Structure Structure
TM7 260 R 7.28x27 Structure Structure
TM7 261 W 7.29x28 Structure Structure
TM7 262 L 7.30x29 Structure Structure
TM7 263 V 7.31x30 Structure Structure
TM7 264 H 7.32x31 Structure Structure
TM7 265 I 7.33x32 Structure Structure
TM7 266 M 7.34x33 Structure Structure
TM7 267 S 7.35x34 Structure Structure
TM7 268 D 7.36x35 Structure Structure
TM7 269 I 7.37x36 Structure Structure
TM7 270 A 7.38x37 Structure Structure
TM7 271 N 7.39x38 Structure Structure
TM7 272 M 7.40x39 Structure Structure
TM7 273 L 7.41x40 Structure Structure
TM7 274 A 7.42x41 Structure Structure
TM7 275 L 7.43x42 Structure Structure
TM7 276 L 7.44x43 Structure Structure
TM7 277 N 7.45x45 Structure Structure
TM7 278 T 7.46x46 Structure Structure
TM7 279 A 7.47x47 Structure Structure
TM7 280 I 7.48x48 Structure Structure
TM7 281 N 7.49x49 Structure Structure
TM7 282 F 7.50x50 Structure Structure
TM7 283 F 7.51x51 Structure Structure
TM7 284 L 7.52x52 Structure Structure
TM7 285 Y 7.53x53 Structure Structure
TM7 286 C 7.54x54 Structure Structure
TM7 287 F 7.55x55 Structure Structure
TM7 288 I 7.56x56 Structure Structure
H8 289 S 8.47x47 Structure Structure
H8 290 K 8.48x48 Structure Structure
H8 291 R 8.49x49 Structure Structure
H8 292 F 8.50x50 Structure Structure
H8 293 R 8.51x51 Structure Structure
H8 294 T 8.52x52 Structure Structure
H8 295 M 8.53x53 Structure Structure
H8 296 A 8.54x54 Structure Structure
H8 297 A 8.55x55 Structure Structure
H8 298 A 8.56x56 Structure Structure
H8 299 T 8.57x57 Structure Structure
H8 300 L 8.58x58 Structure Structure
H8 301 K 8.59x59 Structure Structure
H8 302 A 8.60x60 Structure Structure
H8 303 F 8.61x61 Structure Structure
H8 304 F 8.62x62 Structure Structure
C-term 305 K - AF2 AF2
C-term 306 C - AF2 AF2
C-term 307 Q - AF2 AF2
C-term 308 K - AF2 AF2
C-term 309 Q - AF2 AF2
C-term 310 P - AF2 AF2
C-term 311 V - AF2 AF2
C-term 312 Q - AF2 AF2
C-term 313 F - AF2 AF2
C-term 314 Y - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 I 288 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 I 288 7x56 G.H5 E 392 G.H5.24
Polar H8 R 291 8x49 G.H5 Y 391 G.H5.23
Polar ICL2 P 133 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 133 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 133 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM4 A 143 4x40 G.HN Q 31 G.HN.48
Polar ICL2 H 137 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 137 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 137 34x54 G.hns1 R 38 G.hns1.02
Polar H8 R 291 8x49 G.H5 R 389 G.H5.21
Hydrophobic ICL2 K 135 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 134 34x51 G.H5 C 379 G.H5.11
Van-der-waals ICL2 L 134 34x51 G.H5 C 379 G.H5.11
Ionic H8 R 291 8x49 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 134 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM4 Y 141 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 Y 141 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL3 R 219 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 R 219 - G.H5 R 385 G.H5.17
Polar TM3 V 130 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 130 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 134 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 134 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL3 F 216 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 P 133 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 133 34x50 G.H5 Q 384 G.H5.16
Polar TM2 S 62 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM3 R 126 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 126 3x50 G.H5 L 393 G.H5.25
Polar TM3 D 125 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 125 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 125 3x49 G.H5 Y 391 G.H5.23
Van-der-waals ICL3 F 216 - G.S6 C 359 G.S6.01
Aromatic ICL2 Y 136 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 136 34x53 G.H5 H 387 G.H5.19
Polar H8 R 291 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 R 291 8x49 G.H5 Q 390 G.H5.22
Polar H8 K 290 8x48 G.H5 E 392 G.H5.24
Polar TM3 R 126 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 133 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 133 34x50 G.H5 I 383 G.H5.15
Polar ICL2 L 134 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 134 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 134 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM6 L 230 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 230 6x37 G.H5 L 393 G.H5.25
Polar H8 S 289 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 289 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 289 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 V 130 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 130 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM6 K 225 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 225 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM3 V 130 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL3 R 219 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 R 219 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM4 P 142 4x39 G.HN K 34 G.HN.51
Hydrophobic ICL2 L 134 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL3 F 216 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 F 216 - G.H5 R 385 G.H5.17
Polar ICL3 L 218 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 L 218 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM2 K 60 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 K 60 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM6 I 229 6x36 G.H5 L 393 G.H5.25
Polar TM6 T 226 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 226 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 226 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 129 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 133 34x50 G.H5 R 380 G.H5.12
Polar ICL3 R 219 - G.H5 L 394 G.H5.26
Hydrophobic TM4 Y 141 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 Y 141 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 L 218 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 L 218 - G.h4s6 T 350 G.h4s6.03
Aromatic ICL3 F 216 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 F 216 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 F 216 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM2 S 62 2x39 G.H5 Y 391 G.H5.23