Refined structure (7WQ3) of Gi1 - GAL1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 225 from structure (63.6%), 129 from model (36.4%)
Residue sidechains - 221 from structure (62.4%), 133 from model (37.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 289 from structure (87.8%), 40 from model (12.2%)
Residue sidechains - 289 from structure (87.8%), 40 from model (12.2%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 L - AF2 AF2
N-term 4 A - AF2 AF2
N-term 5 V - AF2 AF2
N-term 6 G - AF2 AF2
N-term 7 N - AF2 AF2
N-term 8 L - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 E - AF2 AF2
N-term 11 G - AF2 AF2
N-term 12 N - AF2 AF2
N-term 13 A - AF2 AF2
N-term 14 S - AF2 AF2
N-term 15 W - AF2 AF2
N-term 16 P - AF2 AF2
N-term 17 E - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 P - AF2 AF2
N-term 20 A - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 E - AF2 AF2
N-term 23 P - AF2 AF2
N-term 24 G - AF2 AF2
N-term 25 P - AF2 AF2
N-term 26 L - AF2 AF2
N-term 27 F - AF2 AF2
N-term 28 G - AF2 AF2
N-term 29 I - AF2 AF2
TM1 30 G 1.29x29 AF2 AF2
TM1 31 V 1.30x30 AF2 AF2
TM1 32 E 1.31x31 Structure Structure
TM1 33 N 1.32x32 Structure Structure
TM1 34 F 1.33x33 Structure Structure
TM1 35 V 1.34x34 Structure Structure
TM1 36 T 1.35x35 Structure Structure
TM1 37 L 1.36x36 Structure Structure
TM1 38 V 1.37x37 Structure Structure
TM1 39 V 1.38x38 Structure Structure
TM1 40 F 1.39x39 Structure Structure
TM1 41 G 1.40x40 Structure Structure
TM1 42 L 1.41x41 Structure Structure
TM1 43 I 1.42x42 Structure Structure
TM1 44 F 1.43x43 Structure Structure
TM1 45 A 1.44x44 Structure Structure
TM1 46 L 1.45x45 Structure Structure
TM1 47 G 1.46x46 Structure Structure
TM1 48 V 1.47x47 Structure Structure
TM1 49 L 1.48x48 Structure Structure
TM1 50 G 1.49x49 Structure Structure
TM1 51 N 1.50x50 Structure Structure
TM1 52 S 1.51x51 Structure Structure
TM1 53 L 1.52x52 Structure Structure
TM1 54 V 1.53x53 Structure Structure
TM1 55 I 1.54x54 Structure Structure
TM1 56 T 1.55x55 Structure Structure
TM1 57 V 1.56x56 Structure Structure
TM1 58 L 1.57x57 Structure Structure
TM1 59 A 1.58x58 Structure Structure
TM1 60 R 1.59x59 Structure Structure
TM1 61 S 1.60x60 Structure Structure
ICL1 62 K - Structure Structure
ICL1 63 P - Structure Structure
ICL1 64 G - Structure Structure
ICL1 65 K - Structure Structure
ICL1 66 P - Structure Structure
ICL1 67 R - Structure Structure
TM2 68 S 2.37x37 Structure Structure
TM2 69 T 2.38x38 Structure Structure
TM2 70 T 2.39x39 Structure Structure
TM2 71 N 2.40x40 Structure Structure
TM2 72 L 2.41x41 Structure Structure
TM2 73 F 2.42x42 Structure Structure
TM2 74 I 2.43x43 Structure Structure
TM2 75 L 2.44x44 Structure Structure
TM2 76 N 2.45x45 Structure Structure
TM2 77 L 2.46x46 Structure Structure
TM2 78 S 2.47x47 Structure Structure
TM2 79 I 2.48x48 Structure Structure
TM2 80 A 2.49x49 Structure Structure
TM2 81 D 2.50x50 Structure Structure
TM2 82 L 2.51x51 Structure Structure
TM2 83 A 2.52x52 Structure Structure
TM2 84 Y 2.53x53 Structure Structure
TM2 85 L 2.54x54 Structure Structure
TM2 86 L 2.55x55 Structure Structure
TM2 87 F 2.56x551 Structure Structure
TM2 88 C 2.57x56 Structure Structure
TM2 89 I 2.58x57 Structure Structure
TM2 90 P 2.59x58 Structure Structure
TM2 91 F 2.60x59 Structure Structure
TM2 92 Q 2.61x60 Structure Structure
TM2 93 A 2.62x61 Structure Structure
TM2 94 T 2.63x62 Structure Structure
TM2 95 V 2.64x63 Structure Structure
TM2 96 Y 2.65x64 Structure Structure
TM2 97 A 2.66x65 Structure Structure
TM2 98 L 2.67x66 Structure Structure
ECL1 99 P - Structure Structure
ECL1 100 T 23.49x49 Structure Structure
ECL1 101 W 23.50x50 Structure Structure
ECL1 102 V 23.51x51 Structure Structure
ECL1 103 L 23.52x52 Structure Structure
TM3 104 G 3.21x21 Structure Structure
TM3 105 A 3.22x22 Structure Structure
TM3 106 F 3.23x23 Structure Structure
TM3 107 I 3.24x24 Structure Structure
TM3 108 C 3.25x25 Structure Structure
TM3 109 K 3.26x26 Structure Structure
TM3 110 F 3.27x27 Structure Structure
TM3 111 I 3.28x28 Structure Structure
TM3 112 H 3.29x29 Structure Structure
TM3 113 Y 3.30x30 Structure Structure
TM3 114 F 3.31x31 Structure Structure
TM3 115 F 3.32x32 Structure Structure
TM3 116 T 3.33x33 Structure Structure
TM3 117 V 3.34x34 Structure Structure
TM3 118 S 3.35x35 Structure Structure
TM3 119 M 3.36x36 Structure Structure
TM3 120 L 3.37x37 Structure Structure
TM3 121 V 3.38x38 Structure Structure
TM3 122 S 3.39x39 Structure Structure
TM3 123 I 3.40x40 Structure Structure
TM3 124 F 3.41x41 Structure Structure
TM3 125 T 3.42x42 Structure Structure
TM3 126 L 3.43x43 Structure Structure
TM3 127 A 3.44x44 Structure Structure
TM3 128 A 3.45x45 Structure Structure
TM3 129 M 3.46x46 Structure Structure
TM3 130 S 3.47x47 Structure Structure
TM3 131 V 3.48x48 Structure Structure
TM3 132 D 3.49x49 Structure Structure
TM3 133 R 3.50x50 Structure Structure
TM3 134 Y 3.51x51 Structure Structure
TM3 135 V 3.52x52 Structure Structure
TM3 136 A 3.53x53 Structure Structure
TM3 137 I 3.54x54 Structure Structure
TM3 138 V 3.55x55 Structure Structure
TM3 139 H 3.56x56 Structure Structure
ICL2 140 S 34.50x50 Structure Structure
ICL2 141 R 34.51x51 Structure Structure
ICL2 142 R 34.52x52 Structure Structure
ICL2 143 S 34.53x53 Structure Structure
ICL2 144 S 34.54x54 Structure Structure
ICL2 145 S 34.55x55 Structure Structure
ICL2 146 L 34.56x56 Structure Structure
ICL2 147 R 34.57x57 Structure Structure
TM4 148 V 4.38x38 Structure Structure
TM4 149 S 4.39x39 Structure Structure
TM4 150 R 4.40x40 Structure Structure
TM4 151 N 4.41x41 Structure Structure
TM4 152 A 4.42x42 Structure Structure
TM4 153 L 4.43x43 Structure Structure
TM4 154 L 4.44x44 Structure Structure
TM4 155 G 4.45x45 Structure Structure
TM4 156 V 4.46x46 Structure Structure
TM4 157 G 4.47x47 Structure Structure
TM4 158 C 4.48x48 Structure Structure
TM4 159 I 4.49x49 Structure Structure
TM4 160 W 4.50x50 Structure Structure
TM4 161 A 4.51x51 Structure Structure
TM4 162 L 4.52x52 Structure Structure
TM4 163 S 4.53x53 Structure Structure
TM4 164 I 4.54x54 Structure Structure
TM4 165 A 4.55x55 Structure Structure
TM4 166 M 4.56x56 Structure Structure
TM4 167 A 4.57x57 Structure Structure
TM4 168 S 4.58x59 Structure Structure
TM4 169 P 4.59x60 Structure Structure
TM4 170 V 4.60x61 Structure Structure
TM4 171 A 4.61x62 Structure Structure
TM4 172 Y 4.62x63 Structure Structure
TM4 173 H 4.63x64 Structure Structure
TM4 174 Q 4.64x65 Structure Structure
ECL2 175 G - Structure Structure
ECL2 176 L - Structure Structure
ECL2 177 F - Structure Structure
ECL2 178 H - Structure Structure
ECL2 179 P - Structure Structure
ECL2 180 R - Structure Structure
ECL2 181 A - Structure Structure
ECL2 182 S - Structure Structure
ECL2 183 N - Structure Structure
ECL2 184 Q - Structure Structure
ECL2 185 T - Structure Structure
ECL2 186 F - Structure Structure
ECL2 187 C 45.50x50 Structure Structure
ECL2 188 W 45.51x51 Structure Structure
ECL2 189 E 45.52x52 Structure Structure
ECL2 190 Q - Structure Structure
ECL2 191 W - Structure Structure
ECL2 192 P - Structure Structure
TM5 193 D 5.31x32 Structure Structure
TM5 194 P 5.32x33 Structure Structure
TM5 195 R 5.33x34 Structure Structure
TM5 196 H 5.34x35 Structure Structure
TM5 197 K 5.35x36 Structure Structure
TM5 198 K 5.36x37 Structure Structure
TM5 199 A 5.37x38 Structure Structure
TM5 200 Y 5.38x39 Structure Structure
TM5 201 V 5.39x40 Structure Structure
TM5 202 V 5.40x41 Structure Structure
TM5 203 C 5.41x42 Structure Structure
TM5 204 T 5.42x43 Structure Structure
TM5 205 F 5.43x44 Structure Structure
TM5 206 V 5.44x45 Structure Structure
TM5 207 F 5.45x46 Structure Structure
TM5 208 G 5.46x461 Structure Structure
TM5 209 Y 5.47x47 Structure Structure
TM5 210 L 5.48x48 Structure Structure
TM5 211 L 5.49x49 Structure Structure
TM5 212 P 5.50x50 Structure Structure
TM5 213 L 5.51x51 Structure Structure
TM5 214 L 5.52x52 Structure Structure
TM5 215 L 5.53x53 Structure Structure
TM5 216 I 5.54x54 Structure Structure
TM5 217 C 5.55x55 Structure Structure
TM5 218 F 5.56x56 Structure Structure
TM5 219 C 5.57x57 Structure Structure
TM5 220 Y 5.58x58 Structure Structure
TM5 221 A 5.59x59 Structure Structure
TM5 222 K 5.60x60 Structure Structure
TM5 223 V 5.61x61 Structure Structure
TM5 224 L 5.62x62 Structure Structure
TM5 225 N 5.63x63 Structure Structure
TM5 226 H 5.64x64 Structure Structure
TM5 227 L 5.65x65 Structure Structure
TM5 228 H 5.66x66 Structure Structure
TM5 229 K 5.67x67 Structure Structure
TM5 230 K 5.68x68 Structure Structure
TM5 231 L 5.69x69 Structure Structure
ICL3 232 K - Structure Structure
ICL3 233 N - Structure Structure
ICL3 234 M - Structure Structure
TM6 235 S 6.23x23 Structure Structure
TM6 236 K 6.24x24 Structure Structure
TM6 237 K 6.25x25 Structure Structure
TM6 238 S 6.26x26 Structure Structure
TM6 239 E 6.27x27 Structure Structure
TM6 240 A 6.28x28 Structure Structure
TM6 241 S 6.29x29 Structure Structure
TM6 242 K 6.30x30 Structure Structure
TM6 243 K 6.31x31 Structure Structure
TM6 244 K 6.32x32 Structure Structure
TM6 245 T 6.33x33 Structure Structure
TM6 246 A 6.34x34 Structure Structure
TM6 247 Q 6.35x35 Structure Structure
TM6 248 T 6.36x36 Structure Structure
TM6 249 V 6.37x37 Structure Structure
TM6 250 L 6.38x38 Structure Structure
TM6 251 V 6.39x39 Structure Structure
TM6 252 V 6.40x40 Structure Structure
TM6 253 V 6.41x41 Structure Structure
TM6 254 V 6.42x42 Structure Structure
TM6 255 V 6.43x43 Structure Structure
TM6 256 F 6.44x44 Structure Structure
TM6 257 G 6.45x45 Structure Structure
TM6 258 I 6.46x46 Structure Structure
TM6 259 S 6.47x47 Structure Structure
TM6 260 W 6.48x48 Structure Structure
TM6 261 L 6.49x49 Structure Structure
TM6 262 P 6.50x50 Structure Structure
TM6 263 H 6.51x51 Structure Structure
TM6 264 H 6.52x52 Structure Structure
TM6 265 I 6.53x53 Structure Structure
TM6 266 I 6.54x54 Structure Structure
TM6 267 H 6.55x55 Structure Structure
TM6 268 L 6.56x56 Structure Structure
TM6 269 W 6.57x57 Structure Structure
TM6 270 A 6.58x58 Structure Structure
TM6 271 E 6.59x59 Structure Structure
TM6 272 F 6.60x60 Structure Structure
TM6 273 G 6.61x61 Structure Structure
ECL3 274 V - Structure Structure
ECL3 275 F - Structure Structure
ECL3 276 P - Structure Structure
ECL3 277 L - Structure Structure
TM7 278 T 7.28x27 Structure Structure
TM7 279 P 7.29x28 Structure Structure
TM7 280 A 7.30x29 Structure Structure
TM7 281 S 7.31x30 Structure Structure
TM7 282 F 7.32x31 Structure Structure
TM7 283 L 7.33x32 Structure Structure
TM7 284 F 7.34x33 Structure Structure
TM7 285 R 7.35x34 Structure Structure
TM7 286 I 7.36x35 Structure Structure
TM7 287 T 7.37x36 Structure Structure
TM7 288 A 7.38x37 Structure Structure
TM7 289 H 7.39x38 Structure Structure
TM7 290 C 7.40x39 Structure Structure
TM7 291 L 7.41x40 Structure Structure
TM7 292 A 7.42x41 Structure Structure
TM7 293 Y 7.43x42 Structure Structure
TM7 294 S 7.44x43 Structure Structure
TM7 295 N 7.45x45 Structure Structure
TM7 296 S 7.46x46 Structure Structure
TM7 297 S 7.47x47 Structure Structure
TM7 298 V 7.48x48 Structure Structure
TM7 299 N 7.49x49 Structure Structure
TM7 300 P 7.50x50 Structure Structure
TM7 301 I 7.51x51 Structure Structure
TM7 302 I 7.52x52 Structure Structure
TM7 303 Y 7.53x53 Structure Structure
TM7 304 A 7.54x54 Structure Structure
TM7 305 F 7.55x55 Structure Structure
TM7 306 L 7.56x56 Structure Structure
H8 307 S 8.47x47 Structure Structure
H8 308 E 8.48x48 Structure Structure
H8 309 N 8.49x49 Structure Structure
H8 310 F 8.50x50 Structure Structure
H8 311 R 8.51x51 Structure Structure
H8 312 K 8.52x52 Structure Structure
H8 313 A 8.53x53 Structure Structure
H8 314 Y 8.54x54 Structure Structure
H8 315 K 8.55x55 Structure Structure
H8 316 Q 8.56x56 Structure Structure
H8 317 V 8.57x57 Structure Structure
H8 318 F 8.58x58 Structure Structure
H8 319 K 8.59x59 Structure Structure
C-term 320 C - Structure Structure
C-term 321 H - AF2 AF2
C-term 322 I - AF2 AF2
C-term 323 R - AF2 AF2
C-term 324 K - AF2 AF2
C-term 325 D - AF2 AF2
C-term 326 S - AF2 AF2
C-term 327 H - AF2 AF2
C-term 328 L - AF2 AF2
C-term 329 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 137 3x54 G.H5 L 353 G.H5.25
Polar TM6 T 248 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 136 3x53 G.H5 C 351 G.H5.23
Hydrophobic H8 E 308 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 308 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 133 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 133 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 227 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 227 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 231 5x69 G.H5 I 344 G.H5.16
Polar H8 N 309 8x49 G.H5 K 349 G.H5.21
Hydrophobic TM5 V 223 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 S 140 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 K 230 5x68 G.H5 I 344 G.H5.16
Van-der-waals H8 N 309 8x49 G.H5 D 350 G.H5.22
Polar ICL2 R 141 34x51 G.s2s3 K 192 G.s2s3.01
Polar TM6 K 236 6x24 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 K 236 6x24 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 K 236 6x24 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 K 237 6x25 G.h4s6 K 317 G.h4s6.11
Polar TM6 T 248 6x36 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 137 3x54 G.H5 N 347 G.H5.19
Polar ICL3 N 233 - G.H5 D 341 G.H5.13
Hydrophobic TM6 K 237 6x25 G.H5 K 345 G.H5.17
Hydrophobic ICL2 S 140 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 L 231 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 231 5x69 G.H5 D 341 G.H5.13
Polar TM6 K 237 6x25 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 K 237 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 S 307 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 307 8x47 G.H5 G 352 G.H5.24
Aromatic TM6 K 244 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 244 6x32 G.H5 F 354 G.H5.26
Polar ICL2 S 140 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 S 140 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 S 140 34x50 G.H5 N 347 G.H5.19
Van-der-waals TM6 K 236 6x24 G.h4s6 D 315 G.h4s6.09
Polar TM3 R 133 3x50 G.H5 C 351 G.H5.23
Polar TM6 T 245 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 245 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 245 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 241 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 S 241 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 137 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 137 3x54 G.H5 L 348 G.H5.20
Polar ICL2 S 143 34x53 G.H5 N 347 G.H5.19
Polar TM6 S 235 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 235 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 235 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 L 227 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 231 5x69 G.H5 L 348 G.H5.20
Hydrophobic ICL2 R 141 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 R 141 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM2 T 70 2x39 G.H5 C 351 G.H5.23