Refined structure (7WVU) of Gi1 - FPR1

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.6%), 136 from model (38.4%)
Residue sidechains - 201 from structure (56.8%), 153 from model (43.2%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure AF2
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure AF2
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure AF2
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure AF2
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure AF2
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure AF2
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 296 from structure (90.8%), 30 from model (9.2%)
Residue sidechains - 279 from structure (85.6%), 47 from model (14.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 E - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 N - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 L - AF2 AF2
N-term 8 P - AF2 AF2
N-term 9 T - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 I - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 G - AF2 AF2
N-term 14 G - AF2 AF2
N-term 15 T - AF2 AF2
N-term 16 P - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 V - AF2 AF2
TM1 19 S 1.25x25 AF2 AF2
TM1 20 A 1.26x26 AF2 AF2
TM1 21 G 1.27x27 Structure Structure
TM1 22 Y 1.28x28 Structure Structure
TM1 23 L 1.29x29 Structure Structure
TM1 24 F 1.30x30 Structure Structure
TM1 25 L 1.31x31 Structure Structure
TM1 26 D 1.32x32 Structure Structure
TM1 27 I 1.33x33 Structure Structure
TM1 28 I 1.34x34 Structure Structure
TM1 29 T 1.35x35 Structure Structure
TM1 30 Y 1.36x36 Structure Structure
TM1 31 L 1.37x37 Structure Structure
TM1 32 V 1.38x38 Structure Structure
TM1 33 F 1.39x39 Structure Structure
TM1 34 A 1.40x40 Structure Structure
TM1 35 V 1.41x41 Structure Structure
TM1 36 T 1.42x42 Structure Structure
TM1 37 F 1.43x43 Structure Structure
TM1 38 V 1.44x44 Structure Structure
TM1 39 L 1.45x45 Structure Structure
TM1 40 G 1.46x46 Structure Structure
TM1 41 V 1.47x47 Structure Structure
TM1 42 L 1.48x48 Structure AF2
TM1 43 G 1.49x49 Structure Structure
TM1 44 N 1.50x50 Structure Structure
TM1 45 G 1.51x51 Structure Structure
TM1 46 L 1.52x52 Structure Structure
TM1 47 V 1.53x53 Structure Structure
TM1 48 I 1.54x54 Structure Structure
TM1 49 W 1.55x55 Structure Structure
TM1 50 V 1.56x56 Structure Structure
TM1 51 A 1.57x57 Structure Structure
TM1 52 G 1.58x58 Structure Structure
TM1 53 F 1.59x59 Structure Structure
TM1 54 R 1.60x60 Structure Structure
TM1 55 M 1.61x61 Structure Structure
ICL1 56 T - Structure Structure
ICL1 57 H - Structure Structure
TM2 58 T 2.37x37 Structure Structure
TM2 59 V 2.38x38 Structure Structure
TM2 60 T 2.39x39 Structure Structure
TM2 61 T 2.40x40 Structure Structure
TM2 62 I 2.41x41 Structure Structure
TM2 63 S 2.42x42 Structure Structure
TM2 64 Y 2.43x43 Structure Structure
TM2 65 L 2.44x44 Structure Structure
TM2 66 N 2.45x45 Structure Structure
TM2 67 L 2.46x46 Structure Structure
TM2 68 A 2.47x47 Structure Structure
TM2 69 V 2.48x48 Structure Structure
TM2 70 A 2.49x49 Structure Structure
TM2 71 D 2.50x50 Structure Structure
TM2 72 F 2.51x51 Structure Structure
TM2 73 C 2.52x52 Structure Structure
TM2 74 F 2.53x53 Structure Structure
TM2 75 T 2.54x54 Structure Structure
TM2 76 S 2.55x55 Structure Structure
TM2 77 T 2.56x56 Structure Structure
TM2 78 L 2.57x57 Structure Structure
TM2 79 P 2.58x58 Structure Structure
TM2 80 F 2.59x59 Structure Structure
TM2 81 F 2.60x60 Structure Structure
TM2 82 M 2.61x61 Structure Structure
TM2 83 V 2.62x62 Structure Structure
TM2 84 R 2.63x63 Structure Structure
TM2 85 K 2.64x64 Structure Structure
TM2 86 A 2.65x65 Structure Structure
TM2 87 M 2.66x66 Structure Structure
TM2 88 G 2.67x67 Structure Structure
ECL1 89 G - Structure Structure
ECL1 90 H 23.49x49 Structure Structure
ECL1 91 W 23.50x50 Structure Structure
ECL1 92 P 23.51x51 Structure Structure
ECL1 93 F 23.52x52 Structure Structure
TM3 94 G 3.21x21 Structure Structure
TM3 95 W 3.22x22 Structure Structure
TM3 96 F 3.23x23 Structure Structure
TM3 97 L 3.24x24 Structure Structure
TM3 98 C 3.25x25 Structure Structure
TM3 99 K 3.26x26 Structure Structure
TM3 100 F 3.27x27 Structure Structure
TM3 101 V 3.28x28 Structure Structure
TM3 102 F 3.29x29 Structure Structure
TM3 103 T 3.30x30 Structure Structure
TM3 104 I 3.31x31 Structure Structure
TM3 105 V 3.32x32 Structure Structure
TM3 106 D 3.33x33 Structure Structure
TM3 107 I 3.34x34 Structure Structure
TM3 108 N 3.35x35 Structure Structure
TM3 109 L 3.36x36 Structure Structure
TM3 110 F 3.37x37 Structure Structure
TM3 111 G 3.38x38 Structure Structure
TM3 112 S 3.39x39 Structure Structure
TM3 113 V 3.40x40 Structure Structure
TM3 114 F 3.41x41 Structure Structure
TM3 115 L 3.42x42 Structure Structure
TM3 116 I 3.43x43 Structure Structure
TM3 117 A 3.44x44 Structure Structure
TM3 118 L 3.45x45 Structure Structure
TM3 119 I 3.46x46 Structure Structure
TM3 120 A 3.47x47 Structure Structure
TM3 121 L 3.48x48 Structure Structure
TM3 122 D 3.49x49 Structure Structure
TM3 123 R 3.50x50 Structure Structure
TM3 124 C 3.51x51 Structure Structure
TM3 125 V 3.52x52 Structure Structure
TM3 126 C 3.53x53 Structure Structure
TM3 127 V 3.54x54 Structure Structure
TM3 128 L 3.55x55 Structure Structure
TM3 129 H 3.56x56 Structure Structure
ICL2 130 P 34.50x50 Structure Structure
ICL2 131 V 34.51x51 Structure Structure
ICL2 132 W 34.52x52 Structure Structure
ICL2 133 T 34.53x53 Structure Structure
ICL2 134 Q 34.54x54 Structure Structure
ICL2 135 N 34.55x55 Structure Structure
ICL2 136 H 34.56x56 Structure Structure
ICL2 137 R 34.57x57 Structure Structure
TM4 138 T 4.38x38 Structure Structure
TM4 139 V 4.39x39 Structure Structure
TM4 140 S 4.40x40 Structure Structure
TM4 141 L 4.41x41 Structure Structure
TM4 142 A 4.42x42 Structure Structure
TM4 143 K 4.43x43 Structure Structure
TM4 144 K 4.44x44 Structure Structure
TM4 145 V 4.45x45 Structure Structure
TM4 146 I 4.46x46 Structure Structure
TM4 147 I 4.47x47 Structure Structure
TM4 148 G 4.48x48 Structure Structure
TM4 149 P 4.49x49 Structure Structure
TM4 150 W 4.50x50 Structure Structure
TM4 151 V 4.51x51 Structure Structure
TM4 152 M 4.52x52 Structure Structure
TM4 153 A 4.53x53 Structure Structure
TM4 154 L 4.54x54 Structure Structure
TM4 155 L 4.55x55 Structure Structure
TM4 156 L 4.56x56 Structure Structure
TM4 157 T 4.57x57 Structure Structure
TM4 158 L 4.58x59 Structure Structure
TM4 159 P 4.59x60 Structure Structure
TM4 160 V 4.60x61 Structure Structure
TM4 161 I 4.61x62 Structure Structure
TM4 162 I 4.62x63 Structure Structure
TM4 163 R 4.63x64 Structure Structure
TM4 164 V 4.64x65 Structure Structure
ECL2 165 T - Structure AF2
ECL2 166 T - Structure Structure
ECL2 167 V - Structure Structure
ECL2 168 P - Structure Structure
ECL2 169 G - Structure Structure
ECL2 170 K - Structure AF2
ECL2 171 T - Structure Structure
ECL2 172 G - Structure Structure
ECL2 173 T - Structure AF2
ECL2 174 V - Structure Structure
ECL2 175 A - Structure Structure
ECL2 176 C 45.50x50 Structure Structure
ECL2 177 T 45.51x51 Structure Structure
ECL2 178 F 45.52x52 Structure Structure
ECL2 179 N - Structure Structure
ECL2 180 F - Structure AF2
ECL2 181 S - Structure Structure
ECL2 182 P - Structure Structure
ECL2 183 W - Structure Structure
ECL2 184 T - Structure Structure
ECL2 185 N - Structure AF2
TM5 186 D 5.23x24 Structure Structure
TM5 187 P 5.24x25 Structure Structure
TM5 188 K 5.25x26 Structure AF2
TM5 189 E 5.26x27 Structure AF2
TM5 190 R 5.27x28 Structure Structure
TM5 191 I 5.28x29 Structure Structure
TM5 192 N 5.29x30 Structure Structure
TM5 193 V 5.30x31 Structure Structure
TM5 194 A 5.31x32 Structure Structure
TM5 195 V 5.32x33 Structure Structure
TM5 196 A 5.33x34 Structure Structure
TM5 197 M 5.34x35 Structure Structure
TM5 198 L 5.35x36 Structure Structure
TM5 199 T 5.36x37 Structure Structure
TM5 200 V 5.37x38 Structure Structure
TM5 201 R 5.38x39 Structure Structure
TM5 202 G 5.39x40 Structure Structure
TM5 203 I 5.40x41 Structure Structure
TM5 204 I 5.41x42 Structure Structure
TM5 205 R 5.42x43 Structure Structure
TM5 206 F 5.43x44 Structure Structure
TM5 207 I 5.44x45 Structure Structure
TM5 208 I 5.45x46 Structure Structure
TM5 209 G 5.46x461 Structure Structure
TM5 210 F 5.47x47 Structure Structure
TM5 211 S 5.48x48 Structure Structure
TM5 212 A 5.49x49 Structure Structure
TM5 213 P 5.50x50 Structure Structure
TM5 214 M 5.51x51 Structure AF2
TM5 215 S 5.52x52 Structure Structure
TM5 216 I 5.53x53 Structure Structure
TM5 217 V 5.54x54 Structure Structure
TM5 218 A 5.55x55 Structure Structure
TM5 219 V 5.56x56 Structure Structure
TM5 220 S 5.57x57 Structure Structure
TM5 221 Y 5.58x58 Structure Structure
TM5 222 G 5.59x59 Structure Structure
TM5 223 L 5.60x60 Structure Structure
TM5 224 I 5.61x61 Structure Structure
TM5 225 A 5.62x62 Structure Structure
TM5 226 T 5.63x63 Structure Structure
TM5 227 K 5.64x64 Structure Structure
TM5 228 I 5.65x65 Structure Structure
TM5 229 H 5.66x66 Structure Structure
TM5 230 K 5.67x67 Structure Structure
TM5 231 Q 5.68x68 Structure Structure
TM5 232 G 5.69x69 Structure Structure
ICL3 233 L - Structure Structure
ICL3 234 I - Structure AF2
ICL3 235 K - Structure AF2
ICL3 236 S - Structure Structure
TM6 237 S 6.31x31 Structure Structure
TM6 238 R 6.32x32 Structure Structure
TM6 239 P 6.33x33 Structure Structure
TM6 240 L 6.34x34 Structure Structure
TM6 241 R 6.35x35 Structure Structure
TM6 242 V 6.36x36 Structure Structure
TM6 243 L 6.37x37 Structure AF2
TM6 244 S 6.38x38 Structure Structure
TM6 245 F 6.39x39 Structure Structure
TM6 246 V 6.40x40 Structure Structure
TM6 247 A 6.41x41 Structure Structure
TM6 248 A 6.42x42 Structure Structure
TM6 249 A 6.43x43 Structure Structure
TM6 250 F 6.44x44 Structure Structure
TM6 251 F 6.45x45 Structure Structure
TM6 252 L 6.46x46 Structure Structure
TM6 253 C 6.47x47 Structure Structure
TM6 254 W 6.48x48 Structure Structure
TM6 255 S 6.49x49 Structure Structure
TM6 256 P 6.50x50 Structure Structure
TM6 257 Y 6.51x51 Structure Structure
TM6 258 Q 6.52x52 Structure Structure
TM6 259 V 6.53x53 Structure Structure
TM6 260 V 6.54x54 Structure Structure
TM6 261 A 6.55x55 Structure Structure
TM6 262 L 6.56x56 Structure Structure
TM6 263 I 6.57x57 Structure Structure
TM6 264 A 6.58x58 Structure Structure
TM6 265 T 6.59x59 Structure Structure
TM6 266 V 6.60x60 Structure Structure
TM6 267 R 6.61x61 Structure Structure
ECL3 268 I - Structure Structure
ECL3 269 R - Structure Structure
ECL3 270 E - Structure Structure
ECL3 271 L - Structure Structure
ECL3 272 L - Structure Structure
ECL3 273 Q - Structure Structure
ECL3 274 G - Structure Structure
ECL3 275 M - Structure Structure
TM7 276 Y 7.28x27 Structure Structure
TM7 277 K 7.29x28 Structure AF2
TM7 278 E 7.30x29 Structure AF2
TM7 279 I 7.31x30 Structure Structure
TM7 280 G 7.32x31 Structure Structure
TM7 281 I 7.33x32 Structure Structure
TM7 282 A 7.34x33 Structure Structure
TM7 283 V 7.35x34 Structure Structure
TM7 284 D 7.36x35 Structure Structure
TM7 285 V 7.37x36 Structure Structure
TM7 286 T 7.38x37 Structure Structure
TM7 287 S 7.39x38 Structure Structure
TM7 288 A 7.40x39 Structure Structure
TM7 289 L 7.41x40 Structure Structure
TM7 290 A 7.42x41 Structure Structure
TM7 291 F 7.43x42 Structure Structure
TM7 292 F 7.44x43 Structure Structure
TM7 293 N 7.45x45 Structure Structure
TM7 294 S 7.46x46 Structure Structure
TM7 295 C 7.47x47 Structure Structure
TM7 296 L 7.48x48 Structure Structure
TM7 297 N 7.49x49 Structure Structure
TM7 298 P 7.50x50 Structure Structure
TM7 299 M 7.51x51 Structure AF2
TM7 300 L 7.52x52 Structure Structure
TM7 301 Y 7.53x53 Structure Structure
TM7 302 V 7.54x54 Structure Structure
TM7 303 F 7.55x55 Structure Structure
TM7 304 M 7.56x56 Structure Structure
H8 305 G 8.47x47 Structure Structure
H8 306 Q 8.48x48 Structure AF2
H8 307 D 8.49x49 Structure AF2
H8 308 F 8.50x50 Structure Structure
H8 309 R 8.51x51 Structure Structure
H8 310 E 8.52x52 Structure Structure
H8 311 R 8.53x53 Structure Structure
H8 312 L 8.54x54 Structure Structure
H8 313 I 8.55x55 Structure Structure
H8 314 H 8.56x56 Structure Structure
H8 315 A 8.57x57 Structure Structure
H8 316 L 8.58x58 Structure Structure
C-term 317 P - AF2 AF2
C-term 318 A - AF2 AF2
C-term 319 S - AF2 AF2
C-term 320 L - AF2 AF2
C-term 321 E - AF2 AF2
C-term 322 R - AF2 AF2
C-term 323 A - AF2 AF2
C-term 324 L - AF2 AF2
C-term 325 T - AF2 AF2
C-term 326 E - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 Y 64 2x43 G.H5 C 351 G.H5.23
Van-der-waals TM2 Y 64 2x43 G.H5 C 351 G.H5.23
Hydrophobic TM6 P 239 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 242 6x36 G.H5 L 353 G.H5.25
Polar ICL2 N 135 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 135 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL3 K 235 - G.h4s6 K 317 G.h4s6.11
Polar TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 123 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 243 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 243 6x37 G.H5 L 353 G.H5.25
Polar ICL2 Q 134 34x54 G.hns1 R 32 G.hns1.03
Polar TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 134 34x54 G.H5 I 343 G.H5.15
Ionic ICL2 R 137 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 137 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 V 131 34x51 G.S3 L 194 G.S3.01
Ionic ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 235 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 Q 134 34x54 G.hns1 A 31 G.hns1.02
Polar ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 135 34x55 G.hns1 R 32 G.hns1.03
Polar TM4 T 138 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 T 138 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 138 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 V 131 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 131 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 K 235 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 K 235 - G.H5 K 345 G.H5.17
Hydrophobic TM3 V 127 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 T 133 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 T 133 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 126 3x53 G.H5 I 344 G.H5.16
Van-der-waals TM3 C 126 3x53 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 V 131 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 V 131 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 130 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 130 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM5 I 228 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 233 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 L 233 - G.H5 D 341 G.H5.13
Hydrophobic TM3 V 127 3x54 G.H5 L 348 G.H5.20
Polar TM4 S 140 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 S 140 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 S 140 4x40 G.HN E 28 G.HN.52
Hydrophobic ICL3 L 233 - G.H5 I 344 G.H5.16
Polar TM2 T 60 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 60 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 60 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 Q 134 34x54 G.S3 L 194 G.S3.01
Hydrophobic TM6 P 239 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 239 6x33 G.H5 L 353 G.H5.25
Polar TM6 R 238 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 238 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 238 6x32 G.H5 F 354 G.H5.26
Polar ICL3 K 235 - G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 K 235 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 K 235 - G.h4s6 D 315 G.h4s6.09